Claims
- 1. An aromatic heterocyclic compound having the formula ##STR23## wherein R.sub.1 represents ##STR24## R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms, mono or polyhydroxyalkyl, or R.sub.3 represents ##STR25## wherein r' and r" represent hydrogen, or lower alkyl, or r' and r" together with the nitrogen atom to which they are attached form pyrrolidino,
- R.sub.2 represents hydrogen or --CH.sub.3,
- Ar represents ##STR26## Y represents a nitrogen atom, and X represents sulfur.
- 2. The compound of claim 1 wherein said lower alkyl has 1-6 carbon atoms.
- 3. The compound of claim 2 wherein said lower alkyl is methyl, ethyl, isopropyl, butyl or t.butyl.
- 4. The compound of claim 1 wherein said monohydroxyalkyl has 2-3 carbon atoms and is selected from the group consisting of 2-hydroxyethyl and 2-hydroxypropyl and wherein said polyhydroxyalkyl is derived from glycerol, pentaerythritol or mannitol.
- 5. The compound of claim 1 having the formula ##STR27## wherein R.sub.1 represents ##STR28## R.sub.3 represents OR.sub.4 or ##STR29## R.sub.4 represents hydrogen, --CH.sub.3 or --CH.sub.2 CH.sub.2 OH, r' and r" each independently represent hydrogen, lower alkyl or together with the nitrogen atom to which they are attached form a morpholino ring,
- Y represents a nitrogen atom, and
- X represents sulfur.
- 6. The compound of claim 1 selected from the group consisting of:
- methyl 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-6-benzothiazole carboxylate, and
- 2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-6-benzothiazole carboxylic acid.
- 7. A pharmaceutical composition for enteral, parenteral, topical or ocular administration comprising in a pharmaceutically acceptable carrier an effective amount of the compound of claim 1.
- 8. The composition of claim 7 for topical application wherein said compound is present in an amount ranging from 0.0005 to about 5 percent by weight, based on the total weight of said composition.
- 9. A cosmetic composition for hair and body hygiene comprising in a cosmetically acceptable carrier an effective amount of the compound of claim 1.
- 10. The composition of claim 9 wherein said compound is present in an amount ranging from 0.0005 to 2 percent by weight, based on the total weight of said composition.
- 11. The composition of claim 9 wherein said compound is present in an amount ranging from 0.01 to 1 percent by weight, based on the total weight of said composition.
- 12. A composition for the treatment of dermatologic ailments linked to a keratinization disorder comprising in a pharmaceutically acceptable carrier the compound of claim 1 in an amount effective to treat said disorder.
- 13. An aromatic heterocyclic compound having the formula ##STR30## wherein: R.sub.1 represents ##STR31## R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms, mono or polyhydroxyalkyl, or R.sub.3 represents ##STR32## wherein r' and r" represent hydrogen, or lower alkyl, or r' and r" together with the nitrogen atom to which they are attached form a heterocycle, selected from the group consisting of piperidino, piperazino, morpholino, pyrrolidino,
- R.sup.2 represents hydrogen or --CH.sub.3,
- Ar represents an aromatic radical having a formula selected from the group consisting of: ##STR33## wherein: Z is O or S,
- Y represents a nitrogen atom, and
- X represents sulfur.
Priority Claims (1)
Number |
Date |
Country |
Kind |
85 544 |
Sep 1984 |
LUX |
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Parent Case Info
This application is a division of application Ser. No. 07/696,708, filed May 7, 1991, now U.S. Pat. No. 5,260,295, which is a division of application Ser. No. 07/430,286, filed Nov. 2, 1989, now U.S. Pat. No. 5,059,621, which is a division of application Ser. No. 07/172,494, filed Mar. 24, 1988, now U.S. Pat. No. 4,920,140, which is a division of application Ser. No. 06/839,269, filed Mar. 13, 1986, now U.S. Pat. No. 4,740,519, which is a continuation-in-part of application Ser. No. 06/777,728, filed Sep. 19, 1985, now abandoned.
Foreign Referenced Citations (1)
Number |
Date |
Country |
0306708 |
Mar 1989 |
EPX |
Non-Patent Literature Citations (1)
Entry |
Wada et al., J. Med. Chem., vol. 16, No. 8, pp. 930-934 (Aug. 1973). |
Divisions (4)
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Number |
Date |
Country |
Parent |
696708 |
May 1991 |
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Parent |
430286 |
Nov 1989 |
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Parent |
172494 |
Mar 1988 |
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Parent |
836269 |
Mar 1986 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
777728 |
Sep 1985 |
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