The present disclosure is directed at implants for replacing a portion of an articular surface of a joint and systems and method for delivering implants to an implant site.
Articular cartilage, found at the ends of articulating bone in the body, is typically composed of hyaline cartilage, which has many unique properties that allow it to function effectively as a smooth and lubricious load bearing surface. Hyaline cartilage problems, particularly in knee, hip joints, and should joints, are generally caused by disease such as occurs with rheumatoid arthritis or wear and tear (osteoarthritis), or secondary to an injury, either acute (sudden), or recurrent and chronic (ongoing). Such cartilage disease or deterioration can compromise the articular surface causing pain and eventually, loss of joint movement. As a result, various methods have been developed to treat and repair damaged or destroyed articular cartilage.
For smaller defects, traditional options for this type of problem include leaving the lesions or injury alone and living with it, or performing a procedure called abrasion arthroplasty or abrasion chondralplasty. The principle behind this procedure is to attempt to stimulate natural healing. The bone surface is drilled using a high speed rotary burr or shaving device and the surgeon removes about 1 mm of bone from the surface of the lesion. This creates an exposed subchondral bone bed that will bleed and will initiate a fibrocartilage healing response. One problem with this procedure is that the exposed bone is not as smooth as it originally was following the drilling and burring which tends to leave a series of ridges and valleys, affecting the durability of the fibrocartilage response. Further, although this procedure can provide good short term results, (1-3 years), fibrocartilage is seldom able to support long-term weight bearing and is prone to wear, soften and deteriorate.
Another procedure, called Microfracture incorporates some of the principles of drilling, abrasion and chondralplasty. During the procedure, the calcified cartilage layer of the chondral defect is removed. Several pathways or “microfractures” are created to the subchondral bleeding bone bed by impacting a metal pick or surgical awl at a minimum number of locations within the lesion. By establishing bleeding in the lesion and by creating a pathway to the subchondral bone, a fibrocartilage healing response is initiated, forming a replacement surface. Results for this technique may be expected to be similar to abrasion chondralplasty. Another means used to treat damaged articular cartilage is a cartilage transplant. Essentially, this procedure involves moving cartilage from an outside source or other knee or from within the same knee into the defect. Typically, this is done by transferring a peg of cartilage with underlying bone and fixing it in place with a screw or pin or by a press fit. Although useful for smaller defects, large defects present a problem, as this procedure requires donor pegs proportionate to the recipient bed. Large diameter lesions may exceed the capacity to borrow from within the same knee joint and rule out borrowing from another source.
Larger defects, however, generally require a more aggressive intervention. Typically treatment requires replacing a portion or all of the articular surface with an implant or prosthetic having an outer layer that that is polished or composed of a material that provides a lubricious load bearing surface in approximation of an undamaged cartilage surface. Replacement of a portion, or all, of the articular surface requires first cutting, boring, or reaming the damaged area to remove the damaged cartilage. A recess to receive an implant or prosthetic is formed at the damaged site. The implant or prosthetic is then secured to the bone in an appropriate position in the recess.
The treatment and/or replacement procedure often requires direct access to the damaged surface of the cartilage. While the most commonly damaged portions of some joints may easily be accessed for repair using a minimally invasive procedure some joints are not nearly as accessible. For example, the superior or medial femoral head, the medial humeral head, the glenoid, etc. do not permit direct access sufficient to carry out replacement of the articular surface in a minimally invasive manner. In fact, repair of such obstructed joints often requires an invasive procedure and necessitates complete dislocation of the joint. Procedures of such an invasive nature may be painful and require an extended recovery period.
completely dislocating the joint.
Features and advantages of the disclosed subject matter will be apparent from the following descriptions of embodiments consistent therewith, which description should be considered in conjunction with the accompanying drawings, wherein:
As shown, the implant 100 may generally include an implant body 102. The implant body 102 may include a load bearing surface 104 at one end of the implant body 102. The load bearing surface 104 may be a surface configured to interact with a cooperating articulating feature. The proximal end 106 of the implant body 102, opposite the load bearing surface 104, may be provided having a generally tapered and/or conical profile. In further embodiments, the proximal end 106 may have a generally truncated conical profile.
As best shown in
The angular relationship of the load bearing surface 104 relative to the axis of the implant body 102 may be varied according to specific applications. According to one aspect, the angle of the load bearing surface 104 relative to the axis of the implant body 102 may be related to the configuration and/or angle of the implant site 101 to the portion of the articular surface 103 to be replaced. Accordingly, depending upon the relationship between the portion of the articular surface 103 to be replaced and the implant site 101, the angular relationship between the load bearing surface 104 and the axis of the implant body 102 may vary between a very shallow angle, e.g., less than 45 degrees, up to a perpendicular orientation. In the specific illustrated embodiment, the load bearing surface 104 may be at an angle of about 60 degrees relative to the implant body 102. As the angle of the load bearing surface 104 relative to the implant body 102 is application specific, an implant 100 consistent with the present disclosure should not be considered to be limited by any particular angular relationship.
From a general perspective, the load bearing surface 104 may have a contour and/or geometry that may be capable of cooperating with an interacting articulating surface and/or feature. In one embodiment, the interacting articulating surface and/or feature may include an interacting articular surface of a joint. For example, in an embodiment in which the implant may be employed to replace at least a portion of an articular surface of a tibia, the load bearing surface of the implant may have a contour and/or geometry that may be capable of cooperating with an interacting articular surface of a femur. According to a further embodiment, such as may occur in a uni-compartmental and/or total knee replacement, the implant may be employed to replace at least a portion of the articular surface of a tibia. The load bearing surface of the implant may have a geometry capable of cooperating with an interacting implant replacing at least a portion of an articular surface of a femur. Consistent with the present disclosure, the implant may suitable be employed to replace at least a portion of various articular surfaces in addition to a portion of an articular surface of a tibia. For example, an implant herein may suitably be employed to replace a portion of an articular surface of a knee joint, a hip joint, a shoulder joint, etc. Accordingly, the foregoing example should not be construed as limiting on the application of an implant consistent with the present disclosure.
Consistent with the foregoing, an implant may include a load bearing surface having a contour and/or geometry that may be capable of cooperating with an interacting articulating surface. As such, the load bearing surface may have a contour and/or geometry that may generally approximate and/or be based on a contour and/or geometry of the portion of the articular surface being replaced by the implant. In an embodiment, the portion of the articular surface being replaced may be mapped using various know techniques to quantitatively and/or qualitatively represent the contour and/or geometry of the portion of the articular surface that may be replaced by the implant. An implant may be constructed and/or selected from a set of implants having various contours and/or geometries. Consistent with such an embodiment, the load bearing surface of the implant may be based on the contour and/or geometry of the portion of the articular surface to be replaced by the implant. In an alternative embodiment, an implant may be fabricated or selected from a set of standard size and/or shape implants to provide a general approximation of the articular surface being replaced. Selection or fabrication of an implant may rely on various degrees of quantitative reference to the articular surface being replaced, including no quantitative reference to the articular surface.
Different articular surfaces and/or different regions of an articular surface may be susceptible to replacement by implants having a load bearing surface various contours and/or geometries. In some applications a convex load bearing surface may be suitable. In other applications a planar, concave, and/or compound curved load bearing surface may provide a suitable implant load bearing surface geometry.
Referring to
According to another embodiment, the load bearing surface 104 may have a contour and/or geometry corresponding to the second curve 110 lofted along the first curve 108. In one such embodiment, the contour and/or geometry of the load bearing surface 104 may be achieved by sweeping the second curve 110 along the first curve 108 while maintaining the second curve 110 normal to the first curve 108. In such an embodiment, the first curve 108 may be provided in a first plane, e.g. a plane defined by the X and Z axis. The second curve 110 may be provided in a perpendicular plane. The angular pitch of the perpendicular plane relative to the first plane may vary along the first curve 108 to maintain the second curve 110 normal to the first curve 108 along the sweep of the first curve 108. According to another embodiment, the second curve 110 may be swept along the first curve 108 with the first curve 108 and the second curve 110 in orthogonal planes. For example, the first curve 108 may be provided in a first plane, e.g., a plane defined by the Y and Z axis and the second curve may be provided in an orthogonal plane, e.g., a plane defined by the X and Z axis.
In one aspect, the first and second curves 108, 110 may generally correspond to measurements of the curvature and/or geometry of the portion of the articular surface 103 to be replaced by the implant 100. In such an embodiment, perpendicular measurements of the contour and/or geometry of the portion of the articular surface 103 to be replaced may be taken. Measurement of the contour and/or geometry of the portion of the articular surface 103 to be replaced by the implant 100 may be achieved using direct contour mapping of the articular surface 103 and/or using various imaging techniques, such as radiological imaging techniques.
The implant 100 may include a relieved edge 112 around the perimeter of the load bearing surface 104. The relieved edge 112 may include a rounded over, e.g., radiused, edge, a chamfer edge, etc. According to one aspect, when the implant 100 is installed in an articular surface 103 and replacing at least a portion of the articular surface 103, the relieved edge 112 around the load bearing surface 104 may reduce the presence of a hard edge at a transition between the implant 100 and surrounding articular surface 103. A reduction and/or elimination of a hard edge at the transition between the load bearing surface 104 of the implant 100 and the surrounding articular surface 103 may reduce and/or eliminate scraping of an interacting articular surface during articulation of the joint. Additionally, the relieved edge 112 may accommodate manufacturing and/or installation tolerances. The relieved edge 112 may permit smooth operation of the joint in a situation in which the implant 100 sits slightly proud above and/or slightly recessed below the surrounding articular surface 103.
As shown, the implant 100 may include a plurality of grooves 114 on the exterior surface of the implant body 102. The grooves 114 may facilitate anchoring the implant 100 in position in an implant site 101 created in the articular surface 103 and the underlying bone 105. Consistent with an embodiment herein, the implant 100 may be secured, at least in part, in the implant site 101 using bone cement. When the implant 100 is installed into the implant site 101 using bone content, the bone cement may be squeezed, forced, and/or caused to flow to at least partially fill at least a portion of one of the grooves 114. The bone cement at least partially filling at least a portion of one of the grooves 114 may provide a mechanical lock between the bone cement and the grooves 114 in the implant body 102. The mechanical lock between the bone cement and the implant 100 may assist in securing the implant 100 in position in the implant site 101. Additionally, the mechanical lock between the bone cement and the grooves 114 may assist in retaining the implant 100 in the implant site 101 in the event of a partial and/or total adhesive failure between the bone cement and the implant.
Similar to the grooves 114 in the implant body 102, the proximal end 106 of the implant 100 may also include one or more grooves 116. The grooves 116 in the proximal end of the implant 100 may provide a mechanical lock between bone cement and the implant 100. In one embodiment, the grooves 114 in the implant body 102 and/or the grooves 116 in the proximal end 106 of the implant 100 may include an undercut region. The undercut region may increase the mechanical lock achieved between the bone cement and the implant 100.
An implant 100 herein may be formed from various different biologically compatible materials. The material of the implant may be selected to provide various properties, combinations of properties, and/or compromises between desired properties. For example, the implant may be formed from a metallic material, such as stainless steel, titanium, and/or various other biologically compatible metals and alloys. Metallic materials may provide strength and wear resistance. The load bearing surface of the implant may be polished to provide a relatively low friction surface for cooperating with an interacting articulating feature. Polymeric and/or polymeric based materials, such as ultra-high molecular weight polyethylene, polyethylene, polyvinyl alcohol hydrogel, etc., may also be employed for producing an implant herein. Such polymeric and/or polymer based materials may provide lubricious and/or low friction surfaces, as may be suitable for cooperating with interacting articular features. Additionally, polymeric and/or polymeric based materials may provide some degree of impact cushioning and/or impact absorption. In still further embodiments, the implant may be provided as an assembly including more than one material. For example, the implant may include a body portion formed from a metallic material having a load bearing surface formed from a polymeric and/or polymeric based material. Various other materials may also suitably be employed for producing an implant herein.
An implant consistent with the present disclosure may be produce using a variety of manufacturing techniques. According to one embodiment, the implant may be produced from cylindrical rod stock. The rod stock may be cut at an angle relative to axis of the rod stock, thereby providing a load bearing surface. The rod stock may further be tapered, e.g., by turning on a lathe, to provide a conical proximal end. Features, such as the grooves in the implant body and the proximal end, as well as the relieved edge of the load bearing surface, may subsequently be machined into the implant. In alternative embodiments, the implant may be produced by machining from a blank and/or billet of material. Furthermore, the implant may be produced using various molding processes, such as metal, ceramic and/or polymer casting. Other molding techniques may include metal injection molding, polymer injection molding, etc. Various other manufacturing processes and techniques may also be employed.
Turning next to
Consistent with the illustrated delivery system, the implant 100 may be delivered to the implant site 101 using a cooperating articulating feature 200 as a carrier. In the illustrated embodiment, the implant site 101 may be formed in the articular surface 103 and underlying bone 105 of a tibia. In such and embodiment, the cooperating articulating feature 200 may be an articular surface of a femur. A socket 202, sized to at least partially receive the implant 100, may be formed in the cooperating articulating feature 200. The socket 202 may be formed by drilling, cutting, and/or using other suitable excision techniques.
The cooperating articulating feature 200 may be positioned relative to the articular surface 103 so as to expose the socket 202 in the cooperating articulating feature. In the illustrated embodiment, in which the implant 100 is to be installed in an implant site 101 in a tibia, the knee may be positioned at approximately 80-90 degrees of flexion, thereby exposing the socket formed in the articular surface of the femur. Various other angular relationships may also and/or alternatively suitably be employed. With the socket 202 in the cooperating articulating feature 200 exposed, the implant 100 may be placed in the socket 202. As shown in
Turning to
With the socket 202 in the cooperating articulating feature 200 generally aligned with the implant site 101 in the articular surface, the implant 100 may be transferred from the socket 202 to the implant site 103, as shown in
As mentioned previously, the implant 100 may be secured in the implant site, at least in part, using bone cement. The bone cement may be applied to the implant 100 and/or to the implant site 101 prior to transferring the implant 100 from the socket 202 to the implant site 101. Alternatively, bone cement may be introduced between the implant 100 and the implant site prior to fully seating the implant 100. The bone cement may be introduced in between the implant 100 and the implant site 101 through the access tunnel 107, and/or from the exterior of the implant site 101 adjacent to the articular surface. Various additional and/or alternative fixturing and/or securement techniques may be employed for securing the implant 100 in position in the implant site 101.
In summary, according to one aspect, the present disclosure may provide a method for delivering an articular surface implant. The method may include forming an implant site in an articular surface, in which the implant site is capable of receiving an implant for replacing at least a portion of the articular surface. The method may also include forming a socket in an articulating feature capable of moving relative to the articular surface, and disposing the implant at least partially in the socket. The method may also include generally aligning the socket and the implant site, and transferring the implant from the socket at least partially into the implant site.
According to another aspect, the present disclosure may provide a method of replacing a portion an articular surface of a tibia. The method may include excising an implant site in the articular surface of the tibia, and excising a socket in an articular surface of a femur adjacent to the tibia. The method may also include disposing an implant capable of replacing at least a portion of the articular surface of the tibia in the socket. The method may further include articulating the femur relative to the tibia to generally align the socket and the implant site, and transferring the implant from the socket at least partially into the implant site.
The illustrated system is directed at delivering an implant for replacing at least a portion of an articular surface of a tibia. In the particular illustrated embodiment, the implant may be accommodated in a socket formed in a femoral articular surface and the femur may be articulated relative to the tibia to generally bring the socket in the formal articular surface into alignment with the implant site in the tibial articular surface. With the socket in the femoral articular surface generally aligned with the implant site in the tibial articular surface, the implant may be transferred from the socket in the femoral articular surface to the implant site in the tibial articular surface. However, from a broader perspective, a system consistent with the present disclosure may generally include disposing an implant in a socket, cutout, or natural recess in a cooperating articulating feature and moving the feature to align the implant in the socket with an implant site in an articular surface and transferring the implant from the socket to the implant site. Accordingly, the system herein is susceptible to broader application than the delivery of an implant to an implant site in an articular surface. For example, the system herein may be used to deliver an implant to an articular surface of a hip joint, shoulder joint, elbow, etc. The scope of the present disclosure should not, therefore, be limited to the specific embodiments disclosed therein.
This application claims the benefit of U.S. provisional patent application Ser. No. 60/654,928, filed on Feb. 22, 2005, and is related to U.S. patent application Ser. No. 10/994,453, filed Nov. 22, 2004, the entire disclosures of which are incorporated herein by reference.
Number | Name | Date | Kind |
---|---|---|---|
992819 | Springer | May 1911 | A |
1451610 | Gestas | Apr 1923 | A |
2267925 | Johnston | Dec 1941 | A |
3176395 | Warner et al. | Apr 1965 | A |
3840905 | Deane | Oct 1974 | A |
4016651 | Kawahara et al. | Apr 1977 | A |
4034418 | Jackson et al. | Jul 1977 | A |
4044464 | Schiess et al. | Aug 1977 | A |
4158894 | Worrell | Jun 1979 | A |
4344192 | Imbert | Aug 1982 | A |
4433687 | Burke et al. | Feb 1984 | A |
4462120 | Rambert et al. | Jul 1984 | A |
4474177 | Whiteside | Oct 1984 | A |
4484570 | Sutter et al. | Nov 1984 | A |
4531517 | Forte et al. | Jul 1985 | A |
4535768 | Hourahane et al. | Aug 1985 | A |
4634720 | Dorman et al. | Jan 1987 | A |
4655752 | Honkanen et al. | Apr 1987 | A |
4661536 | Dorman et al. | Apr 1987 | A |
4662371 | Whipple et al. | May 1987 | A |
4664669 | Ohyabu et al. | May 1987 | A |
4673407 | Martin | Jun 1987 | A |
4693986 | Vit et al. | Sep 1987 | A |
4712545 | Honkanen | Dec 1987 | A |
4714478 | Fischer | Dec 1987 | A |
4719908 | Averill et al. | Jan 1988 | A |
4729761 | White | Mar 1988 | A |
4823780 | Odensten et al. | Apr 1989 | A |
4842604 | Dorman et al. | Jun 1989 | A |
4896663 | Vandewalls | Jan 1990 | A |
4911153 | Border | Mar 1990 | A |
4927421 | Goble et al. | May 1990 | A |
4938778 | Ohyabu et al. | Jul 1990 | A |
4940467 | Tronzo | Jul 1990 | A |
4976037 | Hines | Dec 1990 | A |
4979957 | Hodorek | Dec 1990 | A |
4989110 | Zevin et al. | Jan 1991 | A |
4990163 | Ducheyne et al. | Feb 1991 | A |
4997434 | Seedhom et al. | Mar 1991 | A |
4998938 | Ghajar et al. | Mar 1991 | A |
5007930 | Dorman et al. | Apr 1991 | A |
5019104 | Whiteside et al. | May 1991 | A |
5053049 | Campbell | Oct 1991 | A |
5100405 | McLaren | Mar 1992 | A |
5127920 | MacArthur | Jul 1992 | A |
5192291 | Pannek, Jr. | Mar 1993 | A |
5201881 | Evans | Apr 1993 | A |
5211647 | Schmieding | May 1993 | A |
5224945 | Pannek, Jr. | Jul 1993 | A |
5255838 | Gladdish, Jr. et al. | Oct 1993 | A |
5263498 | Caspari et al. | Nov 1993 | A |
5263987 | Shah | Nov 1993 | A |
5282863 | Burton | Feb 1994 | A |
5290313 | Heldreth | Mar 1994 | A |
5312411 | Steele | May 1994 | A |
5314478 | Oka et al. | May 1994 | A |
5314482 | Goodfellow et al. | May 1994 | A |
5336224 | Selman | Aug 1994 | A |
5354300 | Goble et al. | Oct 1994 | A |
5358525 | Fox et al. | Oct 1994 | A |
5360446 | Kennedy | Nov 1994 | A |
5374270 | McGuire et al. | Dec 1994 | A |
5383937 | Mikhail | Jan 1995 | A |
5387218 | Meswania | Feb 1995 | A |
5395401 | Bahler | Mar 1995 | A |
5409494 | Morgan | Apr 1995 | A |
5413608 | Keller | May 1995 | A |
5423822 | Hershberger | Jun 1995 | A |
5458643 | Oka et al. | Oct 1995 | A |
5480443 | Elias | Jan 1996 | A |
5486178 | Hodge | Jan 1996 | A |
5509918 | Romano | Apr 1996 | A |
5520695 | Luckman | May 1996 | A |
5522900 | Hollister | Jun 1996 | A |
5534031 | Matsuzaki et al. | Jul 1996 | A |
5540696 | Booth, Jr. et al. | Jul 1996 | A |
5580353 | Mendes et al. | Dec 1996 | A |
5593450 | Scott et al. | Jan 1997 | A |
5595193 | Walus et al. | Jan 1997 | A |
5601550 | Esser | Feb 1997 | A |
5616146 | Murray | Apr 1997 | A |
5620055 | Javerlhac | Apr 1997 | A |
5624463 | Stone et al. | Apr 1997 | A |
5632745 | Schwartz | May 1997 | A |
5645598 | Brosnahan, III | Jul 1997 | A |
5681311 | Foley et al. | Oct 1997 | A |
5682886 | Delp et al. | Nov 1997 | A |
5683400 | McGuire | Nov 1997 | A |
5683465 | Shinn et al. | Nov 1997 | A |
5683466 | Viatle | Nov 1997 | A |
5700264 | Zucherman et al. | Dec 1997 | A |
5700265 | Romano | Dec 1997 | A |
5702401 | Shaffer | Dec 1997 | A |
5702465 | Burkinshaw | Dec 1997 | A |
5702467 | Gabriel et al. | Dec 1997 | A |
5741266 | Moran et al. | Apr 1998 | A |
5769855 | Bertin et al. | Jun 1998 | A |
5769899 | Schwartz et al. | Jun 1998 | A |
5771310 | Vannah | Jun 1998 | A |
5776137 | Katz | Jul 1998 | A |
5782835 | Hart et al. | Jul 1998 | A |
5810851 | Yoon | Sep 1998 | A |
5817095 | Smith | Oct 1998 | A |
5824105 | Ries et al. | Oct 1998 | A |
RE36020 | Moore et al. | Dec 1998 | E |
5882350 | Ralph et al. | Mar 1999 | A |
5885297 | Matsen, III | Mar 1999 | A |
5885298 | Herrington et al. | Mar 1999 | A |
5888210 | Draenert | Mar 1999 | A |
5893889 | Harrington | Apr 1999 | A |
5895390 | Moran et al. | Apr 1999 | A |
5911126 | Massen | Jun 1999 | A |
5918604 | Whelan | Jul 1999 | A |
5919196 | Bobic et al. | Jul 1999 | A |
5928239 | Mirza | Jul 1999 | A |
5928286 | Ashby et al. | Jul 1999 | A |
5964752 | Stone | Oct 1999 | A |
5964768 | Huebner | Oct 1999 | A |
5964808 | Blaha et al. | Oct 1999 | A |
5968050 | Torrie | Oct 1999 | A |
5989269 | Vibe-Hansen et al. | Nov 1999 | A |
5990382 | Fox | Nov 1999 | A |
5997543 | Truscott | Dec 1999 | A |
5997582 | Weiss | Dec 1999 | A |
6004323 | Park et al. | Dec 1999 | A |
6010502 | Bagby | Jan 2000 | A |
6015411 | Ohkoshi et al. | Jan 2000 | A |
6017348 | Hart et al. | Jan 2000 | A |
6019767 | Howell | Feb 2000 | A |
6045564 | Walen | Apr 2000 | A |
6052909 | Gardner | Apr 2000 | A |
6059831 | Braslow | May 2000 | A |
6071310 | Picha et al. | Jun 2000 | A |
6081741 | Hollis | Jun 2000 | A |
6086593 | Bonutti | Jul 2000 | A |
6102948 | Brosnahan, III | Aug 2000 | A |
6120542 | Camino et al. | Sep 2000 | A |
6132433 | Whelan | Oct 2000 | A |
6146385 | Torrie et al. | Nov 2000 | A |
6149654 | Johnson | Nov 2000 | A |
6159216 | Burkinshaw et al. | Dec 2000 | A |
6165223 | Metzger et al. | Dec 2000 | A |
6168626 | Hyon et al. | Jan 2001 | B1 |
6171340 | McDowell | Jan 2001 | B1 |
6193724 | Chan | Feb 2001 | B1 |
6206885 | Ghahremani et al. | Mar 2001 | B1 |
6217549 | Selmon et al. | Apr 2001 | B1 |
6217619 | Keller | Apr 2001 | B1 |
6235060 | Kubein-Meesenburg | May 2001 | B1 |
6251143 | Schwartz et al. | Jun 2001 | B1 |
6280474 | Cassidy et al. | Aug 2001 | B1 |
6299645 | Ogden | Oct 2001 | B1 |
6299648 | Doubler et al. | Oct 2001 | B1 |
6306142 | Johanson et al. | Oct 2001 | B1 |
6315798 | Ashby et al. | Nov 2001 | B1 |
6322500 | Sikora et al. | Nov 2001 | B1 |
6328752 | Sjostrom et al. | Dec 2001 | B1 |
6342075 | MacArthur | Jan 2002 | B1 |
6358251 | Mirza | Mar 2002 | B1 |
6358253 | Torrie et al. | Mar 2002 | B1 |
6375658 | Hangody et al. | Apr 2002 | B1 |
6383188 | Kuslich | May 2002 | B2 |
6415516 | Tirado et al. | Jul 2002 | B1 |
6443954 | Bramlet et al. | Sep 2002 | B1 |
6461373 | Wyman et al. | Oct 2002 | B2 |
6468309 | Lieberman | Oct 2002 | B1 |
6478178 | Ralph et al. | Nov 2002 | B2 |
6478801 | Ralph et al. | Nov 2002 | B1 |
6482210 | Skiba et al. | Nov 2002 | B1 |
6494914 | Brown | Dec 2002 | B2 |
6520964 | Tallarida et al. | Feb 2003 | B2 |
6527754 | Tallarida et al. | Mar 2003 | B1 |
6530956 | Mansmann | Mar 2003 | B1 |
6537274 | Katz | Mar 2003 | B1 |
6540786 | Chibrac et al. | Apr 2003 | B2 |
6551322 | Lieberman | Apr 2003 | B1 |
6575982 | Bonutti | Jun 2003 | B1 |
6585666 | Suh et al. | Jul 2003 | B2 |
6591581 | Schmieding | Jul 2003 | B2 |
6599321 | Hyde et al. | Jul 2003 | B2 |
6607561 | Brannon | Aug 2003 | B2 |
6610067 | Tallarida | Aug 2003 | B2 |
6679917 | Ek | Jan 2004 | B2 |
6746451 | Middleton et al. | Jun 2004 | B2 |
6755837 | Ebner | Jun 2004 | B2 |
6770078 | Bonutti | Aug 2004 | B2 |
6783550 | MacArthur | Aug 2004 | B2 |
6783551 | Metzger | Aug 2004 | B1 |
6802864 | Tornier | Oct 2004 | B2 |
6814735 | Zirngibl | Nov 2004 | B1 |
6827722 | Schoenefeld | Dec 2004 | B1 |
6860902 | Reiley | Mar 2005 | B2 |
6884246 | Sonnabend et al. | Apr 2005 | B1 |
6923813 | Phillips et al. | Aug 2005 | B2 |
6926739 | OConnor | Aug 2005 | B1 |
6962577 | Tallarida et al. | Nov 2005 | B2 |
6969393 | Pinczewski et al. | Nov 2005 | B2 |
6989016 | Tallarida et al. | Jan 2006 | B2 |
7029479 | Tallarida | Apr 2006 | B2 |
7037341 | Nowakowski | May 2006 | B2 |
7063717 | St. Pierre et al. | Jun 2006 | B2 |
7115131 | Engh et al. | Oct 2006 | B2 |
7156880 | Evans et al. | Jan 2007 | B2 |
7160305 | Schmieding | Jan 2007 | B2 |
7163541 | Ek | Jan 2007 | B2 |
7166133 | Evans et al. | Jan 2007 | B2 |
7192431 | Hangody et al. | Mar 2007 | B2 |
7204839 | Dreyfuss et al. | Apr 2007 | B2 |
7204854 | Guederian et al. | Apr 2007 | B2 |
7235107 | Evans et al. | Jun 2007 | B2 |
7238189 | Schmieding et al. | Jul 2007 | B2 |
7241316 | Evans et al. | Jul 2007 | B2 |
7264634 | Schmieding | Sep 2007 | B2 |
7303577 | Dean | Dec 2007 | B1 |
7311702 | Tallarida et al. | Dec 2007 | B2 |
7510558 | Tallarida | Mar 2009 | B2 |
7569059 | Cerundolo | Aug 2009 | B2 |
20010012967 | Mosseri | Aug 2001 | A1 |
20010039455 | Simon et al. | Nov 2001 | A1 |
20010056266 | Tallarida et al. | Dec 2001 | A1 |
20020055783 | Tallarida et al. | May 2002 | A1 |
20020106393 | Bianchi et al. | Aug 2002 | A1 |
20020138150 | Leclercq | Sep 2002 | A1 |
20020147498 | Tallarida et al. | Oct 2002 | A1 |
20030028196 | Bonutti | Feb 2003 | A1 |
20030060887 | Ek | Mar 2003 | A1 |
20030065391 | Re et al. | Apr 2003 | A1 |
20030105465 | Schmieding et al. | Jun 2003 | A1 |
20030120276 | Tallarida et al. | Jun 2003 | A1 |
20030120278 | Morgan et al. | Jun 2003 | A1 |
20030130741 | McMinn | Jul 2003 | A1 |
20030171756 | Fallin et al. | Sep 2003 | A1 |
20030181878 | Tallarida et al. | Sep 2003 | A1 |
20030204195 | Keane et al. | Oct 2003 | A1 |
20030216669 | Lang et al. | Nov 2003 | A1 |
20030225456 | Ek | Dec 2003 | A1 |
20030225457 | Justin et al. | Dec 2003 | A1 |
20040015170 | Tallarida et al. | Jan 2004 | A1 |
20040034359 | Schmieding et al. | Feb 2004 | A1 |
20040034437 | Schmieding | Feb 2004 | A1 |
20040082906 | Tallarida et al. | Apr 2004 | A1 |
20040106928 | Ek | Jun 2004 | A1 |
20040133276 | Lang et al. | Jul 2004 | A1 |
20040138754 | Lang et al. | Jul 2004 | A1 |
20040138758 | Evans et al. | Jul 2004 | A1 |
20040148030 | Ek | Jul 2004 | A1 |
20040153087 | Sanford et al. | Aug 2004 | A1 |
20040193281 | Grimes | Sep 2004 | A1 |
20040199166 | Schmieding et al. | Oct 2004 | A1 |
20040230315 | Ek | Nov 2004 | A1 |
20040260303 | Carrison | Dec 2004 | A1 |
20050015153 | Goble et al. | Jan 2005 | A1 |
20050038520 | Binette et al. | Feb 2005 | A1 |
20050043808 | Felt et al. | Feb 2005 | A1 |
20050065612 | Winslow | Mar 2005 | A1 |
20050075642 | Felt | Apr 2005 | A1 |
20050143731 | Justin et al. | Jun 2005 | A1 |
20050143745 | Hodorek et al. | Jun 2005 | A1 |
20050143831 | Justin et al. | Jun 2005 | A1 |
20050154398 | Miniaci | Jul 2005 | A1 |
20050209705 | Niederauer et al. | Sep 2005 | A1 |
20050229323 | Mills et al. | Oct 2005 | A1 |
20050287187 | Mansmann | Dec 2005 | A1 |
20060004461 | Justin et al. | Jan 2006 | A1 |
20060020343 | Ek | Jan 2006 | A1 |
20060052878 | Schmieding | Mar 2006 | A1 |
20060058744 | Tallarida et al. | Mar 2006 | A1 |
20060085006 | Ek | Apr 2006 | A1 |
20060149370 | Schmieding et al. | Jul 2006 | A1 |
20060190002 | Tallarida | Aug 2006 | A1 |
20060195112 | Ek | Aug 2006 | A1 |
20060229726 | Ek | Oct 2006 | A1 |
20070073394 | Seedhom et al. | Mar 2007 | A1 |
20070093842 | Schmieding | Apr 2007 | A1 |
20070093890 | Eliasen et al. | Apr 2007 | A1 |
20070118136 | Ek | May 2007 | A1 |
20070123921 | Ek | May 2007 | A1 |
20070179608 | Ek | Aug 2007 | A1 |
20070233128 | Schmieding et al. | Oct 2007 | A1 |
20070250067 | Schmieding et al. | Oct 2007 | A1 |
20070255399 | Eliasen et al. | Nov 2007 | A1 |
20070265700 | Eliasen et al. | Nov 2007 | A1 |
20070288031 | Dreyfuss et al. | Dec 2007 | A1 |
20070299519 | Schmieding | Dec 2007 | A1 |
20080004659 | Burkhart et al. | Jan 2008 | A1 |
20080015709 | Evans et al. | Jan 2008 | A1 |
20080027430 | Montgomery et al. | Jan 2008 | A1 |
20080033443 | Sikora et al. | Feb 2008 | A1 |
20080086139 | Bourke et al. | Apr 2008 | A1 |
20080172125 | Ek | Jul 2008 | A1 |
20080183290 | Baird et al. | Jul 2008 | A1 |
20080188935 | Saylor et al. | Aug 2008 | A1 |
20080275512 | Albertorio et al. | Nov 2008 | A1 |
20080306483 | Iannarone | Dec 2008 | A1 |
20090198288 | Hoof et al. | Aug 2009 | A1 |
20090234452 | Steiner et al. | Sep 2009 | A1 |
Number | Date | Country |
---|---|---|
2001262308 | Dec 2001 | AU |
2003262428 | Aug 2009 | AU |
2933174 | Apr 1980 | DE |
3516743 | Nov 1986 | DE |
EP1335684 | Aug 2003 | DE |
0350780 | Jul 1989 | EP |
0350780 | Jan 1990 | EP |
0485678 | May 1992 | EP |
0327387 | Sep 1992 | EP |
0505634 | Sep 1992 | EP |
0903125 | Mar 1999 | EP |
0903127 | Mar 1999 | EP |
0661023 | Aug 2001 | EP |
1426013 | Sep 2004 | EP |
1278460 | Apr 2009 | EP |
2242068 | Mar 1975 | FR |
2642301 | Mar 1990 | FR |
2676917 | Dec 1992 | FR |
2718014 | Oct 1995 | FR |
2739151 | Mar 1997 | FR |
2372707 | Sep 2002 | GB |
61502029 | Sep 1986 | JP |
63300758 | Dec 1988 | JP |
3504932 | Oct 1991 | JP |
H03-092328 | Nov 1992 | JP |
518511 | Mar 1993 | JP |
06339490 | Dec 1994 | JP |
11244315 | Sep 1999 | JP |
2001525210 | Dec 2001 | JP |
2002291779 | Oct 2002 | JP |
2003534096 | Nov 2003 | JP |
8803781 | Jun 1988 | WO |
8909578 | Oct 1989 | WO |
9427507 | Dec 1994 | WO |
9624304 | Aug 1996 | WO |
9722306 | Jun 1997 | WO |
9920192 | Apr 1999 | WO |
0105336 | Jan 2001 | WO |
0166021 | Sep 2001 | WO |
0166022 | Sep 2001 | WO |
0182677 | Nov 2001 | WO |
0191648 | Dec 2001 | WO |
0191672 | Dec 2001 | WO |
02086180 | Oct 2002 | WO |
03047470 | Jun 2003 | WO |
03051210 | Jun 2003 | WO |
03051211 | Jun 2003 | WO |
03061516 | Jul 2003 | WO |
2004014261 | Feb 2004 | WO |
2004026170 | Apr 2004 | WO |
2004075777 | Sep 2004 | WO |
2005051231 | Jun 2005 | WO |
2006004885 | Jan 2006 | WO |
2006091686 | Aug 2006 | WO |
Number | Date | Country | |
---|---|---|---|
20070005143 A1 | Jan 2007 | US |
Number | Date | Country | |
---|---|---|---|
60654928 | Feb 2005 | US |