Claims
- 1. An artificial pancreas comprising one or more viable and physiologically active pancreatic islet cells capable of producing insulin, encapsulated within a semipermeable spheroidal membrane a polysaccharide mixture of a agarose & agaropectin consisting essentially of gel.
- 2. The artificial pancreas of claim 1, wherein the encapsulated pancreatic islet cells range from about 50 to about 1000 microns in diameter.
- 3. The artificial pancreas of claim 1, wherein the polysaccharide mixture of agarose and agaropectin gel has a molecular weight cut-off below 100,000 daltons.
- 4. An artificial pancreas comprising one or more viable and physiologically active pancreatic islet cells capable of producing insulin, encapsulated within a first semipermeable spheroidal membrane consisting essentially of a polysaccharide mixture of agarose and agaropectin gel; said first spheroidal agar membrane being encapsulated within a second immunoisolating membrane.
- 5. The artificial pancreas of claim 4, wherein the second immunoisolating membrane is a mechanical or synthetic one.
- 6. The artificial pancreas of claim 5, wherein the mechanical membrane is part of a diffusion chamber.
- 7. An artifical pancreatic perfusion device, comprising:
- a. a hollow fiber having a porosity ranging from about 25 Kd to about 200 Kd; said hollow fiber having one end connected to a blood vessel for receiving blood and a second end connected to a blood vessel for returning said blood;
- b. one or more viable and physiologically active pancreatic islet cells capable of producing insulin, encapsulated within a semipermeable spheroidal membrane consisting essentially of a polysaccharide mixture of agarose and agaropectin gel surrounding said hollow fiber; and
- c. a housing for said hollow fiber and islets, comprising a semipermeable membrane having a pore size small enough to offer protection to the islets and host from immune reactive substances.
CROSS REFERENCE TO RELATED APPLICATION
This is a continuation of copending application Ser. No. 08/606,422 filed on Feb. 23, 1996, now abandoned.
US Referenced Citations (14)
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Feb 1994 |
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Tun et al. A newly developed three-layer agarose microcapsule for a promising biohybrid artificial pancreas: rat to mouse xenotransplantation. Cell Transplantation. (1996) 5(5S): S59-S63. |
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Continuations (1)
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606422 |
Feb 1996 |
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