Claims
- 1. A bi-functional conjugate comprising an antibody of non-human origin, wherein said conjugate has
- a) a first binding site that specifically binds the specific pathogen; and
- b) a second binding site that specifically binds a specific class of immunoglobulin;
- wherein the first binding site is an antibody fragment, or the second binding site is an antibody fragment, or both the first binding site and the second binding site are antibody fragments.
- 2. The conjugate of claim 1 comprising an F(ab') antibody fragment.
- 3. The conjugate of claim 1 wherein both the first and the second binding sites are antibody fragments.
- 4. The conjugate of claim 1 wherein the first binding site is an antibody fragment and the second binding site is not an antibody fragment.
- 5. The conjugate of claim 1 wherein the second binding site is an antibody fragment and the first binding site is not an antibody fragment.
- 6. An artificial positive control comprising the conjugate of claim 1, wherein said second binding site of said conjugate is bound to an antibody of said specific class of immunoglobulin.
- 7. The artificial positive control comprising the conjugate of claim 1 in a human serum.
- 8. The conjugate of claim 1 wherein at least one antibody fragment comprising said conjugate is a fragment from a monoclonal antibody.
Priority Claims (1)
Number |
Date |
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4133945 |
Oct 1991 |
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Parent Case Info
This is a divisional application of Ser. No. 08/221,447, filed Apr. 1, 1994, now U.S. Pat. No. 5,491,218, which is a continuation of application Ser. No. 07/958,713, final Oct. 9, 1992, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5635600 |
Fanger et al. |
Jun 1997 |
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Non-Patent Literature Citations (3)
Entry |
Nakamura et al., Chapter 27, vol. 1: 27.1-27.20. ImmunoChemistry from Handbook of Exp. Immunol. in four vols., ed. D. M. Weir, black Scientific Pub. (1984). |
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Divisions (1)
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Number |
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Parent |
221447 |
Apr 1994 |
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Continuations (1)
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Number |
Date |
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Parent |
958713 |
Oct 1992 |
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