Claims
- 1. A member of the formula: ##STR28## and pharmaceutically acceptable salts thereof, wherein: Ar is phenyl, naphthyl, or indole optionally substituted with hydroxy, halo, CF.sub.3, NO.sub.2, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;
- A and A' are each hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or hydroxy;
- X is cyano, nitro, COOR, SR, SOR or SOOR;
- R is H or C.sub.1-6 alkyl;
- n, n' and n" are each 0 to 4; and m, m' and m" are each 1 to 4.
- 2. A pharmaceutical composition for the treatment of cardiovascular diseases comprising as an active ingredient a member of the formula: ##STR29## wherein: Ar is phenyl, naphthyl, or indole optionally substituted with hydroxy, halo, CF.sub.3, NO.sub.2, C.sub.1-6 alkyl or C.sub.1-6 alkoxy;
- A and A' are each hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or hydroxy;
- X is cyano, nitro, COOR, SR, SOR or SOOR;
- R is H or C.sub.1-6 alkyl;
- n, n' and n" are each 0 to 4; and m, m' and m" are each 1 to 4 or pharmaceutically acceptable salts thereof in a pharmaceutically acceptable carrier.
- 3. A method for effecting vasodilation in a mammal in need of such treatment which comprises administering thereto an effective amount of the composition of claim 2.
- 4. N-[4-(3,4-dimethoxyphenyl)-4-cyanocyclohexan-1-yl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride.
Parent Case Info
This application is a division of copending application Ser. No. 932,557, filed on Nov. 20, 1986, now U.S. Pat. No. 4,795,757, which in turn is a continuation-in-part of application Ser. No. 646,735, filed Sept. 4, 1984, now abandoned.
Non-Patent Literature Citations (2)
Entry |
Cantarelli et al., "Chemical Abstracts", vol. 73, 1970, col. 2397r. |
Unger et al., "Chemical Abstracts", vol. 79, 1973, col. 65987c. |
Divisions (1)
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Number |
Date |
Country |
Parent |
732557 |
Nov 1986 |
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Continuation in Parts (1)
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Number |
Date |
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646735 |
Sep 1984 |
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