Claims
- 1. A compound of formula: ##STR304## wherein A is a ring chosen from the group consisting of naphthyl, pyridinyl and cyclohexyl;
- R.sup.1 hydrogen, lower-alkyl, benzyl, naphthyl, thienyl, pyridinyl, phenyl, or phenyl having one or two substituents chosen from the group consisting of lower-alkyl and lower-alkoxy;
- R.sup.2 is hydrogen; lower-alkyl; benzyl; phenyl; phenyl substituted with halogen, lower-alkyl or lower-alkoxy; or
- R.sup.2 is --CH.sub.2 CH.sub.2 R.sup.7 where R.sup.7 is lower-alkoxy; benzyl; di(lower-alkyl)amino, pyrrolidino; piperidino; morpholino; pyridinyl; phenyl; or phenyl substituted with amino, nitro or lower-alkyl sulfonamido;
- R.sup.3 is Y.sub.p --(CH.sub.2).sub.m --X.sub.n --R.sup.8 wherein
- Y is --NH--, --O--, --S--, or ##STR305## p is zero or one; m is an integer from zero to seven; ##STR306## n is zero or one; and R.sup.8 is hydrogen; lower-alkyl; phenyl; furanyl; thienyl, pyridinyl, phenyl having one or two substituents chosen independently from the group consisting of halogen, lower-alkyl, nitro, hydroxy, lower-alkoxy, lower-alkylamido, lower-alkylsulfonamido, di-lower-alkylaminosulfonyl, and amino; or when n is zero and m is other than zero, R.sup.8 is additionally halogen; benzyl(lower-alkyl)amino; di-(lower-alkyl)amino; or a 5- or 6-membered heterocycle containing one or two nitrogens, said heterocycle being unsubstituted or substituted with one lower-alkyl group; or X and R.sup.8 taken together are cyclohexylidine;
- R.sup.4 hydrogen; lower-alkyl; allyl; lower-alkoxy-lower-alkyl; acetyl; lower-alkylaceto; lower-alkyl carboxyl; or a-hydroxy-lower-alkyl; and
- R.sup.5 is hydrogen; lower-alkyl; naphthyl; thienyl; pyridinyl; benzyl; phenyl; or phenyl having one or two substituents chosen independently from the group consisting of lower-alkyl,lower-alkoxy, halogen, hydroxyl, amino, di(lower-alkyl)amino, lower-alkylsulfonamido and lower-acylamino;
- or an acid-addition salt thereof with the proviso that the total number of carbon atoms in R.sup.1 plus R.sup.2 plus R.sup.4 plus R.sup.5 must be five or greater.
- 2. A method for the treatment of cardiac arrhythmia in a patient in need of such treatment which comprises the administration of an antiarrhythmically effective amount of a compound according to claim 1.
- 3. A composition for the treatment of cardiac arrhythmia comprising an antiarrhythmically effective amount of a compound according to claim 1.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a division of prior application Ser. No. 08/308,893, filed Sep. 19, 1994, which in turn is a division of application Ser. No. 08/250,995, filed May 31, 1994, now U.S. Pat. No. 5,380,721, which in turn is a continuation of application Ser. No. 08/021,926, filed Feb. 24, 1993, now abandoned, which in turn is a continuation-in-part of our prior application Ser. No. 07/974,396, filed Nov. 10, 1992, now abandoned which in turn is a continuation-in-part of our prior application Ser. No. 07/743,853, filed Jun. 13, 1991, now abandoned, which in turn is a continuation-in-part of our prior application Ser. No. 07/580,065, filed Sep. 10, 1990, now abandoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3696093 |
Rodriguez et al. |
Oct 1972 |
|
4325957 |
Zeugner et al. |
Apr 1982 |
|
4382030 |
Zeugner et al. |
May 1983 |
|
4840948 |
Lang et al. |
Jun 1989 |
|
Foreign Referenced Citations (5)
Number |
Date |
Country |
66303 |
Dec 1982 |
EPX |
389765 |
Oct 1990 |
EPX |
475527 |
Mar 1992 |
EPX |
59013766 |
Jan 1984 |
JPX |
1183135 |
Mar 1970 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Elslager, E.F. et al "The synthesis of 5,10-dihydro-and 2,3,5,10-tetrahydrothiazolo-[3,2-b] [2,4]benzodiazepines, 1,2,3,4,7,12-hexahydrobenzothiazolo-[3,2-b] [2,4] benzodiazepine, and 9,14-dihydro-6H-[1]benzothiopyrano-[4',3':4,5]thiazolo[3,2-b] [2,4]benzodiazepine via 1,2,4,5-tetrahydro-3H-2,4-benzodiazepine-3-thione", J. Het. Chem. 5:609-613, 1968. |
Divisions (2)
|
Number |
Date |
Country |
Parent |
308893 |
Sep 1994 |
|
Parent |
250995 |
May 1994 |
|
Continuations (1)
|
Number |
Date |
Country |
Parent |
21926 |
Feb 1993 |
|
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
974396 |
Nov 1992 |
|
Parent |
743853 |
Jun 1991 |
|
Parent |
580065 |
Sep 1990 |
|