Claims
- 1. A method for reducing nicotine addiction or aiding in the cessation or lessening of tobacco use in a mammal, comprising administering to said mammal an amount of a compound comprising an amount of a compound of the formula wherein R19 is selected from the group consisting of hydrogen, (C1-C6)alkyl, or unconjugated (C3-C6)alkenyl, or a pharmaceutically acceptable salt thereof, that is effective in reducing nicotine addiction or aiding in the cessation or lessening of tobacco use.
- 2. A method for treating a disorder or condition selected from spastic dystonia, celiac sprue, pouchitis, vasoconstriction, anxiety, panic disorder, depression, bipolar disorder, autism, sleep disorders, jet lag, amyotrophic lateral sclerosis, cognitive dysfunction, hypertension, bulimia, anorexia, obesity, cardiac arrhythmias, gastric acid hypersecretion, pheochromocytoma, progressive supranuclear palsy; chemical dependencies and addictions; dependencies on, or addictions to, nicotine, tobacco products, alcohol, benzodiazepines, barbiturates, opioids or cocaine; stroke, traumatic brain injury, obsessive-compulsive disorder, psychosis, Huntington's chorea, tardive dyskinesia, hyperkinesia, dyslexia, schizophrenia, multi-infarct dementia, age-related cognitive decline, epilepsy, petit mal absence epilepsy, senile dementia of the Alzheimer's type, Parkinson's disease, attention deficit hyperactivity disorder and Tourette's Syndrome in a mammal, comprising administering to a mammal in need of such treatment an amount of a compound of the formula wherein R19 is selected from the group consisting of hydrogen, (C1-C6)alkyl, or unconjugated (C3-C6)alkenyl, or a pharmaceutically acceptable salt thereof; that is effective in treating such disorder or condition.
- 3. A method according to claims 1 or 2, wherein the compound to be administered is 10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene.
Parent Case Info
This application is a continuation-in-part application of U.S. Ser. No. 09/402,010, filed Sep. 28, 1999, now U.S. Pat. No. 6,410,550 which is a national stage entry under 35 U.S.C. § 371 of PCT/IB98/01813, filed Nov. 13, 1998, which claims the benefit of U.S. Provisional Application Ser. No. 60/070,245, filed Dec. 31, 1997.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3471503 |
Carson |
Oct 1969 |
A |
Foreign Referenced Citations (2)
Number |
Date |
Country |
0955301 |
Nov 1999 |
WO |
WO9955680 |
Nov 1999 |
WO |
Non-Patent Literature Citations (2)
Entry |
P. Mazzocchi et al., “Synthesis and Pharmacological Activity of 2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepines,” J. Med. Chem., 22(4), 455-457 (1979). |
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Provisional Applications (1)
|
Number |
Date |
Country |
|
60/070245 |
Dec 1997 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09/402010 |
|
US |
Child |
09/514002 |
|
US |