Claims
- 1. A method for inhibiting the effects of infection by hemorrhagic fever virus (HFV) in a cell, in vitro or in vivo, comprising administering to the cell an effective inhibitory amount of a compound of Formula I:
- 2. The method of claim 1, where R1 is an aryl group substituted with an electron-withdrawing group.
- 3. The method of claim 2, wherein the aryl group is phenyl, naphthyl, or anthryl.
- 4. The method of claim 2, wherein the aryl group is phenyl.
- 5. The method of claim 2, wherein the electron-withdrawing group is a halo.
- 6. The method of claim 2, wherein R1 is para-bromophenyl.
- 7. The method of claim 2, wherein R1 is para-chlorophenyl.
- 8. The method of claim 1, wherein R2 is an a-amino acid or ester thereof.
- 9. The method of claim 1, wherein R2 is —NHCH(CH3)COOCH3.
- 10. The method of claim 2, wherein R1 is para-bromophenyl and R2 is —NHCH(CH3)COOCH3.
- 11. The method of claim 2, wherein R1 is para-chlorophenyl and R2 is —NHCH(CH3)COOCH3.
- 12. The method of claim 1, wherein the hemorrhagic fever virus is an arenavirus.
- 13. The method of claim 1, wherein the hemorrhagic fever virus is Lassa Virus.
- 14. The method of claim 1, wherein the administered compound is a compound of Formula IV:
- 15. The method of claim 1, wherein said administering comprises administering to an animal.
- 16. The method of claim 15, wherein said compound is administered at a dose of about 1 mg/kg body weight to about 500 mg/kg body weight.
- 17. The method of claim 16, wherein said compound is administered at a dose of about 10 mg/kg body weight to about 100 mg/kg body weight.
- 18. The method of claim 15, wherein said inhibiting comprises reducing one or more symptom of HFV infection.
- 19. The method of claim 15, wherein said inhibiting comprises preventing or delaying the onset of one or more symptom of HFV infection.
PRIORITY OF THE APPLICATION
[0001] This application claims priority to U.S. Provisional Application 60/______ entitled “ARYL PHOSPHATE DERIVATIVES OF d4T WITH POTENT ANTI-VIRAL ACTIVITY AGAINST HEMORRHAGIC FEVER VIRUSES” filed on Oct. 21, 2002.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60420242 |
Oct 2002 |
US |