Claims
- 1. A compound having the formula ##STR16## wherein R.sup.1 is a tricycloalkyl or bicycloalkyl group having from 7 to 11 carbon atoms, or indan-2-yl;
- R.sup.2 is methyl or ethyl;
- X is O; and
- Y is ##STR17## R.sup.3 is hydrogen, (C.sub.1-5)alkyl, (C.sub.2-5)alkenyl, benzyl or phenethyl;
- R.sup.4 is hydrogen, (C.sub.1-5)alkyl, (C.sub.1-5)alkanoyl, or benzoyl;
- a pharmaceutically acceptable acid addition salt of said compound having a basic nitrogen atom; or the racemic-diastereomeric mixtures and optical isomers of said compounds.
- 2. A compound according to claim 1 wherein Y is a 5-membered heterocyclyl ring.
- 3. A compound according to claim 2 wherein Y is a saturated 5-membered heterocyclyl ring.
- 4. A compound according to claim 3 wherein Y is ##STR18##
- 5. A compound according to claim 4 wherein X is O.
- 6. A compound according to claim 5 wherein R.sup.3 is (C.sub.1-5)alkyl and R.sup.4 is hydrogen.
- 7. A compound according to claim 6 wherein each of R.sup.2 and R.sup.3 is methyl.
- 8. The compound according to claim 7 wherein R.sup.1 is bicyclo[2.2.1]hept-2-yl.
- 9. The compound according to claim 7 wherein R.sup.1 is bicyclo-2.2.2]oct-2-yl.
- 10. The compound according to claim 7 wherein R.sup.1 is bicyclo[3.2.1]oct-3-yl.
- 11. The compound according to claim 7 wherein R.sup.1 is tricyclo[3.3.1.1.sup.5,7 ]dec-2-yl.
- 12. The compound according to claim 7 wherein R.sup.1 is tricyclo[5.2.1.0.sup.2,6 ]dec-8-yl.
- 13. A compound according to claim 3 wherein Y is ##STR19##
- 14. A compound according to claim 13 wherein R.sup.1 is bicycloalkyl and X is O.
- 15. A compound according to claim 14 wherein R.sup.1 is bicyclo[2.2.1]hept-2-yl.
- 16. The compound according to claim 15 wherein each of R.sup.2 and R.sup.3 is methyl; and R.sup.4 is hydrogen.
- 17. A compound according to claim 2 wherein Y is ##STR20##
- 18. A compound according to claim 17 wherein Y is bicycloalkyl and X is O.
- 19. The compound according to claim 18 wherein Y is bicyclo[2.2.1]hept-2-yl and R.sup.2 is methyl.
- 20. A method for treating depression in a human suffering therefrom which comprises administering to said human an effective anti-depression treating amount of a compound according to claim 1.
- 21. A pharmaceutical composition for treating depression in a human suffering therefrom which comprises an effective anti-depression treating amount of a compound according to claim 1 and a pharmaceutically acceptable carrier.
Parent Case Info
This is a division of application Ser. No. 07/155,932, filed on Jan. 19, 1988.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4193926 |
Schmiechen et al. |
Mar 1980 |
|
4308278 |
Schneider et al. |
Dec 1981 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
155932 |
Jan 1988 |
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