Claims
- 1. 3-[3-phenyl-1,2,4,(1H)-triazol-5-yl]propionic acid monohydrate, and pharmacologically acceptable, non-toxic salts thereof.
- 2. A compound of the formula ##STR12## and pharmacologically acceptable, non-toxic salts thereof wherein: R.sup.1, R.sup.2 and R.sup.3 are always dissimilar;
- R.sup.1 is selected from the group consisting of monochlorophenyl and di-chlorophenyl;
- R.sup.2 is 2-carboxyethyl; and
- R.sup.3 is hydrogen.
- 3. A compound as claimed in claim 2, 3-[1-(3-chloro)-phenyl-1,2,4,(1H)-triazol-3-yl]propionic acid.
- 4. A compound as claimed in claim 2, 3-[1-(3,5,-dichloro)-phenyl-1,2,4,(1H)-triazol-3-yl]propionic acid.
- 5. A compound of the formula ##STR13## and pharmacologically acceptable, non-toxic salts thereof wherein: R.sup.1, R.sup.2 and R.sup.3 are always dissimilar;
- R.sup.1 is hydrogen;
- R.sup.2 is 2-carboxyethyl; and
- R.sup.3 is selected from the group consisting of phenyl, 4-methylphenyl, mono-bromophenyl and mono-chlorophenyl.
- 6. A compound as claimed in claim 5, 3-[3-phenyl-1,2,4,-(1H)-triazol-1-yl]propionic acid.
- 7. A compound as claimed in claim 5, 3-[3-(3-bromo)-phenyl-1,2,4,(1H)-triazol-1-yl]propionic acid.
- 8. A compound as claimed in claim 5, 3-[3-(3-chloro)-phenyl-1,2,4,(1H)-triazol-1-yl]propionic acid.
- 9. A compound as claimed in claim 5, 3-[3-(4-methyl)-phenyl-1,2,4,-(1H)-triazol-1-yl]propionic acid.
- 10. A therapeutic method for treating algia in an individual for whom such therapy is indicated, comprising: administering to the individual an effective analgesic amount of 3-[3-phenyl-1,2,4,-(1H)-triazol-5-yl]propionic acid monohydrate and pharmacologically acceptable, nontoxic salts thereof.
- 11. A therapeutic method for treating algia in an individual for whom such therapy is indicated, comprising:
- administering to the individual an effective analgesic amount of a compound of the formula ##STR14## and pharmacologically acceptable, non-toxic salts thereof wherein: R.sup.1, R.sup.2 and R.sup.3 are always dissimilar;
- R.sup.1 is selected from the group consisting of monochlorophenyl and di-chlorophenyl;
- R.sup.2 is 2-carboxyethyl; and
- R.sup.3 is hydrogen.
- 12. A therapeutic method for treating algia in an individual for whom such therapy is indicated, comprising:
- administering to the individual an effective analgesic amount of a compound of the formula ##STR15## and pharmacologically acceptable, non-toxic salts thereof wherein: R.sup.1, R.sup.2 and R.sup.3 are always dissimilar;
- R.sup.1 is hydrogen
- R.sup.2 is 2-carboxyethyl; and
- R.sup.3 is selected from the group consisting of phenyl, 4-methylphenyl, mono-bromophenyl and mono-chlorophenyl.
REFERENCE TO PRIOR APPLICATION
This is a continuation-in-part of U.S. Patent application Ser. No. 763,504, filed on Jan. 28, 1977, now abandoned which in turn was a continuation-in-part of U.S. Patent application Ser. No. 706,065, filed on July 16, 1976, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3681374 |
Yano et al. |
Aug 1972 |
|
3769411 |
Seidel et al. |
Oct 1973 |
|
3879404 |
Baldwin et al. |
Apr 1975 |
|
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
763504 |
Jan 1977 |
|
Parent |
706065 |
Jul 1976 |
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