Claims
- 1. A compound which is selected from those of formula (I): ##STR21## in which: A represents a --CH.sub.2 --CH.sub.2 -- chain, unsubstituted or substituted with lower alkyl,
- R.sub.1 represents hydrogen or lower alkyl,
- R.sub.2 represents hydrogen, halogen or lower alkyl,
- R.sub.3 and R.sub.4, together with the benzene ring which carries them, form an indole ring-system E.sub.3 on the understanding that the portion of the ring-system E.sub.3 formed by R.sub.3 and R.sub.4 and the two carbon atoms of the benzene ring which carry them is:
- unhydrogenated or partially hydrogenated,
- and unsubstituted or substituted with one or more radicals chosen from: halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkoxycarbonyl, and trifluoromethyl,
- R.sub.5 represents hydrogen or lower alkyl,
- R.sub.6 represents a group ##STR22## in which X represents oxygen and R.sub.7 represents a radical chosen from:
- lower alkyl, unsubstituted or substituted with one or more radicals chosen from halogen, hydroxyl, and lower alkoxy,
- linear or branched alkenyl having 2 to 7 carbon atoms, inclusive, unsubstituted or substituted with one or more radicals chosen from halogen, hydroxyl, and lower alkoxy,
- and --(CH.sub.2).sub.m --E.sub.4 in which m represents 0 or 1 to 4, inclusive, and E.sub.4 represents a mono- or bicyclic cycloalkyl having 3 to 12 carbon atoms, inclusive, unsubstituted or substituted with one or more radicals chosen from halogen, and lower alkyl,
- its optical isomers, and addition salts thereof with a pharmaceutically-acceptable acid or base when R.sub.3 or R.sub.4 represents a satisfiable group,
- on the understanding that the terms "lower alkyl" and "lower alkoxy" denote linear or branched groups having 1 to 6 carbon atoms, inclusive, and that the terms "cycloalkenyl" and "alkenyl" denote hydrocarbon groups containing one or more double bonds.
- 2. A compound as claimed in claim 1 in which R.sub.1 represents a methyl radical.
- 3. A compound as claimed in claim 1 in which R.sub.3 and R.sub.4, together with the benzene ring which carries them, form an indole ring-system E.sub.3 benzofuran, indole, on the understanding that the portion of the ring-system E.sub.3 formed by R.sub.3 and R.sub.4 and the 2 carbon atoms of the benzene ring which carry them is:
- substituted with one or more radicals chosen from: halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkoxycarbonyl and trifluoromethyl.
- 4. A compound as claimed in claim 1 in which R.sub.3 and R.sub.4, together with the benzene ring which carries them, form an indole,
- on the understanding that the benzene ring formed by R.sub.3, R.sub.4 and the 2 carbon atoms which carry them is unhydrogenated and unsubstituted or substituted with one or more radicals chosen from halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkoxycarbonyl, and trifluoromethyl.
- 5. A compound as claimed in claim 1 in which R.sub.1 represents a methyl radical and R.sub.3 and R.sub.4, together with the benzene ring which carries them, form an indole on the understanding that the benzene ring formed by R.sub.3 and R.sub.4 and the 2 carbon atoms which carry them is unsubstituted or substituted with one or more radicals chosen from: halogen, hydroxyl, lower alkyl, lower alkoxy, lower alkoxycarbonyl, and trifluoromethyl.
- 6. A pharmaceutical composition containing as active principle a compound as claimed in claim 1, in combination with one or more pharmaceutically-acceptable excipients.
- 7. A method of treating a mammal afflicted with a sleep disorder comprising the step of administering to the said mammal an amount of a compound as claimed in claim 1 which binds at melatonin receptors and is effective in the treatment of said disorder.
- 8. A compound as claimed in claim 1 which is N-[2-(5-methoxy-4-indolyl)ethyl]acetamide.
- 9. A compound as claimed in claim 1 which is N-[2-(5-methoxy-4-indolyl)ethyl]propionamide.
- 10. A compound as claimed in claim 1 which is N-[2-(5-methoxy-4-indolyl)ethyl]cyclopropylcarboxamide.
- 11. A compound as claimed in claim 1 which is N-[2-(5-methoxy-4-indolyl)ethyl]trifluoroacetamide.
Priority Claims (1)
Number |
Date |
Country |
Kind |
92 11671 |
Oct 1992 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed application Ser. No. 08/375,503, filed Jan. 18, 1995, now U.S. Pat. No. 5,464,872 which in turn is a continuation of our prior-filed application Ser. No. 08/131,207, filed Oct. 1, 1993, now abandoned.
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Number |
Name |
Date |
Kind |
4468520 |
Michel et al. |
Aug 1984 |
|
5059620 |
Stout et al. |
Oct 1991 |
|
5194614 |
Andrieux et al. |
Mar 1993 |
|
5225442 |
Andrieux et al. |
Jul 1993 |
|
5283343 |
Dubocovich et al. |
Feb 1994 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0238868 |
Sep 1987 |
EPX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
375503 |
Jan 1995 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
131207 |
Oct 1993 |
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