Compounds of the formula ##SPC1##Wherein Ar is phenyl or phenyl substituted by one or more halogens, by a trifluoromethyl or a methylenedioxy, by one or more methoxy, by an alkyl having one to 4 carbon atoms or by a dimethylamino,And R is ##EQU1## or --O-- ##EQU2## or ##EQU3## wherein R.sub.1 and R.sub.2 each are hydrogen or alkyl of 1 to 4 carbon atoms, or ##EQU4## is pyrrolidino, morpholino, piperidino or piperazino N'-substituted by alkyl of 1 to 4 carbon atoms, or phenyl; R.sub.3 and R.sub.4 each are alkyl of 1 to 3 carbon atoms or ##EQU5## is morpholino, pyrrolidino, piperidino or hexamethyleneimino, n is an integer of 1 to 5; and R.sub.5 is alkyl of 1 to 4 carbon atoms, 2,3-dihydroxypropyl or 2,2-dimethyl dioxolan-4-yl methyl or hydroxycarbonylmethyl.The compounds are obtained by reacting 2-Ar-2-chloro-6-methyl pyrimidine, with ##SPC2##The compounds possess sedative, antiinflammatory, antiulcerous, vasodilatatory, antibronchoconstrictive, anticholinergic, diuretic, spasmolytic, cardiac analeptic, analgesic and myorelaxant properties.
Description
The present invention relates to novel arylamino pyrimidinic derivatives, their process of preparation and their therapeutic application. The novel derivatives according to the invention correspond to the general formula: ##SPC3## In which: Ar represents an unsubstituted phenyl ring or a phenyl ring substituted by one or more halogen atoms, by a trifluoromethyl or a methylene dioxy group, by one or more methoxy groups, by an alkyl radical containing up to 4 carbon atoms or by a dimethylamino group; and R represents: a carboxamidic group of formula: ##EQU6## in which R.sub.1 and R.sub.2 each represent a hydrogen atom or an alkyl radical containing up to 4 carbon atoms, or form together with the nitrogen atom to which they are attached a heterocyclic ring selected from the following: pyrrolidino, morpholino, piperidino or piperazino N'-substituted by an alkyl radical containing up to 4 carbon atoms or by a phenyl ring, or an amino alkoxy chain of formula: ##EQU7## in which R.sub.3 and R.sub.4 each represent an alkyl radical containing 1 to 3 carbon atoms, or may form togerher with the nitrogen atom to which they are attached, a heterocyclic ring selected from the following: morpholino, pyrrolidino, piperidino and hexamethyleneimino, n being an integer of from 1 to 5, or an alkoxycarbonyl group of formula ##EQU8## in which R.sub.5 represents an alkyl radical containing up to 4 carbon atoms, a 2,3-dihydroxypropyl radical or a 2,2-dimethyl dioxolan -4-yl methyl radical, or a hydroxycarbonylmethyl radical. The process according to the invention consists in condensing in acetic acid and in the presence of hydrochloric acid, a 2-aryl-4-chloro-6-methyl pyrimidine of the general formula: ##SPC4## in which: Ar represents an unsubstituted phenyl ring or a phenyl ring substituted by one or more halogen atoms, by a trifluoromethyl or a methylene dioxy group, by one or more methoxy groups, by an alkyl radical containing up to 4 carbon atoms or by a dimethylamino group, with an anilino derivative of the general formula: ##SPC5## in which R' represents: a carboxamidic group of formula ##EQU9## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or an alkyl radical containing up to 4 carbon atoms, or form together with the nitrogen atom to which they are attached, a heterocyclic ring selected from the following: pyrrolidino, morpholino, piperidino or piperazino N'-substituted by an alkyl radical containing up to 4 carbon atoms or by a phenyl ring, or an amino alkoxy chain of formula ##EQU10## in which R.sub.3 and R.sub.4 each represent an alkyl radical containing 1 to 3 carbon atoms, or may form, together with the nitrogen atom to which they are attached, a heterocyclic ring selected from the following: morpholino, pyrrolidino, piperidino and hexamethyleneimino, n being an integer of from 1 to 5, or an alkoxycarbonyl group of formula ##EQU11## in which R.sub.5 represents an alkyl radical containing up to 4 carbon atoms, or a hydroxycarbonylmethyl radical, to produce a derivative corresponding to the general formula: ##SPC6## and, on occasion, to subject a derivative of formula I', in which R' represents a methoxycarbonyl group, to a transesterification process in the presence of sodium with 2,2-dimethyl-4' hydroxymethyl-1,3-dioxolane to produce a derivative of formula: ##SPC7## which may then be transformed into a derivative of formula: ##SPC8## by opening of the dioxolane ring by the action of 2N hydrochloric acid.
The following preparations are given by way of example to illustrate the invention. EXAMPLE 1 2-(3',4',5'- trimethoxy phenyl)-4-(para pyrrolidino carbonyl phenylamino) -6-methyl pyrimidino (Code No. 72271) A mixture of 44.2g of 2-(3',4',5'-trimethoxy phenyl)-4-chloro-6-methyl pyrimidine and 28.6 g of 4 - pyrrolidino carbonyl anilino in 300 c.c. of acetic acid in the presence of 0.45 cc of concentrated hydrochloric acid is heated at 80.degree.C for 40 minutes. After cooling, the solution is diluted with 2.5 l of water and alkalinised with ammonia. The precipitate formed is filtered, washed with water and recrystallized from ethyl acetate. Melting point = 210.degree.C Yield = 71% Empirical formula = C.sub.25 H.sub.28 N.sub.4 O.sub.4 Elementary analysis: ______________________________________ C H N______________________________________Calculated % 66.94 6.29 12.49Found % 66.85 6.40 12.49______________________________________ EXAMPLE 2 2 - (3' - trifluoromethylphenyl)-4- [ortho (.beta., .gamma.-dihydroxy propoxycarbonyl) phenyl amino] -6-methyl pyrimidine. (Code No: 72 502) 1st stage N - [2-(3'-trifluoromethylphenyl)- 6-methyl-4-pyrimidyl]methyl anthranilate. (Code No: 72 437) This derivative is obtained by the mode of operation described in Example 1 the recrystallisation being carried out in isopropyl alcohol and not ethyl acetate. Melting point = 111.degree.C Yield = 86% Empirical formula = C.sub.20 H.sub.16 F.sub.3 N.sub.3 O.sub.2 Elementary analysis: ______________________________________ C H N______________________________________Calculated % 62.01 4.16 10.85Found % 62.06 4.21 10.76______________________________________ 2nd stage N-[2-(3'trifluoromethyl phenyl) -6-methyl-4-pyrimidyl](2",2" -dimethyl dioxolan -4"-yl) methyl anthranilate. (Code No. 72 495) 500 c.c of 2,2 - dimethyl -4-hydroxymethyl dioxolane and then 0.6 g. of sodium are introduced into a reaction vessel which has previously been purged with nitrogen. The vessel is warmed just until total dissolution of the sodium is effected. After returning to ambient temperature, 162 g of N-[2-(3'-trifluoromethyl phenyl)-6-methyl -4-pyrimidyl] methyl anthanilate, of code No. 72 437 obtained in the preceding stage, is introduced into the reaction vessel. The mixture is heated for 5 hours at 145.degree.C, under nitrogen, the methanol formed during the course of the reaction being distilled off. After cooling, the solution obtained is diluted with 3 liters of water. The precipitate formed is filtered, washed with water and recrystallised from ethanol. Melting point = 107.degree.C Yield = 80% Empirical formula = C.sub.25 H.sub.24 F.sub.3 N.sub.3 O.sub.4 Molecular weight = 487.46 Elementary analysis: ______________________________________ C H N______________________________________Calculated % 61.59 4.96 8.62Found % 61.64 5.04 8.77______________________________________ 3rd stage 2-(3'-trifluoromethyl phenyl)-4- ortho (.xi.,.gamma.-dihydroxy propoxycarbonyl) phenylamino]-6-methyl pyrimidine (Code No. 72 502) A suspension of 111.8g of N-[2-(3'-trifluoromethylphenyl)-6-methyl-4-pyrimidyl] (2",2"-dimethyl dioxolan-4"-yl) methyl anthranilate of code No. 72 495 obtained in the preceding stage, in 750 c.c of 2N hydrochloric acid is heated for 20 minutes under reflux. After cooling, the precipitate obtained is filtered, washed with water, dissolved in 1 l of 50% alcohol and neutralised with triethylamine. The solution is concentrated the residue is taken up in 1 l of water, the precipitate is filtered, washed with water and recrystallised from ethanol Melting point = 154.degree.C Yield = 74% Empirical formula = C.sub.22 H.sub.20 F.sub.3 N.sub.3 O.sub.4 Elementary analysis: ______________________________________ C H N______________________________________Calculated % 59.06 4.51 9.39Found % 59.10 4.64 9.51______________________________________ The derivatives listed in the following Table I have been prepared by the same mode of operation. TABLE I__________________________________________________________________________ Melt- ingCode Empirical Molecular point Yield Elementary analysisNo. Ar formula weight (.degree.C) (%) C H N__________________________________________________________________________ Calculated72 327 C.sub.20 H.sub.19 ClN.sub.4 O 366.84 232 30 % 65.48 5.22 15.27 Found (%) 65.36 5.17 15.18 Calculated72 255 " C.sub.22 H.sub.21 ClN.sub.4 O 392.88 242 50 (%) 67.25 5.39 14.24 Found (%) 67.10 5.25 14.10 Calculated72 256 " C.sub.22 H.sub.21 ClN.sub.4 O.sub.2 408.38 220 50 (%) 64.62 5.18 13.70 Found (%) 64.51 4.98 13.51 Calculated72 276 " C.sub.23 H.sub.23 ClN.sub.4 O 406.90 238 38 (%) 67.89 5.70 13.77 Found (%) 67.89 5.90 13.61 Calculated72 292 " C.sub.23 H.sub.24 ClN.sub.5 O 421.92 215 27 (%) 65.47 5.73 16.60 Found (%) 65.35 5.58 16.67 Calculated72 260 " C.sub.28 H.sub.26 ClN.sub.5 O 479.99 230 54 (%) 69.48 5.42 14.47 Found % 69.40 5.25 14.27 Calculated72 257 C.sub.18 H.sub.15 ClN.sub.4 O 338.79 234 68 % 63.81 4.46 16.54 Found (%) 63.96 4.53 16.35 Calculated72 311 " C.sub.18 H.sub.15 ClN.sub.4 O 338.79 228 58 (%) 63.81 4.46 16.54 Found (%) 63.65 4.56 16.51 Calculated72 283 " C.sub.20 H.sub.18 ClN.sub.3 O.sub.2 367.82 180 84 (%) 65.30 4.93 11.42 Found (%) 65.50 5.13 11.22 Calculated71 442 " C.sub.19 H.sub.16 ClN.sub.3 O.sub.2 353.79 150 40 (%) 64.50 4.56 11.88 Found (%) 64.30 4.38 11.91 Calculated71 488 " C.sub.24 H.sub.24 ClN.sub.3 O.sub.4 453.91 139 50 (%) 63.50 5.33 9.26 Found (%) 63.60 5.42 9.15 Calculated71 530 " C.sub.21 H.sub.20 ClN.sub.3 O.sub.4 413.85 173 50 (%) 60.94 4.87 10.15 Found (%) 60.84 4.94 10.26 Calculated72 755 C.sub.22 H.sub.21 FN.sub.4 O 376.42 246 33 (%) 70.19 5.62 14.89 Found (%) 70.16 5.56 14.95 Calculated72 754 C.sub.22 H.sub.21 FN.sub.4 O.sub.2 392.42 187 71 (%) 67.33 5.39 14.28 Found (%) 67.53 5.33 14.38 Calculated72 741 " C.sub.23 H.sub.23 FN.sub.4 O 390.45 214 66 (%) 70.75 5.94 14.35 Found (%) 70.55 5.90 14.38 Calculated72 783 " C.sub.18 H.sub.15 FN.sub.4 O 322,33 224 72 (%) 67.07 4.69 17.38 Found (%) 66.87 4.87 17.28 Calculated72 773 " C.sub.18 H.sub.15 FN.sub.4 O 322.33 219 55 (%) 67.07 4.69 17.38 Found (%) 67.17 4.66 17.45 Calculated72 778 " C.sub.20 H.sub.18 FN.sub.3 O.sub.2 351.38 168 82 (%) 68.36 5.16 11.96 Found (%) 68.37 5.13 12.06 Calculated72 772 " C.sub.19 H.sub.16 FN.sub.3 O.sub.2 337.34 119 88 (%) 67.64 4.80 12.46 Found (%) 67.80 4.79 12.30 Calculated72 796 " C.sub.24 H.sub.24 FN.sub.3 O.sub.4 437.46 105 63 (%) 65.89 5.53 9.61 Found (%) 65.86 5.42 9.59 Calculated72 826 C.sub.21 H.sub.20 FN.sub.3 O.sub.4 397.39 143 31 (%) 63.47 5.07 10.57 Found (%) 63.43 5.01 10.73730234 " C.sub.19 H.sub.16 FN.sub.3 O.sub.2 +1/2H.sub.2 O 346.35 179 50 (%) 65.88 4.95 12.13 Found (%) 66.03 4.76 12.02 Calculated72 473 C.sub.23 H.sub.21 F.sub.3 N.sub.4 O 426.43 206 55 (%) 64.78 4.96 13.14 Found (%) 64.74 4.76 13.21 Calculated72 420 " C.sub.23 H.sub.21 F.sub.3 N.sub.4 O.sub.2 442.43 193 65 (%) 62.44 4.78 12.66 Found (%) 62.26 4.80 12.50 Calculated72 421 " C.sub.24 H.sub.23 F.sub.3 N.sub.4 O 440.46 204 51 (%) 65.44 5.26 12.72 Found (%) 65.33 5.29 12.72 Calculated72 503 " C.sub.29 H.sub.26 F.sub.3 N.sub.5 O 517.54 198 27 (%) 67.30 5.06 13.51 Found (%) 67.29 5.26 13.33 Calculated72 419 " C.sub.19 H.sub.15 F.sub.3 N.sub.4 O 372.34 193 81 (%) 61.29 4.06 15.05 Found (%) 61.20 4.20 15.03 Calculated72 432 " C.sub.19 H.sub.15 F.sub.3 N.sub.4 O 372.34 180 83 (%) 61.29 4.06 15.05 Found (%) 61.46 3.88 14.83 Calculated72 505 C.sub.21 H.sub.18 F.sub.3 N.sub.3 O.sub.2 401.38 260 71 (%) 62.84 4.58 10.47 Found (%) 62.87 4.67 10.56 Calculated72 623 C.sub.23 H.sub.22 N.sub.4 O.sub.3 402.44 225 69 (%) 68.64 5.51 13.92 Found (%) 68.46 5.60 13.78 Calculated72 621 " C.sub.23 H.sub.22 N.sub.4 O.sub.4 418.44 260 31 (%) 66.01 5.30 13.39 Found (%) 65.97 5.35 13.22 Calculated72 687 " C.sub.24 H.sub.24 N.sub.4 O.sub.3 416.46 248 78 (%) 69.21 5.81 13.45 Found (%) 69.30 5.80 13.27 Calculated72 608 " C.sub.19 H.sub.16 N.sub.4 O.sub.3 348.35 210 51 (%) 65.51 4.63 16.08 Found (%) 65.43 4.69 16.03 Calculated730025 " C.sub.19 H.sub.16 N.sub.4 O.sub.3 348.35 243 45 (%) 65.51 4.63 16.08 Found (%) 65.27 4.70 16.05 Calculated72 613 " C.sub.21 H.sub.19 N.sub.3 O.sub.4 377.39 180 83 (%) 66.83 5.07 11.14 Found (%) 66.67 5.12 11.33 Calculated72 665 " C.sub.20 H.sub.17 N.sub.3 O.sub.4 363.36 163 87 (%) 66.11 4.72 11.57 Found (%) 66.05 4.88 11.57 Calculated72 701 C.sub.25 H.sub.25 N.sub.3 O.sub.6 463,48 149 59 (%) 64,78 5,44 9,07 Found (%) 64.98 5,36 9,23 Calculated72 686 " C.sub.22 H.sub.21 N.sub.3 O.sub.6 423,41 161 73 (%) 62,40 5,00 9,93 Found (%) 62,60 4,98 9,92 Calculated72 536 C.sub.25 H.sub.28 N.sub.4 O.sub.5 464,51 206 72 (%) 64,64 608 12,06 Found (%) 64,50 6,15 11,98 Calculated72 317 " C.sub.26 H.sub.30 N.sub.4 O.sub.4 462,53 217 59 (%) 67,51 6,54 12,11 Found (%) 67,42 6,52 11,91 Calculated72 462 " C.sub.26 H.sub.31 N.sub.5 O.sub.4 477,59 190 37 (%) 65,39 6,54 14,67 Found (%) 65,38 6,66 14,54 Calculated72 450 " C.sub.31 H.sub.33 N.sub.5 O.sub.4 539,61 230 42 (%) 69,00 6,16 12,98 Found (%) 68,80 6,24 12,84 Calculated72 442 C.sub.21 H.sub.22 N.sub.4 O.sub.4 394.42 190 54 (%) 63.94 5.62 14.21 Found (%) 63.94 5.71 14.11 Calculated72 417 " C.sub.21 H.sub.22 N.sub.4 O.sub.4 394.42 212 46 (%) 63.94 5.62 14.21 Found (%) 63.74 5.66 14.19 Calculated72 247 " C.sub.23 H.sub.25 N.sub.3 O.sub.5 423.45 210 81 (%) 65.23 5.95 9.93 Found (%) 65.27 5.98 9.87 Calculated72 479 " C.sub.22 H.sub.23 N.sub.3 O.sub.5 409.43 121 52 (%) 64.53 5.66 10.26 Found (%) 64.74 5.65 10.31 Calculated71 510 " C.sub.27 H.sub.31 N.sub.3 O.sub.7 509.54 118 56 (%) 63.64 6.13 8.25 Found (%) 64,84 6.02 8.34__________________________________________________________________________ Mel- Molec- tingCode Empirical ular point Yield Elementary AnalysisNo. Ar Formula weight (.degree.C) (%) C H N__________________________________________________________________________ Calcu-730136 base C.sub.21 H.sub.24 N.sub.4 O 348.43 155 94 lated % 72.38 6.94 16.08 Found % 72.53 6.86 16.39 hy- Calcu-730282 dro C.sub.25 H.sub.33 ClN.sub.4 O 441.00 220 67 lated % 68.08 7.54 12.71 chlo- Found % 67.95 7.74 12.86 ride Calcu-730218 base C.sub.23 H.sub.26 N.sub.4 O 374.47 157 77 lated % 73.77 7.00 14.96 Found % 73.88 7.09 14.54 Calcu-730221 base C.sub.24 H.sub.28 N.sub.4 O 388.50 130 51 lated % 74.19 7.26 14.42 Found % 74.39 7.36 14.22 Calcu-730591 base C.sub.24 H.sub.30 N.sub.4 O.sub.4 438.51 133 62 lated % 65.73 6.90 12.78 Found % 65.53 6.95 12.76 Calcu-730229 base C.sub.23 H.sub.26 N.sub.4 O.sub.2 390.47 121 57 lated % 70.74 6.71 14.35 Found % 70.93 6.88 14.15 hy- Calcu-730389 dro- C.sub.25 H.sub.31 ClN.sub.4 O 438.99 177 41 lated % 68.40 7.12 12.76 chlo- Found % 68.25 6.92 12.79 ride Calcu-730225 base C.sub.21 H.sub.23 ClN.sub. 382.88 129 53 lated % 65.87 6.06 14.63 Found % 66.07 6.26 14.64 Calcu-730241 base C.sub.22 H.sub.23 F.sub.3 N.sub.4 O 416.44 132 48 lated % 63.44 5.57 13.46 Found % 63.58 5.68 13.56 Calcu-730243 base C.sub.24 H.sub.25 F.sub.3 N.sub.4 O 442.47 133 75 lated % 65.14 5.70 12.66 Found % 65.33 5.70 12.85 Calcu-730224 base C.sub.21 H.sub.23 FN.sub.4 O 366.43 167 55 lated % 68.63 6.33 15.29 Found % 68.94 6.53 15.37 Calcu-730231 base C.sub.24 H.sub.27 FN.sub.4 O 406.49 140 68 lated % 70.91 6.70 13.73 Found % 71.09 6.86 13.66 Calcu-730262 base C.sub.21 H.sub.23 ClN.sub. 382,89 136 50 lated % 65,87 6.06 14.63 Found % 66.04 6.26 14.58 Calcu-730283 base C.sub.25 H.sub.29 ClN.sub. 436,97 126 30 lated % 68.71 6.69 12.82 Found % 68.78 6.91 12.98 Calcu-730633 base C.sub.26 H.sub.32 N.sub.4 O.sub.5 480.55 129 67 lated % 64.98 6.71 11.66 Found % 64.77 7.28 11.60 semi- Calcu-730741 hy- C.sub.24 H.sub.30 N.sub.4 O.sub.4 447.52 111 34 lated % 64.41 6.98 12.52 drate + 1/2 H.sub.2 O Found % 64.88 7.00 12.58 Calcu-730732 base C.sub.23 H.sub.25 ClN.sub. 424.92b.2 134 73 lated % 65.01 5.93 13.19 Found % 64.77 5.90 13.28 Calcu-730695 " C.sub.23 H.sub.25 ClN.sub. 424.92b.2 134 69 lated % 65.01 5.93 13.19 Found % 64.78 6.02 13.24 Calcu-730712 " C.sub.24 H.sub.25 F.sub.3 N.sub.4 O.sub.2 458.47 132 53 lated % 62.87 5.50 12.22 Found % 62.79 5.51 12.40 Calcu-730731 " C.sub.24 H.sub.26 N.sub.4 O.sub.4 434.48 112 72 lated % 66.34 6.03 12.90 Found % 66.20 5.93 12.70 Calcu-740 023 base C.sub.23 H.sub.25 FN.sub.4 O.sub.2 408.46 128 73 lated % 67.63 6.17 13.72 Found % 67.86 6.15 13.60 Calcu-740 108 base C.sub.24 H.sub.28 N.sub.4 O.sub.3 420.50 150 67 lated % 68.55 6.71 13.33 Found % 68.81 6.91 13.15 Calcu-740 087 base C.sub.24 H.sub.28 N.sub.4 O.sub.2 404.50 143 70 lated % 71.26 6.98 13.85 Found % 71.46 7.18 13.68 Calcu-740 140 base C.sub.25 H.sub.31 N.sub.5 O.sub.2 433.54 163 50 lated % 69.26 7.12 16.16 Found % 69.16 7.37 16.06 Calcu-740 067 base C.sub.26 H.sub.32 N.sub.4 O.sub.5 480.55 142 77 lated % 64.98 6.71 11.66 Found % 64.86 6.91 11.46 Calcu-740391 base C.sub. 23 H.sub.28 N.sub.4 O.sub.3 408.49 372 71 lated % 67.62 6.91 13.72 Found % 67.63 6.86 13.71 Calcu-740393 base C.sub.23 H.sub.26 N.sub.4 O.sub.2 390.47 123 43 lated % 70.74 6.71 14.35 Found % 70.87 6.81 14.33 Calcu-740324 base C.sub.24 H.sub.28 N.sub.4 O.sub.2 404.50 124 75 lated % 71.26 6.98 13.85 Found % 71.11 7.09 13.78__________________________________________________________________________ The derivatives of formula I have been tested on animals in the laboratory and have been shown to possess sedative, antiinflammatory, antiulcerous, vasodilatatory, antibronchoconstrictive and anticholinergic, diuretic, spasmolytic, cardiacanaleptic, analgesic and myorelaxant properties, certain of the derivatives possessing hypotensive properties whilst other possess hypertensive properties. 1. Sedative properties The derivatives of formula I, administered by oral means to the mouse, reduce the number of explorations in the escape enclosure and in an actimeter having luminous beams and photoelectric cells. By way of example the following Table II lists the percentage diminution in the number of explorations in the escape enclosure, resulting from the administration of 100mg/kg/p.o. of different derivatives of formula I. TABLE II______________________________________Code No. of Percentage diminution ofderivatives tested number of explorations (%)______________________________________71 510 4072 271 4072 432 3572 442 6072 450 3572 536 7572 773 4572 778 35730 712 32730 741 30______________________________________ Also, the DE 50 of the derivative of code No. 730 229 is 82mg/kg/p.o. for the test on the number of explorations in the escape enclosure and 120mg/kg/p.o. for the test on the number of explorations in the actimeter. 2. Hypertensive properties Administered by intraveinous means, the derivatives of formula I provoke an increase in the arterial pressure of an anaosthetised rat. By way of example, the results obtained by the administration of 2 mg/kg/i.v. of different derivatives of formula I are listed in the following Table III. TABLE III______________________________________Code Nos. of Percentage augmentation Duration ofderivative tested of arterial pressure (%) effect (mm)______________________________________730 712 23 .perspectiveto.30730 741 27 .perspectiveto.35______________________________________ 3. Antiulcerous properties The derivatives of formula I, administered by oral means, reduce the extent of gastric ulcers provoked in a rat by tying of the pylorus (Shay ulcers) Table IV indicated, by way of example, the results obtained by the administration of 50mg/kg/i.d. of different derivatives of formula I. TABLE IV______________________________________Code No. of Percentage reductionderivative tested of shay ulcers %______________________________________71 510 3572 255 3572 257 5072 260 3572 276 4072 311 4072 317 4072 417 4072 432 3572 502 3572 613 7072 621 4072 687 40730 225 53730 231 50730 283 45730 282 5072 754 4072 773 40730 025 35______________________________________ 4. Vasodilatatory properties The derivatives of formula I are capable of augmenting the flow of the coronary vessels of this isolated heart of a guinea - pig, when said derivatives are added in the perfusion liquid of said organ. The percentage augmentation of the flow of the isolated heart of the guinea - pig by adding different derivatives of formula I to the perfusion liquid are given by way of example in the following Table V. TABLE V______________________________________ Percentage augment- ation of flow ofCode No. of Dose administered isolated heart ofderivative tested (.mu.g/ml) guinea - pig (%)______________________________________72 255 1 4572 257 1 8072 260 1 7072 450 1 8572 505 1 5072 613 1 8572 796 1 60730283 0.1 61730241 0.5 77______________________________________ 5. Antibronchoconstrictive and anticholinergic properties Injected by intraduodenal means, the derivatives of formula I are capable of opposing the bronchoconstriction provoked in the guinea - pig by the intraveinous injection of acetylcholine and evaluated by the Konzett method. By way of example, the following Table VI lists the percentage inhibition of the bronchoconstriction following the intraperitoneal injection of 100mg/kg of different derivatives of formula I. TABLE VI______________________________________Code No. of Percentage inhibitionderivative tested of bronchoconstriction (%)______________________________________72 255 5072 276 5072 311 8072 502 5072 608 6572 826 100730 025 50______________________________________ 6. Diuretic properties The derivatives of formula I, administered by oral means to the mouse, simultaneously with a volume of 1ml of an isotonic solution of sodium chloride per 25g of the corporeal weight of the mouse, are capable of provoking an augmentation of the volume of urine emitted by reference to control animals, the volume being measured for 6 hours following administration. The following Table VII indicates, by way of example the percentage augmentation of urinary elimination resulting from the administration of 25mg/kg/p.o. of different derivatives of formula I. TABLE VII______________________________________Code No. of Percentage augmentation ofderivative tested urinary elimination (%)______________________________________72 292 5572 327 8572 417 6572 419 8072 432 20072 495 11572 623 8572 701 4572 754 5072 773 11072 783 8072 826 80730 025 140730 229 129730 695 43730 712 90730 731 37______________________________________ 7. Hypotensive properties Administered by intraveinous means to an anaesthetised rat, the derivatives of formula I provoke a lowering of the arterial pressure. By way of example, the following Table VIII mentions the results obtained by administration of different derivatives of formula I. TABLE VIII______________________________________ Dose Percentage reduction DurationCode No. of administered of arterial pressure of effectderivative tested (mg/kg/i.v.) of anaesthetised rate % (mn)______________________________________ 72 327 1 30 30 72 442 1 30 20740 140 1 40 30730 241 2 24 30730 731 1 29 30______________________________________ 8. Cardiac properties These properties are shown by an augmentation of the force of contractions (positive inotrope action) on the isolated heart of a guinea-pig maintained in a conserving medium and under appropriate experimental conditions. Also, the derivatives of Code Nos. 72419 and 730218 added to the conserving medium, in a concentration of 1 .mu.g/ml and 0.5 .mu.g/ml, respectively, exert a positive inotrope action on the isolated heart of the guinea-pig. Additionally, the derivative of Code No. 730 712 added to the conserving medium in a concentration of 1 .mu.g/ml, permit an augmentation of 140% in the force of contractions on the isolated heart of the guinea- pig. 9. Analgesic properties The derivatives of formula I administered by oral means to the mouse, are capable of reducing the number of painful stretchings caused by the intraperitoneal injection of phenylbenzoquinone, acetic acid or bradykinine and can potentialise the analagesic action of dextromoramide in the Eddy test. Administered by oral means to the rat, they protect the animal against crying and jumping in the Randall and Selitto test. By way of example: the following table IX shows the results obtained by administration of different derivatives of formula I, these results being estimated by the DE 50 of the derivatives and compared to those following administration of: amidopyrine or 4-dimethylamino-2,3-dimethyl-1 phenyl-3-pyrazolin-5-one of glaphenine or N- (7-chloro-4-quinolyl) anthranilic acid 2,3-dihydroxypropyl ester and of acetylsalicylic acid these products being well-known analgesics, and, table X shows the percentages of diminution of the number of painful stretchings observed following the administration of 100 mg/kg/Po of different derivatives. Moreover, the derivatives of formula I, administered rectally to a rabbit, enabled the pain threshold to be raised in the dentary pulp stimulation test. As an example, the following table XI gives the results of a comparative study between the activity of derivative code number 730 229 and that of glaphenine, the activities being estimated by the dentary stimulation test TABLE IX__________________________________________________________________________Nature oftests 105 DE DE 50 DE 50effected Compound tested (mg/kg/PO) (mg/kg/PO) DL 50__________________________________________________________________________ 730 731 27 >>2 000 <<1,5.10.sup.-.sup.2 730 218 37 1 500 2,5.10.sup.-.sup.2 730 224 30 >>2 000 <<1,5.10.sup.-.sup.2 Compounds 730 225 42 >2 000 <2 .10.sup..sup.-2 according 730 229 10 2 800 4.10.sup.-.sup.3 to the 730 231 27 975 3.10.sup.-.sup.2 invention of 730 262 52 2 500 2.10.sup.-.sup.2 Code No. 730 732 23 >>2 000 <<1.10.sup.-.sup.2Test with 740 140 33 >>2 000 <<1,5.10.sup.-.sup.2phenylbenzo amidopyrine 45 1 050 4,5.10.sup.-.sup.2quinone Reference glaphenine 60 1 900 3.10.sup.-.sup.2 compounds acetylsali- 72 700 10.sup.-.sup.1 cyclic acid Compounds according 730 229 45 2 800 1,5.10.sup.-.sup.2 to the invention ofTest with Code No. 730 262 100 2 500 4.10.sup.-.sup.2bradykinine amidopyrine 48 1 050 5.10.sup.-.sup.2 Reference glaphenine 48 1 900 2,5.10.sup.-.sup.2 Compounds acetylsali- 180 700 2,5.10.sup.-.sup.1 cylic acid Compounds according to the 730 229 70 2 800 2,5.10.sup.-.sup.2 invention ofTest with Code No.acetic acid amidopyrine 80 1 050 7,5.10.sup.-.sup.2 Reference compounds galphenine 80 1 900 4.10.sup.-.sup.2 acetylsali- 115 700 1,5.10.sup.-.sup.1 cylic acid Compounds 730 218 50 1 500 3,25.10.sup.-.sup.2 according 730 225 80 >>2 000 <<4.10.sup.-.sup.2 to the invention 730 229 23 2 800 8.10.sup.-.sup.2Eddy of Code No. 730 262 60 2 500 2,5.10.sup.-.sup.2test amidopyrine 35 1 050 3,25.10.sup.-.sup.2 Reference Unactif with compounds glaphenine 400 1 900 acetylsali- >200 (40 % cylic acid with 200) 700 >2,75.10.sup.-.sup.1 Compounds according to the 730 229 45 2 800 1,5.10.sup.-.sup.2Randall invention ofand Code No.Selittotest amidopyrine 110 1 050 1.10.sup.-1 Reference compounds glaphenine 65 1 900 3,25.10.sup.-.sup.2 acetylsali- 110 700 1,5.10.sup.-.sup.1 cylic acid__________________________________________________________________________ TABLE X__________________________________________________________________________ Percentage of Code numero diminution of of derivative Dose adminis. the number ofNature of test effected tested (mg/kg/PO) painful stretchings__________________________________________________________________________ 730 712 100 60 730 695 100 85 730 136 100 46 730 241 100 67 730 282 100 73Test with phenyl- 730 283 100 57benzoquinone 72 442 100 70 72 462 100 40 72 608 100 55 72 686 130 50 72 701 100 45 730 234 100 55Test with bradykinine 730 218 100 40Randall and Selitto test 730 225 100 50__________________________________________________________________________ TABLE XI__________________________________________________________________________ Average Number of increase rabbits whose of pain Dose adm. pain threshold threshold Duration (mg/kg/ DL 50 Dose adm. is increased at the peak Peak of actionCompound tested rectally (mg/kg/PO) DL 50 by 0,5 V of activity action (hours)__________________________________________________________________________Compoundsaccordingto the 730 229 50 2 800 2.10.sup.-.sup.2 7/10 + 2,9 1 h 2inventionof CodeNumeroCompound glaphenine 50 1 900 2,5.10.sup.-.sup.2 4/10 + 0,63 1tested 100 1 900 5.10.sup.-.sup.2 6/10 + 1,4 45 mn 1,5 200 1 900 1.10.sup.-.sup.1 8/10 + 1,5 2__________________________________________________________________________ Tables IX and X clearly show that the compounds of the invention show an analgesic activity superior to that of amidopyrine, glaphenine and acetylsallcylic acid since, to obtain the same effect it is enough to administer them in a dose representing a lesser fraction of the lethal dose. 10. Myorelaxant properties The derivatives of formula I, preventively administered by oral means to the mouse, reduce the mortality caused by the sub-cutaneous injection of strychnine. Thus, the derivative of Code No. 72608, administered in a dose of 100 mg/kg/p.o., permits a 50 % protection against the lethality of strychnine. 11. Spasmolytic properties The derivatives of formula I introduced in the conserving medium, are capable of opposing the contractural action of barium chloride in the isolated duodenum of the rat. This activity is evaluated taking papaverine as standard. Thus, the derivative of Code No. 730 282 presents a spasmolytic activity double to that of papaverine. 12. Antiinflammatory properties These properties are shown by a diminution of the local oedema caused by the sub-plantar injection of a phlogogenic agent, such as carraghenine, in the rat following the oral administration of derivatives of formula I. By way of example, the results obtained by the administration of different derivatives of formula I are listed in the following table XII. Table XIII, as far as it is concerned, gives the results of a comparative study between the antiinflammatory activity of derivative of Code No. 730 229, on the one hand, and the antiinflammatory activity of amidopyrine, glaphenine and acetylsallicylic acid, on the other hand, these reference compounds being those employed in the comparative study of the analgesic properties. TABLE XII______________________________________Code Numero of Dose administered Percentage reductionderivative tested (mg/kg/PO) of subplantar oedema______________________________________71 510 100 4072 255 100 6072 271 100 3572 283 100 4072 311 100 5072 317 100 3572 327 100 3572 419 100 5072 432 100 4572 442 100 5572 462 100 3572 536 100 3572 686 25 3572 773 100 4072 826 100 60730 234 100 35730 243 100 50______________________________________ TABLE XIII__________________________________________________________________________ DE 50 DL 50 DE 50Compound tested (mg/kg/PO) (mg/kg/PO) DL 50__________________________________________________________________________Compound accordingto the invention 730 229 22 2 800 8.10.sup.-.sup.3of Code Numero amidopyrine 140 1 050 1,25..sup.10.sup.-1Reference glaphenine 9 1 900 5.10.sup.-.sup.3compounds acetylsali- 40 700 6.10.sup.-.sup.2 cylic acid__________________________________________________________________________ Table XIII shows that the compound of code numero 730 229 possess a notable antiinflammatory activity, since clearly superior to that of amidopyrine and acetylsalicylic acid, and hardly inferior to that of glaphenine. As a result of a comparison between the pharmacologically active doses mentioned above, and the lethal doses listed in the following table XIV, the difference between the doses is sufficiently great to permit the utilisation of the derivatives of formula I in therapeutics. TABLE XIV______________________________________ Dose administered PercentageCode Numero of to the mouse mortalityderivative tested (mg/kg/PO) (%)______________________________________730 732 2 000 0730 218 1 500 .perspectiveto.50730 136 2 000 0730 221 520 .perspectiveto.50730 224 2 000 0730 225 2 000 .perspectiveto.20730 229 2 800 .perspectiveto.50730 231 975 .perspectiveto.50730 241 2 000 0730 379 625 .perspectiveto.50730 262 2 500 .perspectiveto.50730 282 1 000 .perspectiveto.50730 283 1 000 .perspectiveto.50730 243 1 000 0730 695 2 000 0730 712 2 000 0730 731 2 000 0730 741 1 500 .perspectiveto.50740 140 2 000 071 510 2 000 072 255 2 000 072 257 2 000 072 260 2 000 072 271 2 000 072 276 2 000 072 283 2 000 072 292 2 000 072 311 2 000 072 317 2 000 072 327 2 000 072 417 2 000 072 419 2 000 072 432 2 000 072 442 2 000 072 450 2 000 072 462 2 000 072 495 2 000 072 502 2 000 072 505 2 000 072 536 2 000 072 613 2 000 072 623 2 000 072 686 2 000 072 687 2 000 072 701 2 000 072 754 2 000 072 778 2 000 072 783 2 000 072 796 2 000 072 826 2 000 0730 025 2 000 072 621 2 000 .perspectiveto.3072 773 2 000 .perspectiveto.2072 608 1 600 .perspectiveto.50730 234 2 400 .perspectiveto.50______________________________________ The derivatives of formula (I) are useful in the treatment of gastro-duodenal ulcers, dedemas, anxiety, nervousness, contractions, inflammatory pains and diverse originating pains, cardiac insufficiencies, circulatory insufficiencies, asthma, viscoral spasms and according to the product, hypotension or hypertension. They may be administered by oral means, in the form of tablets, gelules and dragees, containing 25 to 400 mg of active ingredient (1 to 6 times per day), or suspensions containing 0.2 to 5% of active ingredient (10 to 100 drops, 1 to 3 times per day), by parenteral means in the form of injectable ampoules containing 10 to 15C mg of active ingredient (1 to 3 times per day) and by rectal means in the form of suppositories containing 25 to 300 mg of active ingredient (1 to 3 times per day). Accordingly the present invention also relates to a therapeutic composition comprising a derivative of the general formula (I) together with a therapeutically acceptable carrier.
Claims
1. A compound having the formula ##SPC9##
wherein Ar is phenyl or phenyl substituted by a halogen, or a trifluoromethyl, or a methylenedioxy, or one or more methoxy, or an alkyl having one to 4 carbon atoms or a dimethylamino, and wherein R is ##EQU12## wherein n is an integer from 1 to 5, and R.sub.3 and R.sub.4 each is alkyl having one to 3 carbon atoms, or ##EQU13## is morpholino, pyrrolidino, piperidino or hexamethyleneimino.
2. A compound as claimed in claim 1, in which Ar is phenyl and ##SPC10##
3. A compound as claimed in claim 1, in which Ar is phenyl and the symbol ##SPC11##is one of the following:
4-dimethylaminoethoxyphenyl, 4-di(n-propyl)-aminoethoxyphenyl, 4-pyrrolidinoethoxyphenyl, 4-piperidinoethoxyphenyl, 4-morpholinoethoxyphenyl, 2-morpholinoethoxyphenyl, 3-morpholinoethoxyphenyl, 4-hexamethyleneiminoethoxyphenyl and 4-morpholinopropoxyphenyl.
4. A compound as claimed in claim 1 in which Ar is 3-chlorophenyl and the symbol ##SPC12##is one of the following:
4-dimethylaminoethoxyphenyl, 4-hexamethyleneiminoethoxyphenyl and 4-morpholinoethoxyphenyl.
5. A compound as claimed in claim 1, in which Ar is a 4-chlorophenyl and the symbol ##SPC13##is one of the following:
4-dimethylaminoethoxyphenyl and 4-morpholinoethoxyphenyl.
6. A compound as claimed in claim 1, in which Ar is 3-fluorophenyl and the symbol ##SPC14##is one of the following:
4-dimethylaminoethoxyphenyl, 4-piperidinoethoxyphenyl, and 4-morpholinoethoxyphenyl.
7. A compound as claimed in claim 1, in which Ar is 3-trifluoromethylphenyl and the symbol ##SPC15##is one of the following:
4-dimethylaminoethoxyphenyl, 4-pyrrolidinoethoxyphenyl and 4-morpholinoethoxyphenyl.
8. A compound as claimed in claim 1, in which Ar is 3,4-methylenedioxyphenyl and the symbol ##SPC16##is
4-morpholinoethoxyphenyl.
9. A compound as claimed in claim 1, in which Ar is 3,4,5-trimethoxyphenyl and the symbol ##SPC17##is one of the following:
4-dimethylaminoethoxyphenyl, 4-morpholinoethoxyphenyl, 2-dimethylaminoethoxyphenyl and 2-morpholinoethoxyphenyl.
10. A compound as claimed in claim 1, in which Ar is 4-methoxyphenyl, 4-methylphenyl or 4-dimethylaminophenyl and the symbol ##SPC18##
Patent Grant
3978055
