Patent Application
20150007818
This disclosure relates to an assembly for an inhalation device and to the use of a sealing member for mechanical cooperation with a metering element of an inhalation device. The sealing member may be part of the previously mentioned assembly.
An inhalation device is described in document WO 2009/065707 A1, for example.
It is an object of the present disclosure to provide an assembly for an improved inhalation device, e.g. a more efficient inhalation device. Furthermore, it is an object of the present disclosure to provide an improved inhalation device. Furthermore, it is an object of the present disclosure to provide the use of a sealing member to facilitate provision of an improved inhalation device.
This object may, inter alia, be achieved by the subject matter of the independent claims. Advantageous embodiments and refinements are the subject matter of the dependent claims. However, further advantageous concepts may be disclosed herein besides the ones which are claimed.
One aspect relates to an assembly for an inhalation device. The inhalation device may be configured for delivering a plurality of doses of a substance to a patient. The assembly may comprise a storage chamber. The storage chamber may be configured to hold a plurality of doses of the substance. The assembly may further comprise a metering element. The metering element may be configured to be moved, preferably rotated and axially moved, with respect to the storage chamber. The metering element may comprise a metering chamber. The metering chamber may be configured for holding a sub-quantity of the substance. The sub-quantity may be retrieved from the storage chamber by means of the metering chamber when the metering element is moved in a dosing direction with respect to the storage chamber. The assembly may further comprise a sealing member. The sealing member may mechanically cooperate with the metering element. The sealing member may be configured for sealing the metering element. The sealing member may comprise an opening. The opening may be a central opening. The opening may receive the metering element. The metering element may be guided through the sealing member, in particular through the opening, when the metering element is moved with respect to the storage chamber. The sealing member may comprise a main part. The sealing member may further comprise a sealing lip. The main part and the sealing lip may be formed unitarily. The sealing lip and the main part may define a recess. The recess may be arranged between the sealing lip and the main part. The sealing lip may be moveable in the inward and in the outward direction with respect to the main part of the sealing member. The sealing lip may be deflectable into the recess.
The recess may enable the sealing lip to be flexible. Due to the flexibility of the sealing lip, the sealing lip may be able to efficiently seal the metering rod and, thus, the storage chamber. In particular, the sealing lip may be configured to prevent moisture from getting into the storage chamber. The sealing lip may be configured to prevent substance from the storage chamber unintentionally leave the storage chamber via the opening in the sealing member in the direction towards a mouthpiece of the inhalation device.
The degree of flexibility of the sealing lip may be determined by the recess, in particular by a depth and/or a width and/or a radius of curvature of the recess. The dimension of the recess and, thus the flexibility of the sealing lip, are expediently chosen such that the sealing lip can sealingly cooperate with different metering elements, in particular metering elements having different outer diameters of different widths which may arise from manufacturing tolerances. The dimension of the recess and, thus the flexibility of the sealing lip, are expediently chosen such that the sealing lip is in sealing contact with the respective metering element at any position of the metering element with respect to the storage chamber when the metering element and the sealing member mechanically cooperate with one another. In this way, an efficient and reliable sealing of the respective metering element is achieved, irrespective of manufacturing tolerances for the metering elements. Hence, provision of reliable inhalation devices is facilitated, even if the metering elements, e.g. metering rods, applied in different devices have varying dimensions.
A further aspect relates to the use of a sealing member. The sealing member may be used for mechanical cooperation with a metering element of an inhalation device. The sealing member may comprise an opening. The opening may be configured for receiving the metering element. The sealing member may further comprise a main part. The sealing member may further comprise a sealing lip. The sealing lip may be moveable in the inward and in the outward direction with respect to the main part of the sealing member. The sealing lip and the main part may define a recess. The recess may be arranged between the sealing lip and the main part. The sealing lip may be deflectable into the recess. The sealing lip may protrude into the opening.
The recess may enable the sealing lip to be flexible in the inward or the outward direction with respect to the main part. The sealing lip may be flexible such that, in the absence of mechanical cooperation with a metering rod, it protrudes into the opening. Accordingly, due to the sealing lip, the opening, in particular a diameter of the opening, may be reduced. When a metering rod is introduced into the opening, the sealing lip may be moved in the outward direction due to mechanical cooperation with the metering rod. The metering rod, in particular the outer dimension of the metering rod may determine how far the sealing lip is moved in the outward direction. The flexibility of the sealing lip may ensure that the sealing lip can efficiently seal metering rods having different outer diameters or widths arising from manufacturing tolerances. The flexibility of the sealing lip may ensure that the sealing lip is in sealing contact with any of these metering elements, irrespective of their outer dimension or width. In this way, an efficient inhalation device is provided.
According to an advantageous embodiment, an assembly for an inhalation device is provided, wherein the assembly comprises
According to an advantageous embodiment, the use of a sealing member for mechanical cooperation with a metering element of an inhalation device is described. The sealing member comprises an opening configured for receiving the metering element. The sealing member comprises a main part and a sealing lip, wherein the sealing lip and the main part define a recess, wherein the recess is arranged between the sealing lip and the main part, wherein the sealing lip is deflectable into the recess and, wherein the sealing lip protrudes into the opening.
Of course, features described above in connection with different aspects and embodiments may be combined with each other and with features described below.
Further features and refinements become apparent from the following description of the exemplary embodiments in connection with the accompanying figures.
Like elements, elements of the same kind and identically acting elements may be provided with the same reference numerals in the figures.
In
The inhalation device 1 further comprises a mouthpiece 6. Air is sucked into the device 1 via the mouthpiece 6. The inhalation device 1 comprises a cap 7. The cap 7 is used for covering the mouthpiece 6. The cap 7 may comprise a screw cap. The cap 7 may be rotatable about the main longitudinal axis x of the device 1 in a first direction with respect to the housing 3 for screwing the cap 7 onto the device 1 and in a second direction with respect to the housing 3 for unscrewing the cap 7 from the device 1. The outer cylinder 4 is rotationally connected to the cap 7. In particular, the outer cylinder 4 follows rotation of the cap 7 with respect to the housing 3. For a detailed description of the components of the inhalation device 1 and their mechanical cooperation it is referred to document WO 2009/065707 A1, the entire content of which is explicitly incorporated by reference into the present description, in particular as far as the operation of the device 1 is concerned.
The device 1 comprises a storage chamber 15. The storage chamber 15 holds one or more doses of a substance 2. The substance may comprise a drug. The substance 2 may comprise a powder.
The storage chamber 15, in particular the section of the storage chamber 15 which is closest to the mouthpiece 6 of the device 1, is terminated by a chamber ceiling 24. The device 1 further comprises a rotary part 25. The rotary part 25 is connected in a rotationally fixed manner to the outer cylinder 4. Accordingly, the rotary part 25 follows rotation of the outer cylinder 4 and, hence, of the cap 7 about the main longitudinal axis x with respect to the storage chamber 15.
The chamber ceiling 24 comprises a central through-opening. A cylindrical portion 25A of the rotary part 25 passes through the central through-opening of the chamber ceiling 24. The lower free end surface of the cylindrical portion 25A is located in the plane of that surface of the chamber ceiling 24 which covers the storage chamber 15. The diameter of the through-opening in the chamber ceiling 24 is larger than the diameter of the cylindrical portion 25A of the rotary part 25.
The device 1 further comprises a metering element 33. The metering element 33 may comprise a metering rod. The metering element 33 may have a circular or a non-circular cross-section, such as a rectangular cross-section. As can be gathered from the sectional view of the metering element 33, the metering element 33 may comprise a first or broad side 33A and a second or small side 33B (see
The metering element 33 comprises a metering chamber 40. The metering chamber 40 is positioned offset from the rotation axis of the metering element 33. The rotation axis is the main longitudinal axis x of the inhalation device 1. The metering element 33 is configured for functioning as a moving metering chamber 40 for accommodating a sub-quantity 14 of the substance 2 which is to be dispensed during the inhalation action performed by a user. The metering chamber 40 is formed in that end section of the metering element 33 which projects into the substance 2. The metering chamber 40 is disposed eccentrically in relation to the side surface of the metering element 33. For detailed description of the operation of the metering element 33, it is referred to document WO 2009/065707 A1.
The device 1 further comprises a sealing member 31. The cylindrical portion 25A accommodates the sealing member 31 in its center. In particular, the sealing member 31 is arranged subsequently to the cylindrical portion 25A in the radial inward direction with respect to the housing 3. The sealing member 31 is arranged between the cylindrical portion 25A and the metering element 33. The sealing member 31 is arranged circumferentially around the metering element 33, as can be seen in
The sealing member 31 comprises or consists of a rubber material or a similar elastic material. The sealing member 31 comprises a thermoplastic elastomer, for example. The sealing member 31 may be produced by a two-component injection molding process together with the rotary part 25. Alternatively, the sealing member 31 may be produced in a separate manufacturing step. In this embodiment, the sealing member 31 and the rotary part 25 are connected to one another such that the sealing member 31 is secured against axial and rotational movement with respect to the rotary part 25. The sealing member 31 may, for example, be clipped into the rotary part 25.
The sealing member 31 may be snap-fitted to the cylindrical portion 25A of the rotary part 25, for example. For this purpose, the sealing member 31 may comprise connection elements 98 (see
The sealing member 31 is configured for sealing that end of the storage chamber 15 which is closest to the mouthpiece 6. The sealing member 31 is configured for sealing the metering element 33. In particular, the sealing member 31 is configured to prevent moisture from getting into the storage chamber 15 via an opening via which the metering element 33 passes through the sealing member 31 into the storage chamber 14. The sealing member 31 is further configured to prevent substance 2 from the storage chamber 15 to get unintentionally across the sealing member 31 via the opening via which the metering element 33 passes through the sealing member 31 into the storage chamber 15. The sealing member 31 is described in detail in connection with
In plan view, the sealing member 31 may be cylindrically or rectangularly shaped, which can be seen in the
The sealing member 31 comprises a main part 32. The main part 32 extends in the axial direction from a first end 36 of the sealing member 31 to a second end 37 of the sealing member 31. The first end 36 is that end which is closest to the mouthpiece 6. The second end 37 is the end which is furthest away from the mouthpiece 6.
In the section of the first end 36, the sealing member 31, in particular the main part 32, comprises a protrusion 32a (see, in particular,
In the direction towards the storage chamber 15, in particular in the direction towards the second end 37, the opening 31a widens up into a cavity 96 of the sealing member 31. The cavity 96 is delimited by an inner surface 34 of the sealing member 31, in particular of the main part 32.
The sealing member 31 comprises a sealing lip 81. The sealing lip 81 is less rigid than the protrusion 32a. The protrusion 32a protrudes from the main part 32 in the inward direction and transitions in the axial direction into the sealing lip 81. The sealing lip 81 and the main part 32 of the sealing member 31 are formed unitarily. The sealing lip 81 is oriented in an axial direction opposite to the first or dosing direction in which the metering element 33 is moved with respect to the storage chamber 15 during operation of the device 1. In other words, the sealing lip 81 is oriented in the second direction with respect to the storage chamber 15. The sealing lip 81 is arranged in the section of the first end 36 of the sealing member 31. The sealing lip 81 is circumferentially disposed along opening 31a of the sealing member 31. The contour of the sealing lip 81 is adapted to the cross-section of the metering element 33.
The sealing lip 81 and the main part 32 define a recess 35. In particular, the recess 35 is arranged between the sealing lip 81 and the main part 32. The recess 35 is arranged in the section of the first end 36 of the sealing member 31. The recess 35 is defined by the protrusion 32a. The protrusion 32a has a first end section 41 and a second end section 42. The first end section 41 is the section which is closest to the mouthpiece 6 and the second end section 42 is the section which is furthest away from the mouthpiece 6. The recess 35 is arranged in the second end section 42 of the protrusion 32a. The recess 35 faces towards the storage chamber 15. The recess 90 comprises a lowest point 90. The lowest point 90 is that point of the recess 35 which is furthest away from the storage chamber 15. The sealing lip 81 defines a side wall of the recess 35. In particular the sealing lip 81 defines that side wall of the recess 35 which is arranged most inwardly with respect to the housing 3. The contour of the recess 35 is adapted to the cross-section of the metering element 33.
The sealing lip 81 comprises a tip or end 94. The tip 94 is arranged at that end of the sealing lip 81 which is furthest away from the mouthpiece 6. In one embodiment (see
A distance d1 (see
The sealing lip 81 comprises an interaction face 81b. The interaction face 81b points into the inward direction and towards the metering element 33. The sealing lip 81, in particular the interaction face 81b of the sealing lip 81 mechanically cooperates with the metering element 33. In particular, the metering element 33 slides along the sealing lip 81 when the metering element 33 is moved in the first or in the second direction with respect to the storage chamber 15. The side face 31b merges into the interaction face 81b. The interaction face 81b of the sealing lip 81 is an extension of the side face 31b. In the absence of mechanical cooperation with the metering element 33 (see
The sealing lip 81 is configured to protrude into the opening 31a of the sealing member 31. In particular, the sealing lip 81 protrudes as far into the opening 31a as it is necessary for the sealing lip 81 to get into sealing contact with the metering element 33. This is explained in the following in detail:
The sealing lip 81 is flexible. In particular, the sealing lip 81 is moveable in the inward or the outward direction with respect to the main part 32. Thereby, the sealing lip 81 may be deflected into the recess 35. In other words, the recess 35 enables the sealing lip 81 to be moved in the inward and/or outward direction. The dimensioning of the recess 35, in particular the depth and/or the radial extension of the recess 35, may determine the degree of flexibility of the sealing lip 81. The deeper and wider the recess 35, the more flexible is the sealing lip 81, for example.
The sealing lip 81 must be flexible such that, in a pre-assembly state of the device 1, i.e. a state where the components of the device 1 are not yet assembled, in particular when the metering element 33 is not yet guided through the opening 31a of the sealing member 31 (see
The sealing member 31 comprises a first longitudinal axis 92. The longitudinal axis 92 is parallel to the main longitudinal axis mx of the metering element 33. The longitudinal axis 92 is parallel to a main longitudinal axis sx of the sealing member 31. The sealing member 31 comprises a second longitudinal axis 93. The second longitudinal axis 93 is parallel to the main longitudinal axis mx of the metering element 33. The second longitudinal axis 93 is parallel to the main longitudinal axis sx of the sealing member 31. The second longitudinal axis 93 crosses the end or tip 94 of the sealing lip 81. In the embodiment where the end of tip 94 is flat (see
The device 1 comprises a line 91 which extends perpendicularly to the first and second longitudinal axis 92, 93. In particular, the line 91 is perpendicular to the main longitudinal axes sx and mx. The perpendicular line 91 runs through the lowest point 90 of the recess 35. The perpendicular line 91 crosses or runs through the surface of the sealing member 31 within the opening 31a, in particular it crosses or runs through the side face 31b, at a certain point P. The first longitudinal axis 92 crosses the perpendicular line 91 at that point P. The distance d between the first longitudinal axis 92 and the second longitudinal axis 93 is that distance for which the sealing lip 81 protrudes into the opening 31a. Accordingly, the distance d between the first longitudinal axis 92 and the second longitudinal axis 93 is smaller than or equal to 0.5 mm.
In an assembled state of the inhalation device 1 (see
Due to manufacturing tolerances, different metering elements 33 may comprise different outer dimensions, i.e. different side faces 33A, 33B. In particular, the outer dimensions of different metering elements 33 may differ from one another by up to 1.0 mm, for example. For example, one metering element 33 may comprise a first side 33A which is equal to 6 mm and second side which is equal to 1 mm. A further metering element 33 may comprise a first side 33A which is equal to 5 mm and a second side which is equal to 1.5 mm, for example. The sealing member 31, in particular the sealing lip 81, is configured to compensate said manufacturing tolerances. In particular, the sealing member 31 is adapted to receive and to seal metering elements 33 with any outer dimension or with any width which may arise from the manufacturing process. Thereby, for a metering rod 33 which comprises a larger first side 33A, e.g. having a width of 7.0 mm, as compared to an average first side of about 6 mm, for example, the sealing lip 81 is forced farther in the outward direction with respect to the metering element 33 by mechanical cooperation with the metering element 33. At most, the sealing lip 81 may be forced in the outward direction such that the interaction face 81b of the sealing lip 81 runs parallel to the first longitudinal axis 92 (not explicitly shown in the Figures). On the other hand, for a metering rod 33 which comprises a smaller first side 33A, e.g. 5 mm, as compared to the average first side 33A of 6 mm, the sealing lip 81 may be deflected only marginally in the outward direction with respect to the metering element 33 by mechanical cooperation with the metering element 33. All in all, due to the flexibility of the sealing lip 81, variations in the outer dimension of different metering elements 33, which variations arise from manufacturing tolerances, can be compensated and the respective metering element 33 can be efficiently sealed by means of the sealing member 31.
For different metering elements 33, in particular metering elements 33 with different outer dimensions, the sealing lip 81 provides a constant force onto the metering element 33, in particular onto the sides 33A, 33B of the metering element 33, as described above. In other words, the sealing lip 81 provides the same force for different outer dimensions of different metering elements 33. As described above, said force onto the sides 33A, 33B of the metering element 33 is constant at any position of the respective metering element 33 with respect to the storage chamber 15 where the sealing member 31, in particular the sealing lip 81, and the metering element 33 cooperate with one another. In this way, powdery substance 2, in particular the sub-quantity 14 of the powdery substance 2, retained in the metering chamber 40 is prevented from dropping out of the metering chamber 40 when the sealing lip 81 mechanically cooperates with the metering chamber 40 when the metering element 33 is moved in the first direction. In other words, when the metering element 33 is moved in the first direction, the metering chamber 40 slides along the sealing lip 81, the sealing lip 81 thereby providing a constant force onto the sides 33A, 33B of the metering element 33 and, thus, onto the metering chamber 40 of the metering element 33. In this way, the sealing lip 81 prevents dropping out of substance 2 from the metering chamber 40 during movement of the metering chamber 40 out of the storage chamber 15.
For being able to compensate the variations described above, in a first step, a plurality of metering elements 33 are manufactured. In a next step, the variation for the distribution of the outer dimension, in particular of the widths of the sides 33A, 33B, with respect to an average value must be determined for each metering element 33 of the plurality of manufactured metering elements 33. In a next step, the sealing lip 81 must be adjusted such that, upon mechanical cooperation with the respective metering element 33, it exerts a constant force onto the sides 33A, 33B of each of the different metering elements 33. For this purpose, the dimension of the recess 35 may be adjusted, in particular the depth and/or the width and/or the radius of curvature of the recess 35 can be adjusted, such that the sealing lip 81 exerts a constant force onto the sides 33A, 33B, of each of the metering elements 33. The depth of the recess 35 may be equal to 0.1 mm, for example. The depth of the recess 35 may be greater than 0.05 mm, for example. The depth of the recess 35 may be less than 0.25 mm, for example. The radius of curvature may amount to 0.2 mm, for example. The radius of curvature may be less than 0.5 mm, preferably less than 0.3 mm. The radius of curvature may be greater than 0.05 mm, preferably greater than 0.1 mm. In a next step, the device 1 is assembled, in particular the metering element 33 is guided through the opening 31a of the sealing member 31. In particular, for each metering element 33 the sealing member 31 and, in particular, the sealing lip 81 can be adapted and arranged such that the sealing lip 81 is forced in the outward direction when it mechanically cooperates with the metering rod 33. In this way, an efficient and reliable sealing is provided by way of a single sealing member 31 which is adapted to be used with metering elements 33 having different dimensions due to manufacturing tolerances.
It may, furthermore, occur that a fraction of the substance 2, i.e. excess substance 95 (see
When the metering element 33 is moved in the first direction, it slides along the sealing lip 81. When the metering element 33 and, in particular the sides 33A, 33B, slide along the sealing lip 81, the sealing lip 81 scrapes or wipes the excess substance 95 off the outer surface, in particular off the sides 33A, 33B, of the metering element 33. The excess substance 95 is moved in the outward direction with respect to the sealing lip 81 and into the recess 35. From the recess 35, the excess powdery substance 95 may be guided along the inner surface 34 through the cavity 96 of the sealing member 31 in the second direction with respect to the storage chamber 15 and back into the storage chamber 15. Alternatively, from the recess 35, the excess-substance 95 may fall back onto the surface formed by the substance 2 within the storage chamber 15. Accordingly, the excess powdery substance 95 is moved back into the storage chamber 15 for being available for a subsequent dose setting and dose delivery operation.
Furthermore, when the metering element 33 is moved with the respect to the storage chamber 15, the sealing lip 81 expediently does not protrude into the metering chamber 40. If the sealing lip 81 protruded into the metering chamber 40 the sub-quantity 14 could be unintentionally removed from the metering chamber 40 upon mechanical cooperation with the sealing lip 81. The sealing lip 81 and the recess 35 are configured such that the sealing lip 81 is prevented from protruding into the metering chamber 40 when the metering element 33 is moved with respect to the sealing lip 81, in particular when the metering chamber 40 passes the sealing lip 81. For this purpose, the distance by which the sealing lip 81 protrudes into the opening 31a in a pre-assembled state as described above should not be greater than 0.5 mm. In addition, the direction of orientation of the sealing lip 81 must be chosen such that the sealing lip 81 does not protrude into the metering chamber 40. In particular, an angle 97 between the interaction face 81b of the sealing lip 81 and the second longitudinal axis 93 should be less than 5 degrees and greater than 0.5 degree, for example. The angle 92 should amount to 4 degrees, for example. In addition to that, the flexibility of the sealing lip 81 should be chosen so as to prevent the sealing lip 81 from protruding into the metering chamber 40. In particular, the width and/or the depth and/or the radius of curvature of the recess 35 should be chosen such that the sealing lip 81 is efficiently deflected into the recess 35 and does not protrude in the metering chamber 40 when the metering element 30 is moved with respect to the storage chamber 15, in particular when the metering chamber 40 mechanically cooperates with the sealing lip 81. The recess 35 should have a maximum depth, i.e. the depth at the deepest point 90, which is less than 0.25 mm, for example. Preferably, the maximum depth amounts to 0.1 mm. In this way, it is prevented that the sealing lip 81 protrudes into the metering chamber 40. In addition to that, the shape of the tip or end 94 of the sealing lip 81 can be chosen such that the sealing lip 81 is prevented from protruding into the metering chamber 40 when the metering element 33 is moved with respect to the sealing lip 81. The tip or end 94 may be rounded or curved, for example.
The term drug as used herein may mean a pharmaceutical formulation containing at least one pharmaceutically active compound, for example for the treatment of obstructive airway or lung diseases such as asthma or chronic obstructive pulmonary disease (COPD), local respiratory tract oedema, inflammation, viral, bacterial, mycotic or other infection, allergies, diabetes mellitus.
The active pharmaceutical compound is preferably selected from the group consisting of active pharmaceutical compounds suitable for inhalation, preferably antiallergenic, antihistamine, anti-inflammatory, antitussive agents, bronchodilators, anticholinergic drugs, and combinations thereof
The active pharmaceutical compound may for example be chosen from:
an insulin such as human insulin, e.g. a recombinant human insulin, or a human insulin analogue or derivative, a glucagon-like peptide (GLP-1) or an analogue or derivative thereof, or exendin-3 or exendin-4 or an analogue or derivative of exendin-3 or exendin-4;
an adrenergic agent such as a short acting β2-agonists (e.g. Salbutamol, Albuterol, Levosalbutamol, Fenoterol, Terbutaline, Pirbuterol, Procaterol, Bitolterol, Rimiterol, Carbuterol, Tulobuterol, Reproterol), a long acting β2-agonist (LABA, e.g. Arformoterol, Bambuterol, Clenbuterol, Formoterol, Salmeterol), an ultra LABA (e.g. Indacaterol) or another adrenergic agent (e.g. Epinephrine, Hexoprenaline, Isoprenaline (Isoproterenol), Orciprenaline (Metaproterenol));
a glucocorticoid (e.g. Beclometasone, Budesonide, Ciclesonide, Fluticasone, Mometasone, Flunisolide, Betamethasone, Triamcinolone);
an anticholinergic agent or muscarinic antagonist (e.g. Ipratropium bromide, Oxitropium bromide, Tiotropium bromide);
a mast cell stabilizer (e.g. Cromoglicate, Nedocromil);
a xanthine derivative (e.g. Doxofylline, Enprofylline, Theobromine, Theophylline, Aminophylline, Choline theophyllinate);
an eicosanoid inhibitor, such as a leukotriene antagonist (e.g. Montelukast, Pranlukast, Zafirlukast), a lipoxygenase inhibitor (e.g. Zileuton) or a thromboxane receptor antagonist (e.g. Ramatroban, Seratrodast);
a phosphodiesterase type-4 inhibitor (e.g. Roflumilast);
an antihistamine (e.g. Loratadine, Desloratadine, Cetirizen, Levocetirizine, Fexofenadine);
an allergen immunotherapy (e.g. Omalizumab);
a mucolytic (e.g. Carbocisteine, Erdosteine, Mecysteine);
an antibiotic or antimycotic;
or a combination of any two, three or more of the above-mentioned compound classes or compounds (e.g. Budesonide/Formoterol, Fluticasone/Salmeterol, Ipratropium bromide/Salbutamol, Mometasone/Formoterol);
or a pharmaceutically acceptable salt or solvate or esters of any of the above named compounds.
Pharmaceutically acceptable salts are for example acid addition salts and basic salts. Acid addition salts are e.g. a chloride, bromide, iodide, nitrate, carbonate, sulfate, methylsulfate, phosphate, acetate, benzoate, benzenesulfonate, fumarate, malonate, tartrate, succinate, citrate, lactate, gluconate, glutamate, edetate, mesylate, pamoate, pantothenate or a hydroxy-naphthoate salt. Basic salts are for example salts having a cation selected from alkali or alkaline, e.g. Na+, or K+, or Ca2+, or an ammonium ion N+(R1)(R2)(R3)(R4), wherein R1 to R4 independently of each other mean: hydrogen, an optionally substituted C1-C6-alkyl group, an optionally substituted C2-C6-alkenyl group, an optionally substituted C6-C10-aryl group, or an optionally substituted C6-C10-heteroaryl group. Further examples of pharmaceutically acceptable salts are described in “Remington's Pharmaceutical Sciences” 17. ed. Alfonso R. Gennaro (Ed.), Mark Publishing Company, Easton, Pa., U.S.A., 1985 and in Encyclopedia of Pharmaceutical Technology. Pharmaceutically acceptable ester may for example be acetates, propionates, phosphates, succinates or etabonates.
Pharmaceutically acceptable solvates are for example hydrates.
Other implementations are within the scope of the following claims. Elements of different implementations may be combined to form implementations not specifically described herein.
| Number | Date | Country | Kind |
|---|---|---|---|
| 11193067.3 | Dec 2011 | EP | regional |
| 12181886.8 | Aug 2012 | EP | regional |
The present application is a U.S. National Phase Application pursuant to 35 U.S.C. §371 of International Application No. PCT/EP2012/075097 filed Dec. 11, 2012, which claims priority to European Patent Application No. 11193067.3 filed Dec. 12, 2011 and European Patent Application No. 12181886.8 filed Aug. 27, 2012. The entire disclosure contents of these applications are herewith incorporated by reference into the present application.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2012/075097 | 12/11/2012 | WO | 00 |
