Adler, T. R., Beall, G. N., Curd, J. G., Heiner, D. C., Shabharwal, U. K. Clin. Exp. Immunol. 56, 383 (1984). |
Altschuh, D. et al., "Localization of Antigenic Determinants of a Viral Protein by Inhibition of Enzyme-Linked Immunosorbent Assay (ELISA) with Tryptic Peptides", J. Immunology Methods, v.50, p.99 (1982). |
Amit, A. G. et al., "Three-Dimensional Structure of an Antigen-Antibody Complex of 2.8 A Resolution", Science 233: 747 (1986). |
Amzel, L. M. et al., "Three-Dimensional Structure of Immunoglobulins", Ann. Rev, Biochem. 48:961 (1979). |
Anglister, J. et el., "NMR Study of the Complexes Between a Synthetic Peptide Derived from the B Subunit of Cholera Toxin and Three Monoclonal Antibodies Against It", American Chemical Soc. 006-2960/88/0427-0717 (1988). |
Aruffo, A. et al., "Molecular Cloning of a CD38 cDNA by a high-efficiency COS cell expression system", Proc. Natl., Acad. Sci., 84:8573-8577 (1987). |
Atassi, N. Z., "Surface-Simulation Synthesis and its Application in Protein Molecular Recognition", Protein Engineering--Applications in Science, Medicine and Industry, edited by Inouye, M. and Sarma, R., (Academic Press) pp. 125-153 (1986). |
Azuma, T. et al., "Diversity of the Variable-joining Region Boundary of Light Chains has a Pronounced Effect on Immunoglobulin in Ligand-Binding Activity", Proc. Natl. Acad. Sci. USA v. 81 p. 6139, (Oct. 1984). |
Baldwin, E. et al., Science v.245, pp. 1104-1107 (1989). |
Baldwin, E. and Schultz, P. G., "Generation of a catalytic antibody by site-directed mutagenesis", Science, 244:1152 (1989). |
Barrett, A. J., Proteinase Inhibitors (Editors A. J. Barrett and G. Salvesen), pp 3-22, Elsevier, London, (1986). |
Baum, R., "Catalytic Antibodies Open Up New Strategy For Protein Engineering", Science, C&EN, 30-33 (Apr. 6, 1987). |
Baum, R., "Catalytic Antibody Cuts Peptide Bond", C & E N, 5, 7-8 (1989). |
Benjamini, E. et al., "Immunochemical Studies on the Tobacco Mosaic Virus Protein. VI. Characterization of Antibody Population Following Immunization with TMV Protein", Biochemistry, v.7, No. 4, pp. 1253-1260 (1968). |
Benjamini, E. et al., "Immunochemical Studies on the Tobacco Mosaic Virus Protein. VII. The Binding of Octanoylated Peptides of the TMV Protein with Antibodies to the Whole Protein", Biochemistry, v.7, No. 4, pp. 1261-1264 (1968). |
Berchtold et el., Blood, Vol. 74, No. 7, pp. 2414-2417 (1989). |
Better, M. et al., "Escherichia coli Secretion of an Active Chimeric Antibody Fragment", Science, 240: 1041-1043 (1988). |
Bigazzi, P. E. and Rose, N. R., In The Autoimmune Diseases, Noel R. Rose and Ian R. Mackay, Eds. (Academic Press, Orlando, 1985), pp. 161-199. |
Blackburn, G. M., Kang, A. S., et al., "Catalytic Antibodies", Biochem. J., 262:381 (1989). |
Bloom, S. R., Barnes, A. J., Adrian, T. E., Polak, J. M., "Autoimmunity in Diabetics Induced by Hormonal Contaminants of Insulin", Lancet i:14-17, 1979. |
Bogner, U., Schleusener, H., Well, J. R. J. Endocrinol. Metab. 59, 734 (1984). |
Burd, J. et al., "Specific Protein-Binding Reactions Monitored by Enzymatic Hydrolysis of Ligands-Fluorescent Dye Conjugates", Analytical Biochemisstry, 77, 56-67 (1977). |
Chalufour, A. et al., "Rare Sequence Motifs are Common Constituents of Hypervariable Antibody Regions", Ann. Inst. Pasteur/Immunology, 138:671, Elsevier, Paris (1987). |
Chaudhary, V. J. et al., "A recombinant immunotoxin consisting of two antibody variable domains fused to Psuedomonas exotoxin", Nature 339: 394 (1989). |
Chothia, C. et al., "Canonical Structures for the Hypervariable Regions of Immunoglobulins", J. Mol. Biol. 196: 901 (1987). |
Chothia, C. et al., "The Predicted Structure of Immunoglobulin in D1.3 and its Comparison with the Crystal Structure", Reports, 755 (Aug. 1986). |
Clagget, J. A., Wilson, C. B., Weigle, W. O., J. Exp. Med. 140, 1439 (1974). |
Cochran, A. G. et al., "Photosensitized Cleavage of a Thymine Dimer by an Antibody", J. Am. Chem. Soc. 110: 7888-7890 (1988). |
Colman, P. M. et al., "Three-Dimensional Structure of a Complex of Antibody with Influenza Virus Neuraminidase", Nature 326: 358 (Mar. 1987). |
Corey, D. R. et al., "Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease", Reports 1401 (Dec. 1987). |
David, G. S., et al., "The Hybridoma-An Immunochemical Laser", Clin. Chem., 27, (9), 1580-1585 (1981). |
de la Paz, P. et al., "Modelling of the Combining Sites of Three Anti-Lysozyme Monoclonal Antibodies and of the Complex Between One of the Antibodies and its Epitope", EMBO J., 5:2, 415 (1986). |
Dietrich, G., Kazatchkine, M. D., J. Clin. Invest, 85, 620 (1990). |
Dimaline, R. et al., "Purification and Characterization of VIP from Two Species of Dogfish", Peptides, 7(Suppl. 1): 21-26 (1986). |
Dimaline, R., et al., "A novel VIP from elasmobranch intestine has full affinity for mammalian pancreatic VIP receptors", Biochemica et Biophysica Acta., 930, 97-100 (1987). |
Dixon, M. et al., Enzymes, Third Edition, London, (1979). |
Dong, Q., Ludgate, M., Vassart, G. J. Endocrinol. 122, 169 (1989). |
Durfor, C. N., R. J. Bolin, R. J. Sugasawara, R. J. Massey, J. W. Jacobs, P. G. Schultz, "Antibody Catalysis in Reverse Micelles", J. Am. Chem. Soc. 110, 8713 (1988). |
Edelhoch, H. and Lippoldt, R. F., J. Biol. Chem. 235, 1335 (1960). |
Edelman, G. M. et al., "Reconstruction of Immunologic Activity by Interaction of Polypeptide Chains of Antibodies", Proc. Natl. Acad. Sci., 50: 753-761 (1963). |
Edwards et al., "Human Monoclonal Antibodies and the Selection AF Antigens Suitable for Therapy" in Monoclonal Antibodies '84: Biological and Clinical Applications: Proceedings of the International Symposium on Monoclonal Antibodies '84 held in Florence, Italy, Oct. 16-19, 1984. |
Emr, S. D. et al., "Sequence analysis of mutations that prevent export of receptor, an Escherichia coli outer membrane protein", Nature, 285: 82-85 (1980). |
Erhan, S. et al., "Do immunoglobulins have proteolytic activity?", Nature, v.251 pp. 353-355 (Sep. 27, 1974). |
Fisher, G., "Acyl Group Transfer-Aspartic Proteinases", In Enzyme Mechanisms, M. I. Page and A. Williams, eds., Royal Society of Chemistry, 230 (London, 1987). |
Frackelton, Jr., A. R., et al., "Functional Diversity of Antibodies Elicited by Bacterial .beta.-O Galactosidase", J. Bio. Chem., 255 (11), 5286-5290 (1980). |
Franek, F. and Nezlin, R. S., "Recovery of Antibody Combining Activity By Interaction of Different Peptide Chains Isolated From Purified Horse Antitoxins", Folia Microbiol., 8: 128-130 (1963). |
Franek, F. and Nezlin, R. S., Biokhimiya, 28: 193 (1963). |
Gao, Q. S., Sun, M., Tyutyulkova, S., Webster, D., Rees, A., Tramontano, A., Massey, R. J., Paul, S., "Substrate-driven formation of a proteolytic antibody light chain." Abstract presented at New York Academy of Sciences Conference on Immunoglobulin Gene Expression in Development and Disease, Montreal, Canada, Jul. 13-17, 1994. |
Gavish, M. et al., "Preparation of a Semisynthetic Antibody", Am. Chem. Soc. (1978), 006-2960/78/0417-1345. |
Geysen, H. M. et al., "A Priori Delineation of a Peptide Which Mimics a Discontinuous Antigenic Determinant", Molecular Immunology, 23:7 p. 709 (1986). |
Giam, C. Z. et al., "In Vivo Autoprocessing of Human Immunodeficiency Virus Protease Expressed in Escherichia coli", J. Biol. Chem., 263: 14617-14620 (1985). |
Gish et al., J. Med. Chem., 14: 1159-1162, (1971). |
Hansen, D., "Antibodies with Some Bite", Nature, 325, 304 (1987). |
Harper, J. W. et al., "Enzymatically Active Angiogenin-Ribonuclease A Hybbrids Formed by Peptide Interchange", Abstract, Am. Chem. Soc. (1988), 006-2960/88/0427-0219. |
Hendershot, L. M., et al., "Identity of the immunoglobulin Heavy-Chain-Binding Protein with the 78,000-Dalton Glucose-Regulated Protein and the Role of Posttranslational Modifications in its Binding Function", Mol. and Cellular Bio., 8 (10), 4250-4256 (1988). |
Highfeld, R., "Aids Drug A Step Nearer", The Daily Telegraph, 9, Aug. 4, 1987. |
Hilvert, D. et al., "Catalysis of Concerted Reactions by Antibodies: The Claisen Rearrangement", Proc. Natl. Acad. Sci. USA, v.85, pp. 4953-4955 (Jul. 1988). |
Hochman, J. et al., "An Activity Antibody Fragment (Fv) Composed of the Variable Portions of Heavy and Light Chains", Biochemistry 12: 1130 (1973). |
Huse, W. D. et al., "Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda", Science, 246: 1275-1281 (1989). |
Inbar, D. et al., "Localization of Antibody-Combining Sites within the Variable Portions of Heavy and Light Chains", Proc. Natl. Acad. Sci. USA, 69: 2659 (1972). |
Inbar, D. et al., "Crystallization with Hapten of the Fab Fragment from a Mouse IgA Myeloma Protein with Antidinitrophenyl Activity", J. of Biol. Chem. 246: 6272 (1971). |
Itoh, N., Obata, K.-I., Yanaihara N., Okamoto, H., "Human Preprovasoactive Intestinal Polypeptide Contains A Novel PHI-27-Like Peptide, PHM-27", Nature 304:547-549, 1983. |
Iversen, B. L., and Lerner, R. A., "Sequence-Specific Peptide Cleavage Catalyzed by an Antibody", Science, 243:1184 (1989). |
Izadyar, I., Priboulet, A., Remy, M. H., Rosero, A., Thomas, D. Proc. Natl. Acad. Sci. USA 90, 8876 (1993). |
Jackson, D. Y. et al., "A Mutagenesis Study of a Catalytic Antibody", Proc. Natl. Acad. Sci. U.S.A., v.88, pp. 58-62 (Jan. 1991). |
Jackson, D. Y., J. W. Jacobs, R. Sugasawara, S. H. Reich, P. A. Bartlett, P. G. Schultz, "An Antibody-Catalyzed Claisen Rearrangement", J. Am. Chem Soc. 110, 4841 (1988). |
Jacobs, J. et al., "Catalytic Antibodies", J. Am. Chem. Soc., 109, 2174-2176 (1987). |
Janda, K. D. et al., "Induction of an Antibody that Catalyzes the Hydrolysis of an Amide Bond", Science 241, 1188-1191 (1988). |
Jaton, J. C. et al., "Recovery of Antibody Activity Upon Reoxidation of Completely Reduced Polyalanyl Heavy Chains and its Fd Fragment Derived from Anti-2,4-dinitrophenyl Antibody", Biochemistry, 7: 4185-4195 (1968). |
Jencks, W. P., "What Everyone Wanted to Know About Tight Binding and Enzyme Catalysis, but Never Thought of Asking", Molecular Biol. Biochem. & Biophys., 32, 3-25, (1980). |
Jencks, W. P., "Binding Energy, Specificity and Enzymic Catalysis: The Circe Effect", Adv. Enzym., 43, 219-410 (1975). |
Jencks, W. P., In "Catalysis in Chemistry end Ezymology", 282-320, 288 (McGraw Hill, New York) (1969). |
Jerne, N. K. et al., "Recurrent ldiotopes and Internal Images", EMBO J., v.1, No .2, 243-247 (1982). |
Kabat, E. A. et al., In "Sequences of Proteins of Immunological Interest (5th Edition)", v.1, 2, 3, U.S. Department of Health and Human Services (1991). |
Kaveri, S. V., Wang, H. T., Rowen, D., Kazatchkine, M. D., Kohler, H. Clin. Immunol. Immunolpathol. 69, 333 (1993). |
Klein, J. In "Immunology: The Science of Self-Nonself Discrimination", pp. 168-169 (John Wiley & Sons, New York) (1982). |
Knisley, K.A. et al., "Affinity Immunoblotting, High Resolution Isoelectric Focusing Analysis of Antibody Clonotype Distribution", J. Immunological Methods, 95, 79-87, Elsevier (1986). |
Koerner and Nieman, "High Performance Liquid Chromatographic Determination of Glucosides", J. Chromatography 449, 216-228, (1988). |
Kohen, F. et al., "Nonradioisotopic Homogeneous Steroid Immunoassays", J. Steroid Biochemistry, 11, 161-167 (1979). |
Kohen, F. et al., FEBS Letters, 104, 201-205 (1979). |
Kohen, F. et al., "A Steroid Immunoassay Based on Antibody-Enhanced Hydrolysis of a Steroid-Umbelliferone Conjugate", FEBS Letters, 100, 137-140 (1979). |
Kohen, R., Kim, J. B., Lindner, H. R., Eshhar, Z., Green, B., "Antibody enhanced hydrolysis of steroid esters", FEBS. |
Kohen, F. et al., "Monoclonal Immunoglobulin G Augments Hydrolysis of an Ester of the Homologous Hapten", FEBS Letters, 111, 427-431 (1980). |
Kohen, F. et al., "Antibody-Enhanced Hydrolysis of Steroid Esters", Biochimia et Biophysica Acta, 629, 328-337 (1980). |
Kohler G., Milstein C., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", Nature 256:445-497 (1975). |
Kozbor, D., and Roder, J., "The Production of Monoclonal Antibodies from Human Lymphocytes", Immunology Today, 4: 72-79 (1983). |
Kozbor, D., Steinitz, M., Klein, G., Koskimies, S., Maketa, O., "Establishment of Anti-TNP Antibody-producing Human Lymphoid Lines by Preselection for Hapten Binding Followed by EBV Transformation", Scand. J. Immunol. 10:187-194, 1979. |
Kubiak, T. et al., "Synthetic Peptides V.sub.H (27-68) and V.sub.H (16-68) of the Myeloma Immunoglobulin M603 Heavy Chain and their Association with the Natural Light Chain to Form an Antigen Binding Site", Abstract, Am. Chem. Soc. (1987), 006-2960/87/0426-7849. |
Kwan, S. et al., "Production of Monoclonal Antibodies", Genetic Engineering, 2, 31-46, (1980). |
Lee, F. et al., "Isolation and Characterizaton of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell and mast-cell stimulating activities", Proc. Natl. Acad. Sci. U.S.A. 83: 2061-2065 (1986). |
Lerner, R. A. et al., "Catalytic Antibodies", Scientific American, 258(3), 42-50 (1988). |
Lerner, R. A. et al., "Antibodies as Enzymes", Trends Biochem. Science, 12(11), 427-430 (1987). |
Lerner, R. A., "Antibodies of Predetermined Specificity in Biology and Medicine", Adv. In Immun., 36, 1-40 (1984). |
Lerner, R. A. et al., "At the Crossroads of Chemistry and Immunology: Catalytic Antibodies", Science, 252, 659-667 (May 1991). |
Lerner, R. A., "Antibodies Of Predetermined Specificity In Biology And Medicine", Adv. In Immun., 36, 1-40 (1984). |
Loh, E. Y. et al., "Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor & Chain", Science, 243: 217-220 (1989). |
Lorberboum-Galski, H. et al., "Cytotoxic Activity of an interleukin 2-Pseudomonas Exotoxin Chimeric Protein Produced in Escherichia coli", Proc. Natl. Acad. Sci., U.S.A., 85: 1922-1926 (1988). |
MacDonald, R. J. et al., "Isolation of RNA Using Quanidine Salts", Meth. Enzymol., 152: 219-226 (1987). |
Machleidt, W. et al., In "Mechanism of Inhibition of Papain by Chicken Egg White Cystatin", (Biomedical Division, Elsevier Science Publishers), v. 243, No. 2, p. 234, (Jan. 1989) 00145793/89. |
Mariuzza, R. A. et al., "The Structurre Basis of Antigen-Antibody Recognition", Ann. Rev. Biophys. Chem., 16: 139 (1987). |
Marx, J., "Making Antibodies Work Like Enzymes", Science 234, 1497-1498 (1986). |
Massey, R., "Catalytic Antibodies Catching On", Nature, 328, No. 6129, 457-458 (1987). |
Matsukawa, S. and Hosoya, T. J. Biochem. 86, 199 (1979). |
Meek, T. D. et al., "Inhibition of HIV-1 Protease in Infected T-Lymphocytes by Synthetic Analogues", Nature, 343: 390-392 (1990). |
Melchers, F. et al., "Enhanced Stability Against Heat Denaturization of E. Coli Wild Type and Mutant .beta.-Galactosidase in the Presence of Specific Antibodies", Biochemical And Biophysical Research Commnunication, 40(3), 570-575 (1970). |
Mercken, L., Simons, M. J., Swillens, S., Massaer, M., Vassart, G. Nature 316, 647 (1985). |
Mierendorf, R. C. et al., "Direct Sequencing of Denatured Plasmid DNA", Meth. Enzymol., 152: 556-562 (1987). |
Milstein, C., "Monoclonal Antibodies", Sci. Am., 234(4), 66-74 (1980). |
Moe, K., "Scripps, UC Create `Killer` Antibodies", S.D. Union, Dec. 12, 1986. |
Mutter, M., "The Construction of New Proteins and Enzymes--A Prospect for the Future?", Agnew. Chem. Int. Ed. Engl. 24, p. 639 (1985). |
Napper, A., "A Stereospecific Cyclization Catalyzed by an Antibody", Science, 237, 1041-1043 (1987). |
Nilsson, A., "Structure of the Vasoactive Intestinal Peptide from Chicken Intestine. the Amino Acid Sequence", FEBS Letters, 60: 322-326 (1975). |
Nishi, N. et al., "Apparent Autolysis of the N-Terminal Tetrapeptide of VIP", Chem. Pharm. Bull. 31(3), p. 1067 (1983). |
Nobeyuki et al., Nature, Vol. 34, pp. 547-549 (1983). |
Offord, R. E., "REVIEW Protein Engineering by Chemical Means?", Protein Engineering, v.1, No. 5, p. 151 (1987). |
Opstad, K., "The Plasma VIP Response to Exercise is Increased After Prolonged Strain, Sleep and Energy Deficiency and Extinguished by Glucose Infusion", Peptidases, 8, 175-178 (1986). |
Orlandi, R. et al., "Cloning immunoglobulin variable domains for expression by the polymerase chain reaction", Proc. Natl. Acad. Sci. U.S.A., 86: 3833-3837 (1989). |
Paul S., Gao, Q. S., Huang, H., Sun, M., Thompson, A., Rennard, S., Landers, D., Abstract to be presented at the 37th Annual Thomas L. Perry Aspen Lung Conference, Aspen, Colorado, Jun. 8-11, 1994. |
Paul, S., Said, S. I., "Human Autoantibody to Vasoactive Intestinal Peptide: Increased Incidence in Muscular Exercise", Life Sciences 43: 1079-1084 (1988). |
Paul, S., Erian, H. P., Said, S. I., "Autoantibody to Vasoactive Intestinal Peptide in Human Circulation", Biochem. Biophys. Res. Commun. 130: 479-485 (1985). |
Paul, S., Wood, K., Said, S. I., "Purification of [.sup.125 I]-Vasoactive Intestinal Peptide by Reverse-Phase HPLC", Peptides 5: 1085-1087 (1987). |
Paul, S. et al., "Regulatory Aspects of the VIP Receptor in Lung", Annals of New York Academy of Science, v. 527, pp. 282-295 (Jun. 1988). |
Paul, S., Volle, D. J., Beach, C. M., Johnson, D. R. Powell, M. J. and Massey, J. J., "Catalytic Hydrolysis of Vasoactive Intestinal Peptide by Human Autoantibody", Science, 244: 1158-1162 (1989). |
Paul, S., Sun, M., Mody, R., Tewary, H. K., Stemmer, P., Massey, R. J., Gianferrara, T., Mehrota, S., Dreyer, T., Meidal, M., Tramontano, A. J. Biol. Chem. 267, 13142 (1992). |
Paul, S., Volle, D. J., Powell, M. J., Massey, R. J. J. Biol. Chem., 265, 11910 (1990). |
Paul, S. et al., "Affinity Chromatography of Catalytic Autoantibody to Vasoactive Intestinal Peptide", J. Immunology, v. 145, No. 4, pp. 1196-1199 (Aug. 1990). |
Paul, S., Said, S. I., Thompson, A., Volle, D. J., Agrawal, D. K., Foda, H., De la Rocha, S., "Characterization of Autoantibodies to VIP in Asthma", J. Neuroimmunol, 23:133-142, 1989. |
Paul, S., Said, S. I., "Characterization of Receptors for Vasoactive Intestinal Peptide from the Lung", J. Biol. Chem. 262: 158-162, 1987. |
Paul, S. et al., "High Affinity Peptide Histidine Isoleucine-Preferring Receptors in Rat Liver", Life Sciences, v.41, pp. 2373-2380 (1987). |
Paul, S. et al., "Elevated Levels of Atrial Natriuretic Peptide and Vasoactive Intestinal Peptide in Exercising Man", Clin. Res., 35: 112A (1987). |
Paul, S. et al., In "Autoabzyme Catalyzed Cleavage of Vasoactive Intestinal Peptide", Progress in Immunology, v. VIII, pp. 833-836 (editors F. Melchers et al.) Springer Verlag, Berlin (1989). |
Paul, S., "A New Effector Mechanism for Antibodies: Catalytic Cleavage of Peptide Bonds", Cold Spring Harbor Symposium on Immunological Research, v. 54 (1989). |
Pauling, L., "Nature of Forces Between Large Molecules of Biological Interest", Nature, 161:707, (1948). |
Pollack, S. J., J. W. Jacobs, P. G. Schultz, "Selective Chemical Catalysis by an Antibody", Science 234, 1570-1573 (1986). |
Pollack, S. J., and Schultz, P. G., "Antibody Catalysis by Transition State Stabilization", Cold Spring Harbor Symposium on Quantitative Biology, 52, 97-104 (1987). |
Porter, R. R. et al., "Subunits of immunoglobulins and their relationship to Antibody Specificity", J. Cell Physiol., 67 (Suppl. 1): 51-64 (1966). |
Raso, V., and Stollar, B. D., "Antibodies Specific for Conformationally Distinct Coenzyme Substrate Transition State Analogs . . . ", J. Am. Chem. Soc., 95(5), 1621-1628 (1973). |
Raso, V. and Stollar, B. D., "The Antibody-Enzyme Analogy. Characterization of Antibodies to Phosphopyriodoxyltyrosine Derivatives", Biochemistry, 14, 584-591 (1975). |
Raso, V. et al., "The Antibody-Enzyme Analogy. Comparison of Enzymes and Antibodies Specific for Phosphopyriodoxyltyrosine", Biochemistry, 14, 591-599 (1975). |
Rees, A. R. et al., "Investigating Antibody Specificity Using Computer Graphics and Protein Engineering", Trends in Biochemical Sciences, 11: 144 (Mar. 1986). |
Rich, D. H., "Inhibitors of Aspartic Proteinases", Proteinase Inhibitors (Editors A. J. Barrett and G. Salvesen), Elsevier, pp. 179-217 (1986). |
Roberts, R. J., "Directory of Restriction Endonuclease", Methods In Enzymology, 68, 27-31 (Academic Press, New York, R. Wu, Editor (1979). |
Roberts, S. et al., The Cloning and Expression of an Anti-Peptide Antibody: A System for Rapid Analysis of the Binding Properties of Engineered Antibodies", (IRL Press Limited, Oxford, England) p. 59. |
Roder, J., Cole, D., Kozzbor, D., "The EBV-Hybridoma Technique", Methods in Enzymology, 121:140-167 (1986). |
Rohott, O. et al., "Specific Combination of H and L chains of Rabbit -Globulins", Proc. Natl. Acad. Sci., 51: 173-178 (1964). |
Rose, N. R., Molowhnikoff, M. F., Twarog, F. J. Immunol. 24, 859 (1973). |
Rose, N. R., Bresler, H. S., Burek, C. L., Gleason, S. L., Kuppers, R. C. Isr. J. Med Sci. 26, 666 (1990). |
Rosselin, G., "The Receptors for the VIP Family Peptides (VIP, Secretin, GRF, PHI, PHM, GIP, Glucagon and Oxyntomodulin). Specificities and Identity.", Peptides, 7(Suppl. 1): 89-100 (1986). |
Royer, G. P., "Enzyme-Like Synthetic Catalysts (Synzymes)", Advances In Catalysis, 29:197-227 (1980). |
Ruff, M. R. et al., "CD4 Receptor Binding Peptides that Block HIV Infectivity cause Human Monocyte Chemotaxis", FEBS Letters, 211:17-22 (1987). |
Sacerdote, P. et al., "Vasoactive Intestinal Peptide 1-12: A Ligand for the CD4 (T4)/Human Immunodeficiency of Virus Receptor", J. of Neuroscience Res., 18, 102-107 (1987). |
Sacks, D. L. et al., "Immunization of Mice Against African Trypanosomiasis Using Anti-Idiotypic Antibodies", J. Expr. Med., 155, 1108-1119 (1982). |
Sarath, G., De La Motte, R. S. and Wagner, F. W., In Proteolytic Enzymes a Practical Approach, eds. Beynon, R. J. and Bond, J. S. (IRL Press, Oxford, UK) pp. 25-55, 1989. |
Sastry, L., et al., "Cloning of the immunological repertoire in Escherichia coli for generation of monoclonal catalytic antibodies", Proc. Natl. Acad. Sci. U.S.A., 86: 5728-5732 (1989). |
Schultz, P. G., "Catalytic Antibodies", Acc. Chem. Res. 22:287 (1989). |
Schultz, P. G., "The Interplay Between Chemistry and Biology in the Design of Enzymatic Catalysts", Science, 240: 426 (1988). |
Selmi, S. and Rousset, B. Biochem. J. 253, 523 (1998). |
Shenkin, P. S. et al., "Predicting Antibody Hypervariable Loop Conformtion. I. Ensembles of Random Conformation for Ringlike Structures", Biopolymers 26: 2053 (1987). |
Sheriff, S. et al., "Three-Dimensional Structure of an Antibody-antigen Complex", Proc. Natl. Acad. Sci. U.S.A., 84: 8075 (1987). |
Shokat, K. M. et al., "A New Strategy for the Generation of Catalytic Antibodies", Nature, v. 338, pp. 269-271 (Mar. 1989). |
Shokat, K., C. H. Leumann, R. Sugasawara, P. G. Schultz, "An Antibody-Mediated Redox Reaction", Angew. Chem. Int. Ed. Engl., 27, 1172 (1988). |
Shuster, A. M., Gololobov, G. V., Kvashuk, O. A., Bogomolova, A. E., Smirnov, I. V., Gabibov, A. G. Science 256, 665 (1992). |
Skerra, A. et al., "Assembly of a Functional Immunoglobulin F.sub.V Fragment in Escherichia coli", Science, 240: 1038-1043 (1988). |
Slobin, L., "Preparation and Some Properties of Antibodies with Specificity Towards p-Nitrophenylesters", Biochemistry, 5: 2836-2844 (1966). |
Smith-Gill, S. J. et al., "Contributions of Immunoglobulin in Heavy and Light chains to Antibody Specificity for Lysozyme and Two Haptens", J. Immunology, 139: 4135 (1987). |
Steinitz, M., Izak, G., Cohen, S., Ehrenfeld, M., Flechner, I., "Continuous Production of Monoclonal Rheumatoid Factor by EBV-Transformed Lymphocytes", Nature, 287:443-445 (1980). |
Steinitz, M., Seppala, I., Eichmann, K., Klein, G., "Establishment of a Human Lymphoblastoid Cell Line with Specific Antibody Production Against Group A Streptococcal Carbohydrate", Immunobiology, 156: 41-47 (1979). |
Steinitz, M., Klein, G., Koskimies, S., Makela, O., "EB Virus-Induced B Lymphocyte Lines Producing Specific Antibody", Nature 269:420-422, 1977. |
Stewart, J. M. et al., "Solid Phase Peptide Synthesis", Pierce Chemical Co., Rockford, Illinois (1984). |
Summers, J. B., Jr., "Catalytic Principles of Enzyme Chemistry: Antibody Models And Stereo Electronic Control", Harvard University Ph.D. Thesis, 22-101 (1983). |
Sun, L. K. et al., Proc. Natl. Acad. Sci. U.S.A, 84: 214-218 (1987). |
Tomazi, C. V., Rose, N. R. Clin. Immunol Immunopathol 4, 511 (1975). |
Tramontano, A. et al., "Antibodies as Enzymic Catalysts", J. Cellular Biochemistry, Supp. 11C, p. 199, Abstract N 022 (1987). |
Tramontano, A. et al., "Catalytic Antibodies", Science, 234, 1566-1570 (1986). |
Tramontano, A. et al., "Chemical Reactivity at an Antibody Binding Site Elicited by Mechanistic Design of a Synthetic Antigen", Proc. Natl. Acad. Sci. U.S.A., 83: 6736-6740 (1986). |
Tramontano, A. et al., "Specificity and Mechanism of Esterolytic Antibodies", J. of Cellular Biochemistry, Supp. 11C, Abstract N 417, p. 238 (1987). |
Tramontano, A., A. A. Amman, R. A. Lerner, "Antibody Catalysis Approaching the Activity of Enzymes", J. Am. Chem Soc. 110, 2282 (1988). |
Turner, J. T., Bylund, D. B., "Characterization of the VIP Receptor in Rat Submandibular Bland: Radioligand Binding Assay in Membrane Preparations", J. Pharmacol Exp. Therap. 242:873-881, 1987. |
Unkeless, J. C., et al., "Structure and Function of Human and Murine Receptors for IgG", Ann. Rev. Immunol., 6, 251-81 (1988). |
Van Brunt, J., "Antibodies Find a New Role -- As Enzymes", Biotechnology, 5: 767 (1987). |
Van der Eb, A. J. et al., "Assay of Transforming Activity of Tumor Virus DNA", Meth. Enzymol., 65: 826-839 (1980). |
Van Regenmortel, R. H. V., Synthetic Peptides as Antigens, Laboratory Techniques in Biochemistry and Molecular Biology Series (Editors R. H. Burdon and P. H. van Knippenberg), 19: 1-39 (1988). |
Ward, E. S. et al., "Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli", Nature, 341: 544-546 (1989). |
Weetman, A. P. and McGregor, A. M., Endocrine Rev. 5, 309 (1984). |
White, A. et al., Principles of Biochemistry, 200, 201, 217-221, 573, 575 and 585 (McGraw Hill Book Company, New York, Fourth Edition) (1968). |
Winter, G. P., "Antibody Engineering", Phil Trans. R. Soc. Lond., B 324, 537-547 (1989). |
Woie, L. et al., "Increase in Plasma VIP in Muscular Exercise", Gen. Pharmacol., 17: 321-326 (1987). |
Wong, G. C. et al., "Human GM-CSF: Molecular Cloining of the Complementary DNA and Purification of the Natural and Recombinant Proteins", Science, 228: 810-815 (1985). |
Yang, Y. C. et al., "Human IL-3 (Multi-CSF): Identification by Expression Cloning of a Novel Hematopoietic Growth Factor Related to Murine IL-3", Cell, 47: 3-10 (1986). |
Yokota, T. et al., "Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell and T-cell stimulatory activities", Proc. Natl. Acad. Sci. U.S.A., 83: 5894-5896 (1986). |
"Abzylutely Spot On", The Economist, 80-81 (Feb. 7, 1987). |
"Abzymes", Scientific American, 256, No. 2, 84-85 (1987). |
"Antibody Catalyzes Stereospecific Reaction", Science/Technology Concentrates, C&EN, 15 (Aug. 31, 1987). |
"Cancer Breakthrough Seen--IGEN Discovers New Protein Class", Rockville Gazette (Jan. 21, 1987). |
"Making Antibodies Act Like Enzymes", Science News, 130, Nos. 25 & 26 (Dec. 20 & 27, 1986). |
Affinity Chromatography Principles and Methods, Pharmacia, pp. 12-18 (Uppsala, Sweden) (1986). |
Bulletin, Office Of Public Information, Berkeley Campus, University of California (Dec. 9, 1986). |
FPLC.TM. Ion Exchange and Chromatofocusing--Principles and Methods, Pharmacia, pp. 59-106, Uppsala, Sweden (1987). |
PhastGel. Silver Kit Instruction Manual, Pharmacia (Uppsala, Sweden), 1987. |
Proceedings of the Symposium of Immunological Recognition, vol. III, Springer Verlag (1989). |
Kalaga et al., The Journal of Immunology, "Unexpected Presence of Polyreactive Catalytic Antibodies in IgG from Unimmunized Donors and Decreased Levels in Rheumatoid Arthritis", 1995, 155:2695-2702. |
Gao et al., The Journal of Biological Chemistry, "Molecular Cloning of a Proteolytic Antibody Light Chain", Dec. 23, 1994, vol. 269, No. 51, pp. 32389-32393. |
Paul et al., The Journal of Biological Chemistry, "Cleavage of Vasoactive Intestinal Peptide at Multiple Sites by Autoantibodies", Aug. 25, 1991, vol. 266, No. 24, pp. 16128-16134. |
Veljkovic et al., Biochemical and Biophysical Research Communications, "Spectral and Sequence Similarity Between Vasoactive Intestinal Peptide and the Second Conserved Region of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein (gp120): Possible Consequences on Prevention and Therapy of Aids", Dec. 15, 1992, vol. 189, No. 2, pp. 705-710. |
Lee et al., Science, "Functional Interaction and Partial Homology Between Human Immunodeficiency Virus and Neuroleukin", Aug. 28, 1987, 237:1047-1051. |
Santis et al., The Journal of Infectious Diseases, "Cross-Reactive Response to Human Immunodeficiency Virus Type 1 (HIV-1) gp120 and HLA Class I Heavy Chains Induced by Receipt of HIV-1-Derived Envelope Vaccines", 1993, 168:1396-403. |
Bermas et al., Aids Research and Human Retroviruses, "Binding of Glycoprotein 120 and Peptides from the HIV-1 Envelope Autoantibodies in Mice with Experimentally Induced Systemic Lupus Erythematosus and in Patients with the Disease", 1994, vol. 10, No. 9, pp. 1071-1077. |
Gololobov et al., Proc. Natl. Acad. Sci, USA, "Cleavage of Supercoiled Plasmid DNA by Autoantibody Fab Fragment: Application of the Flow Linear Dichroism Technique", Jan. 1995, vol. 92, pp. 254-257. |
Kalaga et al., The 9th International Congress of Immunology, "gp 120 Hydrolysis by Catalytic Antibody Light Chain", 1995, abstract #4893, p. 825. |
Li et al., The Journal of Immunology, "Catalytic Activity of Anti-Thyroglobulin Antibodies", 1995, 154:3328-3332. |
Matsuura et al., Biochemical and Biophysical Research Communications, "Amidase Activity of Human Bence Jones Proteins", Oct. 14, 1994, vol. 204, No. 1, pp. 57-62. |