This invention concerns the field of pathological anatomy, in particular the sector related to the reading of slides used in hospital departments, and more specifically an automated system for reading codes printed on the slides.
In the present state of the art, it is known that samples of tissue from biopsies are placed in histology cassettes, processed, including in paraffin, cut using a microtome in hundredth slices and positioned on the upper side of a slide. It is known that, to read the codes on the slides, these are placed inside trays, normally marked on coordinates with letters and numbers to facilitate identification of each individual slide; said trays are comprised of housing formed by vertical walls along the entire length of the same, thus forming “n” side-by-side columns.
Each column is as wide as the slides and includes tabs separating the slides, placed one after the other, ensuring each slide is kept in position, normally vertically or slanting slightly.
A slide is intended to mean a small plate, generally of glass, of known indicative size of 75*25 mm and approximately 1 mm thick, on which a “slice” of a histological section deriving from the processing of a sample of tissue. Said “slice” is secured on the slide by means of a second plate known as a “slide cover”, since its purpose is to cover the specimen of biological material to be analysed with a microscope. Furthermore, it is known that slides are marked with identification codes that can be:
Operators generally have to handle a large number of slides and often need to identify them quickly and easily, while guaranteeing compliance with quality and reliable traceability requirements, and ensuring that the probability of making mistakes is minimal.
It is also known that slides are placed in containers, inside which the slides are:
By stacking the slides one on top of the other either horizontally or vertically:
In the present state of the art, document WO2016016814 A1 is known and discloses a method and a device for the management of slides for specimens of biological material. Said slides are arranged in succession along a line (L) and are perpendicular to the latter. The slides can be moved vertically by a means of movement in order to reach different distances ranging between a rest position and a reading position. Said means of movement are mobile along the line (L) or parallel to said line (L) and move at least one slide at a time.
The disadvantage of this known device is that it moves at least one slide at a time or, when it moves more than one slide, the movement is always along the line (L) where the slides are arranged in succession. This results in a lengthy identification process, since while the slide being read is in the operative position, the one immediately after it is in a slightly lower position and therefore, before the second slide can be identified, the first one must already have been read, it must have returned to the rest position and the second slide must have been provided with enough time to reach the operational position. At the state of the art, in the sector related to the reading of slides the following documents are also known:
The object of this invention is to create a system that rapidly and easily identifies the codes on slides that are grouped and stored in a container. Another object of this invention is to create a system that limits the possibility of making mistakes when identifying slides.
Another object of this invention is to create a system that enables simultaneous reading of multiple slides placed side by side or one after the other, using various types of containers.
Finally, the object of this invention is to create a system that is able to facilitate slide identification operations, resolving issues relating to the prior art.
These and other objects are attained with this invention, which relates to an automated system to identify the codes of slides containing histology sections from biological specimens.
Additional characteristics and advantages of the invention will become more apparent from the description of a preferred, but not exclusive, form of implementation of the system forming the subject matter of this patent application, illustrated by way of indication, but not limited to, the drawing units below:
In accordance with a preferred—but not limiting—form of implementation, this invention concerns an automated reading system (S) of identification codes printed on slides (13).
Said system (S) includes:
The system (S) forming the subject matter of this patent application can be used with containers of any size and is based on the concurrent lifting of multiple slides (13) arranged in the same row by means of the lifting comb (2), which passes through the slots (14).
The containers (12) have slots (14) cut at a regular pitch.
The automation and therefore the speeding up of the reading of the slides presupposes that the slides are positioned vertically (or tilted slightly) in a stable manner to ensure slide (13) descent after reading; furthermore, the slides (13) are spaced apart to facilitate manual removal of the same from the container (12) and to enable automatic lifting of the slides from their housing along the vertical axis, so that the upper part of the slides can be read, before being repositioned in the relevant housing once reading has taken place.
The slides (13) are lifted by means of the comb device (2), which in turn is actuated by the lifting lever (3).
Moving on the axes of movement (7), said lifting lever (3) moves to under the row of slides (13) to be lifted, enters the slot (14) in the container (12) and actuates the raising of the row of slides (13).
The positions that can be taken by the axis (7) (which can be programmed using software) are those relative to the positioning heights of each row, which can be modified in accordance with various container types (12) and various rows of slides (13).
Each programmed position represents a position of the slide (13) reported in a PC screen window to which the code read on the slide (13) is associated. By reading all the slides (13) present in the container (12), any missing slides (13) will not be read and the PC will consider the relevant positions either empty or unidentified.
By means of the lifting lever (3), the slides (13) rise until only the bands on which the codes are printed are exposed. The slides do not ever rise completely out of the container (12).
In an alternative form of creation, the system (S) can be equipped with more than one comb device (2) with each device being actuated by its own lifting lever (3); in this case, two or more rows can be read lifting them in different ways, ensuring that the bands are always exposed.
In an alternative form of creation, a static display container (15) enabling the slides (13) to be read without being moved can be created. In said container (15), each row of slides (13) is arranged in order that the slide reading bands are exposed. The reading sensor (4) moves vertically with respect to the display container (15) maintain the same reading distance. Alternatively, a sensor capable of reading the entire area of the vertical container (15) can be used.
A further alternative can be to move the step-by-step or continuous reading sensor (4) along an electric axle (16) fitted on a bracket (5bis) in order to read the row of slides (13) in succession; said bracket (5bis) is connected to a central motorised mobile carriage (6bis), which is located under a lifting lever (3bis) and slides on respective central axes of movement (7bis), as per FIG. 16A.
In any event, by being partially lifted, the slides (13) do not suffer any damage or alteration, as no pressure or friction is applied to the same. The entire system (S) is actuated by means of a motor (9) which drives the pulleys (8) connected together by belts (10); two mobile carriages (6) move following the actuation of the pulleys (8). Said mobile carriages (6) are mechanically or electrically connected together and simultaneously move the comb device (2) and the bracket (5) on which the reading sensor (4) is located. As a result of this feature, the distance between the reading sensor (4) and the slides (13) to be read is identical for each movement and synchronous with the row of slides (13) to be lifted.
In addition to 1D and 2D codes, the reading sensor (4) is also able to read alphanumeric codes.
The axes of movement (7) of the carriages (6) are not fitted with drive belts and move synchronously with each other by means of individual motors connected to an electric shaft.
The axes of movement (7) are designed to identify the lifting point on the slide or slides (13) to be read. Said identification can be carried out to map the entire container (12) or, if required, it may serve to remove slides (13) from the container (12) on a temporary basis.
As an alternative to the axes of movement (7), central axes of movement (7bis) with a single mobile carriage (6bis) located below the comb device (2) and the lifting lever (3bis) can be fitted.
The lifting lever (3) can be individual to lift the entire row of slides (13) or, alternatively, with single actuators to lift each slide (13) in the row.
With regard to both storage and reading for extraction, the system is fully programmable using a PC.
Once the system has read all the rows of slides (13), it returns to its starting position, in order to be able to start reading a new container (12) when loaded.
Said reading system is used in combination with traceability and filing management software, eliminating human error in full. The materials and sizes of the invention as described above, illustrated in the accompanying drawings and claimed hereunder, may be of any variation in accordance with requirements. In addition, all details can be replaced with other technically equivalent details without departing from the scope of this patent application.
Number | Date | Country | Kind |
---|---|---|---|
102017000128171 | Nov 2017 | IT | national |
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/EP2018/025284 | 11/7/2018 | WO | 00 |