The present invention relates to an autosampler that can be used by an analysis device such as a liquid chromatograph or a gas chromatograph.
In a chromatograph, an autosampler is used to inject a sample into a mobile phase supplied to a column. In the autosampler, a temperature adjustment function for maintaining a temperature of each sample at a predetermined constant temperature is provided in order to prevent alteration of a plurality of samples held by a sample plate, for example.
For example, in the autosampler described in Patent Document 1, with the sample plate placed on a plate holder, the sample plate is directly cooled by a cooling element provided in the plate holder. Thus, the temperature of the plurality of samples held by the plate holder is adjusted.
While the temperature of the plurality of samples held by the sample plate can be adjusted in a relatively short period of time with the above-mentioned temperature adjusting method described in Patent Document 1 (hereinafter referred to as a direct temperature adjusting method), it is difficult to adjust the temperature of the entire sample plate to a uniform temperature. In a case where large variations are generated in temperature distribution of the sample plate, differences are generated in temperature of the plurality of samples respectively held by a plurality of portions of the sample plate.
In contrast to the above-mentioned direct temperature adjusting method, a method of adjusting the temperature of a sample by adjusting the temperature of air surrounding the sample plate (hereinafter referred to as an air temperature adjusting method) has been known. With the air temperature adjusting method, the temperature of the entire space surrounding the sample plate is adjusted, whereby variations in temperature distribution in the sample plate are reduced as compared to the direct temperature adjusting method. Thus, the temperatures of the plurality of samples can be adjusted easily to a uniform temperature. Also with the air temperature adjusting method, it is required to adjust the temperature of air highly efficiently in order to adjust the temperature of the plurality of samples held by the sample plate in a short period of time.
An object of the present invention is to provide an autosampler that can highly efficiently adjust a temperature in a space storing a sample.
In the autosampler, the circulation device causes gas to circulate between the sample storage space and the temperature adjustment space through the first and second opening regions. At this time, the temperature of gas flowing in the temperature adjustment space is adjusted by the heat exchanger. Thus, the temperature of gas surrounding the sample in the sample storage space is adjusted.
During the temperature adjustment of gas by the heat exchanger, a portion of a circulating gas flows through a portion (hereinafter referred to as a first space portion) located between the first portion in the second opening region and the first opening region of the separating member in the temperature adjustment space. Further, another portion of the circulating gas flows through a portion (hereinafter referred to as a second space portion) located between the second portion in the second opening region and the first opening region of the separating member in the temperature adjustment space.
Here, the shortest distance between the first portion in the second opening region and the first opening region of the separating member is larger than the shortest distance between the second portion in the second opening region and the first opening region of the separating member. In this case, when gas flows between the first opening region and the second opening region, a difference is generated between a pressure in the first space portion and a pressure in the second space portion. Therefore, a flow rate of gas flowing in the first space portion tends to be smaller than a flow rate of gas flowing in the second space portion.
In regard to such tendency, with the above-mentioned configuration, because the aperture ratio of the first portion is larger than the aperture ratio of the second portion, a flow rate of gas flowing in the first space portion can be increased. Thus, the flow rates of gas flowing in the first and second space portions can be made uniform. Therefore, the temperatures of gas flowing in the first and second space portions can be adjusted to a uniform temperature, and efficiency of temperature adjustment by the heat exchanger is improved. As a result, the temperature in the sample storage space can be adjusted highly efficiently.
In this case, during temperature adjustment of gas by the heat exchanger, yet another portion of a circulating gas flows through a portion (hereinafter referred to as a third space portion) located between the third portion in the second opening region and the first opening region of the separating member in the temperature adjustment space.
Here, the shortest distance between the first portion in the second opening region and the first opening region of the separating member is larger than the shortest distance between the third portion in the second opening region and the first opening region of the separating member. In this case, when gas flows between the first opening region and the second opening region, a difference is generated between a pressure in the first space portion and a pressure in the third space portion. Therefore, a flow rate of gas flowing in the first space portion tends to be smaller than a flow rate of gas flowing in the third space portion.
In regard to such tendency, with the above-mentioned configuration, because the aperture ratio of the first portion is larger than the aperture ratio of the third portion, the flow rates of gas flowing in the first and third space portions can be made uniform. Therefore, the temperatures of gas flowing in the first, second and third space portions can be adjusted to a uniform temperature by the heat exchanger, and efficiency of temperature adjustment by the heat exchanger is improved. As a result, the temperature in the sample storage space can be adjusted more highly efficiently.
In this case, in the separating member, the first unit region and the second unit region are arranged in the first direction, the first unit region and the third unit region are arranged in the second direction, the second unit region and the fourth unit region are arranged in the second direction, and the third unit region and the fourth unit region are arranged in the first direction. Thus, an increase in size of the separating member in one of the first direction and the second direction is suppressed. Therefore, an increase in size of the autosampler in one direction is suppressed.
In this case, flow rates of gas flowing in the above-mentioned first space portion and second space portion can be made uniform with a simple configuration.
In this case, flow rates of gas flowing in the above-mentioned first space portion and third space portion can be made uniform with a simple configuration.
In this case, in the temperature adjustment space, gas can flow in the second direction from the first side of the heat exchanger. Further, gas can flow in the first direction from the second side of the heat exchanger. Thus, because gas can flow throughout the entire heat exchanger, the temperature in the sample storage space can be adjusted even more highly efficiently.
The present invention enables highly efficient adjustment of temperature in a space storing a sample.
An autosampler according to one embodiment of the present invention will be described below with reference to the drawings. The autosampler according to the present embodiment is used to inject a sample into a mobile phase supplied to a column of a chromatograph.
As shown in
The sample storage space 41 is a space for storing a sample to be analyzed by the chromatograph. The temperature adjustment space 42 is a space used to adjust the temperature of a sample stored in the sample storage space 41.
In the casing 20, a plurality of thermal insulators 29 are provided to cover the sample storage space 41 from the front and cover the sample storage space 41 and the temperature adjustment space 42 from above, below, the right and the left. A thermal insulation board 50 having a rectangular shape is provided between the sample storage space 41 and the temperature adjustment space 42 to be orthogonal to the front-and-rear direction. The plurality of thermal insulators 29 and the thermal insulation board 50 are formed of a polyethylene resin foaming material, for example. In the following description, a thermal insulator 29 that covers the sample storage space 41 from below out of the plurality of thermal insulators 29 is referred to as a lower thermal insulator 29u.
The sample storage space 41 and the temperature adjustment space 42 are separated by the thermal insulation board 50 in the casing 20. Two openings 51, 52 that cause the sample storage space 41 and the temperature adjustment space 42 to communicate with each other are formed in the thermal insulation board 50.
In
As shown in
Further, an air guiding member 60 for guiding air flowing forwardly from the fan 70 to a position below the sample storage space 41 is provided at the front surface of the thermal insulation board 50. The air guiding member 60 extends forwardly from the front surface of the thermal insulation board 50 by a certain distance.
In the front end portion of the casing 20, an opening 21 through which a plurality of sample plates 90 are taken in and out between a position farther forward than the casing 20 and the sample storage space 41 is formed. Each sample plate 90 is a plate configured to be capable of holding a plurality of sample vials or a plurality of samples. The opening 21 is formed at a position farther upward than the lower thermal insulator 29u by a certain height. Further, the opening 21 is formed to extend in the left-and-right direction.
The autosampler 1 includes a sample rack 30. The sample rack 30 is configured to be insertable into the sample storage space 41 through the opening 21 from a position farther forward than the casing 20 and drawable to a position farther forward than the casing 20 from the sample storage space 41 through the opening 21.
The sample rack 30 has a front board portion 31 and a bottom board portion 32. The front board portion 31 has one surface configured to be capable of closing an opening 21 of the casing 20 and another surface configured be holdable by a user. The bottom board portion 32 is constituted by a board-shaped member that can support the plurality (three in the example of
An air guiding board 34 is attached to the tip of the bottom board portion 32. The air guiding board 34 projects upwardly from the tip of the bottom board portion 32 and extends from the one side to the other side of the bottom board portion 32.
The user places the plurality of sample plates 90 on the bottom board portion 32 of the sample rack 30 and inserts the bottom board portion 32 into the opening 21 while holding the front board portion 31. Thus, the one surface of the front board portion 31 closes the opening 21, a gap G is formed between the bottom board portion 32 and the lower thermal insulator 29u and the air guiding board 34 abuts against the front end of the air guiding member 60. In this state, the sample rack 30 is fixed to the casing 20, and the plurality of sample plates 90 are stored in the sample storage space 41.
On the other hand, the user holds the front board portion 31 of the sample rack 30 and draws the sample rack 30 to a position farther forward than the autosampler 1. Thus, the plurality of sample plates 90 are taken out from the sample storage space 41.
At a position farther rearward than the thermal insulation board 50, a plurality (four in the present example) of radiators RA are provided to be arranged upwardly, downwardly, leftwardly and rightwardly. As shown in
One heat exchanging fin 131 of each radiator RA is arranged in the temperature adjustment space 42, and the other heat exchanging fin 133 of each radiator RA is arranged rearwardly of the temperature adjustment space 42. In the present embodiment, the rear end of the casing 20 is opened. Thus, the other heat exchanging fin 133 of each radiator RA is exposed rearwardly of the autosampler 1. When the temperature adjusting element 132 of each radiator RA is driven, heat is exchanged between the two heat exchanging fins 131, 133 of the radiator RA, and the temperature of air flowing in the temperature adjustment space 42 is adjusted.
With the sample rack 30 inserted into the casing 20, the fan 70 operates while the temperature of air in the temperature adjustment space 42 is adjusted. In this case, as indicated by the thick two-dotted and dash lines in
The temperature of the space surrounding the plurality of sample plates 90 is adjusted by the air flowing through the gap G and air guided to a position above the bottom board portion 32. Thus, the temperature of a plurality of samples held by each sample plate 90 is adjusted (heated, cooled or maintained) together with a sample plate 90 supported by the sample rack 30.
In the sample storage space 41, an injection device (not shown) for injecting the plurality of samples held by each sample plate 90 into a mobile phase used by a chromatograph is provided.
In
The first unit region R1 is located at an upper left position in the thermal insulation board 50, the second unit region R2 is located at an upper right position in the thermal insulation board 50, the third unit region R3 is located at a lower left position in the thermal insulation board 50 and the fourth unit region R4 is located at the lower right position in the thermal insulation board 50. Thus, the first unit region R1 and the second unit region R2 are arranged in the left-and-right direction, and the first unit region R1 and the third unit region R3 are arranged in the up-and-down direction. Further, the second unit region R2 and the fourth unit region R4 are arranged in the up-and-down direction, and the third unit region R3 and the fourth unit region R4 are arranged in the left-and-right direction.
The first to fourth unit regions R1 to R4 respectively overlap with the four radiators RA of
The one opening 51 is formed to be located in the fourth unit region R4. Further, the other opening 52 is formed to be located in the first unit region R1, the second unit region R2 and the third unit region R3.
A portion located in the first unit region R1 in the opening 52 is referred to as a first portion 521. A portion located in the second unit region R2 in the opening 52 is referred to as a second portion 522. A portion located in the third unit region R3 in the opening 52 is referred to as a third portion 523.
The shortest distance D1 between the first portion 521 and the opening 51 is larger than the shortest distance D2 between the second portion 522 and the opening 51 and the shortest distance D3 between the third portion 523 and the opening 51.
In the first unit region R1, the first portion 521 extends rightwardly and downwardly from a position in the vicinity of one corner (the upper left corner) that is at the farthest distance from the center of the thermal insulation board 50 out of the four corners in the first unit region R1. The upper edge (first edge) of the first portion 521 extends in the left-and-right direction to be in parallel with a first side S1 of the heat exchanger 131 and the upper side of the upper left radiator RA of
In the second unit region R2, the second portion 522 extends rightwardly from the first portion 521 in the first unit region R1. The width of the second portion 522 in the up-and-down direction is constant. Further, the upper edge (first edge) of the second portion 522 extends in the left-and-right direction to be in parallel with the first side S1 of the heat exchanger 131 and the upper side of the upper right radiator RA of
In the third unit region R3, the third portion 523 extends downwardly from the first portion 521 in the first unit region R1. The width of the third portion 523 in the left-and-right direction is constant and equal to the width of the second portion 522 in the up-and-down direction. Further, the left edge (second edge) of the third portion 523 extends in the up-and-down direction to be in parallel with the second side S2 of the heat exchanger 131 and the left side of the lower left radiator RA of
Here, in the first portion 521, a bending portion between a portion having a constant width and extending in the left-and-right direction and a portion having a constant width and extending in the up-and-down direction forms a substantially triangular shape. Therefore, the width of the bending portion (the width in the direction of a diagonal line that connects a lower right top and an upper left top of the thermal insulation board 50 to each other) is larger than the above-mentioned width of each of the second portion 522 and the third portion 523. With such a configuration, the aperture ratio of the first portion 521 in the first unit region R1 is larger than each of the aperture ratio of the second portion 522 in the second unit region R2 and the aperture ratio of the third portion 523 in the third unit region R3.
As described above, the shortest distance D1 between the first portion 521 and the opening 51 is larger than each of the shortest distance D2 between the first portion second portion 522 and the opening 51 and the shortest distance D3 between the third portion 523 and the opening 51. In this case, when gas flows between the opening 51 and the opening 52, a difference is generated between a pressure generated in the first space portion and a pressure generated in the second and third space portions. Therefore, a flow rate of gas flowing in the first space portion tends to be smaller than a flow rate of gas flowing in each of the second and third space portions. A flow rate of gas refers to an amount of gas flowing in a subject space per unit time.
As such, in the present embodiment, as described above, the thermal insulation board 50 is formed such that the aperture ratio of the first portion 521 in the first unit region R1 is larger than the aperture ratio of the second portion 522 in the second unit region R2. Further, the thermal insulation board 50 is formed such that the aperture ratio of the first portion 521 in the first unit region R1 is larger than the aperture ratio of the third portion 523 in the third unit region R3.
In this case, a flow rate of gas flowing in the first space portion can be increased. Thus, a flow rate of gas flowing in each of the first, second and third space portions can be made uniform. Therefore, the temperatures of gas flowing in the first, second and third space portions can be adjusted to a uniform temperature by the plurality of radiators RA, and efficiency of temperature adjustment by the radiators RA is improved. As a result, the temperature in the sample storage space 41 can be adjusted highly efficiently. Therefore, a sample stored in the sample storage space 41 can be adjusted to a desired temperature in a short period of time.
The inventors of the present invention fabricated a thermal insulation board 50 according to an inventive example and fabricated an autosampler 1 including the thermal insulation board 50 in order to confirm a change in temperature distribution of a plurality of heat exchanging fins 131 in accordance with the shape of an opening 52 formed in the thermal insulation board 50.
In the thermal insulation board 50 of
With the configuration of
According to the thermographic image of
Further, the inventors of the present invention fabricated a thermal insulation board 50 according to a comparative example and fabricated an autosampler 1 including the thermal insulation board 50.
In the thermal insulation board 50 of
The opening 54 is closed by a transparent film TF except for one upper left portion. Thus, the conditions of the surfaces of the upper left, upper right and lower left heat exchanging fins 131 can be viewed from the sample storage space 41. In
With the configuration of
According to the thermographic image of
The above-mentioned thermal insulation board 50 functions as a separating member that separates the sample storage space 41 and the temperature adjustment space 42 from each other. In a case where a plurality of separating members that separate the sample storage space 41 and the temperature adjustment space 42 from each other are present, two openings 51, 52 may be formed in each of the plurality of separating members.
In the autosampler 1 of
The space located rearwardly of the thermal insulation board 150 and surrounded by the thermal insulation member 190 is the temperature adjustment space 42. In the temperature adjustment space 42, heat exchanging fins 131 of a plurality of radiators RA are arranged similarly to the example of the above-mentioned embodiment.
With such a configuration, an opening 51 is formed in the thermal insulation board 150, and an opening 91 is formed in the thermal insulation member 190. In this case, during an operation of a fan 70 (not shown), air in the temperature adjustment space 42 is supplied to the sample storage space 41 through the opening 51, and air in the sample storage space 41 is returned to the temperature adjustment space 42 through the opening 91.
Here, as indicated by the dotted lines in
The opening 91 is formed to be located in the first to third unit regions R1 to R3 of
In the present example, similarly to the above-mentioned embodiment, the shortest distance between the first portion 911 and the opening 51 is larger than each of the shortest distance between the second portion 912 and the opening 51 and the shortest distance between the third portion 913 and the opening 51. Further, the aperture ratio of the first portion 911 in the first unit region R1 is larger than each of the aperture ratio of the second portion 912 in the second unit region R2 and the aperture ratio of the third portion 913 in the third unit region R3. Thus, air can flow uniformly to the plurality of radiators RA in the temperature adjustment space 42, and the effects similar to that of the above-mentioned embodiment can be obtained.
In the following paragraphs, non-limiting examples of correspondences between various elements recited in the claims below and those described above with respect to various preferred embodiments of the present disclosure are explained.
In the above-mentioned embodiment, a portion of the casing 20 and a portion of the thermal insulator 29 that form the sample storage space 41 are examples of sample storages, a portion of the casing 20 and a portion of the thermal insulator 29 that form the temperature adjustment space 42 are examples of adjustors, the opening 51 is an example of a first opening region, and the openings 52, 91 are examples of second opening regions. Further, the thermal insulation boards 50, 150 and the thermal insulation member 190 are examples of separating members, the fan 70 is an example of a circulation device, and the plurality of radiators RA are an example of heat exchangers.
Further, the direction in which air flows from an upper left position to a lower right position in the temperature adjustment space 42 is an example of a direction of an airflow generated between the first opening region and the first portion in the second opening region by the circulation device, and a direction in which air flows from above toward below in the temperature adjustment space 42 is an example of a direction of an airflow generated between the first opening region and the second portion in the second opening region by the circulation device.
As each of various elements recited in the claims, various other elements having configurations or functions described in the claims can be also used.
Filing Document | Filing Date | Country | Kind |
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PCT/JP2018/040996 | 11/5/2018 | WO |
Publishing Document | Publishing Date | Country | Kind |
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WO2020/095345 | 5/14/2020 | WO | A |
Number | Name | Date | Kind |
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20150003494 | Yokoyama | Jan 2015 | A1 |
20160274011 | Maeda | Sep 2016 | A1 |
20190383844 | Miyazaki | Dec 2019 | A1 |
20190383845 | Miyazaki | Dec 2019 | A1 |
Number | Date | Country |
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2016-176749 | Oct 2016 | JP |
2019-219203 | Dec 2019 | JP |
2019-219205 | Dec 2019 | JP |
2019244198 | Dec 2019 | WO |
Entry |
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International Search Report for corresponding Application No. PCT/JP2018/040996, mailed Jan. 15, 2019. |
Written Opinion for corresponding Application No. PCT/JP2018/040996, mailed Jan. 15, 2019 (machine translation). |
Office Action in corresponding Chinese Patent Application No. 201880098914.2 dated Nov. 1, 2023, with English machine translation. |
Number | Date | Country | |
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20210404997 A1 | Dec 2021 | US |