Claims
- 1. An azaheterocyclylmethyl-chroman of the formula: ##STR43## in which A, B and D independently of one another represent hydrogen, halogen, cyano, azido, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxyl or carboxyl; or represent straight-chain or branched alkyl, alkenyl, alkanoyl or alkoxycarbonyl having in each case up to 8 carbon atoms; or
- represent a group of the formula --NR.sup.1 R.sup.2, --NR.sup.3 --L--R.sup.4 or --OR.sup.5 ;
- wherein
- R.sup.1, R.sup.2 and R.sup.3 are identical or different and represent hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms, phenyl or benzyl;
- L represents --CO-- or --SO.sub.2 --;
- R.sup.4 represents straight-chain or branched alkyl having up to 8 carbon atoms or benzyl, or represents hydrocarbyl aryl having 6-10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, or by straight-chain or branched alkyl or alkoxy having up to 6 carbon atoms;
- R.sup.5 represents straight-chain or branched alkyl or alkenyl having in each case up to 8 carbon atoms, which are optionally substituted by cycloalkyl having 3 to 6 carbon atoms or phenyl;
- R.sup.6 represents hydrogen, hydroxyl, halogen or phenyl; and
- n represents an integer 1-8;
- an optically isomeric form thereof or a salt thereof.
- 2. The azaheterocyclylmethyl-chroman according to claim 1, wherein
- A, B and D independently of one another represent hydrogen, fluorine, chlorine, bromine, cyano, trifluoromethyl, difluoromethoxy, trifluoromethoxy or hydroxyl; or
- represent straight-chain or branched alkyl, alkenyl, alkanoyl or alkoxycarbonyl having in each case up to 6 carbon atoms; or
- represent a group of the formula --NR.sup.1 R.sup.2, --NR.sup.3 --L--R.sup.4 or --OR.sup.5 ;
- wherein
- R.sup.1, R.sup.2 and R.sup.3 are identical or different and represent hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms;
- L represents --CO--or --SO2--;
- R.sup.4 represents straight-chain or branched alkyl having up to 6 carbon atoms or benzyl, or represents phenyl, which is optionally substituted by fluorine, chlorine, bromine, hydroxyl, trifluoromethyl, trifluoromethoxy, or by straight-chain or branched alkyl or alkoxy having up to 4 carbon atoms;
- R.sup.5 represents straight-chain or branched alkyl or alkenyl having in each case up to 6 carbon atoms, which are optionally substituted by cyclopropyl, cyclopentyl, cyclohexyl or phenyl;
- R.sup.6 represents hydrogen, hydroxyl, fluorine, chlorine, bromine or phenyl; and
- n represents an integer 1-8;
- an optically isomeric form thereof or a salt thereof.
- 3. The azaheterocyclylmethyl-chroman according to claim 1, wherein
- A, B and D independently of one another represent hydrogen, fluorine, chlorine, bromine, cyano, trifluoromethyl, trifluoromethoxy or hydroxyl; or
- represent straight-chain or branched alkyl or alkenyl having in each case up to 4 carbon atoms; or
- represent a group of the formula --NR.sup.1 R.sup.2 or --OR.sup.5 ;
- wherein
- R.sup.1 and R.sup.2 are identical or different and represent hydrogen or straight
- chain or branched alkyl having up to 4 carbon atoms;
- R.sup.5 represents straight-chain or branched alkyl or alkenyl having in each case up to 4 carbon atoms, which are optionally substituted by cyclopropyl or phenyl;
- R.sup.6 represents hydrogen, hydroxyl, fluorine or chlorine; and
- n represents an integer 1-8;
- an optically isomeric form thereof or a salt thereof.
- 4. A pharmaceutical composition system comprising, a therapeutical effective amount therefor of a compound or salt thereof according to claim 1 and a pharmacologically acceptable diluent.
- 5. A method of treating anxiety in a patient in need thereof which comprises administering to such patient an amount effective therefor of a compound or a salt thereof according to claim 1.
Priority Claims (1)
Number |
Date |
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41 40 540.4 |
Dec 1991 |
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Parent Case Info
This is a division of application Ser. No. 07/984,076, filed Nov. 30, 1992, now U.S. Pat. No. 5,371,096.
US Referenced Citations (3)
Non-Patent Literature Citations (2)
Entry |
Athen et al "Clinical Effects of Moderate and High Doses of Carpipramine" Index Medicus abs. No. 013711 (1977). |
Traber et al. "5-HT1a receptor related anxiolytics" TIPS vol. 8, (1987) pp. 432-437. |
Divisions (1)
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Number |
Date |
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Parent |
984076 |
Nov 1992 |
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