Claims
- 1. A compound of formula (I) or a pharmaceutically acceptable salt or N-oxide thereof: ##STR6## in which R.sup.1 is 1,2,4- or 1,3,4-oxadiazole;
- R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1-6 alkyl;
- R.sup.4 and R.sup.5 together form a group --A-- where A is (CR.sup.13 R.sup.14).sub.q where q is 2 and R.sup.13 and R.sup.14 are hydrogen;
- R.sup.6 is a group --(CH.sub.2).sub.p --R.sup.15 where p is 2 and R.sup.15 is OR.sup.16 or SR.sup.16 where R.sup.16 is hydrogen or C.sub.1-6 alkyl or R.sup.15 is NR.sup.10 R.sup.11 where R.sup.10 and R.sup.11 are independently hydrogen or C.sub.1-6 alkyl;
- R.sup.7 and R.sup.8 are hydrogen;
- B is oxygen;
- m is 2; and
- n is 1.
- 2. A compound according to claim 1 in which R.sup.2 is C.sub.1-6 alkyl.
- 3. A compound according to any one of claim 1 in which R.sup.6 is a group (CH.sub.2).sub.2 OH.
- 4. A compound according to claim 1 which is:
- 1'-(2-Hydroxyethyl)-5-(2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-2-yl)biphenyl-4-carbonyl)-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine],
- ' -(2-Hydroxyethyl)-5-(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carbonyl)-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine],
- 1'-(2-Dimethylaminoethyl)-5-(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carbonyl)-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine],
- 1'-(2-Methoxyethyl)-5-(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carbonyl)-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine], or a pharmaceutically acceptable salt or N-oxide thereof.
- 5. A pharmaceutical composition which comprises a compound according to claim 1 in association with a pharmaceutically acceptable carrier or excipient.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9522845 |
Nov 1995 |
GBX |
|
Parent Case Info
This application is a 371 of PCT/EP96/04657 filed Oct. 23, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/EP96/04657 |
10/23/1996 |
|
|
5/8/1998 |
5/8/1998 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO97/17350 |
5/15/1997 |
|
|
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
5356893 |
Bradshaw et al. |
Oct 1994 |
|
5952325 |
Wayman et al. |
Sep 1999 |
|
5972951 |
Gaster |
Oct 1999 |
|