Claims
- 1. A process for preparing an azetidinone derivative represented by the formula (I) ##STR42## wherein R.sup.1 is phenyl optionally substituted with methyl, chlorine or nitro or phenoxy optionally substituted with methyl, chlorine or nitro;
- R.sup.2 is hydrogen, amino-protecting group or a group of the formula (II), (III) or (VI) ##STR43## R.sup.6 is hydrogen or carboxyl-protecting group; Z.sup.1 and Z.sup.2 are the same or different and are each hydrogen, halogen, methylthio, ethylthio, phenylthio, p-nitrophenylthio, pentachlorophenylthio, 2-pyridylthio, 2-benzothiadiazolylthio, 1,3,4-thiadiazole-5-ylthio, 1,2,3,4-tetrazole-5-ylthio, 1-methyl-1,2,3,4-tetrazole-5-ylthio, O-ethyldithiocarbonate, N,N-diethyldithiocarbamate, phenylsulfonyl, p-methylphenylsulfonyl, hydroxy, methoxy, ethoxy, acetoxy, benzoyloxy, nitrosooxy, nitriloxy, dimethylamino or piperidine-1-yl, and W is protected hydroxyl group;
- X.sup.1 and X.sup.2 are the same or different and are halogen, hydroxyl, alkoxy, acyloxy, SR.sup.4 (wherein R.sup.4 is straight chain or branched chain lower alkyl, phenyl optionally substituted with chlorine or nitro, pyridyl or benzothiazolyl), amino or hydrogen, one of X.sup.1 and X.sup.2 not being hydrogen when the other is, or ##STR44## is >C.dbd.O or >C.dbd.NOR.sup.3 (wherein R.sup.3 is hydrogen, or lower alkyl); and
- R.sup.5 is phenyl optionally substituted with chlorine or nitro, pyridyl, 2-benzothiazolyl, 1,3,4-thiadiazolyl optionally substituted with methyl or phenyl, tetrazolyl optionally substituted with methyl or phenyl, or benzimidazolyl, the process comprising reacting in a hydrous organic solvent in the presence of an acid a thiazolinoazetidinone derivative represented by the formula (IV) ##STR45## wherein R.sup.1, R.sup.2 and ##STR46## are as defined above with a disulfide represented by the formula (V):
- R.sup.5 --S--S--R.sup.5 (V)
- wherein R.sup.5 is as defined above.
Priority Claims (1)
Number |
Date |
Country |
Kind |
57-210490 |
Nov 1982 |
JPX |
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Parent Case Info
This is a division of application Ser. No. 908,970, filed 9/17/86, abandoned, which is a continuation of application Ser. No. 553,306, filed on 11/17/83, abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4482491 |
Torii |
Nov 1984 |
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Non-Patent Literature Citations (1)
Entry |
Maki J.A.C.S 99, 5091 (1977). |
Divisions (1)
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Number |
Date |
Country |
Parent |
908970 |
Sep 1986 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
553306 |
Nov 1983 |
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