Some embodiments relate to magnetic resonance imaging, and more particularly to magnetic field inhomogeneity correction.
Implantable Cardioverter Defibrillators (ICDs) are implanted in patients to prevent sudden cardiac death by electrically pacing the heart or delivering an electric shock when the device detects a potentially lethal arrhythmia. These arrhythmias commonly occur in the setting of a prior myocardial infarction. In the United States, ICDs are implanted in 150,000 patients per year, and there are over 2 million patients with implanted devices.
ICDs may be constructed as a flat “disk-like” shaped box that is placed over the rib cage beneath the skin and subcutaneous fat layers, with lead wires that go from this box to selected cardiac chambers. The box may contain the battery of the system and a ferromagnetic transformer that is used in order to inductively charge the ICD's capacitor. The ferromagnetic transformer, found even in MRI-conditional ICD units which have been rendered MRI-safe from incurring heating effects resulting from the MRI scanner's radio-frequency pulses, as well as rendered safe from reprogramming resulting from the MRI scanner's gradient pulses, creates a magnetic field around it. However, even MRI-conditional ICD units are sometimes counter-indicated for cardiac MRI scans due to large artifacts resulting from the ferromagnetic transformer.
Since the ICD box is generally situated in the upper chest (and frequently on the left side), the ferromagnetic transformer may be distanced 6 to 15 cm from portions of the heart. The distance of regions of the heart from the ferromagnetic transformer depends on the placement location of the box in the chest, the patient's anatomy (the thickness of the fat layers below the ICD, etc.), and the location and orientation of the heart.
Cardiac MRI (CMR) is an emerging area of MRI with a growing number of procedures each year. CMR deals with the diagnosis and treatment of cardiovascular disease using several MR imaging techniques, to investigate vascular anatomy and the chambers of the heart. In the areas where the heart is closest to the transformer, the superposition of the transformer's field, which strongly varies spatially, on the MRI scanner's homogeneous static (BO) magnetic field leads to a strongly inhomogeneous field. The size of the field inhomogeneity may be expressed in several different ways, such as magnetic field units as milli-Tesla (mT), as Parts Per Million of the main field (PPM), or as a Frequency offset (in Hertz) since 1 PPM is 63.8 Hertz or 123.2 Hertz at 1.5 T and 3 T, respectively. Field inhomogeneities of the order of 0.15 mT or 100 PM or more have been observed in patients with implanted ICDs.
Magnetic inhomogeneity leads to spatial distortions of the image, referred to as image artifacts. These image artifacts may include “pile up effects,” which are areas of the image where the geometry is shrunken so that the image elements (voxels) have higher intensity, causing the region to appear larger or smaller than it should be. The artifacts may also include areas where no signal is seen, e.g., a “black hole” in the image, due to the field inhomogeneity in the region exceeding the acquisition frequency boundaries of the specific sequence. The effects of the field inhomogeneity in the heart may be exacerbated by the physiological motion of the heart since the magnetic field inhomogeneity is variable during MR image acquisition. One reason for the variable inhomogeneity is that the heart moves relative to the position of the ferromagnetic transformer, and image acquisition may span several cardiac and respiratory cycles. Accordingly, the magnetic field inhomogeneities may affect different image components with varying degrees, which reduces image coherency, and therefore leads to reduced image quality (e.g., spatial and temporal resolution, inter-tissue contrast).
The different MR sequence types (including but not limited to Spin Echo (SE), Gradient Recalled Echo (GRE), Echo Planar Imaging (EPI), and Spiral Imaging), as well as the specific imaging parameters used with them, are sensitive to different levels of static magnetic field homogeneity. This sensitivity determines the location volume, and the topology of the region in the heart where the MR Imaging picture is considerably distorted geometrically or completely unseen (i.e., a “black hole” is seen in the image). Specialized MRI sequences have been developed to help with this issue, termed “wide-band GRE sequences” which are GRE sequences that are still able to acquire data in the presence of 4 KHz (e.g., ˜0.10 mT, or ˜62 PPM at 1.5T or ˜31 PPM at 3 T) magnetic field inhomogeneity. Wide-band sequences considerably reduce the region of the heart that cannot be imaged, but in many patients (and especially for those that do not have thick fat layers between the ICD and rib cage) the resulting images still contain residual black holes, considerable spatially distorted regions, and reduced image fidelity (e.g., spatial blurring, reduced inter-tissue contrast) due to severe motion artifacts in the presence of the field inhomogeneity.
Commonly-used sequences in CMR for assessing cardiac function include steady-state free precession (SSFP) sequences, which can only tolerate ˜1.0 KHz of field inhomogeneity, and consequently cannot be used in most of the ICD patients. Another important application of CMR is in the assessment of patients with diseases that result in ischemic (or fibrotic) regions such as in patients after heart attacks, where the objective is to detect the scarred regions of the anatomy. Typically, imaging of these scarred regions is performed with late gadolinium enhancement (LGE) sequences, which are inversion-recovery gradient echo (IR-GRE) sequences that are acquired a long time (e.g., ˜15 minutes) after contrast injection. Some wide-band sequences are modifications of standard IR-GRE sequences which allow LGE scans of patients implanted with ICDs, who are at risk of future diseases or require intervention. Since standard LGE scans are already lower in SNR relative to other MR sequences, the wide-band LGE sequences in the presence of a strong static field inhomogeneity are frequently blurred and very low in inter-tissue contrast.
An embodiment of the present invention is a device for magnetic resonance artifact correction, including an array of multiple shim coils that are sequentially arranged to receive a current, such that a first force on the array arising from an interaction of a magnetic field with the current in any one of the shim coils is balanced by a second force on the array arising from interactions of the magnetic field with the current in all other shim coils when the array is operated within an imaging volume of a magnetic resonance system. The device further includes a frame composed of non-ferromagnetic material positioned proximate to the imaging volume, the frame being configurable to provide selectable positioning of the array within the imaging volume. The device further includes a signal processor configured to receive a measurement of a magnetic field inhomogeneity within a selected region of the imaging volume, and, using the measurement of the magnetic field inhomogeneity, determine a current for the shim coils and a set of coordinates for positioning the array within the imaging volume, such that applying the current to the array at the set of coordinates generates a correction field to reduce the magnetic field inhomogeneity within the selected region of the imaging volume.
Another embodiment of the present invention is a magnetic resonance system including a magnet system configured to provide a substantially homogenous magnetic field over an imaging volume in the absence of ferromagnetic materials proximate to the imaging volume, and a magnetic field gradient system positioned proximate to the imaging volume, the magnetic field gradient system being configured to generate spatial encoding in the substantially homogeneous magnetic field. The magnetic resonance system further includes a radiofrequency (RF) system arranged proximate to the imaging volume and configured to acquire multiple MR signals from the imaging volume, and a device for magnetic resonance artifact correction. The device includes an array of multiple shim coils that are sequentially arranged to receive a current, such that a first force on the array arising from an interaction of a magnetic field with the current in any one of the shim coils is balanced by a second force on the array arising from interactions of the magnetic field with the current in all other shim coils when the array is operated within the imaging volume. The device further includes a frame composed of non-ferromagnetic material positioned proximate to the imaging volume, the frame being configurable to provide selectable positioning of the array within the imaging volume. The device further includes a signal processor configured to receive a measurement of a magnetic field inhomogeneity within a selected region of the imaging volume, and, using the measurement of the magnetic field inhomogeneity, determine a current for the shim coils and a set of coordinates for positioning the array within the imaging volume, such that applying the current to the array at the set of coordinates generates a correction field to reduce the magnetic field inhomogeneity within the selected region of the imaging volume.
Further objectives and advantages will become apparent from a consideration of the description, drawings, and examples.
Some embodiments of the current invention are discussed in detail below. In describing embodiments, specific terminology is employed for the sake of clarity. However, the invention is not intended to be limited to the specific terminology so selected. A person skilled in the relevant art will recognize that other equivalent components can be employed, and other methods developed, without departing from the broad concepts of the current invention.
All references cited anywhere in this specification, including the Background and Detailed Description sections, are incorporated by reference as if each had been individually incorporated.
As used herein, the term “shimming” refers to a process of correction of a magnetic field inhomogeneity (e.g., during magnetic resonance imaging (MRI) or nuclear magnetic resonance (NMR) experiments). Since the inhomogeneities may cause image artifacts which degrade signal quality, and therefore shimming is also a process to correct these artifacts and improve signal quality. An inhomogeneity may arise from any of a number of sources, including but not limited to the presence of bone, foreign metal, and voids of air. For example, an inhomogeneity may be created or caused by the placement near the imaging volume of objects or medical devices (e.g., an ICD) that contain ferromagnetic components.
As used herein, the term “shim coil” refers to a coil that during operation, corrects the magnetic field inhomogeneity. As an example, MRI shim coils are coils that are intended to remove or reduce inhomogeneities in an MR system's static magnetic field (BO). In order to effectively perform shimming, a shim coil may be calibrated to determine the amount of current flowing through the coil and to determine the position of the shim coil within the magnetic field. The terms “shim coil array,” “shim coil assembly,” and “shim coil” may be used interchangeably in the below discussion.
In some embodiments, the shimming system 105 includes a force-balanced static magnetic field shim coil assembly 107 comprised of an array of multiple shim coils. The shim coil assembly 107 may be equivalently referred to as a shim coil or a shimming device. In some embodiments, the shim coil assembly 107 may be placed anywhere within the MR system 100. For example, the shim coil assembly 107 may be placed outside any MRI radio-frequency receive-array coils (not shown in
Since the shim coil assembly 107 may be used inside the MRI bore, and its current is ramped up and down within the strong magnetic field of the MR system 100 (which can induce very strong forces on the shim coil assembly 107), the shim coil assembly 107 may be configured to have a balanced torque and/or a balanced force, so that changing the current will not cause the shim coil assembly 107 to move, rotate, or deform within the bore.
In some embodiments, the multiple shim coils within the shim coil assembly 107 are sequentially arranged to receive a current, such that when the shim coil assembly 107 is operated within an imaging volume 130 (denoted by a dashed oval in
In some embodiments, the force-balanced shim coil assembly 107 has a large shim volume and can be moved inside the bore without resistance, and used during imaging without the coil moving. The specific coil design of some embodiments is based on a limited number of relatively long linear coil segments, which can be optimized to provide a maximal correction field while minimizing the current amplitude required to correct the perturbation of the magnetic field by the ICD 110. For example, in some embodiments, the shim coil assembly 107 uses two coils placed in opposing directions that are driven in series, so that the shim coil assembly 107 is balanced in force and torque. In other embodiments, more than two coils may be used, and positioned to achieve balance in force and torque during operation.
The shim coil assembly 107 may be placed inside the MRI bore, quite close to the patient 115, with its powering cabling running to the MRI room's penetration panel (not shown in
In some embodiments, the shimming system 105 further includes a frame assembly 125 positioned proximate to the imaging volume 130 of the MR system 100. The frame assembly 125 may be securely anchored to the patient table 120 (e.g., an MRI stretcher). In some embodiments, the frame assembly 125 allows the shim coil assembly 107 to be moved, so that the frame assembly 125 is able to accommodate a variety of patients of differing sizes and in whom the ICD 110 may be implanted in different locations.
In some embodiments, the frame assembly 125 is composed of non-ferromagnetic material that is not magnetic or electrically conductive. For example, the frame assembly 125 may be constructed of an MR-compatible material, such as a non-ferrous and/or non-conducting material or alloy, including but not limited to a plastic or fiberglass.
The frame assembly 125 may be configurable to provide selectable positioning of the shim coil assembly 107 at least partially within the imaging volume 130. For example, the frame assembly 125 may allow the shim coil assembly 107 to be securely moved in three spatial directions (x, y, z) within the magnet bore, so that the shim coil assembly 107 can be used for patients with ICDs placed at various locations in the chest. The actual motion of the shim coil assembly 107 can be controlled in some embodiments by a motion controller system (not shown in
In some embodiments, the shim coil assembly 107 can be used correct the magnetic field inhomogeneity arising from the presence of the ICD 110 by using measures of the field inhomogeneity, which are obtained from MRI multiple-echo acquisitions. For example, the shimming system 105 may include a signal processor 135 configured to use data from MRI acquisitions to map the magnetic field inhomogeneity within a selected region of the imaging volume 130. The signal processor 135 may be configured to use the measurement of the magnetic field inhomogeneity to determine (a) a current for the shim coil assembly 107 and (b) a set of coordinates for positioning the shim coil assembly 107 at least partially within the imaging volume 130, such that applying the determined current to the shim coil assembly 107 while positioned at the determined set of coordinates generates a correction field to reduce the magnetic field inhomogeneity within the selected region of the imaging volume 130.
For example, in some embodiments, the signal processor 135 executes software to provide an initial estimate of the location and strength of a dipole magnetic field that can correct the magnetic field inhomogeneity. The initial estimate triggers a movement of the shim coil assembly 107 to an initial location in the bore where the shim coil assembly 107 can be used to correct the specific inhomogeneity. In some embodiments, these initial steps are repeated to perform an iterative correction of the initial estimates, so that optimal imaging of the anatomy can be performed. The signal processor 135 may be in some embodiments part of a computer system (not shown in
As discussed above, in some embodiments, a software program is used to compute a magnetic field map, e.g., a perturbed static magnetic field map, of the perturbed static magnetic field in the presence of an ICD 110. The magnetic field map may be computed in some embodiments based on a phase map acquired using a magnetic resonance imaging pulse sequence, including but not limited to a dual-echo Ultrashort Echo-Time (UTE) or a dual-echo Gradient-echo (GRE) sequence. As discussed above, the software program may use the computed magnetic field map to provide a desired location for the shim coil assembly 107 to be placed, and further use the magnetic field map to determine the desired current that should be driven through the shim coil assembly 107 in order to perform the correction of the magnetic field inhomogeneities.
As discussed above, a mapping sequence, such as but not limited to a UTE sequence, may be used in some embodiments to acquire data over the volume of interest. This data is used by the software program to compute the perturbed static magnetic field map. As an example, a UTE sequence may have a bandwidth (e.g. 784 KHz at 1.5 T) that is much larger than the bandwidth of conventional MRI sequences (e.g., up to 6 KHz at 1.5 T), and can therefore detect much larger field inhomogeneities.
In some embodiments, after computing the perturbed static magnetic field map in the presence of the ICD, in some embodiments the software program may fit a dipole-shaped magnetic field profile to the required correction field, and then use the fitted dipole-field shape to compute (a) the optimal three-dimensional location of the center of the shim coil assembly 107, as well as (b) the magnitude and direction of the current required to correct the perturbed field.
In some embodiments, the software provides output to a user (not shown in
In some embodiments, the software provides output to a user (not shown in
In some embodiments, the shim coil assembly 107 may be able to correct inhomogeneities of the order of 0.15 mT in the selected region of the imaging volume 130 (the selected region also referred to as a volume of interest), without significantly increasing the field distortion outside the volume of interest. The use of multiple windings (or turns) within the shim coil assembly 107 may prevent introducing currents greater than 10 amperes into the MR system 100. In some embodiments, using a DC current along with a large series inductor may prevent the shim coil assembly 107 from coupling with gradient coils (not shown in
In some embodiments, the shim coil assembly 107 may reduce inhomogeneities to the order of 0.05 mT (1600 Hz at 1.5T) within a 5×5×5 cm3 region in the heart, which will enable the use of many MRI sequences in this region.
The applications of the above-described shimming system 105 are not limited solely to ICDs, but in other embodiments, can also be applied to correcting for magnetic field inhomogeneities due to other (e.g., non-MRI compatible) implanted devices, including but not limited to pacemakers, vascular stents, chamber closure devices, as well as orthopedic implants, located in different parts of the body. The shimming system 105 may also be used in some embodiments for correcting for physiological magnetic-field inhomogeneities, including but not limited to air soft-tissue interfaces in the lower head or spine, and lung-heart interfaces. The shimming system 105 can also be applied in some embodiments to imaging different regions of the body at high magnetic fields (e.g., 3 Tesla, 7 Tesla or even higher), which have exacerbated inhomogeneity effects whose severity scales with the magnetic field.
In some embodiments, the shimming system 105 can be applied to moving ferromagnetic particles in the body to specified locations by producing magnetic field gradients (albeit with larger currents than would be used for merely correcting inhomogeneity effects). In some embodiments, the shimming system 105 can provide the ability to perform scans with pulse sequences (e.g., EPI, SSFP, etc.) that require higher magnetic field homogeneity in higher field MRI scanners, or within reduced homogeneity MRI scanners.
Panel A of
Panel B of
Panel C of
Panel D of
The following discussion describes technical details of various embodiments of a force-balanced static magnetic-field shim coil array. In some cases, like reference numerals have been used to refer to the same or similar components. A detailed description of such components may be omitted, and the following discussion may focus on the differences between these embodiments. Any of the various features discussed with any one of the embodiments discussed herein may also apply to and be used with any other embodiments.
Panel A of
In some embodiments, the shim coil assembly 407 includes additional current segments, to reduce coupling of the shim coil assembly 407 to the gradient coil of the MR system without distorting a target field of view. Additional coil elements permit higher-order shimming, and/or larger field of view for larger ROIs. Imaging reconstruction algorithms are also used in some embodiments to correct for residual field distortions beyond the optimal dipole field correction.
In some embodiments, the shim coil assembly 407 may include MRI-visible markers that are used to register the location of the shim coil assembly 407 to the reference frame of the acquired MRI images. In some embodiments the coil former may be made of a material which is MRI-visible. In other embodiments, lasers or other optical methods may be used to perform spatial registration of the shim coil assembly 407 to the imaging reference frame.
Additional RF shielding may also be used for the shim coil assembly 407 in some embodiments. Use of such shielding may provide reduced loss of SNR, interference with MRI gradients during imaging, and may enable use of any imaging sequence, including sequences such as SSFP, which deliver exact gradient and RF patterns in order to display the correct inter-tissue contrast. Without such RF shielding, imaging may be largely limited to GRE sequences.
In some embodiments, the shim coil assembly 407 may be anchored strongly to the MRI stretcher so it cannot move freely or due to magnetic forces. However, it is desirable to move the shim coil assembly in 3 directions within the bore, after releasing its locks, to be centered properly. To accomplish this, a frame assembly is utilized in some embodiments, to permit moving the shim coil assembly in the left-right (X), up-down (Y) and superior-inferior (Z) directions.
The frame assembly 525 in this example is constructed of aluminum. In other embodiments, the frame assembly 525 may be made of a different non-ferrous material, metal, or metal alloy. In some embodiments, the frame assembly 525 may be made of a non-ferrous and non-conductive material, such as a plastic or composite.
Panel A of
The shim coil holder portion of the frame assembly 525 can be moved (e.g. slid) vertically in the Y direction (up and down, relative to the patient table). In this example, the vertical motion is enabled using four locks indicated by arrows 535a, 535b, 535c, and 535d. Two locks (indicated by arrows 537a, 537b) also allow moving the shim coil assembly 527 in the X direction (left and right, relative to the patient table) within the frame assembly 525, while keeping the frame assembly 525 stationary. In addition, four locks (indicated by arrows 539a, 539b, 539c, 539d) allow sliding the frame assembly 525 in and out of the magnet bore, along the railings 529a, 529b in the Z direction (superior-inferior, relative to the patient table).
Some embodiments also may incorporate ferromagnetic shim elements (e.g., thin steel strips) to improve cancellation of the ICD distortion as well as to reduce the amount of current needed for the shim coil assembly 527. Furthermore, in some embodiments, instead of mounting the shim coil assembly 527 to the frame assembly 525 within the bore, the shim coil assembly 527 may be cantilevered to provide more flexibility in the positioning of the device and maximize patient clearance size.
A DC power supply 713 in an MRI control room 714 outputs currents that go to a penetration panel 715, where radio frequency interference (RFI) filters 720a, 720b conduct the currents onwards into an RF-shielded MRI room 725, where the MRI system 712 is located. A cylindrical water phantom 730 is placed on an MRI stretcher 735, which has an MRI spine array receiver coil 740 underneath. The ICD 710 is placed on the upper outer surface of the cylindrical water phantom 730. An MRI body array receiver coil 755 is placed above the phantom 730, and the shim coil assembly 707 is positioned above the phantom 730, with the center of the shim coil assembly 707 lying immediately above the ICD 710.
The DC power supply 713, located outside the MRI room 725, is configured to drive a controlled amplitude of current (e.g., measured in Amperes) into the balanced-force shim coil assembly 707. The RFI filters 720a, 720b are placed on the MRI system's penetration panel 715 to prevent Radio Frequency (RF) noise from getting into the MRI room 725 on the electrical lines that carry current into the shim coil assembly 707. Inside the MRI room 725, the currents are carried on thick coaxial cables to the shim coil assembly 707 itself.
In some embodiments, the shim coil assembly 707 is configured so as to avoid introducing radio-frequency noise at the MRI frequency into the MRI system 712. For example, to avoid introducing such noise, the current generator (e.g., the DC power supply 713) and cabling may be filtered for radio-frequency interference.
The decoupling is important as any induced currents in the shim coil assembly 807 from the gradient coils will introduce artifacts into the image. The value of the inductors used is dependent upon the gradient switching time and the desired decoupling as well as practical considerations such as size and MRI safety.
The shimming system 705 described above was used to experimentally test the concept. As discussed above, a cylindrical water phantom 730 was used with an ICD 710 placed on top of it, to emulate the clinical scenario depicted in
From the results of panels A to H, it is possible to see that presence of the ICD severely distorts the shape of the cylinder (compresses some portions and stretches others) and also erases (“blanks out”) the majority of its cross-section (e.g., panel B). However, the application of increasingly large negative polarity (−) current (panels C to G) recovers increasingly larger portions of the phantom (e.g., increases the size of the visible cylinder) and reduces its geometric distortion, whereas application of a positive polarity (+) current (
Since in this experiment, the mapping of the static magnetic field BO was performed at all of the current steps using a wideband (785 KHz, ˜1200 PPM) UTE sequence, it is possible to understand the effects seen in panels A to H of
In some embodiments, the shimming system 705 includes a capability for real-time shimming, with a visual display of the shimming performance while changing settings (e.g. the current in the shim coil assembly 707, and the location of the shim coil assembly 707).
The top series 1505 in
The bottom series 1510 in
The term “computer” is intended to have a broad meaning that may be used in computing devices such as, e.g., but not limited to, standalone or client or server devices. The computer may be, e.g., (but not limited to) a personal computer (PC) system running an operating system such as, e.g., (but not limited to) MICROSOFT® WINDOWS® NT/98/2000/XP/Vista/Windows 7/8/etc. available from MICROSOFT® Corporation of Redmond, Wash., U.S.A. or an Apple computer executing MACR OS from AppleR of Cupertino, Calif., U.S.A. However, the invention is not limited to these platforms. Instead, the invention may be implemented on any appropriate computer system running any appropriate operating system. In one illustrative embodiment, the present invention may be implemented on a computer system operating as discussed herein. The computer system may include, e.g., but is not limited to, a main memory, random access memory (RAM), and a secondary memory, etc. Main memory, random access memory (RAM), and a secondary memory, etc., may be a computer-readable medium that may be configured to store instructions configured to implement one or more embodiments and may comprise a random-access memory (RAM) that may include RAM devices, such as Dynamic RAM (DRAM) devices, flash memory devices, Static RAM (SRAM) devices, etc.
The secondary memory may include, for example, (but is not limited to) a hard disk drive and/or a removable storage drive, representing a floppy diskette drive, a magnetic tape drive, an optical disk drive, a compact disk drive CD-ROM, flash memory, etc. The removable storage drive may, e.g., but is not limited to, read from and/or write to a removable storage unit in a well-known manner. The removable storage unit, also called a program storage device or a computer program product, may represent, e.g., but is not limited to, a floppy disk, magnetic tape, optical disk, compact disk, etc. which may be read from and written to the removable storage drive. As will be appreciated, the removable storage unit may include a computer usable storage medium having stored therein computer software and/or data.
In alternative illustrative embodiments, the secondary memory may include other similar devices for allowing computer programs or other instructions to be loaded into the computer system. Such devices may include, for example, a removable storage unit and an interface. Examples of such may include a program cartridge and cartridge interface (such as, e.g., but not limited to, those found in video game devices), a removable memory chip (such as, e.g., but not limited to, an erasable programmable read only memory (EPROM), or programmable read only memory (PROM) and associated socket, and other removable storage units and interfaces, which may allow software and data to be transferred from the removable storage unit to the computer system.
The computer may also include an input device may include any mechanism or combination of mechanisms that may permit information to be input into the computer system from, e.g., a user. The input device may include logic configured to receive information for the computer system from, e.g. a user. Examples of the input device may include, e.g., but not limited to, a mouse, pen-based pointing device, or other pointing device such as a digitizer, a touch sensitive display device, and/or a keyboard or other data entry device (none of which are labeled). Other input devices may include, e.g., but not limited to, a biometric input device, a video source, an audio source, a microphone, a web cam, a video camera, and/or other camera. The input device may communicate with a processor either wired or wirelessly.
The computer may also include output devices which may include any mechanism or combination of mechanisms that may output information from a computer system. An output device may include logic configured to output information from the computer system. Embodiments of output device may include, e.g., but not limited to, display, and display interface, including displays, printers, speakers, cathode ray tubes (CRTs), plasma displays, light-emitting diode (LED) displays, liquid crystal displays (LCDs), printers, vacuum florescent displays (VFDs), surface-conduction electron-emitter displays (SEDs), field emission displays (FEDs), etc. The computer may include input/output (I/O) devices such as, e.g., (but not limited to) communications interface, cable and communications path, etc. These devices may include, e.g., but are not limited to, a network interface card, and/or modems. The output device may communicate with processor either wired or wirelessly. A communications interface may allow software and data to be transferred between the computer system and external devices.
The term “data processor” is intended to have a broad meaning that includes one or more processors, such as, e.g., but not limited to, local processors or processors that are connected to a communication infrastructure (e.g., but not limited to, a communications bus, cross-over bar, interconnect, or network, etc.). The term data processor may include any type of processor, microprocessor and/or processing logic that may interpret and execute instructions (e.g., for example, a field programmable gate array (FPGA)). The data processor may comprise a single device (e.g., for example, a single core) and/or a group of devices (e.g., multi-core). The data processor may include logic configured to execute computer-executable instructions configured to implement one or more embodiments. The instructions may reside in main memory or secondary memory. The data processor may also include multiple independent cores, such as a dual-core processor or a multi-core processor. The data processors may also include one or more graphics processing units (GPU) which may be in the form of a dedicated graphics card, an integrated graphics solution, and/or a hybrid graphics solution. The data processor may be onboard, external to other components, or both. Various illustrative software embodiments may be described in terms of this illustrative computer system. After reading this description, it will become apparent to a person skilled in the relevant art(s) how to implement the invention using other computer systems and/or architectures.
The term “data storage device” is intended to have a broad meaning that includes removable storage drive, a hard disk installed in hard disk drive, flash memories, removable discs, non-removable discs, etc. In addition, it should be noted that various forms of electromagnetic radiation, such as wireless communication, electrical communication carried over an electrically conductive wire (e.g., but not limited to twisted pair, CAT5, etc.) or an optical medium (e.g., but not limited to, optical fiber) and the like may be encoded to carry computer-executable instructions and/or computer data that embodiments of the invention on e.g., a communication network. These computer program products may provide software to the computer system. It should be noted that a computer-readable medium that comprises computer-executable instructions for execution in a processor may be configured to store various embodiments of the present invention.
The term “network” is intended to include any communication network, including a local area network (“LAN”), a wide area network (“WAN”), an Intranet, or a network of networks, such as the Internet.
The term “software” is meant to include firmware residing in read-only memory or applications stored in magnetic storage, which can be read into memory for processing by a processor. Also, in some embodiments, multiple software inventions can be implemented as sub-parts of a larger program while remaining distinct software inventions. In some embodiments, multiple software inventions can also be implemented as separate programs. Finally, any combination of separate programs that together implement a software invention described here is within the scope of the invention. In some embodiments, the software programs, when installed to operate on one or more electronic systems, define one or more specific machine implementations that execute and perform the operations of the software programs.
The embodiments illustrated and discussed in this specification are intended only to teach those skilled in the art how to make and use the invention. In describing embodiments of the invention, specific terminology is employed for the sake of clarity. However, the invention is not intended to be limited to the specific terminology so selected. The above-described embodiments of the invention may be modified or varied, without departing from the invention, as appreciated by those skilled in the art in light of the above teachings. It is therefore to be understood that, within the scope of the claims and their equivalents, the invention may be practiced otherwise than as specifically described. Moreover, features described in connection with one embodiment may be used in conjunction with other embodiments, even if not explicitly stated above.
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This application claims priority to U.S. Provisional Application No. 63/276,967, filed Nov. 8, 2021, which is incorporated herein by reference in its entirety.
This invention was made with government support under grants R01 HL094610, R01 HL157259, and R01 EB022011 awarded by the National Institutes of Health. The government has certain rights in the invention.
Filing Document | Filing Date | Country | Kind |
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PCT/US2022/048731 | 11/2/2022 | WO |
Number | Date | Country | |
---|---|---|---|
63276967 | Nov 2021 | US |