Patent Grant
11492795
NOT APPLICABLE
NOT APPLICABLE
Embodiments of the present invention generally relate to chemical or physical laboratory clean room enclosures. Specifically, they relate to modular buildings that are joined together laterally with tension cables to form a large, ballroom-style open area in which utility connections are aligned with one another.
U.S. Pat. No. 9,765,980, issued to Holtz et al., discloses a modular, self-contained, mobile clean room, also shortened to “cleanroom.” About the size of a modular building, the cleanroom can be pre-fabricated in a factory and then transported by semitrailer, railcar, or cargo aircraft to a final location. Unlike non-modular buildings, such cleanrooms often employ lightweight construction, aluminum frames with steel and aluminum panels, and lack a substantial amount of heavy drywall.
Such cleanrooms can come complete with their own mechanical rooms that house heating, ventilation, and air conditioning (HVAC) air handling units, plumbing utilities, and circuit breaker panels. Ducts, piping, and electrical conduit run from the mechanical room through the walls to the cleanroom or over its ceiling to where they need to go. Additionally or alternatively, utilities can be provided directly from a surrounding “gray space” building without running through a mechanical room.
Multiple such cleanrooms can be set together in warehouses or other gray space buildings. The clean rooms can provide electricity, chilled and hot water, HVAC (heating ventilation, and air conditioning), clean gases, drainage hookups, and communications wiring. Besides their use as analysis laboratories, the mobile cleanrooms are a relatively quick way to support the manufacture of pharmaceuticals and biopharmaceuticals. Some cleanrooms are certifiable to ISO5 air purity.
Sometimes housed inside the cleanrooms are heavy, bulky laboratory and manufacturing equipment. For example, a cleanroom may contain a centrifuge, tissue culture hood, chemical handling unit, stirrer tank, chromatography column, cell sorter, bioreactor, refrigerator, freezer, incubator, biosafety cabinet, temperature cycler, vacuum, or freeze dryer. Some equipment within the cleanrooms is on heavy duty casters so that it may be repositioned to a new station or otherwise transported by rolling on the cleanroom floor. The advent of single use technology has reduced the size of equipment and reduced the need for hard piping within cleanrooms, which has opened the door for a more modular approach.
There is a need in the art for modern, transportable cleanrooms that are larger and have more flexible space than before while preserving serviceability and maintainability.
Generally, a large, open, ballroom-style of cleanroom is constructed from multiple modular building sections by tying the building sections together with tension cables. The tension wires can be run through extruded tubes under the floor. Each modular building section may have a standardized utility panel on its ceiling, floor, or walls, depending on the amount of equipment housed in it. After the modular building sections are joined together, the utility panels, which are at the same location in each building section, are connected to pipes, electrical conduit, cable raceways, HVAC ductwork, and other utilities that run laterally over the cleanrooms in a shortest distance between them.
During assembly, air bearings beneath the modular building sections are pressurized so that the sections can be aligned and pushed together by hand. The tension cables are fed through the extruded tubes, which provide structural support to the respective section, and then tightened with jackscrews to draw the sections together snugly.
Some embodiments of the present invention are related to a rapid deployment cleanroom system including multiple modular building structures positioned side-by-side with respect to each other, each modular building structure having a longitudinal dimension and a lateral dimension, each modular building structure including a floor, a ceiling, and at least two walls defining an interior, hollow tubes extending laterally across the modular building structure and below the floor of or above the ceiling of the modular building structure, and a utility panel having a set of connections for power outlets, data, pressurized gas, and water, a longitudinal location of the utility panel within the interior of each modular building structure being substantially identical among the modular building structures, and fasteners within the hollow tubes of the modular building structures configured to join the modular building structures together, wherein the joined modular building structures form a large sealable, sterilizable cleanroom, wherein the utility panels of the modular building structures are aligned with one another in the cleanroom interior.
The fasteners can include tension cables extending through the hollow tubes and between opposite sides of the joined modular building structures. Alignment blocks can be placed between the modular building structures. Air bearings can be installed beneath the floor of each modular building structure configured to support the modular building structure on a cushion of air to facilitate joining them together.
A number and type of connections in each set can be substantially identical between utility panels in different modular building structures. The utility panels can be located on ceilings of the modular building structures. Gas pipes can extend laterally over the modular building structures and connecting the pressurized gas connections, and water pipes can be collocated with the gas pipes extending laterally over the modular building structures and connecting the water connections. Electrical conduit can extend laterally across the modular building structures and connect the power outlets, and data cables can extend laterally across the modular building structures and connect the data connections. The electrical conduit can include flexible conduit and junction boxes between the modular building structures.
Each modular building structure can further include an air vent opening to the interior, an air handling duct connected with the air vent, and the cleanroom system can include ductwork extending laterally across the modular building structures and connecting the air vents. The large sealable, sterilizable cleanroom can include an area that is uninterrupted by pillars or structural walls.
Some embodiments include a method of assembling modular building structures into a larger ballroom-style cleanroom. The method can include positioning multiple modular building structures side-by-side with respect to each other, each modular building structure having a longitudinal dimension and a lateral dimension, each modular building structure including a floor, a ceiling, and at least two walls defining an interior, hollow tubes extending laterally across the modular building structure and below the floor of or above the ceiling of the modular building structure, and a utility panel having a set of connections for power outlets, data, pressurized gas, and water, a longitudinal location of the utility panel within the interior of each modular building structure being substantially identical among the modular building structures. The method further includes removing tie down lugs from the hollow tubes, inserting a tension cable through the hollow tubes of the side-by-side modular building structures, tightening the tension cables to join the modular building structures together and form a large sealable, sterilizable cleanroom, and connecting the utility panels of the side-by-side modular building structures, wherein the utility panels of the modular building structures are aligned with one another in the cleanroom interior.
Air bearings beneath the floor of each modular building structure can be pressurized to support the modular building structure on a cushion of air during the tightening.
A number and type of connections in each set of connections can be substantially identical between utility panels in different modular building structures. The utility panels can be located on ceilings of the modular building structures.
The connecting can include connecting the pressurized gas connections with gas pipes extending laterally over the modular building structures, and connecting the water connections with water pipes collocated with the gas pipes extending laterally over the modular building structures. The connecting can include connecting the power outlets with electrical conduit extending laterally across the modular building structures, and connecting the data connections with twisted pair, coax, or other data cables extending laterally across the modular building structures. The electrical conduit can include flexible conduit and junction boxes between the modular building structures.
Each modular building structure can further include an air vent opening to the interior and an air handling duct connected with the air vent, the method further including connecting the air vents with ductwork extending laterally across the modular building structures.
The large sealable, sterilizable cleanroom can include a “ballroom” area that is uninterrupted by pillars or structural walls.
Similar-length modular building structures/sections are strapped together with tension cables or other fasteners from end-to-end in order to create a larger, “ballroom-style” open room with few or no pillars or other intervening structures. Utility panels are set in the floor, walls, or ceiling of each or almost each section at the same position. When the structures are joined together, the utility panels line up.
A “ballroom-style cleanroom” includes a large interior room for personnel & equipment that is unbroken by pillars or structural walls, sealable from dust, and whose surfaces are predominantly smooth and sterilizable, or as otherwise known in the art. Such cleanrooms can include double, triple, quadruple, or greater assemblies of modular buildings that avoid major structural side walls between the modular buildings where the ballroom is and mainly have outer perimeter walls.
A “utility panel” includes a fixture on a building to provide two or more utilities, such as electrical power, computer network access, gases such as oxygen, nitrogen, carbon dioxide, and compressed air, liquid chilled water, including its supply and return, and other utilities, or as otherwise known in the art.
Air bearings that can lift each modular building structure on a warehouse floor can be set at its four corners and edges. Some commercially available air bearings are each about 45 centimeters (cm) (18 inches) in diameter and under 6.2 cm (2.4375 inches) tall. When pressurized, they can allow one or two workers to almost effortlessly move and rotate the relatively large mobile building structures
Technical advantages of various embodiments are many. A ballroom-style open cleanroom allows for larger laboratory or manufacturing equipment to be mounted within than rooms that are obstructed with pillars and unmovable internal walls. The open space is flexible, allowing analysis and production items, laboratory benches and desks, to be re-stationed as desired. Tension cable fasteners provide the advantages of being lightweight, extremely strong, and adjustable at the installation location. Along with air bearings, they allow a small team to push together the modular building sections on a flat warehouse/gray space floor and tighten them together from one side. They do not need to be tightened from the inside, thus, preserving the cleanliness of the cleanroom, which may have elements that are factory sealed. The cables are also uninstallable or replaceable if necessary without having to access the inside of the cleanroom. Having the utility panels aligned with one another within the interior not only simplifies the layout for users, but it can minimize the length of pipes, electrical conduit, cable trays, ductwork, and other utilities necessary to connect the building. The same jigs and templates may be used to install the utility panels. Also, users may find that the utility panels are in predictable areas of the inside, simplifying the task of determining where items go and workflow procedures should be performed.
Cleanroom 102 is defined by floor 104, ceiling 106, and walls 108. In the figure, there are no pillars or internal walls to obstruct the space, much like a ballroom. Thus, it is referred to as a “ballroom” space.
Each modular building section includes utility panel 110 on its ceiling. The utility panels include outlets for electrical power, network connectivity, chilled water for cooling, compressed air, and various purified gases. The positions of the panels are at the same longitudinal position on each of the modular building section's ceilings 106. They are also at the same lateral position on the ceiling of each section.
When the modular building sections were assembled and joined together, the utility panels aligned in line 112 with each other. This makes for a predictable, simple user experience. Wherever a particular utility is needed along the long direction of the entire room, the outlet for the utility is in a common position from the walls, directly overhead.
In the exemplary embodiment, each utility panel is standardized, such that a set of connections for the same utilities may be found on any of the utility panels. For example, there may be two chilled water outlets and two returns on every single panel. In addition, there may be four Ethernet data ports and six electrical outlets on each panel. And there may be two compressed air, one oxygen, one carbon dioxide, and one nitrogen connection. Other utilities can be provided. The number and type of connections in each set of connections are identical between the different utility panels. In other embodiments, different combinations of connections can be presented on the utility panels.
“Substantially identical” numbers or types include having a commonality of 75%, 80%, 85%, 90%, 95%, or more between the total numbers of items and types, or as otherwise known in the art. For example, a first utility panel with ten different connections and a second utility with nine different connections may be substantially identical if eight or all nine of the utilities are the same between the first and second utilities.
Cleanroom 202 has floor 204, low ceiling 206, high ceiling 207, and walls 208. There are four structural pillars in the view, but these still leave empty a large, unobstructed floor in the middle between the two sets of pillars, forming a ballroom with a high bay on one side.
Utility panels 210 are aligned with one another on low ceiling 206 and on high ceiling 207, running along lines 212. High ceiling 207 is the ceiling of the high bay. Like in the previous embodiment, personnel are presented with mostly common panels no matter where they are in the great space. The utility panels feature connections for various compressed cases, compressed air, chilled and hot water and returns, network connections, and power outlets, as well as alarm feeds and such.
Some utility panels can be different due to user needs. For example, in some embodiments, the high bay utility panels are different from the low ceiling utility panels. In other embodiments, several of the utility panels can be the same in a low and high section but then change to simpler or more complex utility panels at other points in the room.
Five of the modular building sections include similarly sized maintenance/utility rooms, while end section 330 happens to have a smaller utility closet. Several units have external doorways for moving personnel and materials into and out of the cleanroom. Some units are configured so that when the sections are joined, there will be internal walls. Yet among sections 320, 322, and 324 there will be a large, internal ballroom-sized space without intervening posts or walls.
Each modular building section has a set of air bearings 334, like those shown for modular building section 330. There is at least one air bearing in each lower corner. When pressurized, the air bearings lift the modular building section on a thin cushion of air so that it may be moved by just a few installation personnel. The air bearings share a bottom space with structural elements.
Hollow, extruded tubes 332 extend laterally across the bottom of each modular building section, such as those shown for modular building section 330. In some embodiments, hollow tubes are on the top. The hollow tubes have a rounded-corner square cross section but can have other shaped cross sections as well. Being structural, the hollow tubes can house tie down lugs for travel. After unloading at a destination, the tie down lugs are removed and tension cables inserted through the hollow tubes.
Tension cable 436 is run through hollow tube 332. At a far end, tension cable 436 is connected through an all thread rod to dead man's billet 438. At the near end, tension cable is connected to turnbuckle 440. Other tension cables are run through the other hollow tubes 332 with similar attachments.
When turned, turnbuckle 440, and the turnbuckles of the other tension cables, pull the tension cable tight, compressing modular building sections 320, 322, 324, 326, 328, and 330 together.
After the modular building sections are connected together into one big building, utilities connections are laid in place and connected. For example, gas pipes, water pipes, electrical conduit, and data cables are mounted laterally over the modular building sections. Because the utility panels are in the same longitudinal location on each section, less pipe, conduit, and cabling is required than if the utility panels were in different areas. Similarly, HVAC ductwork can also be laid laterally across the modular building structures and connected to air handing ducts and air vents.
In the interstitial space above the ceiling is air handling duct 550, among other utility lines. Air handling duct connects to air vent 548 within the interior of cleanroom 502, providing filtered, slightly pressurized air to the cleanroom. A slight pressurization minimizes dust and other impurities from seeping in.
An “interstitial volume” or “interstitial space” is an area above a ceiling of a cleanroom and below a roof of a modular building structure surrounding the cleanroom, or as otherwise known in the art.
In ceiling 506 is set utility panel 510. Utility panel 510 hosts a set of utility connections 540, 542, 544, and 546. The connections are power outlets, Ethernet jacks, pressurized gas connections, and water outlets and returns. These four types of connections may be replicated in utility panels of other modular building structures with which modular building structure 520 will be joined.
On the roof of the modular building assembly, walkable floor panels are supported between joists. Each floor panel can be independently removable from its surrounding joists to provide for access by personnel. In the exemplary embodiment, a swath of floor panels extends an entire width and length of the unitary frame of modular building section 520.
It is contemplated that any embodiment discussed in this specification can be implemented with respect to any method, kit, reagent, or composition of the invention, and vice versa. Furthermore, compositions of the invention can be used to achieve methods of the invention.
It will be understood that particular embodiments described herein are shown by way of illustration and not as limitations of the invention. The principal features of this invention can be employed in various embodiments without departing from the scope of the invention. Those skilled in the art will recognize or will be able to ascertain using no more than routine experimentation, numerous equivalents to the specific procedures described herein. Such equivalents are considered to be within the scope of this invention and are covered by the claims.
All publications and patent applications mentioned in the specification are indicative of the level of skill of those skilled in the art to which this invention pertains. All publications and patent applications are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference.
The use of the word “a” or “an” when used in conjunction with the term “comprising” in the claims and/or the specification may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.” The use of the term “or” in the claims is used to mean “and/or” unless explicitly indicated to refer to alternatives only or the alternatives are mutually exclusive, although the disclosure supports a definition that refers to only alternatives and “and/or.” Throughout this application, the term “about” is used to indicate that a value includes the inherent variation of error for the device, the method being employed to determine the value, or the variation that exists among the study subjects.
As used in this specification and claim(s), the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”) or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps.
The term “or combinations thereof” as used herein refers to all permutations and combinations of the listed items preceding the term. For example, “A, B, C, or combinations thereof” is intended to include at least one of: A, B, C, AB, AC, BC, or ABC, and if order is important in a particular context, also BA, CA, CB, CBA, BCA, ACB, BAC, or CAB. Continuing with this example, expressly included are combinations that contain repeats of one or more item or term, such as BB, AAA, MB, BBC, AAABCCCC, CBBAAA, CABABB, and so forth. The skilled artisan will understand that typically there is no limit on the number of items or terms in any combination, unless otherwise apparent from the context.
As used herein, words of approximation such as, without limitation, “about”, “substantial” or “substantially” refers to a condition that when so modified is understood to not necessarily be absolute or perfect but would be considered close enough to those of ordinary skill in the art to warrant designating the condition as being present. The extent to which the description may vary will depend on how great a change can be instituted and still have one of ordinary skilled in the art recognize the modified feature as still having the required characteristics and capabilities of the unmodified feature. In general, but subject to the preceding discussion, a numerical value herein that is modified by a word of approximation such as “about” may vary from the stated value by at least ±1, 2, 3, 4, 5, 6, 7, 10, 12 or 15%.
All of the compositions and/or methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.
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| Number | Date | Country | |
|---|---|---|---|
| 20220064935 A1 | Mar 2022 | US |
