Claims
- 1) A method for treating dermatological infections comprising:
topically applying to an infected area of the skin a composition comprising an effective amount of at least one lytic enzyme produced by bacteria infected with a bacteriophage specific for said bacteria..
- 2) The method according to claim 1, further comprising delivering said composition in a pharmaceutically acceptable carrier.
- 3) The method according to claim 2, wherein said carrier is selected from the group consisting of an aqueous liquid, an alcohol base, a water soluble gel, a lotion, an ointment, a nonaqueous liquid base, a mineral oil base, a blend of mineral oil and petrolatum, lanolin, liposomes, hydrophilic gelling agents, cross-linked acrylic acid polymers (carbomer), cellulose polymers, hydroxy ethyl cellulose, cellulose gum, MVE/MA decadiene crosspolymers, PVM/MA copolymers, and any combinations thereof.
- 4) The method according to claim 1, wherein the form in which the composition is delivered is selected from the group consisting of a spray, a smear, a time release patch, a liquid absorbed wipe, and any combinations thereof.
- 5) The method according to claim 1, wherein the at least one lytic enzyme is in an environment having a pH which allows for activity of said at least one lysin enzyme.
- 6) The method according to claim 5, wherein said composition further comprises a buffer that maintains pH of the composition at a range between about 4.0 and about 9.0.
- 7) The method according to claim 6, wherein said buffer maintains the pH of the composition at the range of between about 5.5 and about 7.5.
- 8) The method according to claim 6, wherein said buffer comprises a reducing agent.
- 9) The method according to claim 8, wherein said reducing agent is dithiothreitol.
- 10) The method according to claim 1, wherein said composition further comprises a mild surfactant in an amount effective to potentiate effects of the at least one lytic enzyme.
- 11) The method according to claim 1, wherein the composition further comprises at least one complementary agent which potentiates the bactericidal activity of the at least one lytic enzyme, said complementary agent being selected from the group consisting of penicillin, synthetic penicillins bacitracin, methicillin, cephalosporin, polymyxin, cefaclor. Cefadroxil, cefamandole nafate, cefazolin, cefixime, cefmetazole, cefonioid, cefoperazone, ceforanide, cefotanme, cefotaxime, cefotetan, cefoxitin, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, cefriaxone moxalactam, cefuroxime, cephalexin, cephalosporin C, cephalosporin C sodium salt, cephalothin, cephalothin sodium salt, cephapirin, cephradine, cefuroximeaxetil, dihydratecephalothin, moxalactam, loracarbef. mafate and chelating agents in an amount effective to synergistically enhance effects of the lytic enzyme.
- 12) The method according to claim 1, wherein the composition further comprises lysostaphin for the treatment of any Staphylococcus aureus bacteria.
- 13) The method according to claim 1, wherein said at least one lytic enzyme is present in an amount ranging from about 100 to about 500,000 units per milliliter.
- 14) The method according to claim 1, wherein said method is used for prophylactically treating dermatological infections.
- 15) The method according to claim 1, wherein said method is used for therapeutically treating dermatological infections.
Parent Case Info
[0001] The following application is a continuation-in-part of Ser. No. 09/497,495 filed Apr. 18, 2000 which is a continuation of Ser. No. 09/395,636 filed Sep. 14, 2000, now U.S. Pat. No. 6,056,954 which is a continuation-in-part of U.S. patent application Ser. No. 08/962,523, filed Oct. 31,1997, now U.S. Pat. No. 5,997,862.
Continuations (3)
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Number |
Date |
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Parent |
09932460 |
Aug 2001 |
US |
Child |
10465889 |
Jun 2003 |
US |
Parent |
09671882 |
Sep 2000 |
US |
Child |
09932460 |
Aug 2001 |
US |
Parent |
09395636 |
Sep 1999 |
US |
Child |
09497495 |
Apr 2000 |
US |
Continuation in Parts (2)
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Number |
Date |
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Parent |
09497495 |
Apr 2000 |
US |
Child |
09671882 |
Sep 2000 |
US |
Parent |
08962523 |
Oct 1997 |
US |
Child |
09395636 |
Sep 1999 |
US |