Claims
- 1. A compound selected from the group consisting of the following formulae: ##STR12## wherein R.sup.1 and R.sup.3 are independently hydrogen, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, --N(R.sup.8)R.sup.9, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --C(O)N(R.sup.8)CH.sub.2 C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)R.sup.8, --N(R.sup.8)S(O).sub.2 R.sup.12, or --N(R.sup.8)C(O)N(R.sup.8)CH.sub.2 C(O)N(R.sup.8)R.sup.9 ;
- R.sup.2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of carboxy, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl, carboxyalkyl, and alkoxycarbonylalkyl);
- or R.sup.2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkyl, aralkyl, carboxy, carboxyalkyl, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl and alkoxycarbonylalkyl);
- R.sup.4 and R.sup.7 are independently hydrogen, halo, alkyl, nitro, --OR.sup.8, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)R.sup.9, --N(H)C(O)R.sup.8, or --N(H)S(O).sub.2 R.sup.12 ;
- R.sup.5 is --C(NH)NH.sub.2, --C(NH)N(H)OR.sup.8, --C(NH)N(H)C(O)OR.sup.12, --C(NH)N(H)S(O).sub.2 R.sup.12, --C(NH)N(H)C(O)N(R.sup.8)R.sup.9, or --C(NH)N(H)C(O)R.sup.8 ;
- R.sup.6 is (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl);
- each R.sup.8 and R.sup.9 are independently hydrogen, alkyl, aryl, or aralkyl; and
- R.sup.12 is alkyl, aryl or aralkyl;
- or a pharmaceutically acceptable salt thereof.
- 2. The compound of claim 1 selected from formula (I) wherein:
- R.sup.1 and R.sup.3 are independently hydrogen, fluoro, chloro, haloalkyl, --N(R.sup.8)R.sup.9, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)R.sup.8, or --N(R.sup.8)S(O).sub.2 R.sup.12 ;
- R.sup.2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of carboxy, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl, carboxyalkyl, and alkoxycarbonylalkyl);
- or R.sup.2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkyl, aralkyl, carboxy, carboxyalkyl, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl and alkoxycarbonylalkyl);
- R.sup.4 is hydrogen, --OR.sup.8 or --N(R.sup.8)R.sup.9 ;
- R.sup.5 is --C(NH)NH.sub.2 ;
- R.sup.6 is (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl);
- R.sup.7 is hydrogen, halo, alkyl, --OR.sup.8, --C(O)N(R.sup.8)R9;
- R.sup.8 and R.sup.9 are independently hydrogen, methyl, ethyl or phenyl; and
- R.sup.12 is methyl, ethyl, phenyl or benzyl.
- 3. The compound of claim 2 wherein:
- R.sup.1 and R.sup.3 are independently hydrogen, fluoro, chloro, trifluoromethyl, amino, --C(O)N(R.sup.8)R.sup.9, or --NHC(O)NHR.sup.9 ;
- R.sup.2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of carboxyalkyl and alkoxycarbonylalkyl);
- or R.sup.2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of carboxy, carboxyalkyl, alkoxycarbonyl and alkoxycarbonylalkyl);
- R.sup.4 is hydrogen, amino, hydroxy, or methoxy;
- R.sup.5 is --C(NH)NH.sub.2 ;
- R.sup.6 is (1,2)-imidazolyl substituted by alkyl, or 2-imidazolinyl substituted by alkyl;
- R.sup.7 is hydrogen, methoxy, or hydroxy; and
- R.sup.8 and R.sup.9 are independently hydrogen, methyl, ethyl, or phenyl.
- 4. The compound of claim 3 wherein
- R.sup.1 and R.sup.3 are independently hydrogen, fluoro, or chloro;
- R.sup.4 is amino, hydrogen, hydroxy or methoxy;
- R.sup.6 is (1,2)-imidazolyl substituted by methyl, or 2-imidazolinyl optionally substituted by methyl; and
- R.sup.7 is hydrogen or hydroxy.
- 5. The compound of claim 4 wherein
- R.sup.4 is hydroxy;
- R.sup.6 is (1,2)-imidazolyl substituted by methyl or 2-imidazolinyl substituted by methyl; and
- R.sup.7 is hydrogen.
- 6. The compound of claim 1 selected from the group consisting of the following:
- 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(5-carboxypyrrolidin-3-yloxy)pyridin-2-yl)oxy]benzamidine;
- 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-((1-ethoxycarbonylmethyl)piperidin-4-yloxy)pyridin-2-yl)oxy]benzamidine;
- 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(5-ethoxycarbonylpyrrolidin-3-yloxy)pyridin-2-yl)oxy]benzamidine;
- 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(1-carboxymethylpiperidin-4-yloxy)pyridin-2-yl)oxy]benzamidine;
- 4-hydroxy-3-[(3,5-difluoro-6-(3-(1-methylimidazolin-2-yl)phenoxy)-4-(1-(1-carboxy-1-methylethyl)piperidin-4-yloxy)pyridin-2-yl)oxy]benzamidine.
- 7. A pharmaceutical composition useful in treating a human having a thrombotic complication associated with myocardial infarction, deep vein thrombosis following orthopedic surgery, transient ischemic attack, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, acute promyelocytic leukemia, diabetes, multiple myelomas, septic shock, purpura fulminanas, adult respiratory distress syndrome, angina, or aortic valve or vascular prosthesis, which composition comprises a therapeutically effective amount of a compound selected from the group consisting of the following formulae: ##STR13## wherein R.sup.1 and R.sup.3 are independently hydrogen, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, --N(R.sup.8)R.sup.9, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --C(O)N(R.sup.8)CH.sub.2 C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)R.sup.8, --N(R.sup.8)S(O).sub.2 R.sup.12, or --N(R.sup.8)C(O)N(R.sup.8)CH.sub.2 C(O)N(R.sup.8)R.sup.9 ;
- R.sup.2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of carboxy, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl, carboxyalkyl, and alkoxycarbonylalkyl);
- or R.sup.2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkyl, aralkyl, carboxy, carboxyalkyl, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl and alkoxycarbonylalkyl);
- R.sup.4 and R.sup.7 are independently hydrogen, halo, alkyl, nitro, --OR.sup.8, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)R.sup.9, --N(H)C(O)R.sup.8, or --N(H)S(O).sub.2 R.sup.12 ;
- .sup.5 is --C(NH)NH.sub.2, --C(NH)N(H)OR.sup.8, --C(NH)N(H)C(O)OR.sup.12, --C(NH)N(H)S(O).sub.2 R.sup.12, --C(NH)N(H)C(O)N(R.sup.8)R.sup.9, or --C(NH)N(H)C(O)R.sup.8 ;
- R.sup.6 is (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl);
- each R.sup.8 and R.sup.9 are independently hydrogen, alkyl, aryl, or aralkyl; and
- R.sup.12 is alkyl, aryl or aralkyl;
- or a pharmaceutically acceptable salt thereof in a admixture with a pharmaceutically acceptable carrier.
- 8. A method of treating a human having a thrombotic complication associated with myocardial infarction, deep vein thrombosis following orthopedic surgery, transient ischemic attack, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, acute promyelocytic leukemia, diabetes, multiple myelomas, septic shock, purpura fulminanas, adult respiratory distress syndrome, angina, or aortic valve or vascular prosthesis, which method comprises administering to a human in need thereof a therapeutically effective amount of a compound selected from the group consisting of the following formulae: ##STR14## wherein R.sup.1 and R.sup.3 are independently hydrogen, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, --N(R.sup.8)R.sup.9, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --C(O)N(R.sup.8)CH.sub.2 C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)C(O)R.sup.8, --N(R.sup.8)S(O).sub.2 R.sup.12, or --N(R.sup.8)C(O)N(R.sup.8)CH.sub.2 C(O)N(R.sup.8)R.sup.9 ;
- R.sup.2 is (3,4)-piperidinyloxy (optionally substituted by one or more substituents selected from the group consisting of carboxy, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl, carboxyalkyl, and alkoxycarbonylalkyl);
- or R.sup.2 is 3-pyrrolidinyloxy (optionally substituted by one or more substituents selected from the group consisting of alkyl, aralkyl, carboxy, carboxyalkyl, --C(O)N(R.sup.8)R.sup.9, alkoxycarbonyl and alkoxycarbonylalkyl);
- R.sup.4 and R.sup.7 are independently hydrogen, halo, alkyl, nitro, --OR.sup.8, --C(O)OR.sup.8, --C(O)N(R.sup.8)R.sup.9, --N(R.sup.8)R.sup.9, --N(H)C(O)R.sup.8, or --N(H)S(O).sub.2 R.sup.12 ;
- R.sup.5 is --C(NH)NH.sub.2, --C(NH)N(H)OR.sup.8, --C(NH)N(H)C(O)OR.sup.12, --C(NH)N(H)S(O).sub.2 R.sup.12, --C(NH)N(H)C(O)N(R.sup.8)R.sup.9, or --C(NH)N(H)C(O)R.sup.8 ;
- R.sup.6 is (1,2)-imidazolyl (optionally substituted by alkyl), or (1,2)-imidazolinyl (optionally substituted by alkyl);
- each R.sup.8 and R.sup.9 are independently hydrogen, alkyl, aryl, or aralkyl; and
- R.sup.12 is alkyl, aryl or aralkyl;
- or a pharmaceutically acceptable salt thereof.
CROSS-REFERENCE
This application is a 371 of PCT/US96/02,641 filed Mar. 8, 1996.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US96/02641 |
3/8/1996 |
|
|
12/8/1997 |
12/8/1997 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO96/28427 |
9/19/1996 |
|
|
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5691364 |
Buckman et al. |
Nov 1997 |
|