Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses

Description

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of the following patent applications:

1. Patent application number 200910045056.8 titled “Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses”, filed on Jan. 8, 2009 in the State Intellectual Property Office of the People's Republic of China.
2. Patent application number 201010000050.1 titled “Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses”, filed on Jan. 5, 2010 in the State Intellectual Property Office of the People's Republic of China.

The specifications of the above referenced applications are incorporated herein by reference in their entirety.

FIELD OF THE INVENTION

The present invention relates to benzimidazole carboxamide derivatives, in particular, relates to the benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses.

BACKGROUND OF THE INVENTION

The diseases caused by virus infections severely threaten human health and life and have become major problems in the medical fields. Almost 70% of epidemic diseases are caused by viruses infections statistically. The infectious diseases caused by enteroviruses have often occurred all over the world. The enteroviruses belong to picornaviridae comprising polio viruses, cosxackie viruses, enteric cytopathogenic human orphan virus and new enteroviruses. Each viruses has many serums, at least more than 70 types, which can violate many kinds of tissues, such as nerves, cardiac muscles, muscles, skins and eye conjunctiva etc and can cause lots of infectious diseases all over the world. There are lots of categories of the cosxackie viruses, whose transmission route and pathogenesis are similar to that of poliomyelitis virus, and often occurs latent infections. Their symptom shows slight upper respiratory infections or diarrhea, and occasionally inflects central nervous systems, damages spinal cord anterior horn motor neurons, and causes flaccid paralysis of limbs, however, this symptom is relatively light. The cosxackie viruses can violate many tissues and systems, such as respiratory tracts, intestinal tracts, skins, muscles, hearts, livers, adrenal gland and central nervous systems, Clinical manifestations have various of symptoms such as (1) respiratory tract infection, (2) herpangina, (3) febrile rush, (4) hand-foot-and-mouth disease, (5) diarrhea of children, (6) central nervous system syndrome, (7) myocarditis and pericarditis, (8) epidemic chest pain or epidemic myalgia, (9) epidemic conjunctivitis, (10) coxsackie virus hepatitis and so on.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide benzimidazole-4-carboxamide derivatives having anti-coxsackie virusesor a pharmaceutically acceptable salts thereof as shown in Formula (I).

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Wherein, X represents monosubstituted or bissubstituted or polysubstitued C₁-C₁₄alkoxy, monosubstituted or bisubstituted or polysubstitued C₁-C₁₄alkyl, monosubstituted or bisubstituted or polysubstitued C₂-C₁₄alkenyl, monosubstituted or bisubstituted or polysubstitued C₆-C₁₄aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom;

Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C₁-C₁₆alkyl, monosubstituted or bisubstituted or polysubstitued C₆-C₁₂aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom.

Wherein: X is selected from one of the following groups:

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wherein R is selected from —H, or

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wherein n is selected from 0 to 5, R_wy1, R_wy2, R_wy3, R_wy4and R_wy5are respectively and independently selected from —H, —CH₃, or —CH₂CH₃;

n=0˜5; R₁, R₂, R₃, R₄and R₅are respectively and independently selected from —H, —CH₃, —F, —Cl, —Br, —I, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —NH—CH₃, —NH—CH₂CH₃, —NH—CH₂CH₂OH,

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or phenyl substituted by one or several substituents Ra, Ra is selected from —F, —Cl, —Br, —I, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —CH₂CH₂OH, —NO₂, —NH₂, —N(CH₃)₂, —N(CH₂CH₃)₂, —N(CH₂CH₂OH)₂, —CN, —COOH, —COOCH₃, —COOCH₂CH₃, or —COOC₆H₅;

R₁′, R₂′ and R₃′ are respectively and independently selected from —H, —CH₃, —CH₂CH₃, or

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wherein n is an integer between 0 and 5; R₁″ and R₂″ are respectively and independently selected from —H, —CH₃, or —CH₂CH₃;

R₉, R₁₀, R₁₁, R₁₂and R₁₃are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —COOH, —COOCH₃, —COOCH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —CN, —F, —Cl, —Br, —I, or —NH₂, —N(CH₃)₂, or —N(CH₂CH₃)₂;

R₁₇, R₁₈, R₁₉, R₂₀, R′₁₇, R′₁₈, R′₁₉, R′₂₀, R″₁₇, R″₁₈, R″₁₉and R″₂₀are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH_3,—OCH₂CH₃, —CF₃, —CCl₃, —CBr₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —NO or —NO₂, which cannot represent H simultaneously;

R₂₃, R₂₄, R₂₅, R′₂₃, R′₂₄and R′₂₅are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —F, —Cl, —Br, —I, —OH, —OCH_3,—OCH₂CH₃, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —COOH, —COOCH₃, or —COOCH₂CH₃;

R₂₉, R₃₀and R₃₁are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R₃₄, R₃₆and R₄₁are respectively and independently selected from —H, —(CH₂)_nCH₃, —CH₂OH, —CH₂CH₂OH, —CH(CH₃)₂or —CH₂CH(OH)CH₃, n is an integer between 0 and 5;

R₃₅, R₃₇, R₃₈, R₃₉, R₄₀, R₄₂and R₄₃are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Z is selected from N, O or S.

R₄₄, R₄₅, R₄₆, R′₄₄, R′₄₅and R′₄₆are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —CN or —COOH, —COOCH₃, or —COOCH₂CH₃;

R_s1, R_s2, R′_s1and R′_s2are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, —I, or NHCOCH₃, NHCOCH₂CH₃, or NHCOC₆H₅;

R_m1, R_m2, R_m3, R′_m1, R′_m2and R′_m3are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —F, —Cl, —Br, —I, —OH, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂,

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or —NHC₆H₅;

R_k1, R_k2, R_k3, R_k4, R_k5and R_k6are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R_P1, R_P2, R_P3and R_P4are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R_y1, R_y2, R_y3and R_y4are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Rmz1 is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅; Rmz2 and Rmz3 are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Rbz1 is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅; Rbz2 and Rbz3 are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Y is selected from one group of the following groups:

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wherein, R₅₀, R₅₁, R₅₂, R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉, R₆₀, R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇, R₆₈, R₆₉, R₇₀, R₇₁, R₇₂and R₇₃are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —CH₂OH, —OH, —OCH_3,—OCH₂CH₃, —CN, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, —I, or —C₆H₅, —C₆H₄—CH₃, —C₆H₄—OH, —C₆H₄—NO₂, or —C₆H₄—NH₂;

R₇₇, R₇₈, R₇₉, R₈₀and R₈₁are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —CN, —COOH, —COOCH₃, —COOCH₂CH₃, —F, —Cl, —Br, —I, —CF₃, —CCl₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R₈₅, R₈₆and R₈₇are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH or —NH₂; R′₈₅, R′₈₆and R′₈₇are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —C₆H₅, or —CH₂C₆H₄;

Q is selected from N, O or S;

R₈₈, R₈₉, R₉₀, R′₈₈, R′₈₉and R′₉₀are respectively and independently selected from —H, —CH₂CH₃, —OH, —OCH_3,—OCH₂CH₃, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —CN, —COOH, —COOCH₃, or —COOCH₂CH₃;

R₉₄, R₉₅, R′₉₄and R′₉₅are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, —I, or —NHCOCH₃, NHCOCH₂CH₃, or NHCOC₆H₅;

R₉₆is selected from —H, —CH₃, —CH₂CH₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂; R′₉₆is selected from —H, —CH₃, —CH₂CH₃, —C₆H₅, or —CH₂C₆H₄;

R_b1, R_b2, R_b3and R_b4are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —CH₂OH, —OH, —OCH_3,—OCH₂CH₃, —CN, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, or —I;

R_mz1is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅; R_mz2and R_mz3are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —CONH₂, or —COOH;

R_pl1and R_pl2are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, F, Cl, Br, or I; R_pl3is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅.

Preferably, X represents monosubstituted or polysubstitued or unsubstituted alkoxy, monosubstituted or polysubstitued or unsubstituted alkyl, monosubstituted or polysubstituted or unsubstituted alkenyl, monosubstituted or bisubstituted or unsubstituted thienyl, monosubstituted or bisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyridazinyl, monosubstituted or bisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted phenyl, monosubstituted or bisubstituted or unsubstituted pyrimidinyl, monosubstituted or bisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or unsubstituted quinolinyl, monosubstituted or bisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or unsubstituted indolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrazolyl.

More preferably, X represents C1-C6 alkyloxy substituted by nitro, amino, hydroxyl or aryl; C1-C6 alkyl substituted by nitro, amino, hydroxyl or aryl; C2-C14 alkenyl substituted by alkyl, hydroxyl or aryl; thienyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted thienyl; pyridyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted pyridyl; quinolinyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted quinolinyl; indolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted indolyl; pyridyl monosubstituted or bisubstituted by C1-C6 alkoxy; pyridyl monosubstituted or bisubstituted by C1-C3 dialkylamino; pyridyl monosubstituted or bisubstituted by C1-C6 alkyl; unsubstituted pyridyl; pyridazinyl monosubstituted by C1-C6 alkoxy; pyridazinyl monosubstituted by C1-C6 alkyl; unsubstituted pyridazinyl; unsubstituted piperazinyl; piperazinyl bisubstituted by C1-C6 alkyl; unsubstituted piperidinyl; unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted imidazolyl; thiazolyl bisubstituted by C1-C6 alkyl and nitro; unsubstituted pyrimidinyl; pyrimidinyl monosubstituted by phenyl; pyrimidinyl bisubstituted by amino and a group selected from nitro, —F, —Cl, —Br or —I; phenyl trisubstituted by trihydroxyl; phenyl trisubstituted by trimethoxyl; phenyl bisubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from methyl, ethyl, carboxyl or amido; pyrazolyl bisubstituted or trisubstituted by a group selected from C1-C6 alkyl or aryl and a group selected from —F, —Cl, —Br or —I.

Preferably, Y represents hydroxyl, C₁-C₆alkyl, monosubstituted or bisubstituted or trisubstituted phenyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzpyrimidinyl, monosubstituted or bisubstituted or trisubstituted or tetrasubstituted or unsubstituted benzimidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzimidazolonyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted purinyl.

More preferably, Y represents hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C₁-C₆alkylphenyl, phenyl monosubstituted by —F, —Cl, —Br or —I, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C₁-C₆alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, pyridyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted, by C₁-C₆alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, thiazolyl monosubstituted by C₁-C₆alkyl, pyrimidinyl monosubstituted or bisubstituted or unsubstituted by C₁-C₆alkyl, pyrimidinyl monsubstituted by C₁-C₆alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted C₁-C₆alkyl and bisubstituted or trisubstituted by —F, —Cl, —Br or —I, purinyl monosubstituted or bisubstituted or unsubstituted by C₁-C₆alkyl, purinyl monosubstituted by C₁-C₆alkyl and substituted or trisuvstituted by hydroxyl.

Most preferably, the benzimidazole-4-carboxamide derivatives as shown in Formula (1) includes the following compounds:

(1) (L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(2) (L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(3) (L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide
(4) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(5) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(6) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide
(7) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide
(8) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(9) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-chlorophenyl)amide
(10) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-bromophenyl)amide
(11) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(12) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-chlorophenyl)amide
(13) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-bromophenyl)amide
(14) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-methylphenyl)amide
(15) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-hydroxylphenyl)amide
(16) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(17) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-methylphenyl)amide
(18) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-hydroxylphenyl)amide
(19) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(20) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-methylphenyl)amide
(21) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-hydroxylphenyl)amide
(22) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(23) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(24) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(25) 2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(26) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(27) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide
(28) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide
(29) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(30) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(31) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(32) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(33) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(34) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(35) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(36) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(37) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(38) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(39) 2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(40) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(41) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(42) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(43) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(44) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(45) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(46) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(47) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(48) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(49) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(50) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(51) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(52) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(53) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(54) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(55) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(56) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(57) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(58) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(59) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(60) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(61) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(62) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(63) 2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(64) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(65) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(66) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(67) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(68) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(69) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(70) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(71) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(72) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(73) (L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(74) (L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(75) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(76) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(77) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(78) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(79) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(80) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(81) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(82) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(83) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(84) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(85) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(86) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(87) 2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(88) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(89) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(90) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(91) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(92) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(93) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(94) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(95) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(96) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(97) (L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(98) (L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(99) 2-N-piperazinyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(100) 2-N-piperazinyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(101) 2-N-piperazinyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(102) 2-N-piperazinyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(103) 2-N-piperazinyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(104) 2-N-piperazinyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(105) 2-N-piperazinyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(106) 2-N-piperazinyl-1H-benzimidazole-4-(N-m-aminophenyl)amide
(107) 2-N-piperazinyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(108) 2-N-piperazinyl-1H-benzimidazole-4-(N-p-aminophenyl)amide
(109) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(110) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(111) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(112) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(113) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(114) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(115) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(116) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(117) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(118) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(119) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(120) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(121) (L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(122) (L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(123) 2-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(124) 2-thiazolyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(125) 2-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(126) 2-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(127) 2-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(128) 2-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(129) 2-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(130) 2-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide
(131) 2-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(132) 2-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide
(133) (L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(134) (L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(135) 5-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(136) 5-thiazolyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(137) 5-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(138) 5-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(139) 5-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(140) 5-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(141) 5-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(142) 5-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide
(143) 5-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(144) 5-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide
(145) (L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(146) (L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(147) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(148) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(149) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(150) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(151) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(152) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(153) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(154) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(155) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(156) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(157) (L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(158) (L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(159) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(160) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(161) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(162) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(163) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(164) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(165) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(166) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(167) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(168) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(169) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(170) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(171) 2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(172) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(173) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(174) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(175) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(176) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(177) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(178) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(179) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(180) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(181) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(182) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(183) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(184) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(185) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(186) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(187) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(188) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(189) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(190) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(191) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(192) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(193) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(194) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(195) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(196) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(197) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(198) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(199) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(200) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(201) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(202) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(203) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(204) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(205) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(206) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(207) 2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(208) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(209) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(210) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(211) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(212) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(213) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(214) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(215) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(216) (L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(217) (L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(218) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(219) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(220) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(221) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(222) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(223) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(224) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(225) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(226) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(227) (L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(228) (L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(229) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(230) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(231) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(232) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(233) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(234) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(235) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(236) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(237) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(238) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(239) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(240) 2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(241) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(242) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(243) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(244) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(245) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(246) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(247) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(248) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(249) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(250) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(251) 2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(252) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(253) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(254) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(255) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(256) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(257) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(258) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(259) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(260) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(261) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(262) 2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(263) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(264) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(265) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(266) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(267) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(268) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(269) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(270) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(271) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(272) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(273) 2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(274) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(275) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(276) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(277) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(278) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(279) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(280) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(281) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(282) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(283) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(284) 2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(285) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(286) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(287) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(288) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(289) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(290) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(291) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(292) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(293) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(294) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(295) 2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(296) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(297) 2-(3-indolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(298) 2-(3-indolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(299) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(300) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(301) 2-(3-indolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(302) 2-(3-indolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(303) 2-(3-indolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(304) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(305) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(306) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(307) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(308) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(309) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(310) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(311) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(312) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(313) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(314) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(315) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(316) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(317) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(318) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(319) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(320) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(321) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(322) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(323) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(324) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(325) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(326) (L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(327) (L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(328) 2-methoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(329) 2-methoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(330) 2-methoxy-1H-benzimidazole-4-(N-2-piperazinyl)amide
(331) 2-methoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(332) 2-methoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(333) 2-methoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide
(334) 2-methoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(335) 2-methoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(336) 2-methoxy-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(337) 2-methoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide
(338) 2-methoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(339) 2-methoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(340) 2-methoxy-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(341) 2-methoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(342) 2-methoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(343) 2-methoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(344) 2-methoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(345) 2-methoxy-1H-benzimidazole-4-(N-2-pyridyl)amide
(346) 2-methoxy-1H-benzimidazole-4-(N-3-pyridyl)amide
(347) 2-methoxy-1H-benzimidazole-4-(N-4-pyridyl)amide
(348) 2-methoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(349) 2-methoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide
(350) 2-methoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(351) 2-methoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(352) 2-methoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(353) 2-methoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(354) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(355) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(356) 2-ethoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(357) 2-ethoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(358) 2-ethoxy-1H-benzimidazole-4-(N-2-piperazinyl)amide
(359) 2-ethoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(360) 2-ethoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(361) 2-ethoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide
(362) 2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(363) 2-ethoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(364) 2-ethoxy-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(365) 2-ethoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide
(366) 2-ethoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(367) 2-ethoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(368) 2-ethoxy-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(369) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(370) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(371) 2-ethoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(372) 2-ethoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(373) 2-ethoxy-1H-benzimidazole-4-(N-2-pyridyl)amide
(374) 2-ethoxy-1H-benzimidazole-4-(N-3-pyridyl)amide
(375) 2-ethoxy-1H-benzimidazole-4-(N-4-pyridyl)amide
(376) 2-ethoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(377) 2-ethoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide
(378) 2-ethoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(379) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(380) 2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(381) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(382) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(383) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(384) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(385) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(386) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(387) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(388) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(389) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(390) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(391) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(392) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(393) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(394) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(395) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(396) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(397) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(398) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(399) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(400) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(401) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(402) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(403) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(404) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(405) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(406) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(407) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(408) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(409) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(410) (L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(411) (L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(412) 2-pyrazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(413) 2-pyrazolyl-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(414) 2-pyrazolyl-1H-benzimidazole-4-(N-2-piperazinyl)amide
(415) 2-pyrazolyl-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(416) 2-pyrazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(417) 2-pyrazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(418) 2-pyrazolyl-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(419) 2-pyrazolyl-1H-benzimidazole-4-(N-4′ -carbonamido-5′-imidazolyl)amide
(420) 2-pyrazolyl-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(421) 2-pyrazolyl-1H-benzimidazole-4-(N-2-imidazolyl)amide
(422) 2-pyrazolyl-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(423) 2-pyrazolyl-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(424) 2-pyrazolyl-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(425) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(426) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(427) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(428) 2-pyrazolyl-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(429) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyridyl)amide
(430) 2-pyrazolyl-1H-benzimidazole-4-(N-3-pyridyl)amide
(431) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyridyl)amide
(432) 2-pyrazolyl-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(433) 2-pyrazolyl-1H-benzimidazole-4-(N-5-thiazolyl)amide
(434) 2-pyrazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(435) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(436) 2-pyrazolyl-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(437) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(438) (L)-2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(439) (L)-2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(440) 2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(441) 2-(2′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(442) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(443) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(444) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(445) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(446) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(447) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(448) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(449) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(450) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(451) 2-(2′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(452) 2-(2′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(453) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(454) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(455) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(456) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(457) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(458) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(459) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(460) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(461) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(462) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(463) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(464) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(465) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(466) (L)-2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(467) (L)-2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(468) 2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(469) 2-(3′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(470) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(471) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(472) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(473) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(474) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(475) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(476) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(477) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(478) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(479) 2-(3′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(480) 2-(3′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(481) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(482) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(483) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(484) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(485) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(486) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(487) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(488) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(489) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(490) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(491) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(492) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(493) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(494) (L)-2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(495) (L)-2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(496) 2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(497) 2-(4′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(498) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(499) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(500) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(501) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(502) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(503) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(504) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(505) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(506) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(507) 2-(4′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(508) 2-(4′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(509) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(510) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(511) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(512) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(513) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(514) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(515) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(516) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(517) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(518) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(519) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(520) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(521) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(522) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(523) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(524) 2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(525) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(526) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(527) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(528) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(529) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(530) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(531) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(532) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(533) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(534) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(535) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(536) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(537) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(538) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(539) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(540) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(541) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(542) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(543) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(544) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(545) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(546) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(547) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(548) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(549) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(550) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(551) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(552) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(553) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(554) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(555) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(556) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(557) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(558) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(559) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(560) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(561) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(562) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(563) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(564) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(565) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(566) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(567) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(568) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(569) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(570) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(571) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(572) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(573) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(574) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(575) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(576) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(577) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(578) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(579) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(580) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(581) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(582) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(583) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(584) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(585) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(586) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(587) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(588) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(589) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(590) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(591) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(592) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(593) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(594) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(595) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(596) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(597) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(598) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(599) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(600) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(601) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(602) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(603) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(604) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(605) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(606) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(607) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(608) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(609) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(610) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(611) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(612) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(613) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(614) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(615) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(616) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(617) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(618) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(619) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(620) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(621) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(622) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(623) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(624) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(625) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(626) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(627) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(628) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(629) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(630) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(631) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(632) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(633) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(634) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(635) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(636) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(637) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(638) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(639) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(640) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(641) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(642) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(643) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(644) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(645) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(646) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(647) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(648) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(649) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(650) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(651) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(652) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(653) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(654) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(655) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(656) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(657) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(658) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(659) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(660) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(661) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(662) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(663) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(664) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(665) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(666) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(667) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(668) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(669) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(670) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(671) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(672) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(673) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(674) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(675) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(676) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(677) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(678) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(679) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(680) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(681) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(682) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(683) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(684) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(685) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(686) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(687) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(688) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(689) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(690) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(691) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(692) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(693) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(694) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(695) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(696) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(697) 2-(2-piperazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(698) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(699) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(700) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(701) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(702) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(703) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(704) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(705) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(706) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(707) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(708) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(709) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(710) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(711) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(712) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(713) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(714) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(715) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(716) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(717) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(718) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(719) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(720) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(721) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(722) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(723) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(724) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(725) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(726) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(727) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(728) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(729) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(730) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(731) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(732) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(733) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(734) 2-(2-thiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(735) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(736) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(737) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(738) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(739) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(740) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(741) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(742) 2-(2-thiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(743) 2-(2-thiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(744) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(745) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(746) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(747) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(748) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(749) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(750) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(751) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(752) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(753) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(754) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(755) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(756) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(757) 2-(5-thiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(758) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(759) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(760) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(761) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(762) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(763) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(764) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(765) 2-(5-thiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(766) 2-(5-thiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(767) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(768) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(769) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(770) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(771) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(772) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(773) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(774) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(775) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(776) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(777) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(778) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(779) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(780) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(781) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(782) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(783) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(784) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(785) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(786) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(787) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(788) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(789) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(790) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(791) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(792) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(793) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(794) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(795) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(796) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(797) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(798) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(799) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(800) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(801) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(802) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(803) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(804) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(805) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(806) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(807) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(808) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(809) 242-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(810) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(811) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(812) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(813) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(814) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(815) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(816) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(817) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(818) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(819) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(820) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(821) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(822) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(823) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(824) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(825) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(826) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(827) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(828) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(829) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(830) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(831) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(832) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(833) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(834) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(835) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(836) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(837) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(838) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(839) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(840) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(841) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(842) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(843) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(844) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(845) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(846) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(847) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(848) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(849) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(850) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(851) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(852) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(853) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(854) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(855) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(856) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(857) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(858) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(859) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(860) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(861) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(862) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(863) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(864) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(865) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(866) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(867) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(868) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(869) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(870) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(871) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(872) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(873) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(874) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(875) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(876) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(877) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(878) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(879) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(880) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(881) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(882) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(883) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(884) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(885) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(886) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(887) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(888) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(889) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(890) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(891) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(892) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(893) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(894) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(895) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(896) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(897) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(898) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(899) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(900) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(901) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(902) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(903) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(904) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(905) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(906) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(907) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(908) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(909) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(910) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(911) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(912) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(913) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(914) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(915) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(916) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(917) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(918) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(919) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(920) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(921) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(922) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(923) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(924) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(925) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(926) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(927) 2-(2-quinolinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(928) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(929) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(930) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(931) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(932) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(933) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(934) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(935) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(936) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(937) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(938) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(939) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(940) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(941) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(942) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(943) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(944) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(945) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(946) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(947) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(948) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(949) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(950) 2-(2-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(951) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(952) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(953) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(954) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(955) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(956) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(957) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(958) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(959) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(960) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(961) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(962) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(963) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(964) 2-(3-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(965) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(966) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(967) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(968) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(969) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(970) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(971) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(972) 2-(3-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(973) 2-(3-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(974) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(975) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(976) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(977) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(978) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(979) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(980) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(981) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(982) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(983) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(984) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(985) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(986) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(987) 2-(4-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(988) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(989) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(990) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(991) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(992) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(993) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(994) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(995) 2-(4-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(996) 2-(4-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(997) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(998) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(999) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1000) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1001) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1002) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1003) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1004) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1005) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1006) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1007) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1008) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1009) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1010) 2-(3-indolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1011) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1012) 2-(3-indolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1013) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1014) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1015) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1016) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1017) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1018) 2-(3-indolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1019) 2-(3-indolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1020) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1021) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1022) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1023) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1024) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1025) 2-(3-indolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1026) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1027) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1028) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1029) 2-(3-indolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1030) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1031) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1032) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1033) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1034) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1035) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1036) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1037) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1038) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1039) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1040) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1041) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1042) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1043) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1044) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1045) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1046) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1047) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1048) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1049) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1050) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1051) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1052) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1053) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1054) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1055) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1056) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1057) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1058) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1059) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1060) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1061) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1062) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1063) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1064) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1065) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1066) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1067) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1068) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1069) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1070) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1071) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1072) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1073) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1074) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1075) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1076) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1077) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1078) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1079) (L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1080) (L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-44N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1081) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1082) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1083) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1084) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1085) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1086) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1087) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1088) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1089) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1090) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1091) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1092) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1093) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1094) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1095) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1096) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1097) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1098) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1099) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1100) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1101) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1102) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1103) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1104) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-bromo-5-pyridine)-2-pyrimidinyl)amide
(1105) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1106) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1107) (L)-2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1108) (L)-2-(2-amino-3-pyridine)-1H-benzimidazole-44N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1109) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1110) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1111) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1112) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1113) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1114) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1115) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1116) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1117) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1118) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1119) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1120) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1121) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1122) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1123) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1124) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1125) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1126) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1127) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1128) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1129) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1130) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1131) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1132) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimidinyl)amide
(1133) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1134) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1135) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1136) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1137) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1138) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1139) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1140) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1141) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1142) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1143) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1144) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1145) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1146) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1147) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1148) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1149) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1150) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1151) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1152) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1153) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1154) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1155) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1156) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyridyl)amide
(1157) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1158) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1159) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1160) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-pyrrolidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide
(1161) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1162) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1163) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1164) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1165) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1166) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1167) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1168) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1169) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1170) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1171) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1172) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1173) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1174) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1175) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1176) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1177) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1178) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1179) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1180) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1181) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1182) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1183) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1184) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1185) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1186) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(5-thiazolyl)amide
(1187) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1188) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-piperidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide
(1189) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1190) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1191) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1192) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1193) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1194) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1195) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1196) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1197) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1198) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1199) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1200) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1201) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1202) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1203) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1204) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1205) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1206) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1207) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1208) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1209) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1210) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1211) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1212) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1213) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1214) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(5-thiazolyl)amide
(1215) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1216) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-cyclopropylamino-5-pyrimidinyl)-2-pyrimidinyl)amide
(1217) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1218) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1219) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1220) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1221) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1222) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1223) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1224) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1225) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1226) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1227) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1228) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1229) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1230) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1231) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1232) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1233) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1234) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1235) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1236) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1237) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1238) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1239) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1240) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1241) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1242) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(5-thiazolyl)amide
(1243) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1244) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1245) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1246) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1247) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1248) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1249) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1250) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1251) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1252) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1253) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1254) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1255) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1256) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1257) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1258) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1259) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1260) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1261) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1262) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1263) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1264) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1265) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1266) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1267) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1268) 2-N-piperazinyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1269) 2-N-piperazinyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1270) 2-N-piperazinyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1271) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1272) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1273) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1274) 2-thiazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1275) 2-thiazolyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1276) 2-thiazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1277) 5-thiazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1278) 5-thiazolyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1279) 5-thiazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1280) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1281) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1282) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1283) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1284) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1285) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1286) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1287) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1288) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1289) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1290) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1291) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1292) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1293) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1294) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1295) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1296) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1297) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1298) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1299) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1300) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1301) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1302) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1303) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1304) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1305) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1306) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1307) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1308) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1309) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1310) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1311) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1312) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1313) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1314) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1315) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1316) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1317) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1318) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1319) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1320) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1321) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1322) 2-methoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1323) 2-methoxy-1H-benzimidazole-4-(N-6-purinyl)amide
(1324) 2-methoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1325) 2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1326) 2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide
(1327) 2-ethoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1328) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1329) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1330) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1331) 2-pyrazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1332) 2-pyrazolyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1333) 2-pyrazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1334) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1335) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1336) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1337) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1338) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1339) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1340) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1341) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1342) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1343) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1344) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1345) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1346) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1347) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1348) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1349) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1350) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide;
(1351) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1352) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1353) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1354) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1355) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1356) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1357) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1358) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1359) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1360) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1361) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1362) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1363) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1364) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1365) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1366) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1367) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1368) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1369) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1370) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1371) 2-(2-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1372) 2-(2-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1373) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1374) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1375) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1376) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1377) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1378) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1379) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1380) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1381) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1382) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1383) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1384) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1385) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1386) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1387) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1388) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1389) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1390) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1391) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1392) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1393) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1394) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1395) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1396) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1397) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1398) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1399) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1400) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1401) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1402) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1403) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1404) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1405) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1406) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1407) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide
(1408) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1409) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1410) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide
(1411) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1412) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1413) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1414) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1415) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1416) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1417) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1418) 2-(2-cyclopropylamino)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1419) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1420) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1421) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1422) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1423) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1424) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide.

Preferably, the pharmaceutically acceptable salts of benzimidazole-4-carboxamide derivatives are inorganic acid salts thereof selected from sulfate, hydrochloride, nitrate, phosphate or boratethe, or organic acid salts thereof selected from citrate, succinate, tartrate, lactate or mesylate.

Another purpose of the present invention is to provide anti-cosxackie-viruses pharmaceutical compositions. The pharmaceutical compositions comprise a therapeutically effective amount of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1˜7, and one or more pharmaceutically acceptable thinner, excipient and/or inert carrier.

A further purpose of the present invention is to provide uses of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts for for preparation of antivirus medications, wherein the viruses are Coxsackie Virus, echovirus and enterovirus which belong to picornaviridae.

Another purpose of the present invention is to provide a method of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof as shown in Formula (I), comprising the following steps:

(1) 2-aminoacetyl-3-nitrobenzoic acid is Undergoing Reactions of Ammonolysis, Hoffman Degradation and Reduction in Turn, to Produce 2,3-diamino benzoic acid
(2) 2,3-diamino benzoic acid is Condensed with Aldehydes X—CHO in the Presence of Catalyst of Cupric Acetate, to Produce benzimidazole-4-carboxylic acid of Formula (II)

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(3) benzimidazole-4-carboxylic acid is Reacted with thionyl chloride to Produce acyl chloride, and then Condensing the acyl chloride and an amine NH₂—Y, to Produce the benzimidazole-4-carboxamide Derivative of Formula (I)

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The above reaction conditions are as follows: benzimidazole-4-carboxylic acid is reated with thionyl chloride at temperature of 0˜80° C. in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1˜20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0˜100° C. to produce benzimidazole-4-carboxamide derivatives. Wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene, and so on.

The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof of the present invention may be administered orally or not. The dosage varies with different drugs, the dosage is 10˜300 mg per day in general conditions.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows ¹HNMR spectrogram of 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-carboxylic acid in Example 9.

FIG. 2 shows ¹HNMR spectrogram of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl))amide in Example 21.

FIG. 3 shows ¹HNMR spectrogram of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide in Example 28.

FIG. 4 shows ¹HNMR spectrogram of (L)-2-(2-pyridyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide in Example 194.

FIG. 5 shows ¹HNMR spectrogram of 2-(4-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide in Example 663.

FIG. 6 shows ¹HNMR spectrogram of (L)-2-(3-hydroxyphenyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide in Example 664.

DETAILED DESCRIPTION OF THE INVENTION

Hereafter, the present invention will be described specifically with reference to examples. The examples are given only for illustration of the technical solution of the present invention and should not be construed to limit the present invention.

The method of preparing for benzimidazole-4-amide derivatives of the present invention is as follows: using 2-aminoacetyl-3-nitrobenzoic acid as an initiating raw material, 2-aminoacetyl-3-nitrobenzoic acid in turn is undergoing ammonolysis, Hoffman degradation and reduction, to produce 2,3-diamino benzoic acid; and then condensing 2,3-diamino benzoic acid and aldehydes X—CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid; and then reacting benzimidazole-4-carboxylic acid with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH₂—Y, to produce the benzimidazole-4-carboxamide derivative.

EXAMPLE 1
Synthesis of 2.3-diamino benzoic acid
Step 1: Synthesis of 2-aminoacetyl-3-nitrobenzoic acid

30 g of 3-nitro phthalic anhydride is added into 45 ml of concentrated ammonia with 28 g/g % concentration; and heat it to 60° C. under stiffing for 30 minutes; and then to cool it to 10° C. till precipitate needle shape crystals; and to acidize the needle shape crystals with concentrated chlorhydric acid to produce white solids; and then to filter and dry it to obtain 29.4 g of 2-aminoacetyl-3-nitrobenzoic acid.

Step 2: Synthesis of 2-amino-3-nitrobenzoic acid

13.9 g of bromine is dropped into 100 ml of sodium hydroxide aqueous-solution containing 7.3 g of sodium hydroxide to a solution. Then 17 g of 2-aminoacetyl-3-nitrobenzoic acid is added into the above solution; and to heat it to 80° C. to precipitate a large amount of red solids; to filter and then acidize it with the concentrated chlorhydric acid to produce yellow solid products; to dry it to obtain 13.7 g of 2-amino-3-nitrobenzoic acid; and then recrystallize the yellow solid products by adding hot water to obtain the yellow needle shape crystals.

Step 3: Synthesis of 2,3-diaminobenzoic acid

3 g of the above mentioned 2-amino-3-nitrobenzoic acid is added into 30 ml of methanol, 20% sodium hydroxide aqueous solution with the same molar as 2-amino-3-nitrobenzoic acid is dropped into the above methanol solution till dissolve completely. 0.2 g of Raney nickel at the moment is added in to the methanol solution, and to heat it to 65° C. and reflux it at the temperature; and then drop 80 g/g % hydrazine hydrate (about 1.5 equivalent weight×1.1) till the yellow disappears completely. Hot Raney nickel is filtered; and then heat and concentrate the mother liquid and acidize it with the concentrated chlorhydric acid to produce 2.3 g of red 2,3-diaminobenzoic acid; afterwards isolate and purify the crude product of red 2,3-diaminobenzoic acid by column chromatography.

EXAMPLE 2
Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid

2.0 g of 2,3-diaminobenzoic acid is dissolved into 60 ml of methanol, and methanol solution of 5-nitrofurfural is added into the methanol under stirring. Then 0.5 g of cupric acetate (Cu(Ac)₂.H₂O) is added into the above methanol, and then to heat and reflux it; and then to filter hot solution after 2,3-diaminobenzoic acid disappears. 20% sodium sulfide aqueous solution is added into the filtrate and heat it till boiling; and then filtrate the copper sulfide deposition while it is hot; and then to evaporate the filtrate to dry, purify it through column chromatography to obtain 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid. The yield is about 65%.

EXAMPLES 3-20
Synthesis of Intermediates of benzimidazole-4-carboxylic acid

Synthesize the benzimidazole-4-carboxylic acid as shown in Formula (II) according to the method of Example 2. The difference is to use aldehydes with different X group as listed in Table 1.

TABLE 1

(II)

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No. of

prod-

Yield

ucts
Compounds
X
%

4
2-(2-pyrimidinyl)-1H- benzimidazole- 4-carboxylic acid

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75

5
2-(2-thienyl)-1H- benzimidazole-4- carboxylic acid

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76

6
2-methyl-1H- benzimidazole-4- carboxylic acid
—CH3
72

7
2-phenyl-1H- benzimidazole-4- carboxylic acid

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80

8
2-(4-(dimethylamino)- phenyl)-1H- benzimidazole-4- carboxylic acid

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75

9
2-(2,3,4- trihydroxyphenyl)- 1H-benzimidazole- 4-carboxylic acid

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65

10
2-(4-methoxy-2- pyridyl)-1H- benzimidazole-4- carboxylic acid

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68

11
2-(6-methoxy-2- pyridyl)-1H- benzimidazole-4- carboxylic acid

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70

12
2-(4-(dimethylamino)- 2-pyridyl)-1H- benzimidazole-4- carboxylic acid

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75

13
2-(3-pyridazinyl)- 1H-benzimidazole- 4-carboxylic acid

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60

14
2-(2-piperazinyl)- 1H-benzimidazole- 4-carboxylic acid

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61

15
2-(5-amino-4-methyl- 2-thiazolyl)-1H- benzimidazole- 4-carboxylic acid

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70

16
2-(3-quinolinyl)- 1H-benzimidazole- 4-carboxylic acid

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63

17
2-(2-pyrrolyl)- 1H-benzimidazole- 4-carboxylic acid

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75

18
2-(3-indolyl)- 1H-benzimidazole- 4-carboxylic acid

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71

19
2-(2-piperidinyl)- 1H-benzimidazole- 4-carboxylic acid

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68

20
2-(2-quinolinyl)- 1H-benzimidazole- 4-carboxylic acid

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Structure Identification of Products:
(4) 2-(2-pyrimidinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.80(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.09(d,1H), 9.10-9.12(d,1H);

(5) 2-(2-thienyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.15-7.18(t,1H), 7.41-7.45(t,1H), 7.68-7.70(d,1H), 7.85(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(6) 2-methyl-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 2.51(s,3H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(7) 2-phenyl-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.41-7.45(t,1H), 7.38-7.42(t,1H) 7.50-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.30(d,2H);

(8) 2-(4-(dimethylamino)-phenyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 3.06(s,6H) 6.82-6.84(d,2H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.97-7.99(d,2H);

(9) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-carboxylic acid (Refer to FIG. 1)

¹HNMR (DMSO, 400 MHz) δ: 6.43-6.46 (d, 1H), 7.28-7.32 (t, 1H), 7.77-7.79 (d, 1H), 7.82-7.85 (m, 1H), 8.57(s, 1H), 9.54 (s, 1H), 12.11(s, 1H), 13.16(s, 1H);

(10) 2-(4-(methoxy)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.41-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.48-8.49(d,1H);

(11) 2-(6-methoxy-2-pyridyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,3H), 6.50-6.51(d,1H), 7.38-7.39(d,1H), 7.41-7.45(t,1H), 7.72-7.75(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(12) 2-(4-(dimethylamino)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 7.16-7.18(d,1H), 7.41-7.45(t,1H), 7.71(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.05-8.07(d,1H);

(13) 2-(3-pyridazinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.41-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.06-8.08(d,1H), 9.34-9.37(d,1H);

(14) 2-(2-piperazinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,2H), 2.60-2.62(m,1H), 2.65-2.66(m,1H), 2.67-2.70(m,1H), 2.72-2.75(m,1H), 2.84-2.88(m,1H), 3.09-3.14(m,1H), 4.14-4.19(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(15) 2-(5-amino-4-methyl-2-thiazolyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.03-1.09(d,3H), 3.70-3.73(m,1H), 4.17-4.22(m,1H), 5.11-5.13(d,2H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(16) 2-(3-quinolinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.41-7.45(t,1H), 7.60-7.65(t,1H), 7.78-7.80(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.97-7.99(d,1H), 8.06-8.09(d,1H), 8.22(s,1H), 8.57(s,1H);

(17) 2-(2-pyrrolyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.17(t,1H), 6.39-6.40(d,1H), 6.95-6.98(t,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(18) 2-(3-indolyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.05(t,1H), 7.31-7.34(t,1H), 7.41-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60(s,1H);

(19) 2-(2-piperidinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.47-1.49(m,2H), 1.50-1.55(m,2H), 1.67-1.92(m,2H), 4.01-4.03(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(20) 2-(2-quinolinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.46-1.47(m,1H), 1.49-1.51(m,1H), 1.53-1.55(m,1H), 1.67-1.70(m,1H), 1.92-1.96(m,1H), 2.69-2.71(m,1H), 2.78-2.80(m,1H), 4.01-4.03(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H)

EXAMPLE 21
Synthesis of (L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide

1.0 g of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid in Example 2 is added into 15 ml of thionyl chloride and is reacted for 60 minutes, after end of the reaction completely, (L)-2-amino-1-p-nitrophenyl-1,3-propylene glycol (1.1 eq.) is added into the reaction mixture under stirring for 2 hours at the room temperature; and then filter the inorganic salt, evaporate the solvent to dry and obtain the final product of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide. The yield is about 93%. ¹HNMR spectrum is shown in FIG. 2.

Structure Identification of Product:

¹HNMR(DMSO,400 MHz) δ: 3.59-3.60(m,1H),3.65-3.67(t,1H),4.16-4.22(q,1H),5.07-5.08(t,1H),5.27-5.28(t,1H),6.16-6.17(d,1H),7.35-7.39(t,1H),7.53-7.54(d,1H),7.72-7.75(m,2H),7.77-7.79(m,2H),8.00-8.01(d,1H),8.05-8.07(d,3H),10.04-10.06(d,2H),14.05(s,1H).

EXAMPLE 22
Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-methyl-2-p-chlorophenylhydroxyethyl)amide

1.0 g of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid is added into 15 ml of thionyl chloride; and to heat and reflux it for 60 minutes. After end of the reaction, 2-amino-1-p-chlorophenyl-1-propanol (1.1 eq) is dissolved into tetrahydrofuran, and then drop acyl chloride to the above tetrahydrofuran mixture under stirring at the room temperature and then filter inorganic salt, evaporate the solvent to dry, and then isolate the mixture through column chromatography to obtain 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide. The yield is about 92%.

Structure Identification of Product:

¹HNMR (DMSO, 400 MHz) δ: 1.10-1.16(d,3H), 3.26-3.28(m,1H), 3.64-3.66(d,1H), 4.71-4.74(m,1H), 7.28-7.30(d,2H), 7.35-7.38(d,2H), 7.41-7.45(t,1H), 7.56-7.58(d,1H), 7.62-7.68(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H).

EXAMPLES 23-67

Use the same process as Example 22 to synthesize the compound as shown in Table 2.

TABLE 2

Field

No.
Compounds
X
Y
%

23
2-(2-pyridyl)-1H-benzimidazole- 4-N-hydroxyethylamide

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—NHCH2CH2OH
88

24
2-(2-pyridyl)-1H- benzimidazole-4-N-o- hydroxyphenylcarboxylamide

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80

25
2-(2-hydroxyphenyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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82

26
(L)-2-(2-hydroxyphenyl)- 1H-benzimidazole-4- [N-(1-hydroxyl-2-p- nitrophenylhydroxyethyl)]amide

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91

27
2-(5-nitro-2-thienyl)- 1H-benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

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90

28
2-(5-nitro-2-thienyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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89

29
2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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93

30
2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4- (N-hydroxyethyl)amide

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—NHCH2CH2OH
86

31
2-(2-piperidinyl)-1H-benzimidazole- 4-(4-N′-ethyl-N-piperazinyl)amide

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95

32
2-(2-pyridyl)-1H-benzimidazole- 4-(4-N′-ethyl-N-piperazinyl)amide

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94

33
(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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90

34
(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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89

35
2-(2,6-dimethyl-2,6-octadienyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

36
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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90

37
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4- (N-2-piperazinyl)amide

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89

38
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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91

39
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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88

40
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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87

41
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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90

42
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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87

43
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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87

44
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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90

45
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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91

46
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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93

47
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4- methyl-5-thiazolyl)amide

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90

48
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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85

49
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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94

50
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4- chloro-6-amino-2-pyrimidinyl)amide

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88

51
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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90

52
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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93

53
2-(2,6-dimethyl-2,6-octadienyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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86

54
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4- (N-6-purinyl)amide

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90

55
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-6- hydroxy-2-purinyl)amide

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91

56
(L)-2-(2-thienyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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90

57
(L)-2-(2-thienyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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92

58
2-(2-thienyl)-1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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92

59
2-(2-thienyl)-1H-benzimidazole-4- (N-N′-piperidinyl)amide

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91

60
2-(2-thienyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

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88

61
2-(2-thienyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

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93

62
2-(2-thienyl)-1H-benzimidazole-4- (N-o-aminophenyl)amide

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94

63
2-(2-thienyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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90

64
2-(2-thienyl)-1H-benzimidazole-4- (N-4′-carbonamido-5′- imidazolyl)amide

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94

65
2-(2-thienyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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92

66
2-(2-thienyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

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94

67
2-(2-thienyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

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94

68
2-(2-thienyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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93

69
2-(2-thienyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

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90

70
2-(2-thienyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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91

71
2-(2-thienyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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93

72
2-(2-thienyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

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93

73
2-(2-thienyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

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88

74
2-(2-thienyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

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89

75
2-(2-thienyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

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87

76
2-(2-thienyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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92

77
2-(2-thienyl)-1H-benzimidazole-4- (N-6-purinyl)amide

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90

78
2-(2-thienyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

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91

79
(L)-2-(4-methoxypyridyl)-1H- benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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93

80
(L)-2-(4-methoxypyridyl)-1H- benzimidazole-4-[N- (1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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93

81
2-(4-methoxypyridyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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94

82
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

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90

83
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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93

84
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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92

85
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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91

86
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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91

87
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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93

88
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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92

89
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

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93

90
2-(4-methoxypyridyl)-1H- benzimidazole-4- (N-2-pyrazinyl)amide

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94

91
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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92

92
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2-pyridyl)amide

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92

93
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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93

94
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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94

95
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

96
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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94

97
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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92

98
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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94

99
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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94

100
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-6-purinyl)amide

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93

101
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-6-hydroxyl-2- purinyl)amide

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90

102
(L)-2-(6-methoxypyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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91

103
(L)-2-(6-methoxypyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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93

104
2-(6-methoxypyridyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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93

105
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-N′-piperdinyl)amide

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94

106
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2-piperazinyl)amide

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89

107
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2′-benzimidazolyl)amide

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93

108
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-o-aminophenyl)amide

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92

109
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-5-benzimidazolonyl)amide

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90

110
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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89

111
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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93

112
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-(N′-piperazinyl))amide

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93

113
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2-pyrazinyl)amide

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94

114
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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90

115
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2-pyridyl)amide

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93

116
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4- methyl-5-thiazolyl)amide

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92

117
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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86

118
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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91

119
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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90

120
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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92

121
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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93

122
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

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87

123
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-6-purinyl)amide

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92

124
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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88

125
(L)-2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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93

126
(L)-2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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94

127
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

128
2-(4-dimethylaminopyridyl)-1H- benzimidazole-(N-N′- piperidinyl)amide

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94

129
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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92

130
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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94

131
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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94

132
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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93

133
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

134
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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91

135
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

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93

136
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

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93

137
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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88

138
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- pyridyl)amide

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89

139
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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87

140
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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88

141
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

142
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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89

143
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4,6-dichloro- 5-pyrimidinyl)amide

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93

144
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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93

145
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

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88

146
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4- (N-6-purinyl)amide

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90

147
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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93

148
(L)-2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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92

149
(L)-2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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91

150
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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91

151
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

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93

152
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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92

153
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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93

154
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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90

155
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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92

156
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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87

157
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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93

158
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

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94

159
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

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90

160
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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94

161
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4- (N-2-pyridyl)amide

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92

162
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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94

163
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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94

164
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4,6-dimethoxy- 2-pyrimidinyl)amide

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93

165
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4-chloro- 6-amino-2-pyrimidinyl)amide

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90

166
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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91

167
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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93

168
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2-hydroxyl-4- pyrimidinyl)amide

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89

169
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4- (N-6-purinyl)amide

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88

170
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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89

171
(L)-2-(3-hydroxyl-4- methoxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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87

172
(L)-2-(3-hydroxyl-4- methoxyphenyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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90

173
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-[N- (1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

174
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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91

175
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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93

176
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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93

177
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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94

178
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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90

179
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

180
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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92

181
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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91

182
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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91

183
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N- 2-pyrimidinyl)amide

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93

184
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4- (N-2-pyridyl)amide

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92

185
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4-methyl- 5-thiazolyl)amide

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93

186
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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89

187
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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92

188
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4-chloro- 6-amino-2-pyrimidinyl)amide

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92

189
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

embedded image

93

190
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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94

191
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

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90

192
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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94

193
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

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89

194
(L)-2-(2-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethy])]amide

embedded image

94

195
(L)-2-(2-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

196
2-(2-pyridyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

197
2-(2-pyridyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

90

198
2-(2-pyridyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

91

199
2-(2-pyridyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

200
2-(2-pyridyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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89

201
2-(2-pyridyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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88

202
2-(2-pyridyl)-1H-benzimidazole-4- (N-4′-carbonamido-5′- imidazolyl)amide

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86

203
2-(2-pyridyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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87

204
2-(2-pyridyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

embedded image

92

205
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

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90

206
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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91

207
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

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93

208
2-(2-pyridyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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93

209
2-(2-pyridyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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88

210
2-(2-pyridyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

90

211
2-(2-pyridyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

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93

212
2-(2-pyridyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

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92

213
2-(2-pyridyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

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91

214
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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91

215
2-(2-pyridyl)-1H-benzimidazole-4- (N-6-purinyl)amide

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93

216
2-(2-pyridyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

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88

217
(L)-2-(3-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

218
(L)-2-(3-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

94

219
2-(3-pyridyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

embedded image

92

220
2-(3-pyridyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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92

221
(L)-2-(4-pyridyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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93

222
(L)-2-(4-pyridyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

94

223
2-(4-pyridyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

embedded image

90

224
2-(4-pyridyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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94

225
(L)-2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

226
(L)-2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

227
2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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94

228
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-N′- piperdinyl)amide

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93

229
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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90

230
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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91

231
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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93

232
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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93

233
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

234
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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89

235
2-(3-pyridazinyl)-1H- benzimidazole-4-(N- (N′-piperazinyl))amide

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87

236
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

92

237
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

90

238
2-(3-pyridazinyl)-1H- benzimidazole-4- (N-2-pyridyl)amide

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91

239
2-(3-pyridazinyl)-1H- benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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93

240
2-(3-pyridazinyl)-1H- benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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89

241
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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94

242
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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90

243
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4,6-dichloro- 5-pyrimidinyl)amide

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93

244
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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92

245
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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88

246
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-6- purinyl)amide

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91

247
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-6-hydroxyl-2- purinyl)amide

embedded image

87

248
(L)-2-(4-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

249
(L)-2-(4-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

250
2-(4-pyridazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

94

251
2-(4-pyridazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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92

252
(L)-2-(2-pyrazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethy]-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

253
(L)-2-(2-pyrazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

89

254
2-(2-pyrazinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

94

255
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

90

256
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

94

257
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

92

258
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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90

259
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

94

260
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

87

261
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

90

262
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

91

263
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

264
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

265
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

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88

266
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

89

267
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

268
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

92

269
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

90

270
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

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91

271
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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93

272
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

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89

273
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

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94

274
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

89

275
(L)-2-(2-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

276
(L)-2-(2-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

277
2-(2-piperazinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

91

278
2-(2-piperazinyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

91

279
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

93

280
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2,-benzimidazolyl)amide

embedded image

92

281
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

93

282
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

94

283
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

89

284
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

92

285
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

92

286
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

92

287
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

288
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

92

289
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

91

290
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

291
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

90

292
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

88

293
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

294
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

94

295
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

89

296
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

90

297
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

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87

298
(L)-2-(N,N′-diethyl-2-piperazinyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

90

299
(L)-2-(N,N′-diethyl-2-piperazinyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

300
2-(N,N′-diethyl-2-piperazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

90

301
2-(N,N′-diethyl-2-piperazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

91

302
(L)-2-(N-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

303
(L)-2-(N-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

304
2-(N-piperazinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

92

305
2-(N-piperazinyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

93

306
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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91

307
2-(N-piperazinyl)-1H- benzimidazole-4- (N-2′-benzimidazolyl)amide

embedded image

92

308
2-(N-piperazinyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

embedded image

90

309
2-(N-piperazinyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

embedded image

91

310
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′- imidazolyl)amide

embedded image

90

311
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

embedded image

93

312
2-(N-piperazinyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

embedded image

91

313
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

92

314
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

93

315
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- pyridyl)amide

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94

316
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4- methyl-5-thiazolyl)amide

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94

317
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

embedded image

88

318
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

embedded image

90

319
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4-chloro- 6-amino-2-pyrimidinyl)amide

embedded image

91

320
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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93

321
2-(N-piperazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

embedded image

93

322
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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88

323
2-(N-piperazinyl)-1H- benzimidazole-4-(N-6- purinyl)amide

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89

324
2-(N-piperazinyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

embedded image

87

325
(L)-2-(N-ethyl-N′-piperazinyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

326
(L)-2-(N-ethyl-N′-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

327
2-(N-ethyl-N′-piperazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

92

328
2-(N-ethyl-N′-piperazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

93

329
(L)-2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

330
(L)-2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

331
2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

92

332
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

93

333
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

334
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

335
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

90

336
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

91

337
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

85

338
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

90

339
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

92

340
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

95

341
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

94

342
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

94

343
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

95

344
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

345
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

94

346
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino- 2-pyrimidinyl)amide

embedded image

91

347
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

348
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

embedded image

94

349
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

embedded image

86

350
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-6-purinyl)amide

embedded image

92

351
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

embedded image

87

352
(L)-2-(4-methyl-5- aminothiazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

353
(L)-2-(4-methyl-5- aminothiazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

354
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

355
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

94

356
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

90

357
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

embedded image

94

358
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

embedded image

93

359
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

embedded image

94

360
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

embedded image

90

361
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N- 4′-pyrazolyl)amide

embedded image

94

362
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-(N'- piperazinyl))amide

embedded image

92

363
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

94

364
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

94

365
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2-pyridyl)amide

embedded image

93

366
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

embedded image

90

367
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

embedded image

91

368
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4,6-dimethoxy- 2-pyrimidinyl)amide

embedded image

93

369
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

embedded image

93

370
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

88

371
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

embedded image

89

372
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

embedded image

87

373
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-6-purinyl)amide

embedded image

92

374
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-6-hydroxyl-2- purinyl)amide

embedded image

90

375
(L)-2-(2-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

91

376
(L)-2-(2-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

377
2-(2-quinolinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

378
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

94

379
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

380
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

381
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

92

382
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

91

383
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

91

384
2-(2-quinolinyl)-lH-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

93

385
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

92

386
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

387
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

94

388
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

92

389
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

92

390
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

391
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

94

392
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

93

393
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

394
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

395
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

88

396
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

90

397
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

85

398
(L)-2-(3-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

399
(L)-2-(3-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

400
2-(3-quinolinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

93

401
2-(3-quinolinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

402
(L)-2-(2-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

91

403
(L)-2-(2-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

89

404
2-(2-piperidinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

91

405
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

92

406
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

407
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

408
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

93

409
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

93

410
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

85

411
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

89

412
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

87

413
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

414
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

92

415
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

91

416
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

93

417
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

88

418
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

93

419
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

89

420
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

421
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

92

422
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

86

423
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

91

424
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

89

425
(L)-2-(3-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

426
(L)-2-(3-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

427
2-(3-piperidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

428
2-(3-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

94

429
(L)-2-(4-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

430
(L)-2-(4-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

431
2-(4-piperidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

91

432
2-(4-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

433
(L)-2-(3-indolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

434
(L)-2-(3-indolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

88

435
2-(3-indolyl)-1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

90

436
2-(3-indolyl)-1H-benzimidazole-4- (N-N′-piperidinyl)amide

embedded image

94

437
2-(3-indolyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

embedded image

92

438
2-(3-indolyl)-1H-benzimidazole-4- (N-2′-benzimidazolyl)amide

embedded image

90

439
2-(3-indolyl)-1H-benzimidazole-4- (N-o-aminophenyl)amide

embedded image

91

440
2-(3-indolyl)-1H-benzimidazole-4- (N-5-benzimidazolonyl)amide

embedded image

93

441
2-(3-indolyl)-1H-benzimidazole-4- (N-4′-carbonamido- 5′-imidazolyl)amide

embedded image

93

442
2-(3-indolyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

embedded image

88

443
2-(3-indolyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

embedded image

89

444
2-(3-indolyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

embedded image

94

445
2-(3-indolyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

embedded image

92

446
2-(3-indolyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

embedded image

93

447
2-(3-indolyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

embedded image

91

448
2-(3-indolyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

449
2-(3-indoIyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

93

450
2-(3-indolyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

88

451
2-(3-indolyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

92

452
2-(3-indolyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

embedded image

94

453
2-(3-indolyl)-1H-benzimidazole-4- (N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

86

454
2-(3-indolyl)-1H-benzimidazole-4- (N-6-purinyl)amide

embedded image

90

455
2-(3-indolyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

embedded image

86

456
(L)-2-(2′-imidazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

457
(L)-2-(2′-imidazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

458
2-(2′-imidazolyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

88

459
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

93

460
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

461
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

94

462
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

86

463
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

90

464
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

86

465
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

93

466
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

93

467
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

94

468
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

469
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

90

470
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

94

471
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

86

472
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

94

473
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

86

474
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

475
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

476
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

88

477
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

93

478
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

87

479
(L)-2-(3-pyrazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitiophenylhydroxyethyl)]amide

embedded image

94

480
(L)-2-(3-pyrazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

86

481
2-(3-pyrazolyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

90

482
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

94

483
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

93

484
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

485
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

88

486
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

93

487
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

87

488
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

94

489
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

86

490
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

90

491
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

86

492
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

93

493
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

93

494
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

88

495
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

93

496
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

88

497
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

94

498
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

499
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

90

500
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

86

501
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

89

502
(L)-2-(2-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

503
(L)-2-(2-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

88

504
2-(2-pyrimidinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

505
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

90

506
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

94

507
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

92

508
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

90

509
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

86

510
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

87

511
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

93

512
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

88

513
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

514
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

90

515
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

94

516
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

93

517
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

90

518
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

86

519
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

93

520
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

521
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

522
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

88

523
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

90

524
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

86

525
(L)-2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

90

526
(L)-2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

527
2-(2-phenyI-5-pyrimidinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

86

528
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

93

529
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

93

530
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

embedded image

88

531
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

embedded image

93

532
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

embedded image

90

533
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

embedded image

94

534
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

embedded image

90

535
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

embedded image

90

536
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

86

537
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

93

538
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2-pyridyl)amide

embedded image

93

539
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

embedded image

88

540
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2,4-dihydroxyl- 5-pyrimidinyl)amide

embedded image

93

541
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4,6-dimethoxy- 2-pyrimidinyl)amide

embedded image

90

542
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

embedded image

94

543
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

94

544
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

embedded image

90

545
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

86

546
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-6-purinyl)amide

embedded image

93

547
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

embedded image

93

548
(L)-2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

88

549
(L)-2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

550
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

90

551
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

94

552
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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86

553
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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90

554
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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86

555
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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93

556
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

557
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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88

558
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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93

559
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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90

560
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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90

561
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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86

562
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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90

563
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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86

564
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

565
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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90

566
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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88

567
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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93

568
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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90

569
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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91

570
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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93

571
(L)-2-(2-pyrrolidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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94

572
(L)-2-(2-pyrrolidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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90

573
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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94

574
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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92

575
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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94

576
2-( 2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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94

577
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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93

578
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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90

579
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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85

580
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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93

581
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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93

582
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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88

583
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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89

584
2-(2-pyrrolidine-l-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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87

585
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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92

586
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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90

587
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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91

588
2-{ 2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4- chloro-6-amino-2-pyrimidinyl)amide

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93

589
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6-dichloro- 5-pyrimidinyl)amide

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93

590
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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94

591
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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90

592
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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93

593
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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92

594
(L)-2-(2-piperidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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91

595
(L)-2-(2-piperidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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91

596
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2- p-chlorophenylhydroxyethyl)]amide

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93

597
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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92

598
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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93

599
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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94

600
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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92

601
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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92

602
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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85

603
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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94

604
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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90

605
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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94

606
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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92

607
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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94

608
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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94

609
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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93

610
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

611
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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91

612
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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93

613
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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93

614
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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88

615
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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89

616
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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87

617
(L)-2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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92

618
(L)-2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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90

619
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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91

620
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

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93

621
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

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93

622
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

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94

623
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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90

624
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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93

625
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4′-carbonamido- 5′-imidazolyl)amide

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92

626
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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91

627
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

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91

628
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

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93

629
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

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92

630
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

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93

631
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

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94

632
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

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92

633
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

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92

634
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

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93

635
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

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94

636
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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90

637
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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94

638
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

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92

639
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

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94

640
(L)-2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)] amide

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94

641
(L)-2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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93

642
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

643
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-N′-piperidinyl)amide

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91

644
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

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93

645
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2′-benzimidazolyl)amide

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93

646
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-o-aminophenyl)amide

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88

647
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-5-benzimidazolonyl)amide

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89

648
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4′-carbonamido-5′- imidazolyl)amide

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87

649
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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92

650
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

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90

651
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

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91

652
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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93

653
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

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93

654
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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94

655
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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90

656
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

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93

657
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

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92

658
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

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91

659
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

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91

660
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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93

661
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-6-purinyl)amide

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92

662
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-6-hydroxy]-2-purinyl)amide

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93

663
2-(4-hydroxyphenyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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94

664
(L)-2-(3-hydroxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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92

665
2-(3-hydroxyphenyl)-1H- benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

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Structure Identification of Product (refer to FIGS. 3-6):

(23) 2-(2-pyridyl)-1H-benzimidazole-4-N-hydroxyethylamide

¹HNMR (DMSO, 400 MHz) δ: 3.64-3.67(t,1H), 3.73-3.75(m,2H), 4.39-4.42(t,2H), 7.32-7.36(t,1H), 7.38-7.40(t,1H), 7.73-7.75(d,1H), 7.80-7.81(d,1H), 7.85-7.86(t,1H), 8.38-8.40(d,1H), 8.59-8.61(d,1H);

(24) 2-(2-pyridyl)-1H-benzimidazole-4-N-o-hydroxyphenylcarboxylamide

¹HNMR (DMSO, 400 MHz) δ: 5.35(s,1H), 7.13(s,1H), 7.15-7.16(d,2H), 7.34-7.36(t,3H), 7.37-7.39(t,1H), 7.83-7.84(d,1H), 7.85-7.86(t,1H), 7.91-7.92(d,1H), 8.11-8.12(d,1H), 8.38-8.40(d,1H), 8.59-8.61(d,1H);

(25) 2-(2-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.35(s,1H), 6.59-6.61(d,1H), 6.63-6.64(t,1H), 6.95-6.97(t,1H), 6.99-7.00(d,1H), 7.01-7.02(d,1H), 7.07-7.09(t,1H), 7.24-7.25(t,1H), 7.37-7.39(t,1H), 7.62-7.63(d,1H), 7.83-7.84(d,1H), 7.91-7.92(d,1H);

(26) (L)-2-(2-hydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.35(s,1H), 7.01-7.02(d,1H), 7.07-7.09(t,1H), 7.24-7.25(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.66-7.67(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(27) 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.46(t,1H), 7.70-7.72(d,1H), 7.89-7.91(d,1H), 7.93-7.95(d,1H), 8.30-8.33(d,1H), 8.57-8.60(d,1H), 11.53(s,1H);

(28) 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (Refer to FIG. 3)

¹HNMR(DMSO, 400 MHz)δ:7.13-7.19(m,1H),7.23-7.27(t,1H),7.36-7.41(t,1H),7.50-7.54(m,2H), 7.85-7.87(d,1H), 7.94-7.95(d,1H), 8.05-8.07(d,1H), 8.57-8.61(t,1H), 12.19-12.20(d,1H), 14.25(s,1H);

(29) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.33(s,1H), 5.35(s,1H), 5.38(s,1H), 6.59-6.61(d,1H), 6.63-6.64(t,1H), 6.71(s,2H), 6.95-6.97(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(30) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-hydroxyethyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.33(s,1H), 5.35(s,1H), 5.38(s,1H), 2.84-2.88(m,2H), 3.59-3.62(m,2H), 3.65-3.67(t,1H), 6.71(s,2H), 7.43-7.45(t,1H), 7.89-7.90 (d,1H), 7.93-7.94(d,1H);

(31) 2-(2-piperidinyl)-1H-benzimidazole-4-(4-N′-ethyl-N-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 1.43-1.44(m,1H), 1.45-1.47(m,1H), 1.49-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m1H), 1.91-1.94(m,1H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.04(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(32) 2-(2-pyridyl)-1H-benzimidazole-4-(4-N′-ethyl-N-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 7.36-7.38(t,H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.39(d,1H), 8.59-8.61(d,1H);

(33) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.17-3.18(m,1H), 3.19-3.20(d,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(34) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.17-3.18(m,1H), 3.19-3.20(d,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(35) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(36) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.10-3.15(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(37) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 1.91-1.93(m,2H), 2.00-2.06(t,4H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.19-3.20(d,1H), 3.99-4.01(m,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(38) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(39) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(40) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(41) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(42) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

(43) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 1.91-1.95(m,1H), 2.00-2.06(t,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(44) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

(45) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(46) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(47) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 2.45(s,3H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(48) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(49) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 3.82(s,6H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(50) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(51) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(52) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(53) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(54) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(55) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-hydroxy-2-purinyl)amide

(56) (L)-2-(2-thienyl)-1H-benzimidzzole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(57) (L)-2-(2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(58) 2-(2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.17-7.19(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(59) 2-(2-thienyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(60) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(61) 2-(2-thienyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.17-7.19(t,1H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(62) 2-(2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(63) 2-(2-thienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(64) 2-(2-thienyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(65) 2-(2-thienyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(66) 2-(2-thienyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(67) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(68) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.17-7.19(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(69) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(70) 2-(2-thienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(71) 2-(2-thienyl)-1H-benzimidazole-4-[N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.82(s,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(72) 2-(2-thienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(73) 2-(2-thienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.74(s,2H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(74) 2-(2-thienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(75) 2-(2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(76) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.82(s,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(77) 2-(2-thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.86(d,1H), 7.87-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(78) 2-(2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(79) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.49-8.51(d,1H);

(80) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.49-8.51(d,1H);

(81) 2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,3H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.31(s,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(82) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(83) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,3H), 3.99-4.01(m,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(84) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(85) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(86) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(87) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.49-8.51(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(88) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(89) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(90) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.49-8.51(d,1H);

(91) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.93-6.95(t,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.49-8.51(d,1H);

(92) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.49-8.51(d,1H);

(93) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.49-8.51(d,1H);

(94) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.49-8.51(d,1H), 11.53(s,1H);

(95) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 3.85(s,3H), 5.71(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(96) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.98(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(97) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H), 9.34(s,1H);

(98) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(99) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(100) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.49-8.51(d,1H);

(101) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(102) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.80(s,1H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.72-7.74(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(103) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.80(s,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.50-6.52(d,1H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(104) 2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.80(s,1H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.29-7.30(d,2H), 7.38-7.39(d,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.72-7.74(t,1H), 7.93-7.94(d,1H);

(105) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(106) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.80(s,1H), 3.99-4.01(m,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(107) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(108) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.50-6.52(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(109) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.35-6.37(d,1H), 6.50-6.52(d,1H), 6.93(s,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(110) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(111) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(112) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.72-7.74(t,1H), 7.93-7.94(d,1H);

(113) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(114) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 6.93-6.95(t,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(115) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(116) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(117) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(118) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 3.82(s,6H), 5.71(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(119) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 5.98(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.72-7.74(t,1H), 7.93-7.94(d,1H);

(120) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(121) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(122) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 5.46-5.48(d,1H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(123) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(124) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(125) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.32-8.35(d,1H);

(126) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.65-6.67(d,1H), 6.86(s,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.32-8.35(d,1H);

(127) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 2.68(s,6H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(128) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.68(s,6H), 3.10-3.15(t,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(129) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.68(s,6H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(130) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(131) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.65-6.67(d,1H), 6.75-6.76(d,1H), 6.86(s,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(132) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.35-6.37(d,1H), 6.65-6.67(d,1H), 6.86(s,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(133) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(134) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(135) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.68(s,6H), 2.80-2.83(m,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(136) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(137) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.45-8.46(d,2H);

(138) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.62-6.64(t,1H), 6.65-6.67(d,1H), 6.70-6.72(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.32-8.35(d,1H);

(139) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.32-8.35(d,1H);

(140) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.30(s,1H), 8.32-8.35(d,1H), 11.53(s,1H);

(141) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 3.82(s,6H), 5.71(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(142) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 5.98(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(143) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 9.34(s,1H);

(144) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.60-6.61(d,1H), 6.63-6.64(t,1H), 6.66-6.67(d,1H), 6.86(s,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(145) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 5.46-5.48(d,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(146) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.32-8.35(d,1H);

(147) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(148) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(149) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.27(s,2H), 6.50-6.52(d,1H), 6.56-6.58(d,2H), 7.11-7.12(d,2H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(150) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(151) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(152) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,9H), 3.99-4.01(m,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(153) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(154) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.27(s,2H), 6.38-6.40(d,1H), 6.50-6.52(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(155) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.35-6.37(d,1H), 6.50-6.52(d,1H), 6.93(s,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(156) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(157) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(158) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(159) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(160) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.93-6.95(t,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(161) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(162) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(163) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(164) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 3.83(s,9H), 5.71(s,1H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(165) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 5.98(s,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(166) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(167) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(168) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 5.46-5.48(d,1H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(169) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(170) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(171) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(172) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.88-6.90(d,1H), 7.11-7.13(d,2H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(173) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(174) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(175) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,3H), 3.99-4.01(m,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(176) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.12-7.15(d,2H), 7.21(s,1H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(177) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.88-6.90(d,1H), 7.02-7.04(t,1H), 7.21(s,1H), 7.53-7.55(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(178) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.35-6.37(d,1H), 6.88-6.90(d,1H), 6.93(s,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.49-7.52(d,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(179) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(180) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(181) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(182) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(183) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 6.93-6.95(t,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(184) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.51-7.52(d,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(185) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(186)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(187) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.79(s,6H), 3.83(s,3H), 5.35(s,1H), 5.71(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(188)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 5.98(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(189)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(190) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.88-6.90(d,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(191)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 5.46-5.48(d,1H), 6.88-6.90(d,1H), 7.10-7.11(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(192) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(193) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(194) (L)-2-(2-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (Refer to FIG. 4)

¹HMNR(DMSO, 400 MHz)δ:3.57-3.61(m,1H),3.66-3.70(m,1H),4.20-4.22(m,1H),5.08-5.11(q,1H),5.28-5.29(d,1H),6.29-6.30(d,1H), 7.28-7.32(t,1H), 7.57-7.61(m,1H), 7.67-7.73(m,4H), 8.02-8.06(m,3H), 8.57-8.59(m,1H), 8.78-8.80(m,1H), 10.47-10.49(d,1H), 13.62(s,1H);

(195) (L)-2-(2-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(196) 2-(2-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.36-7.38(t,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(197) 2-(2-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(198) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(199) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(200) 2-(2-pyridyl)-1H-benzimidazole-4(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(201) 2-(2-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(202) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(203) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(204) 2-(2-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(205) 2(2-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.38-8.41(d,1H), 8.43-8.45(d,1H), 8.59-8.60(d,1H);

(206) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.45-8.46(d,2H), 8.59-8.60(d,1H);

(207) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(208) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(209) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 11.53(s,1H);

(210) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(211) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(212) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 9.34(s,1H);

(213) 2-(2-pyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(214) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(215) 2-(2-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.87-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(216) 2-(2-pyridyl)-1H-benzimidazole-4(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.57-8.59(d,1H), 8.59-8.60(d,1H), 11.53(s,1H);

(217) (L)-2-(3-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.42-8.44(d,1H), 8.70-8.72(d,1H), 9.24(s,1H);

(218) (L)-2-(3-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.42-8.44(d,1H), 8.70-8.72(d,1H), 9.24(s,1H);

(219) 2-(3-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.42-8.44(d,1H), 8.70-8.72(d,1H), 9.24(s,1H);

(220) 2-(3-pyridyl)-1H-benzimidazole-4(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.41-8.43(d,1H), 8.45-8.46(d,2H), 8.70-8.72(d,1H), 9.24(s,1H);

(221) (L)-2-(4-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(222) (L)-2-(4-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);

(223) 2-(4-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);

(224) 2-(4-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.25-8.28(d,2H), 8.45-8.46(d,2H), 8.75-8.77(d,2H);

(225) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.64-7.67(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8.11(d,1H), 8.17-8.20(d,2H), 9.34-9.37(d,1H);

(226) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(227) 2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(228) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—N′-piperdinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(229) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(230) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(231) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(232) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(233) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carbonamido)-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 9.34-9.37(d,1H), 13.00-13.03(d,1H);

(234) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.34-9.37(d,1H), 13.71-13.75(d,1H);

(235) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(236) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.34-9.37(d,1H);

(237) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.45-8.46(d,2H), 9.34-9.37(d,1H);

(238) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.11-8.13(d,1H), 8.59-8.60(d,1H);

(239) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.12(s,1H), 9.34-9.37(d,1H);

(240) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.33(s,1H), 9.34-9.37(d,1H), 11.53(s,1H);

(241) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(242) 2-(3-pyridazinyl)-1H-benzimidazole-4(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(243) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.32(s,1H), 9.34-9.37(d,1H);

(244) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(245) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(246) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.16-8.18(d,1H), 9.34-9.37(d,1H);

(247) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.57-8.59(d,1H), 9.34-9.37(d,1H), 11.53(s,1H);

(248) (L)-2-(4-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(249) (L)-2-(4-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.30-9.32(d,1H), 9.46(s,1H);

(250) 2-(4-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.30-9.32(d,1H), 9.46(s,1H);

(251) 2-(4-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.30-9.32(d,1H), 9.46(s,1H);

(252) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(253) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(254) 2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(255) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(256) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m, 1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H),

(257) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(258) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(259) 2-(2-pyrazinyl)-b 1-l H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.931(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(260) 2-(2-pyrazinyl)-1H-benzimidazole-4(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.76-8.79(d,2H), 9.24-9.26(d,1H), 9.34(s,1H), 13.00-13.03(d,1H);

(261) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 13.71-13.75(d,1H);

(262) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(263) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(264) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.76-8.79(d,2H), 9.34(s,1H);

(265) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(266) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(267) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H);

(268) 2-(2-pyrazinyl)1H-benzimidazole-4(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(269) 2-(2-pyrazinyl)1H-benzimidazole-4(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(270) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 9.37(s,1H);

(271) 2-(2-pyrazinyl)1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(272) 2-(2-pyrazinyl)-1H)-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(273) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(274) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H);

(275) (L)-2-(2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(276) (L)-2-(2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(277) 2-(2-piperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(278) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.13-3.15(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(279) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,4H), 2.62-2.63(m,2H), 2.65-2.66(m,2H), 2.69-2.70(m,2H), 2.72-2.74(m,2H), 2.77-2.80(m,1H), 2.84-2.86(m,1H), 3.02-3.05(m,1H), 3.09-3.11(m,1H), 3.99-4.01(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(280) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(281) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(282) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(283) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(284) 2(2-piperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(285) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 1.94-1.95(m,1H), 2.62-2.63(m,1H), 2.65-2.67(t,5H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.80-2.83(m,4H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(286) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(287) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(288) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(289) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.45(s,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(290) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(291) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.82(s,6H), 5.71(s,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(292) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(293) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(294) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(295) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(296) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(297) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(298) (L)-2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(299) (L)-2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(300) 2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 1.91-1.93(m,2H), 2.40-2.43(m,4H), 2.59-2.60(d,1H), 2.62-2.63(m,1H), 2.64-2.65(t,1H), 2.66-2.67(m,1H), 2.68-2.70(t,2H), 2.72-2.73(m,1H), 2.74-2.75(t,1H), 2.76-2.78(t,1H), 2.77-2.80(m,1H), 2.88-2.90(d,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 4.14-4.16(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(301) 2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 4.14-4.16(t,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(302) (L)-2-(N-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3.18-3.22(t,4H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(303) (L)-2-(N-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3.18-3.22(t,4H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(304) 2-(N-piperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(305) 2-(N-piperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.10-3.15(t,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(306) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.78-2.82(m,5H), 3.02-3.05(m,1H), 3.17-3.22(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(307) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(308) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(309) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(310) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(311) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(312) 2-(N-piperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,2H), 2.65-2.67(t,4H), 2.78-2.80(m,4H), 2.81-2.83(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(313) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(314) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(315) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(316) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.45(s,3H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(317) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(318) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(319) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(320) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(321) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(322) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(323) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(324) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(325) (L)-2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(326) (L)-2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(327) 2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 1.91-1.93(m,2H), 2.38-2.41(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(328) 2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(329) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(330) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.95-6.97(d,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(331) 2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(332) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(333) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(334) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(335) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.27(s,2H), 6.38-6.39(d,1H), 6.40-6.42(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.95-6.97(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(336) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.35-6.37(d,1H), 6.40-6.42(d,1H), 6.93(s,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(337) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(338) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(339) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(340) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(341) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:6.15-6.18(t,1H),6.40-6.42(d,1H),6.93-6.95(t,1H), 6.98-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(342) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(343) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(344) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:6.15-6.18(t,1H),6.40-6.42(d,1H),6.95-6.97(d,1H),7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(345) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:3.82(s,6H), 5.71(s,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(346) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(347) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(348) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.90-6.93(d,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(349) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:5.46-5.48(d,1H),6.15-6.18(t,1H),6.40-6.42(d,1H),6.95-6.97(d,1H),7.10-7.11(d,1H),7.43-7.45(t,1H),7.82(s,1H),7.89-7.91(d,1H),7.93-7.94(d,1H);

(350) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H),7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(351) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(352) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.99(s,2H),7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(353) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR(DMSO, 400 MHz)δ: 2.45(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.99(s,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(354) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 2.45(s,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.99(s,2H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(355) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.45(s,3H), 3.10-3.15(t,4H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(356) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.45(s,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(357) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(358) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.99(s,2H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(359) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(360) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(361) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(362) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.45(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.99(s,2H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(363) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(364) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.93-6.95(t,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(365) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(366) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,6H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(367) 2-(4-methyl-5-aminothiazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(368) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.82(s,6H), 5.71(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(369) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 5.98(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(370) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(371) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.97(t,1H), 6.99(s,2H), 7.02-7.05(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(372) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 5.46-5.48(d,1H), 6.99(s,2H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(373) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(374) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(375) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.64-7.65(d,2H), 7.76-7.77 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.17-8.20(d,2H), 8.44-8.46(d,1H);

(376) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.40-8.41(d,1H), 8.44-8.46(d,1H);

(377) 2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.35-7.37(d,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(378) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(379) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(380) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(381) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(382) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(383) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.37(s,2H), 8.44-8.46(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(384) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(385) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(386) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.44-8.46(d,1H);

(387) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.40-8.43(d,1H), 8.45-8.46(d,2H);

(388) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.04-8.05(d,1H), 8.07-8.09(d,1H), 8.44-8.46(d,1H);

(389) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.12(s,1H), 8.44-8.46(d,1H);

(390) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.33(s,1H), 8.44-8.46(d,1H), 11.53(s,1H);

(391) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(392) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.74(s,2H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(393) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 9.34(s,1H);

(394) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), s 8.44-8.46(d,1H);

(395) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(396) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.16-8.18(d,1H), 8.44-8.46(d,1H);

(397) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 11.53(s,1H);

(398) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.59-7.60(t,1H), 7.62-7.65(d,2H), 7.77-7.79(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.17-8.20(d,2H), 8.22(s,1H), 8.57(s,1H);

(399) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.77-7.79(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.57(s,1H);

(400) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.57(s,1H);

(401) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.77-7.79(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.45-8.46(d,2H), 8.57(s,1H);

(402) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(403) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(404) 2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(405) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.51(m,1H), 1.53-1.55(m,4H), 1.55-1.57(m,1H), 1.59-1.63(m,2H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.10-3.15(t,4H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(406) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.87-1.88(m,1H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.73(m,1H), 2.75-2.76(m,1H), 2.77-2.80(m,1H), 2.82-2.85(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 4.03-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(407) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(408) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(409) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(410) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(411) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(412) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.84-1.89(m,1H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 2.84-2.85(m,4H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(413) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(414) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(415) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(416) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.45(s,3H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(417) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(418) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(419) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(420) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(421) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(422) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(423) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(424) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(425) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.71-2.73(m,1H), 2.74-7.76(m,1H), 2.78-2.80(m,1H), 2.90-2.92(t,1H), 3.12-3.15(t,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(426) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.71-2.73(m,1H), 2.74-7.76(m,1H), 2.78-2.80(m,1H), 2.90-2.92(t,1H), 3.12-3.15(t,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(427) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.89-1.90(m,2H), 1.92-1.95(m,1H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.69-2.70(m,1H), 2.71-2.72(m,1H), 2.74-7.76(m,1H), 2.77-2.80(m,1H), 2.82-2.84(m,1H), 2.90-2.92(t,1H), 3.02-3.05(m,1H), 3.15-3.17(t,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(428) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

(429) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(430) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(431) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.89-1.90(m,2H), 1.92-1.95(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.67-2.68(m,1H), 2.69-2.71(m,2H), 2.72-2.74(m,1H), 2.75-2.76(m,1H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(432) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(433) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.14-8.16(d,1H), 8.17-8.20(d,2H), 8.60-8.62(d,1H);

(434) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.01-7.04(t,1H), 7.11-7.13(d,2H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(435) 2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.01-7.04(t,1H), 7.29-7.30(d,2H), 7.31-7.33(t,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(436) 2-(3-indolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(437) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(438) 2-(3-indolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(439) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.06-7.08(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(440) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.50-7.52(d,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(441) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(442) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.57-8.59(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(443) 2-(3-indolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(444) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.60-8.62(d,1H);

(445) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.45-8.46(d,2H), 8.60-8.62(d,1H);

(446) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.57-7.58(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(447) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(448) 2-(3-indolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.33(s,1H), 8.60-8.62(d,1H), 11.53(s,1H);

(449) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(450) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(451) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H), 9.34(s,1H);

(452) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.02-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(453) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.01-7.04(t,1H), 7.10-7.11(d,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(454) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.13-8.15(d,1H), 8.17-8.19(d,1H), 8.60-8.62(d,1H);

(455) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.57-8.59(d,1H), 8.60-8.62(d,1H), 11.53(s,1H);

(456) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 13.00-13.03(d,1H);

(457) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 13.00-13.03(d,1H);

(458) 2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(459) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(460) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(461) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(462) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.05-7.08(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(463) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(464) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H), 13.05-13.07(d,1H);

(465) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.00-13.03(d,1H), 13.71-13.75(d,1H);

(466) 2-(2-imidazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(467) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 13.00-13.03(d,1H);

(468) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 13.00-13.03(d,1H);

(469) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 13.00-13.03(d,1H);

(470) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 13.00-13.03(d,1H);

(471) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H), 13.00-13.03(d,1H);

(472) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(473) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(474) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H), 13.00-13.03(d,1H);

(475) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.95-6.96(t,1H), 6.97-6.99(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(476) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(477) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 13.00-13.03(d,1H);

(478) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H), 13.00-13.03(d,1H);

(479) (L)-2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.85-7.87(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 12.62-12.64(d,1H);

(480) (L)-2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.48-6.50(d,1H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 12.62-12.64(d,1H);

(481) 2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.48-6.50(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(482) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(483) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(484) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(485) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.48-6.50(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(486) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.48-6.50(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(487) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 12.62-12.64(d,1H), 13.00-13.03(d,1H);

(488) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 12.62-12.64(d,1H), 13.71-13.75(d,1H);

(489) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(490) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 12.62-12.64(d,1H);

(491) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 12.62-12.64(d,1H);

(492) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 12.62-12.64(d,1H);

(493) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 12.62-12.64(d,1H);

(494) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.85-7.87(t,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H), 12.62-12.64(d,1H);

(495) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(496) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(497) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H), 12.62-12.64(d,1H);

(498) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(499) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 6.48-6.50(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(500) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 12.62-12.64(d,1H);

(501) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H), 12.62-12.64(d,1H);

(502) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(503) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.67-7.70(t,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.08-9.11(d,2H);

(504) 2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(505) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(506) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(507) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(508) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(509) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(510) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.08-9.11(d,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(511) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.08-9.11(d,2H), 13.71-13.75(d,1H);

(512) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(513) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.08-9.11(d,2H);

(514) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.08-9.11(d,2H);

(515) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.08-9.11(d,2H);

(516) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.08-9.11(d,2H);

(517) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.08-9.11(d,2H), 11.53(s,1H);

(518) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.67-7.70(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(519) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(520) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H), 9.34(s,1H);

(521) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(522) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(523) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.08-9.11(d,2H);

(524) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.08-9.11(d,2H), 11.53(s,1H);

(525) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.28-8.31(d,2H), 9.26(s,2H);

(526) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(527) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.38-7.39(t,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(528) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(529) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(530) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(531) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(532) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(533) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.37(s,2H), 9.24-9.26(d,1H), 9.29(s,2H)13.00-13.03(d,1H);

(534) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.61(s,1H), 8.63-8.65(d,1H), 9.26(s,2H), 13.71-13.75(d,1H);

(535) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(536) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.26(s,2H);

(537) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.45-8.46(d,2H), 9.26(s,2H);

(538) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(539) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(540) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.33(s,1H), 9.26(s,2H), 11.53(s,1H);

(541) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(542) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(543) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H), 9.34(s,1H);

(544) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(545) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(546) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(547) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.57-8.59(d,1H), 9.26(s,2H), 11.53(s,1H);

(548) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(549) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.59(s,1H);

(550) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(551) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(552) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(553) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(554) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(555) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(556) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.59(s,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(557) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(558) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.74(s,2H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(559) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.59(s,1H);

(560) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.59(s,1H);

(561) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.59(s,1H);

(562) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.59(s,1H);

(563) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.59(s,1H), 11.53(s,1H);

(564) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(565) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,4H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(566) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H), 9.34(s,1H);

(567) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(568) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(569) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.59(s,1H);

(570) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 8.62(s,1H), 11.53(s,1H);

(571) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.02(s,2H);

(572) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.02(s,2H);

(573) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.92-1.95(m,4H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(574) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.92-1.95(m,4H), 3.10-3.15(t,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(575) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.87-1.89(m,2H), 1.92-1.95(m,4H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.44-3.48(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(576) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(577) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(578) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(579) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(580) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H);

(581) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.87-1.89(m,1H), 1.92-1.95(m,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(582) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H);

(583) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H);

(584) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.02(s,2H);

(585) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 2.45(s,3H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H);

(586) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H);

(587) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(588) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(589) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H);

(590) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(591) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(592) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.02(s,2H);

(593) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H);

(594) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.73-3.77(t,4H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.02(s,2H);

(595) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.71-3.75(t,4H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.02(s,2H);

(596) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.71-3.75(t,4H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(597) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,8H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(598) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.71-3.75(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(599) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(600) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(601) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(602) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(603) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H);

(604) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(605) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H);

(606) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H);

(607) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.02(s,2H);

(608) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 2.45(s,3H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H);

(609) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H);

(610) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(611) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(612) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H);

(613) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(614) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(615) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.02(s,2H);

(616) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H);

(617) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.02(s,2H);

(618) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.02(s,2H);

(619) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.12-1.15(d,3H), 1.35-1.37(m,1H),3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(620) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperodinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.52-1.55(m,4H),1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(621) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(622) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(623) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(624) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(625) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(626) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H);

(627) 2-(2-cyclopropylamino-5-pyrimidinyl)1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.91-1.95(m,1H),2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(628) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H);

(629) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H);

(630) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.02(s,2H);

(631) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 2.45(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H);

(632) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H),7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H);

(633) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.82(s,6H),5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(634) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(635) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H);

(636) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(637) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(638) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.02(s,2H);

(639) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H);

(640) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.95(s,3H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(641) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H),3.17-3.18(m,1H),3.25-3.28(m,1H),3.50-3.52 (m,1H),3.65-3.68(t,1H),3.70-3.72(d,1H),3.95(s,3H),4.73-4.77(t,1H),6.27(s,2H),6.56-6.58 (d,2H),7.11-7.13(d,2H),7.43-7.45(t,1H),7.89-7.90(d,1H),7.93-7.95(d,1H);

(642) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 2.06(s,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.95(s,3H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(643) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.06(s,3H), 3.10-3.15(t,4H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(644) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR(DMSO,400 MHz)δ:1.91-1.93(m,2H), 2.06(s,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.95(s,3H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(645) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(646) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(647) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(648) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(649) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(650) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.06(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.95(s,3H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(651) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(652) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(653) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(654) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 2.45(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(655) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(656) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.82(s,6H), 3.95(s,3H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(657) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(658) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(659) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H), 3.95(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(660) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H), 3.95(s,3H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(661) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(662) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(663) 2-(4-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (Refer to FIG. 5)

¹HNMR(DMSO,400 MHz)δ:7.13-7.19(m,1H),7.23-7.27(t,1H),7.36-7.41(t,1H),7.50-7.54(m,2H), 7.85-7.87(d,1H), 7.94-7.95(d,1H), 8.05-8.07(d,1H), 8.57-8.61(t,1H), 12.19-12.20(d,1H), 14.25(s,1H);

(664) (L)-2-(3-hydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (Refer to FIG. 6)

¹HNMR(DMSO,400 MHz)δ:3.51-3.57(m,1H),3.64-3.72(m,1H),4.22-4.26(m,1H),5.05-5.08(q,1H),5.25-5.27(d,1H),6.16-6.18(d,1H),6.95-6.98(d,1H), 7.23-7.27(t,1H),7.30-7.34(t,1H),7.36-7.40(m,1H),7.65-7.73(m,4H),7.80-7.84(m,1H), 8.03-8.10(m,2H), 9.76(s,1H), 10.43-10.46(d,1H), 13.31(s,1H);

(665) 2-(3-hydroxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.35(s,1H), 6.91-6.93(d,1H), 7.04(s,1H), 7.34-7.36(d,1H), 7.43-7.45(t,1H), 7.84-7.86(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H).

EXAMPLES 666-688

1.0 g of 2,3-diaminobenzoic acid is dissolved into 20 ml of glacial acetic acid. Triethyl orthoformate (2.1 eq.) is added into the above mixture at temperature of 0° C.; and to stir it for 2 hours at temperature of 0˜5° C.; and 150 ml of water is added into it, and then to isolate and filter to produce 2-ethoxy-1H-benzimidazole-4-formic acid. The yield is about 89%. 2-ethoxy-1H-benzimidzzole-4-formic acid is added into 15 ml of thionyl chloride, and to react for 60 minutes, and after end of the reaction completely, and (L)-2-amino-1-p-nitrophenyl-1,3-propylene glycol (1.1 eq) is added into the reaction mixture under stirring for 2 hours at the room temperature, and then to filter the inorganic salt, and evaporate the solvent to dry, to obtain the final product of (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide. The yield is about 91%. Using the same process to prepare the compounds in Table 3.

TABLE 3

Field

No.
Compounds
X
Y
%

666
(L)-2-ethoxy-1H-benzimidazole- 4-[N-(1-hydroxymethyl- 2-p-nitrophenylhydroxyethyl)]amide

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94

667
(L)-2-ethoxy-1H-benzimidazole- 4-[N-(1-hydroxymethyl- 2-p-aminophenylhydroxyethyl)]amide

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91

668
2-ethoxy-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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92

669
2-ethoxy-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

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92

670
2-ethoxy-1H-benzimidazole- 4-(N-2-piperazinyl))amide

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93

671
2-ethoxy-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

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94

672
2-ethoxy-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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89

673
2-ethoxy-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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91

674
2-ethoxy-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

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86

675
2-ethoxy-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

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93

676
2-ethoxy-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

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91

677
2-ethoxy-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

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92

678
2-ethoxy-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

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92

679
2-ethoxy-1H-benzimidazole- 4-(N-2-pyridyl)amide

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93

680
2-ethoxy-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

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94

681
2-ethoxy-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

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85

682
2-ethoxy-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

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94

683
2-ethoxy-1H-benzimidazole- 4-(N-4-chloro-6-amino- 2-pyrimidinyl)amide

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89

684
2-ethoxy-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

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685
2-ethoxy-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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93

686
2-ethoxy-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

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87

687
2-ethoxy-1H-benzimidazole- 4-(N-6-purinyl)amide

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93

688
2-ethoxy-1H-benzimidzzole- 4-(N-6-hydroxyl-2-purinyl)amide

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Structure Identification of Products
(666) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H),3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.29-4.33(m,2H), 4.73-4.77(t,1H), 7.43-7.45(t,1H),7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(667) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H),3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.29-4.33(m,2H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(668) 2-ethoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.32-1.35(t,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.29-4.33(m,2H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(669) 2-ethoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H),4.29-4.33(m,2H),7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(670) 2-ethoxy-1H-benzimidazole-4-(N-2-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m, 1H), 3.99-4.01(m,1H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(671) 2-ethoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(672) 2-ethoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(673) 2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(674) 2-ethoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(675) 2-ethoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(676) 2-ethoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(677) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(678) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(679) 2-ethoxy-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(680) 2-ethoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 2.45(s,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(681) 2-ethoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(682) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 3.82(s,6H), 4.29-4.33(m,2H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(683) 2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(684) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(685) 2-ethoxy-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(686) 2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(687) 2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(688) 2-ethoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H).

Measures of Properties:

Measures of Anti-Coxsackie B3 Viruses Activity of the Compounds

The products are applied for measures of antivirus properties of Vero cells. Refer to the results of Table 3: datum of anti-coxsackie B3 viruses activities of some compounds.

TABLE 3

NAME OF

COMPOUNDS
X
Y
IC₅₀(μg/ml)

(L)-2-(2-pyridyl)-1H- benzimidazole-4-[N-(1-hydroxymethyl- 2-p-nitrophenylhydroxyethyl)]amide

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1.76

2-(2-pyridyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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4.115

2-(3-pyridyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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2.37

(L)-2-(2-thienyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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15.90

2-(2-thienyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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5.30

(L)-2-(5-nitro-2-thienyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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10.69

2-(5-nitro-2-thienyl)-1H- benzimidazole-4-(N-(1-methyl- 2-p-chlorophenylhydroxyethyl))-amide

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7.12

2-thienyl-1H-benzimidazole-4- (N-(2-fluorophenyl)-amide

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1.06

2-(5-nitro-2-thienyl)-1H- benzimidazole-4-(N-(2-fluorophenyl))- amide

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>9.25

(L)-2-(5-amino-2-thienyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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2.3

2-(5-amino-2-thienyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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3.5

2-(5-amino-2-thienyl)-1H- benzimidazole-4-(N-o- methylphenyl)amide

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8.7

2-(5-amino-2-thienyl)-1H- benzimidazole-4-(N-p- hydroxyphenyl)amide

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6.5

2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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10.2

(L)-2-(4-methoxypyridyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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6.3

2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o- hydroxyphenyl)amide

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16.2

2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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13.4

(L)-2-(6-methoxypyridyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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11.2

2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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14.1

2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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15.7

2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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16.8

(L)-2-(4-dimethylaminopyridyl)- 1H-benzimidazole- 4-[N-(1-hydroxymethyl- 2-p-nitrophenylhydroxyethyl)]amide

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10.2

2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- (N-o-fluorophenyl)amide

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9.6

2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- (N-o-hydroxyphenyl)amide

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9.8

2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- (N-p-aminophenyl)amide

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10.2

(L)-2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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5.8

2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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12.3

2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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15.2

2-(3-pyridazinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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10.2

(L)-2-(2-N-methyl-4-N- methylpiperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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9.2

2-(2-N-methyl-4-N- methylpiperazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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8.9

2-(5-methy-2-thienyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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18.5

2-(2-N-methyl-4-N- methylpiperazinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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3.5

(L)-2-(2-pyrazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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2.3

2-(2-pyrazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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6.5

2-(2-pyrazinyl)-1H -benzimidazole-4-(N-o- hydroxyphenyl)amide

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3.5

2-(2-pyrazinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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4.2

(L)-2-N-piperazinyl-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-o- nitrophenylhydroxyethyl)]amide

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4.2

2-N-piperazinyl-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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4.8

2-N-piperazinyl-1H- benzimidazole-4-(N-p- aminophenyl)amide

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6.3

(L)-2-(4-methyl-5- aminothiazolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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8.9

2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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10.2

2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole- 4-(N-p-aminophenyl)amide

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9.8

(L)-2-thiazolyl-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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11.2

5-thiazolyl-1H- benzimidazole-4-(N-p- aminophenyl)amide

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13.5

(L)-2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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10.2

2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4- (N-p-hydroxyphenyl)amide

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11.2

(L)-2-(2-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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9.8

2-(2-pyrimidinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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8.8

2-(2-pyrimidinyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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7.8

2-(2-pyrimidinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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9.8

(L)-2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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12.0

2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- (N-o-fluorophenyl)amide

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12.6

2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- (N-o-hydroxyphenyl)amide

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13.2

2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- (N-p-aminophenyl)amide

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15.2

(L)-2-(4-amino-6-chloro- 5-pyrimidinyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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17.2

2-(4-amino-6-chloro-5- pyrimidinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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11.3

2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole- 4-(N-o-hydroxyphenyl)amide

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12.3

2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole- 4-(N-p-aminophenyl)amide

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14.1

(L)-2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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5.3

2-(2-pyrrolyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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9.2

(L)-2-(3,5-dimethyl-2- pyrrolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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8.6

2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4- (N-o-hydroxyphenyl)amide

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10.2

(L)-2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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11.1

2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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13.2

(L)-2-(2-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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17.2

2-(2-quinolinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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15.3

2-(3-indolyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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10.8

(L-)2-(3-indolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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9.6

RBV
—
—
353.55

In the above table: “-” indicates that these samples don't have anti-coxsackie B3 viruses activities at the maximum nontoxic dose.

IC₅₀indicates half inhibitory concentration for viruses.

RBV indicates triazole nucleoside, is also called ribavirin, virazole.

It may be seen from the result of test, these compounds have better properties of anti-coxsackie B3 viruses. These compounds of the present invention have better effects on the coxsackie viruses of the picornaviridae and can inhibit coxsackie viruses. Although the present invention has been described in connection with the above embodiments, it should be understood that the present invention is not limited to such preferred embodiments and procedures set forth above. The embodiments and procedures were chosen and described in order to best explain the principles of the invention and its practical application, to thereby enable others skilled in the art to best utilize the invention. It will be apparent to those skilled in the art that various substitution, modifications and changes may be thereto without departing from the scope and spirit of the invention. Therefore, the intention is intended to cover all alternative constructions and equivalents falling within the spirit and scope of the invention as defined only by the appended claims and equivalents thereto.

Claims

1. Benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof of the formula,
2. The benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to claim 1, wherein X is selected from the group consisting of monosubstituted, or polysubstituted or unsubstituted alkoxy; monosubstituted, or polysubstituted or unsubstituted alkyl; monosubstituted, or polysubstituted or unsubstituted alkenyl; monosubstituted, or bisubstituted or unsubstituted thienyl; monosubstituted, or bisubstituted or unsubstituted pyridyl; monosubstituted, or bisubstituted or unsubstituted pyridazinyl;monosubstituted, or bisubstituted or unsubstituted piperazinyl; monosubstituted, or bisubstituted or unsubstituted pyrazinyl; monosubstituted, or bisubstituted or unsubstituted thiazolyl; monosubstituted, or bisubstituted or trisubstituted or unsubstituted phenyl; monosubstituted, or bisubstituted or unsubstituted pyrimidinyl; monosubstituted, or bisubstituted or unsubstituted pyrrolyl; monosubstituted, bisubstituted or unsubstituted quinolinyl; monosubstituted, or bisubstituted or unsubstituted piperidinyl; monosubstituted, or bisubstituted or unsubstituted indolyl; monosubstituted, or bisubstituted or trisubstituted or unsubstituted imidazolyl; and monosubstituted, bisubstituted, or trisubstituted or unsubstituted pyrazolyl.
3. The benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to claim 2, wherein X is selected from the group consisting of C1-C6 alkyloxy substituted by nitro, amino, hydroxyl or aryl; C1-C6 alkyl substituted by nitro, amino, hydroxyl or aryl; C2-C14 alkenyl substituted by alkyl, hydroxyl or aryl; thienyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted thienyl; pyridyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted pyridyl; quinolinyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted quinolinyl; indolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted indolyl; pyridyl monosubstituted or bisubstituted by C1-C6 alkoxy; pyridyl monosubstituted or bisubstituted by C1-C3 dialkylamino; pyridyl monosubstituted or bisubstituted by C1-C6 alkyl; unsubstituted pyridyl; pyridazinyl monosubstituted by C1-C6 alkoxy; pyridazinyl monosubstituted by C1-C6 alkyl; unsubstituted pyridazinyl; unsubstituted piperazinyl; piperazinyl bisubstituted by C1-C6 alkyl; unsubstituted piperidinyl; unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted imidazolyl; thiazolyl bisubstituted by C1-C6 alkyl and nitro; unsubstituted pyrimidinyl; pyrimidinyl monosubstituted by phenyl; pyrimidinyl bisubstituted by amino and a group selected from nitro, —F, —Cl, —Br or —I; phenyl trisubstituted by trihydroxyl; phenyl trisubstituted by trimethoxyl; phenyl bisubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from methyl, ethyl, carboxyl or amido; and pyrazolyl bisubstituted or trisubstituted by a group selected from C1-C6 alkyl or aryl and a group selected from —F, —Cl, —Br or —I.
4. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 1, wherein, Y is selected from the group consisting of hydroxyl, C1-C6 alkyl, monosubstituted or bisubstituted or trisubstituted phenyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzpyrimidinyl, monosubstituted or bisubstituted or trisubstituted or tetrasubstituted or unsubstituted benzimidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzimidazolonyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, and monosubstituted or bisubstituted or trisubstituted or unsubstituted purinyl.
5. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 4, wherein Y is selected from the group consisting of hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C1-C6 alkylphenyl, phenyl monosubstituted by —F, —Cl, —Br or —I, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C1-C6 alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyridyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted, by C1-C6 alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, thiazolyl monosubstituted by C1-C6 alkyl, pyrimidinyl monosubstituted or bisubstituted or unsubstituted by C1-C6 alkyl, pyrimidinyl monosubstituted by C1-C6 alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted C1-C6 alkyl and bisubstituted or trisubstituted by —F, —Cl, —Br or —I, purinyl monosubstituted or bisubstituted or unsubstituted by C1-C6 alkyl, and purinyl monosubstituted by C1-C6 alkyl and substituted or trisubstituted by hydroxyl.
6. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 1, wherein the derivatives are one of: (L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-chlorophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-bromophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-chlorophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-bromophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-methylphenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-hydroxylphenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-methylphenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-hydroxylphenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-methylphenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-hydroxylphenyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-N-piperazinyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-N-piperazinyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-thiazolyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,5-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,5-thiazolyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide,(L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide,(L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-methoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-methoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-methoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-methoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-methoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-methoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-methoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-methoxy-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-methoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-methoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-methoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-methoxy-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-methoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-methoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-2-pyridyl)amide,2-methoxy-1H-benzimidazole-4-(N-3-pyridyl)amide,2-methoxy-1H-benzimidazole-4-(N-4-pyridyl)amide,2-methoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-methoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-methoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-ethoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-ethoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-ethoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-ethoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-ethoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-ethoxy-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2-pyridyl)amide,2-ethoxy-1H-benzimidazole-4-(N-3-pyridyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4-pyridyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-ethoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-pyrazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-pyrazolyl-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-pyrazolyl-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2-pyridyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-3-pyridyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4-pyridyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(3-indolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-bromo-5-pyridine)-2-pyrimidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyridyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-pyrrolidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(5-thiazolyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-piperidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(5-thiazolyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-cyclopropylamino-5-pyrimidinyl)-2-pyrimidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide,(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(5-thiazolyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-6-purinyl)amide,2-N-piperazinyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-6-purinyl)amide,2-thiazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-6-purinyl)amide,5-thiazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-methoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-methoxy-1H-benzimidazole-4-(N-6-purinyl)amide,2-methoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide,2-ethoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-6-purinyl)amide,2-pyrazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2′-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(2-cyclopropylamino)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide,2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide, and2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide.
7. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to claim 1, wherein the pharmaceutically acceptable salts of benzimidazole-4-carboxamide derivatives are inorganic acid salts thereof selected from sulfate, hydrochloride, nitrate, phosphate or boratethe, or organic acid salts thereof selected from citrate, succinate, tartrate, lactate or mesylate.
8. A pharmaceutical composition, comprising a therapeutically effective amount of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to claim 1, and one or more pharmaceutically acceptable thinner, excipient and/or inert carrier.
9. A use of benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to claim 1 for preparation of antivirus medications.
10. The use according to claim 9, wherein the viruses comprise coxsackie virus, echovirus and enterovirus of Picornaviridae.
11. A method of preparing for benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof for the compound shown in claim 1, comprising the following steps: undergoing reactions of ammonolysis, Hoffman degradation and reduction by 2-aminoacetyl-3-nitrobenzoic acid to produce 2,3-diamino benzoic acid;condensing 2,3-diamino benzoic acid with aldehydes X—CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid as shown in the formula;
12. The method according to claim 11, wherein benzimidazole-4-carboxylic acid is treated with thionyl chloride at temperature of 0˜80° C. in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1˜20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0˜100° C. to produce benzimidazole-4-carboxamide derivatives.
13. The method according to claim 12, wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene.

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Number	Date	Country	Kind
200910045056.8	Jan 2009	CN	national

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Filing Document	Filing Date	Country	Kind	371c Date
PCT/CN10/00024	1/6/2010	WO	00	7/8/2011

Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses

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