Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of the following patent applications:

1. Patent application number 200910045056.8 titled “Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses”, filed on Jan. 8, 2009 in the State Intellectual Property Office of the People's Republic of China.
2. Patent application number 201010000050.1 titled “Benzimidazole-4-Carboxamide Derivatives, Their Preparation Methods, Pharmaceutical Compositions And Their Uses”, filed on Jan. 5, 2010 in the State Intellectual Property Office of the People's Republic of China.

The specifications of the above referenced applications are incorporated herein by reference in their entirety.

FIELD OF THE INVENTION

The present invention relates to benzimidazole carboxamide derivatives, in particular, relates to the benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses.

BACKGROUND OF THE INVENTION

The diseases caused by virus infections severely threaten human health and life and have become major problems in the medical fields. Almost 70% of epidemic diseases are caused by viruses infections statistically. The infectious diseases caused by enteroviruses have often occurred all over the world. The enteroviruses belong to picornaviridae comprising polio viruses, cosxackie viruses, enteric cytopathogenic human orphan virus and new enteroviruses. Each viruses has many serums, at least more than 70 types, which can violate many kinds of tissues, such as nerves, cardiac muscles, muscles, skins and eye conjunctiva etc and can cause lots of infectious diseases all over the world. There are lots of categories of the cosxackie viruses, whose transmission route and pathogenesis are similar to that of poliomyelitis virus, and often occurs latent infections. Their symptom shows slight upper respiratory infections or diarrhea, and occasionally inflects central nervous systems, damages spinal cord anterior horn motor neurons, and causes flaccid paralysis of limbs, however, this symptom is relatively light. The cosxackie viruses can violate many tissues and systems, such as respiratory tracts, intestinal tracts, skins, muscles, hearts, livers, adrenal gland and central nervous systems, Clinical manifestations have various of symptoms such as (1) respiratory tract infection, (2) herpangina, (3) febrile rush, (4) hand-foot-and-mouth disease, (5) diarrhea of children, (6) central nervous system syndrome, (7) myocarditis and pericarditis, (8) epidemic chest pain or epidemic myalgia, (9) epidemic conjunctivitis, (10) coxsackie virus hepatitis and so on.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide benzimidazole-4-carboxamide derivatives having anti-coxsackie virusesor a pharmaceutically acceptable salts thereof as shown in Formula (I).

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Wherein, X represents monosubstituted or bissubstituted or polysubstitued C₁-C₁₄alkoxy, monosubstituted or bisubstituted or polysubstitued C₁-C₁₄alkyl, monosubstituted or bisubstituted or polysubstitued C₂-C₁₄alkenyl, monosubstituted or bisubstituted or polysubstitued C₆-C₁₄aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom;

Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C₁-C₁₆alkyl, monosubstituted or bisubstituted or polysubstitued C₆-C₁₂aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom.

Wherein: X is selected from one of the following groups:

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wherein R is selected from —H, or

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wherein n is selected from 0 to 5, R_wy1, R_wy2, R_wy3, R_wy4and R_wy5are respectively and independently selected from —H, —CH₃, or —CH₂CH₃;

n=0˜5; R₁, R₂, R₃, R₄and R₅are respectively and independently selected from —H, —CH₃, —F, —Cl, —Br, —I, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —NH—CH₃, —NH—CH₂CH₃, —NH—CH₂CH₂OH,

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or phenyl substituted by one or several substituents Ra, Ra is selected from —F, —Cl, —Br, —I, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —CH₂CH₂OH, —NO₂, —NH₂, —N(CH₃)₂, —N(CH₂CH₃)₂, —N(CH₂CH₂OH)₂, —CN, —COOH, —COOCH₃, —COOCH₂CH₃, or —COOC₆H₅;

R₁′, R₂′ and R₃′ are respectively and independently selected from —H, —CH₃, —CH₂CH₃, or

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wherein n is an integer between 0 and 5; R₁″ and R₂″ are respectively and independently selected from —H, —CH₃, or —CH₂CH₃;

R₉, R₁₀, R₁₁, R₁₂and R₁₃are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —COOH, —COOCH₃, —COOCH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —CN, —F, —Cl, —Br, —I, or —NH₂, —N(CH₃)₂, or —N(CH₂CH₃)₂;

R₁₇, R₁₈, R₁₉, R₂₀, R′₁₇, R′₁₈, R′₁₉, R′₂₀, R″₁₇, R″₁₈, R″₁₉and R″₂₀are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —CF₃, —CCl₃, —CBr₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —NO or —NO₂, which cannot represent H simultaneously;

R₂₃, R₂₄, R₂₅, R′₂₃, R′₂₄and R′₂₅are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —F, —Cl, —Br, —I, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —COOH, —COOCH₃, or —COOCH₂CH₃;

R₂₉, R₃₀and R₃₁are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R₃₄, R₃₆and R₄₁are respectively and independently selected from —H, —(CH₂)_nCH₃, —CH₂OH, —CH₂CH₂OH, —CH(CH₃)₂or —CH₂CH(OH)CH₃, n is an integer between 0 and 5;

R₃₅, R₃₇, R₃₈, R₃₉, R₄₀, R₄₂and R₄₃are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Z is selected from N, O or S.

R₄₄, R₄₅, R₄₆, R′₄₄, R′₄₅and R′₄₆are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —CN or —COOH, —COOCH₃, or —COOCH₂CH₃;

R_s1, R_s2, R′_s1and R′_s2are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, —I, or NHCOCH₃, NHCOCH₂CH₃, or NHCOC₆H₅;

R_m1, R_m2, R_m3, R′_m1, R′_m2and R′_m3are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —F, —Cl, —Br, —I, —OH, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂,

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or —NHC₆H₅;

R_k1, R_k2, R_k3, R_k4, R_k5and R_k6are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R_P1, R_P2, R_P3and R_P4are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R_y1, R_y2, R_y3and R_y4are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Rmz1 is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅; Rmz2 and Rmz3 are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Rbz1 is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅; Rbz2 and Rbz3 are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

Y is selected from one group of the following groups:

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wherein, R₅₀, R₅₁, R₅₂, R₅₃, R₅₄, R₅₅, R₅₆, R₅₇, R₅₈, R₅₉, R₆₀, R₆₁, R₆₂, R₆₃, R₆₄, R₆₅, R₆₆, R₆₇, R₆₈, R₆₉, R₇₀, R₇₁, R₇₂and R₇₃are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —CH₂OH, —OH, —OCH₃, —OCH₂CH₃, —CN, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, —I, or —C₆H₅, —C₆H₄—CH₃, —C₆H₄—OH, —C₆H₄—NO₂, or —C₆H₄—NH₂;

R₇₇, R₇₈, R₇₉, R₈₀and R₈₁are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —CN, —COOH, —COOCH₃, —COOCH₂CH₃, —F, —Cl, —Br, —I, —CF₃, —CCl₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂;

R₈₅, R₈₆and R₈₇are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH or —NH₂; R′₈₅, R′₈₆and R′₈₇are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —C₆H₅, or —CH₂C₆H₄;

Q is selected from N, O or S;

R₈₈, R₈₉, R₉₀, R′₈₈, R′₈₉and R′₉₀are respectively and independently selected from —H, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —CN, —COOH, —COOCH₃, or —COOCH₂CH₃;

R₉₄, R₉₅, R′₉₄and R′₉₅are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, —I, or —NHCOCH₃, NHCOCH₂CH₃, or NHCOC₆H₅;

R₉₆is selected from —H, —CH₃, —CH₂CH₃, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, or —N(CH₂CH₂OH)₂; R′₉₆is selected from —H, —CH₃, —CH₂CH₃, —C₆H₅, or —CH₂C₆H₄;

R_b1, R_b2, R_b3and R_b4are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —CH₂OH, —OH, —OCH₃, —OCH₂CH₃, —CN, —NO₂, —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —F, —Cl, —Br, or —I;

R_mz1is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅; R_mz2and R_mz3are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OCH₃, —CH₂OH, —NO₂or —NH₂, —NHCH₃, —N(CH₃)₂, —NHCH₂CH₃, —N(CH₂CH₃)₂, —NHCH₂CH₂OH, —N(CH₂CH₂OH)₂, —CONH₂, or —COOH;

R_pl1and R_pl2are respectively and independently selected from —H, —CH₃, —CH₂CH₃, —OH, —OCH₃, —OCH₂CH₃, F, Cl, Br, or I; R_pl3is selected from —H, —CH₃, —CH₂CH₃, —CH₂CH₂OH, —C₆H₅, or —CH₂C₆H₅.

Preferably, X represents monosubstituted or polysubstitued or unsubstituted alkoxy, monosubstituted or polysubstitued or unsubstituted alkyl, monosubstituted or polysubstituted or unsubstituted alkenyl, monosubstituted or bisubstituted or unsubstituted thienyl, monosubstituted or bisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyridazinyl, monosubstituted or bisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted phenyl, monosubstituted or bisubstituted or unsubstituted pyrimidinyl, monosubstituted or bisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or unsubstituted quinolinyl, monosubstituted or bisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or unsubstituted indolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrazolyl.

More preferably, X represents C1-C6 alkyloxy substituted by nitro, amino, hydroxyl or aryl; C1-C6 alkyl substituted by nitro, amino, hydroxyl or aryl; C2-C14 alkenyl substituted by alkyl, hydroxyl or aryl; thienyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted thienyl; pyridyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted pyridyl; quinolinyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted quinolinyl; indolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted indolyl; pyridyl monosubstituted or bisubstituted by C1-C6 alkoxy; pyridyl monosubstituted or bisubstituted by C1-C3 dialkylamino; pyridyl monosubstituted or bisubstituted by C1-C6 alkyl; unsubstituted pyridyl; pyridazinyl monosubstituted by C1-C6 alkoxy; pyridazinyl monosubstituted by C1-C6 alkyl; unsubstituted pyridazinyl; unsubstituted piperazinyl; piperazinyl bisubstituted by C1-C6 alkyl; unsubstituted piperidinyl; unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted imidazolyl; thiazolyl bisubstituted by C1-C6 alkyl and nitro; unsubstituted pyrimidinyl; pyrimidinyl monosubstituted by phenyl; pyrimidinyl bisubstituted by amino and a group selected from nitro, —F, —Cl, —Br or —I; phenyl trisubstituted by trihydroxyl; phenyl trisubstituted by trimethoxyl; phenyl bisubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from methyl, ethyl, carboxyl or amido; pyrazolyl bisubstituted or trisubstituted by a group selected from C1-C6 alkyl or aryl and a group selected from —F, —Cl, —Br or —I.

Preferably, Y represents hydroxyl, C₁-C₆alkyl, monosubstituted or bisubstituted or trisubstituted phenyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzpyrimidinyl, monosubstituted or bisubstituted or trisubstituted or tetrasubstituted or unsubstituted benzimidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzimidazolonyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted purinyl.

More preferably, Y represents hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C₁-C₆alkylphenyl, phenyl monosubstituted by —F, —Cl, —Br or —I, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C₁-C₆alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, pyridyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted, by C₁-C₆alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C₁-C₆alkyl, thiazolyl monosubstituted by C₁-C₆alkyl, pyrimidinyl monosubstituted or bisubstituted or unsubstituted by C₁-C₆alkyl, pyrimidinyl monsubstituted by C₁-C₆alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted C₁-C₆alkyl and bisubstituted or trisubstituted by —F, —Cl, —Br or —I, purinyl monosubstituted or bisubstituted or unsubstituted by C₁-C₆alkyl, purinyl monosubstituted by C₁-C₆alkyl and substituted or trisuvstituted by hydroxyl.

Most preferably, the benzimidazole-4-carboxamide derivatives as shown in Formula (1) includes the following compounds:

(1) (L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(2) (L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(3) (L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide
(4) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(5) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(6) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide
(7) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide
(8) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(9) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-chlorophenyl)amide
(10) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-bromophenyl)amide
(11) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(12) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-chlorophenyl)amide
(13) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-bromophenyl)amide
(14) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-methylphenyl)amide
(15) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-hydroxylphenyl)amide
(16) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(17) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-methylphenyl)amide
(18) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-hydroxylphenyl)amide
(19) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(20) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-methylphenyl)amide
(21) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-hydroxylphenyl)amide
(22) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(23) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(24) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(25) 2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(26) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(27) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide
(28) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide
(29) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(30) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(31) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(32) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(33) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(34) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(35) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(36) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(37) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(38) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(39) 2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(40) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(41) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(42) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(43) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(44) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(45) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(46) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(47) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(48) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(49) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(50) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(51) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(52) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(53) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(54) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(55) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(56) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(57) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(58) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(59) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(60) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(61) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(62) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(63) 2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(64) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(65) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(66) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(67) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(68) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(69) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(70) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(71) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(72) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(73) (L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(74) (L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(75) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(76) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(77) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(78) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(79) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(80) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(81) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(82) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(83) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(84) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(85) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(86) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(87) 2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(88) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(89) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(90) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(91) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(92) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(93) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(94) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(95) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(96) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(97) (L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(98) (L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(99) 2-N-piperazinyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(100) 2-N-piperazinyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(101) 2-N-piperazinyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(102) 2-N-piperazinyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(103) 2-N-piperazinyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(104) 2-N-piperazinyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(105) 2-N-piperazinyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(106) 2-N-piperazinyl-1H-benzimidazole-4-(N-m-aminophenyl)amide
(107) 2-N-piperazinyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(108) 2-N-piperazinyl-1H-benzimidazole-4-(N-p-aminophenyl)amide
(109) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(110) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(111) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(112) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(113) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(114) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(115) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(116) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(117) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(118) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(119) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(120) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(121) (L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(122) (L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(123) 2-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(124) 2-thiazolyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(125) 2-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(126) 2-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(127) 2-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(128) 2-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(129) 2-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(130) 2-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide
(131) 2-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(132) 2-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide
(133) (L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(134) (L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(135) 5-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(136) 5-thiazolyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(137) 5-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(138) 5-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(139) 5-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(140) 5-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(141) 5-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(142) 5-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide
(143) 5-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(144) 5-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide
(145) (L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(146) (L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(147) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(148) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(149) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(150) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(151) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(152) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(153) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(154) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(155) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(156) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(157) (L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(158) (L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(159) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(160) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(161) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(162) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(163) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(164) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(165) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(166) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(167) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(168) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(169) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(170) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(171) 2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(172) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(173) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(174) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(175) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(176) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(177) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(178) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(179) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(180) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(181) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(182) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(183) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(184) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(185) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(186) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(187) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(188) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(189) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(190) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(191) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(192) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(193) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(194) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(195) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(196) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(197) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(198) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(199) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(200) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(201) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(202) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(203) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(204) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide
(205) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(206) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(207) 2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(208) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(209) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(210) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(211) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(212) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(213) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(214) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(215) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(216) (L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(217) (L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(218) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(219) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(220) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(221) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(222) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(223) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(224) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(225) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(226) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(227) (L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(228) (L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(229) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(230) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(231) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(232) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(233) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(234) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(235) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(236) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(237) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(238) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(239) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(240) 2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(241) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(242) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(243) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(244) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(245) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(246) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(247) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(248) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(249) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(250) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(251) 2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(252) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(253) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(254) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(255) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(256) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(257) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(258) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(259) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(260) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(261) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(262) 2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(263) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(264) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(265) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(266) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(267) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(268) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(269) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(270) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(271) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(272) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(273) 2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(274) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(275) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(276) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(277) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(278) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(279) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(280) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(281) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(282) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(283) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(284) 2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(285) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(286) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(287) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(288) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(289) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(290) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(291) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(292) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(293) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(294) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(295) 2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(296) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(297) 2-(3-indolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(298) 2-(3-indolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(299) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(300) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(301) 2-(3-indolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(302) 2-(3-indolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(303) 2-(3-indolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(304) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(305) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(306) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(307) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(308) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(309) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(310) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(311) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(312) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(313) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(314) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(315) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(316) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(317) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(318) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide
(319) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide
(320) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide
(321) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(322) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(323) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide
(324) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide
(325) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide
(326) (L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(327) (L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(328) 2-methoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(329) 2-methoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(330) 2-methoxy-1H-benzimidazole-4-(N-2-piperazinyl)amide
(331) 2-methoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(332) 2-methoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(333) 2-methoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide
(334) 2-methoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(335) 2-methoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(336) 2-methoxy-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(337) 2-methoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide
(338) 2-methoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(339) 2-methoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(340) 2-methoxy-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(341) 2-methoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(342) 2-methoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(343) 2-methoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(344) 2-methoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(345) 2-methoxy-1H-benzimidazole-4-(N-2-pyridyl)amide
(346) 2-methoxy-1H-benzimidazole-4-(N-3-pyridyl)amide
(347) 2-methoxy-1H-benzimidazole-4-(N-4-pyridyl)amide
(348) 2-methoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(349) 2-methoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide
(350) 2-methoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(351) 2-methoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(352) 2-methoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(353) 2-methoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(354) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(355) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(356) 2-ethoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(357) 2-ethoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(358) 2-ethoxy-1H-benzimidazole-4-(N-2-piperazinyl)amide
(359) 2-ethoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(360) 2-ethoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(361) 2-ethoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide
(362) 2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(363) 2-ethoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(364) 2-ethoxy-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(365) 2-ethoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide
(366) 2-ethoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(367) 2-ethoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(368) 2-ethoxy-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(369) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(370) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(371) 2-ethoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(372) 2-ethoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(373) 2-ethoxy-1H-benzimidazole-4-(N-2-pyridyl)amide
(374) 2-ethoxy-1H-benzimidazole-4-(N-3-pyridyl)amide
(375) 2-ethoxy-1H-benzimidazole-4-(N-4-pyridyl)amide
(376) 2-ethoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(377) 2-ethoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide
(378) 2-ethoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(379) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(380) 2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(381) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(382) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(383) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(384) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(385) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(386) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(387) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(388) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(389) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(390) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(391) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(392) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(393) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(394) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(395) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(396) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(397) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(398) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(399) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(400) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(401) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(402) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(403) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(404) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(405) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(406) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(407) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(408) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(409) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(410) (L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(411) (L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(412) 2-pyrazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(413) 2-pyrazolyl-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(414) 2-pyrazolyl-1H-benzimidazole-4-(N-2-piperazinyl)amide
(415) 2-pyrazolyl-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(416) 2-pyrazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(417) 2-pyrazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide
(418) 2-pyrazolyl-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(419) 2-pyrazolyl-1H-benzimidazole-4-(N-4′ -carbonamido-5′-imidazolyl)amide
(420) 2-pyrazolyl-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(421) 2-pyrazolyl-1H-benzimidazole-4-(N-2-imidazolyl)amide
(422) 2-pyrazolyl-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(423) 2-pyrazolyl-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(424) 2-pyrazolyl-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(425) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(426) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(427) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(428) 2-pyrazolyl-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(429) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyridyl)amide
(430) 2-pyrazolyl-1H-benzimidazole-4-(N-3-pyridyl)amide
(431) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyridyl)amide
(432) 2-pyrazolyl-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(433) 2-pyrazolyl-1H-benzimidazole-4-(N-5-thiazolyl)amide
(434) 2-pyrazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(435) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(436) 2-pyrazolyl-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(437) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(438) (L)-2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(439) (L)-2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(440) 2-(2′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(441) 2-(2′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(442) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(443) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(444) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(445) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(446) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(447) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(448) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(449) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(450) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(451) 2-(2′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(452) 2-(2′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(453) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(454) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(455) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(456) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(457) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(458) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(459) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(460) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(461) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(462) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(463) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(464) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(465) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(466) (L)-2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(467) (L)-2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(468) 2-(3′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(469) 2-(3′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(470) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(471) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(472) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(473) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(474) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(475) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(476) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(477) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(478) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(479) 2-(3′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(480) 2-(3′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(481) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(482) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(483) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(484) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(485) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(486) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(487) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(488) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(489) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(490) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(491) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(492) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(493) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(494) (L)-2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(495) (L)-2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(496) 2-(4′-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(497) 2-(4′-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(498) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(499) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(500) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(501) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(502) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(503) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(504) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(505) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(506) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(507) 2-(4′-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(508) 2-(4′-pyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(509) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(510) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(511) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(512) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(513) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(514) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(515) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(516) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(517) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(518) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(519) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(520) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(521) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(522) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(523) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(524) 2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(525) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(526) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(527) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(528) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(529) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(530) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(531) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(532) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(533) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(534) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(535) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(536) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(537) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(538) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(539) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(540) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(541) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(542) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(543) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(544) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(545) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(546) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(547) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(548) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(549) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(550) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(551) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(552) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(553) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(554) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(555) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(556) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(557) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(558) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(559) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(560) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(561) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(562) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(563) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(564) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(565) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(566) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(567) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(568) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(569) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(570) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(571) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(572) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(573) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(574) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(575) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(576) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(577) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(578) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(579) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(580) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(581) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(582) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(583) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(584) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(585) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(586) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(587) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(588) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(589) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(590) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(591) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(592) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(593) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(594) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(595) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(596) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(597) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(598) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(599) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(600) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(601) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(602) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(603) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(604) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(605) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(606) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(607) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(608) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(609) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(610) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(611) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(612) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(613) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(614) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(615) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(616) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(617) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(618) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(619) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(620) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(621) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(622) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(623) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(624) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(625) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(626) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(627) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(628) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(629) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(630) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(631) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(632) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(633) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(634) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(635) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(636) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(637) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(638) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(639) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(640) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(641) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(642) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(643) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(644) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(645) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(646) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(647) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(648) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(649) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(650) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(651) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(652) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(653) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(654) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(655) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(656) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(657) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(658) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(659) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(660) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(661) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(662) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(663) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(664) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(665) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(666) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(667) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(668) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(669) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(670) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(671) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(672) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(673) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(674) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(675) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(676) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(677) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(678) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(679) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(680) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(681) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(682) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(683) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(684) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(685) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(686) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(687) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(688) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(689) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(690) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(691) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(692) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(693) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(694) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(695) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(696) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(697) 2-(2-piperazinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(698) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(699) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(700) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(701) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(702) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(703) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(704) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(705) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(706) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(707) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(708) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(709) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(710) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(711) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(712) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(713) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(714) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(715) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(716) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(717) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(718) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(719) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(720) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(721) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(722) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(723) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(724) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(725) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(726) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(727) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(728) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(729) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(730) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(731) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(732) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(733) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(734) 2-(2-thiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(735) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(736) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(737) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(738) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(739) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(740) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(741) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(742) 2-(2-thiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(743) 2-(2-thiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(744) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(745) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(746) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(747) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(748) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(749) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(750) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(751) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(752) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(753) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(754) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(755) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(756) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(757) 2-(5-thiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(758) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(759) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(760) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(761) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(762) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(763) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(764) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(765) 2-(5-thiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(766) 2-(5-thiazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(767) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(768) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(769) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(770) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(771) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(772) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(773) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(774) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(775) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(776) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(777) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(778) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(779) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(780) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(781) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(782) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(783) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(784) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(785) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(786) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(787) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(788) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(789) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(790) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(791) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(792) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(793) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(794) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(795) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(796) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(797) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(798) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(799) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(800) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(801) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(802) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(803) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(804) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(805) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(806) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(807) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(808) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(809) 242-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(810) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(811) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(812) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(813) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(814) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(815) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(816) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(817) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(818) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(819) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(820) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(821) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(822) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(823) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(824) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(825) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(826) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(827) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(828) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(829) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(830) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(831) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(832) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(833) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(834) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(835) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(836) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(837) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(838) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(839) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(840) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(841) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(842) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(843) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(844) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(845) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(846) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(847) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(848) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(849) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(850) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(851) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(852) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(853) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(854) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(855) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(856) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(857) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(858) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(859) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(860) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(861) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(862) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(863) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(864) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(865) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(866) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(867) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(868) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(869) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(870) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(871) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(872) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(873) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(874) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(875) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(876) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(877) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(878) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(879) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(880) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(881) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(882) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(883) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(884) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(885) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(886) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(887) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(888) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(889) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(890) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(891) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(892) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(893) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(894) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(895) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(896) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(897) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(898) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(899) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(900) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(901) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(902) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(903) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(904) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(905) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(906) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(907) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(908) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(909) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(910) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(911) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(912) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(913) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(914) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(915) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(916) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(917) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(918) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(919) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(920) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(921) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(922) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(923) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(924) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(925) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(926) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(927) 2-(2-quinolinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(928) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(929) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(930) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(931) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(932) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(933) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(934) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(935) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(936) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(937) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(938) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(939) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(940) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(941) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(942) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(943) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(944) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(945) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(946) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(947) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(948) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(949) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(950) 2-(2-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(951) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(952) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(953) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(954) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(955) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(956) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(957) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(958) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(959) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(960) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(961) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(962) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(963) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(964) 2-(3-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(965) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(966) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(967) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(968) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(969) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(970) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(971) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(972) 2-(3-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(973) 2-(3-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(974) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(975) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(976) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(977) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(978) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(979) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(980) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(981) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(982) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(983) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(984) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(985) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(986) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(987) 2-(4-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(988) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(989) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(990) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(991) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(992) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(993) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(994) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(995) 2-(4-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(996) 2-(4-piperidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(997) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(998) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(999) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1000) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1001) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1002) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1003) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1004) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1005) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1006) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1007) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1008) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1009) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1010) 2-(3-indolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1011) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1012) 2-(3-indolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1013) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1014) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1015) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1016) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1017) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1018) 2-(3-indolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1019) 2-(3-indolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1020) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1021) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1022) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1023) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1024) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1025) 2-(3-indolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1026) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1027) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1028) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1029) 2-(3-indolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1030) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1031) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1032) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1033) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1034) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1035) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1036) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1037) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1038) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1039) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1040) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1041) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1042) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1043) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1044) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1045) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1046) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1047) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1048) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1049) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1050) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1051) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1052) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1053) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1054) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1055) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1056) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1057) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1058) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1059) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1060) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1061) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1062) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1063) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1064) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1065) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1066) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1067) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1068) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1069) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1070) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1071) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1072) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1073) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1074) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1075) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1076) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1077) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1078) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1079) (L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1080) (L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-44N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1081) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1082) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1083) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1084) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1085) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1086) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1087) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1088) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1089) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1090) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1091) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1092) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1093) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1094) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1095) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1096) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1097) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1098) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1099) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1100) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1101) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1102) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1103) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1104) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-bromo-5-pyridine)-2-pyrimidinyl)amide
(1105) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1106) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1107) (L)-2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1108) (L)-2-(2-amino-3-pyridine)-1H-benzimidazole-44N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1109) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1110) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1111) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide
(1112) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1113) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1114) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1115) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1116) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1117) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1118) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1119) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1120) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1121) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1122) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1123) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1124) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1125) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1126) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1127) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1128) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1129) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1130) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1131) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1132) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimidinyl)amide
(1133) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1134) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1135) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1136) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1137) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1138) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1139) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1140) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1141) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1142) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1143) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1144) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1145) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1146) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1147) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1148) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1149) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1150) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1151) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1152) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1153) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1154) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1155) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1156) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyridyl)amide
(1157) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1158) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide
(1159) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1160) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-pyrrolidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide
(1161) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1162) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1163) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1164) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1165) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1166) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1167) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1168) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1169) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1170) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1171) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1172) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1173) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1174) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1175) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1176) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1177) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1178) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1179) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1180) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1181) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1182) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1183) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1184) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1185) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1186) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(5-thiazolyl)amide
(1187) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1188) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-piperidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide
(1189) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1190) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1191) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1192) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1193) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1194) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1195) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1196) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1197) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1198) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1199) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1200) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1201) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1202) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1203) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1204) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1205) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1206) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1207) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1208) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1209) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1210) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1211) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1212) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1213) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1214) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(5-thiazolyl)amide
(1215) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1216) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-cyclopropylamino-5-pyrimidinyl)-2-pyrimidinyl)amide
(1217) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1218) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1219) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide
(1220) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide
(1221) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide
(1222) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide
(1223) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide
(1224) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide
(1225) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide
(1226) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide
(1227) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide
(1228) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide
(1229) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carboxyl-5′-imidazolyl)amide
(1230) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide
(1231) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide
(1232) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide
(1233) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N′-ethyl-N-piperazinyl)amide
(1234) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide
(1235) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide
(1236) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide
(1237) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide
(1238) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide
(1239) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide
(1240) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide
(1241) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide
(1242) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(5-thiazolyl)amide
(1243) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide
(1244) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide
(1245) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide
(1246) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide
(1247) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1248) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1249) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1250) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1251) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1252) 2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1253) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1254) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1255) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1256) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1257) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1258) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1259) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1260) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1261) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1262) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1263) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1264) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1265) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1266) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1267) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1268) 2-N-piperazinyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1269) 2-N-piperazinyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1270) 2-N-piperazinyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1271) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1272) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1273) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1274) 2-thiazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1275) 2-thiazolyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1276) 2-thiazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1277) 5-thiazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1278) 5-thiazolyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1279) 5-thiazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1280) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1281) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1282) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1283) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1284) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1285) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1286) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1287) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1288) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1289) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1290) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1291) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1292) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1293) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1294) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1295) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1296) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1297) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1298) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1299) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1300) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1301) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1302) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1303) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1304) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1305) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1306) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1307) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1308) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1309) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1310) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1311) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1312) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1313) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1314) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1315) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1316) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1317) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1318) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1319) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1320) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1321) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1322) 2-methoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1323) 2-methoxy-1H-benzimidazole-4-(N-6-purinyl)amide
(1324) 2-methoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1325) 2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1326) 2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide
(1327) 2-ethoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1328) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1329) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1330) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1331) 2-pyrazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1332) 2-pyrazolyl-1H-benzimidazole-4-(N-6-purinyl)amide
(1333) 2-pyrazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1334) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1335) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1336) 2-(2′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1337) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1338) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1339) 2-(3′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1340) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1341) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1342) 2-(4′-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1343) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1344) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1345) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1346) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1347) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1348) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1349) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1350) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide;
(1351) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1352) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1353) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1354) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1355) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1356) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1357) 2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1358) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1359) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1360) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1361) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1362) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1363) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1364) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1365) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1366) 2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1367) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1368) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1369) 2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1370) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1371) 2-(2-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1372) 2-(2-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1373) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1374) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1375) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1376) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1377) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1378) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1379) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1380) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1381) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1382) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1383) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1384) 2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1385) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1386) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1387) 2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1388) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1389) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1390) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1391) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1392) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1393) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1394) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1395) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1396) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1397) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1398) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1399) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1400) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1401) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1402) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1403) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1404) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1405) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1406) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1407) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide
(1408) 2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1409) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1410) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide
(1411) 2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1412) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1413) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1414) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1415) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1416) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1417) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1418) 2-(2-cyclopropylamino)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1419) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1420) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1421) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide
(1422) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide
(1423) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide
(1424) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide.

Preferably, the pharmaceutically acceptable salts of benzimidazole-4-carboxamide derivatives are inorganic acid salts thereof selected from sulfate, hydrochloride, nitrate, phosphate or boratethe, or organic acid salts thereof selected from citrate, succinate, tartrate, lactate or mesylate.

Another purpose of the present invention is to provide anti-cosxackie-viruses pharmaceutical compositions. The pharmaceutical compositions comprise a therapeutically effective amount of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1˜7, and one or more pharmaceutically acceptable thinner, excipient and/or inert carrier.

A further purpose of the present invention is to provide uses of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts for for preparation of antivirus medications, wherein the viruses are Coxsackie Virus, echovirus and enterovirus which belong to picornaviridae.

Another purpose of the present invention is to provide a method of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof as shown in Formula (I), comprising the following steps:

(1) 2-aminoacetyl-3-nitrobenzoic acid is Undergoing Reactions of Ammonolysis, Hoffman Degradation and Reduction in Turn, to Produce 2,3-diamino benzoic acid
(2) 2,3-diamino benzoic acid is Condensed with Aldehydes X—CHO in the Presence of Catalyst of Cupric Acetate, to Produce benzimidazole-4-carboxylic acid of Formula (II)

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(3) benzimidazole-4-carboxylic acid is Reacted with thionyl chloride to Produce acyl chloride, and then Condensing the acyl chloride and an amine NH₂—Y, to Produce the benzimidazole-4-carboxamide Derivative of Formula (I)

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The above reaction conditions are as follows: benzimidazole-4-carboxylic acid is reated with thionyl chloride at temperature of 0˜80° C. in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1˜20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0˜100° C. to produce benzimidazole-4-carboxamide derivatives. Wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene, and so on.

The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof of the present invention may be administered orally or not. The dosage varies with different drugs, the dosage is 10˜300 mg per day in general conditions.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows ¹HNMR spectrogram of 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-carboxylic acid in Example 9.

FIG. 2 shows ¹HNMR spectrogram of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl))amide in Example 21.

FIG. 3 shows ¹HNMR spectrogram of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide in Example 28.

FIG. 4 shows ¹HNMR spectrogram of (L)-2-(2-pyridyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide in Example 194.

FIG. 5 shows ¹HNMR spectrogram of 2-(4-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide in Example 663.

FIG. 6 shows ¹HNMR spectrogram of (L)-2-(3-hydroxyphenyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide in Example 664.

DETAILED DESCRIPTION OF THE INVENTION

Hereafter, the present invention will be described specifically with reference to examples. The examples are given only for illustration of the technical solution of the present invention and should not be construed to limit the present invention.

The method of preparing for benzimidazole-4-amide derivatives of the present invention is as follows: using 2-aminoacetyl-3-nitrobenzoic acid as an initiating raw material, 2-aminoacetyl-3-nitrobenzoic acid in turn is undergoing ammonolysis, Hoffman degradation and reduction, to produce 2,3-diamino benzoic acid; and then condensing 2,3-diamino benzoic acid and aldehydes X—CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid; and then reacting benzimidazole-4-carboxylic acid with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH₂—Y, to produce the benzimidazole-4-carboxamide derivative.

EXAMPLE 1
Synthesis of 2.3-diamino benzoic acid
Step 1: Synthesis of 2-aminoacetyl-3-nitrobenzoic acid

30 g of 3-nitro phthalic anhydride is added into 45 ml of concentrated ammonia with 28 g/g % concentration; and heat it to 60° C. under stiffing for 30 minutes; and then to cool it to 10° C. till precipitate needle shape crystals; and to acidize the needle shape crystals with concentrated chlorhydric acid to produce white solids; and then to filter and dry it to obtain 29.4 g of 2-aminoacetyl-3-nitrobenzoic acid.

Step 2: Synthesis of 2-amino-3-nitrobenzoic acid

13.9 g of bromine is dropped into 100 ml of sodium hydroxide aqueous-solution containing 7.3 g of sodium hydroxide to a solution. Then 17 g of 2-aminoacetyl-3-nitrobenzoic acid is added into the above solution; and to heat it to 80° C. to precipitate a large amount of red solids; to filter and then acidize it with the concentrated chlorhydric acid to produce yellow solid products; to dry it to obtain 13.7 g of 2-amino-3-nitrobenzoic acid; and then recrystallize the yellow solid products by adding hot water to obtain the yellow needle shape crystals.

Step 3: Synthesis of 2,3-diaminobenzoic acid

3 g of the above mentioned 2-amino-3-nitrobenzoic acid is added into 30 ml of methanol, 20% sodium hydroxide aqueous solution with the same molar as 2-amino-3-nitrobenzoic acid is dropped into the above methanol solution till dissolve completely. 0.2 g of Raney nickel at the moment is added in to the methanol solution, and to heat it to 65° C. and reflux it at the temperature; and then drop 80 g/g % hydrazine hydrate (about 1.5 equivalent weight×1.1) till the yellow disappears completely. Hot Raney nickel is filtered; and then heat and concentrate the mother liquid and acidize it with the concentrated chlorhydric acid to produce 2.3 g of red 2,3-diaminobenzoic acid; afterwards isolate and purify the crude product of red 2,3-diaminobenzoic acid by column chromatography.

EXAMPLE 2
Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid

2.0 g of 2,3-diaminobenzoic acid is dissolved into 60 ml of methanol, and methanol solution of 5-nitrofurfural is added into the methanol under stirring. Then 0.5 g of cupric acetate (Cu(Ac)₂.H₂O) is added into the above methanol, and then to heat and reflux it; and then to filter hot solution after 2,3-diaminobenzoic acid disappears. 20% sodium sulfide aqueous solution is added into the filtrate and heat it till boiling; and then filtrate the copper sulfide deposition while it is hot; and then to evaporate the filtrate to dry, purify it through column chromatography to obtain 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid. The yield is about 65%.

EXAMPLES 3-20
Synthesis of Intermediates of benzimidazole-4-carboxylic acid

Synthesize the benzimidazole-4-carboxylic acid as shown in Formula (II) according to the method of Example 2. The difference is to use aldehydes with different X group as listed in Table 1.

TABLE 1

(II)

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No. of

prod-

Yield

ucts
Compounds
X
%

4
2-(2-pyrimidinyl)-1H- benzimidazole- 4-carboxylic acid

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75

5
2-(2-thienyl)-1H- benzimidazole-4- carboxylic acid

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76

6
2-methyl-1H- benzimidazole-4- carboxylic acid
—CH3
72

7
2-phenyl-1H- benzimidazole-4- carboxylic acid

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80

8
2-(4-(dimethylamino)- phenyl)-1H- benzimidazole-4- carboxylic acid

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75

9
2-(2,3,4- trihydroxyphenyl)- 1H-benzimidazole- 4-carboxylic acid

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65

10
2-(4-methoxy-2- pyridyl)-1H- benzimidazole-4- carboxylic acid

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68

11
2-(6-methoxy-2- pyridyl)-1H- benzimidazole-4- carboxylic acid

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70

12
2-(4-(dimethylamino)- 2-pyridyl)-1H- benzimidazole-4- carboxylic acid

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75

13
2-(3-pyridazinyl)- 1H-benzimidazole- 4-carboxylic acid

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60

14
2-(2-piperazinyl)- 1H-benzimidazole- 4-carboxylic acid

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61

15
2-(5-amino-4-methyl- 2-thiazolyl)-1H- benzimidazole- 4-carboxylic acid

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70

16
2-(3-quinolinyl)- 1H-benzimidazole- 4-carboxylic acid

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63

17
2-(2-pyrrolyl)- 1H-benzimidazole- 4-carboxylic acid

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75

18
2-(3-indolyl)- 1H-benzimidazole- 4-carboxylic acid

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71

19
2-(2-piperidinyl)- 1H-benzimidazole- 4-carboxylic acid

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68

20
2-(2-quinolinyl)- 1H-benzimidazole- 4-carboxylic acid

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Structure Identification of Products:

(4) 2-(2-pyrimidinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.80(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.09(d,1H), 9.10-9.12(d,1H);

(5) 2-(2-thienyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.15-7.18(t,1H), 7.41-7.45(t,1H), 7.68-7.70(d,1H), 7.85(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(6) 2-methyl-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 2.51(s,3H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(7) 2-phenyl-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.41-7.45(t,1H), 7.38-7.42(t,1H) 7.50-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.30(d,2H);

(8) 2-(4-(dimethylamino)-phenyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 3.06(s,6H) 6.82-6.84(d,2H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.97-7.99(d,2H);

(9) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-carboxylic acid (Refer to FIG. 1)

¹HNMR (DMSO, 400 MHz) δ: 6.43-6.46 (d, 1H), 7.28-7.32 (t, 1H), 7.77-7.79 (d, 1H), 7.82-7.85 (m, 1H), 8.57(s, 1H), 9.54 (s, 1H), 12.11(s, 1H), 13.16(s, 1H);

(10) 2-(4-(methoxy)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.41-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.48-8.49(d,1H);

(11) 2-(6-methoxy-2-pyridyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,3H), 6.50-6.51(d,1H), 7.38-7.39(d,1H), 7.41-7.45(t,1H), 7.72-7.75(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(12) 2-(4-(dimethylamino)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 7.16-7.18(d,1H), 7.41-7.45(t,1H), 7.71(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.05-8.07(d,1H);

(13) 2-(3-pyridazinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.41-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.06-8.08(d,1H), 9.34-9.37(d,1H);

(14) 2-(2-piperazinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,2H), 2.60-2.62(m,1H), 2.65-2.66(m,1H), 2.67-2.70(m,1H), 2.72-2.75(m,1H), 2.84-2.88(m,1H), 3.09-3.14(m,1H), 4.14-4.19(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(15) 2-(5-amino-4-methyl-2-thiazolyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.03-1.09(d,3H), 3.70-3.73(m,1H), 4.17-4.22(m,1H), 5.11-5.13(d,2H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(16) 2-(3-quinolinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.41-7.45(t,1H), 7.60-7.65(t,1H), 7.78-7.80(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.97-7.99(d,1H), 8.06-8.09(d,1H), 8.22(s,1H), 8.57(s,1H);

(17) 2-(2-pyrrolyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.17(t,1H), 6.39-6.40(d,1H), 6.95-6.98(t,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(18) 2-(3-indolyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.05(t,1H), 7.31-7.34(t,1H), 7.41-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60(s,1H);

(19) 2-(2-piperidinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.47-1.49(m,2H), 1.50-1.55(m,2H), 1.67-1.92(m,2H), 4.01-4.03(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(20) 2-(2-quinolinyl)-1H-benzimidazole-4-carboxylic acid

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.46-1.47(m,1H), 1.49-1.51(m,1H), 1.53-1.55(m,1H), 1.67-1.70(m,1H), 1.92-1.96(m,1H), 2.69-2.71(m,1H), 2.78-2.80(m,1H), 4.01-4.03(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H)

EXAMPLE 21
Synthesis of (L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide

1.0 g of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid in Example 2 is added into 15 ml of thionyl chloride and is reacted for 60 minutes, after end of the reaction completely, (L)-2-amino-1-p-nitrophenyl-1,3-propylene glycol (1.1 eq.) is added into the reaction mixture under stirring for 2 hours at the room temperature; and then filter the inorganic salt, evaporate the solvent to dry and obtain the final product of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide. The yield is about 93%. ¹HNMR spectrum is shown in FIG. 2.

Structure Identification of Product:

¹HNMR(DMSO,400 MHz) δ: 3.59-3.60(m,1H),3.65-3.67(t,1H),4.16-4.22(q,1H),5.07-5.08(t,1H),5.27-5.28(t,1H),6.16-6.17(d,1H),7.35-7.39(t,1H),7.53-7.54(d,1H),7.72-7.75(m,2H),7.77-7.79(m,2H),8.00-8.01(d,1H),8.05-8.07(d,3H),10.04-10.06(d,2H),14.05(s,1H).

EXAMPLE 22
Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-methyl-2-p-chlorophenylhydroxyethyl)amide

1.0 g of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid is added into 15 ml of thionyl chloride; and to heat and reflux it for 60 minutes. After end of the reaction, 2-amino-1-p-chlorophenyl-1-propanol (1.1 eq) is dissolved into tetrahydrofuran, and then drop acyl chloride to the above tetrahydrofuran mixture under stirring at the room temperature and then filter inorganic salt, evaporate the solvent to dry, and then isolate the mixture through column chromatography to obtain 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide. The yield is about 92%.

Structure Identification of Product:

¹HNMR (DMSO, 400 MHz) δ: 1.10-1.16(d,3H), 3.26-3.28(m,1H), 3.64-3.66(d,1H), 4.71-4.74(m,1H), 7.28-7.30(d,2H), 7.35-7.38(d,2H), 7.41-7.45(t,1H), 7.56-7.58(d,1H), 7.62-7.68(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H).

EXAMPLES 23-67

Use the same process as Example 22 to synthesize the compound as shown in Table 2.

TABLE 2

Field

No.
Compounds
X
Y
%

23
2-(2-pyridyl)-1H-benzimidazole- 4-N-hydroxyethylamide

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—NHCH2CH2OH
88

24
2-(2-pyridyl)-1H- benzimidazole-4-N-o- hydroxyphenylcarboxylamide

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80

25
2-(2-hydroxyphenyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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82

26
(L)-2-(2-hydroxyphenyl)- 1H-benzimidazole-4- [N-(1-hydroxyl-2-p- nitrophenylhydroxyethyl)]amide

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91

27
2-(5-nitro-2-thienyl)- 1H-benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

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90

28
2-(5-nitro-2-thienyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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89

29
2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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93

30
2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4- (N-hydroxyethyl)amide

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—NHCH2CH2OH
86

31
2-(2-piperidinyl)-1H-benzimidazole- 4-(4-N′-ethyl-N-piperazinyl)amide

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95

32
2-(2-pyridyl)-1H-benzimidazole- 4-(4-N′-ethyl-N-piperazinyl)amide

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94

33
(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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90

34
(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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89

35
2-(2,6-dimethyl-2,6-octadienyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

36
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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90

37
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4- (N-2-piperazinyl)amide

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89

38
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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91

39
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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88

40
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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87

41
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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90

42
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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87

43
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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87

44
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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90

45
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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91

46
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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93

47
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4- methyl-5-thiazolyl)amide

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90

48
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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85

49
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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94

50
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4- chloro-6-amino-2-pyrimidinyl)amide

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88

51
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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90

52
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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93

53
2-(2,6-dimethyl-2,6-octadienyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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86

54
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4- (N-6-purinyl)amide

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90

55
2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-6- hydroxy-2-purinyl)amide

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91

56
(L)-2-(2-thienyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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90

57
(L)-2-(2-thienyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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92

58
2-(2-thienyl)-1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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92

59
2-(2-thienyl)-1H-benzimidazole-4- (N-N′-piperidinyl)amide

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91

60
2-(2-thienyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

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88

61
2-(2-thienyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

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93

62
2-(2-thienyl)-1H-benzimidazole-4- (N-o-aminophenyl)amide

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94

63
2-(2-thienyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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90

64
2-(2-thienyl)-1H-benzimidazole-4- (N-4′-carbonamido-5′- imidazolyl)amide

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94

65
2-(2-thienyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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92

66
2-(2-thienyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

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94

67
2-(2-thienyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

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94

68
2-(2-thienyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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93

69
2-(2-thienyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

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90

70
2-(2-thienyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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91

71
2-(2-thienyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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93

72
2-(2-thienyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

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93

73
2-(2-thienyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

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88

74
2-(2-thienyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

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89

75
2-(2-thienyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

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87

76
2-(2-thienyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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92

77
2-(2-thienyl)-1H-benzimidazole-4- (N-6-purinyl)amide

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90

78
2-(2-thienyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

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91

79
(L)-2-(4-methoxypyridyl)-1H- benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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93

80
(L)-2-(4-methoxypyridyl)-1H- benzimidazole-4-[N- (1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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93

81
2-(4-methoxypyridyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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94

82
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

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90

83
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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93

84
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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92

85
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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91

86
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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91

87
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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93

88
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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92

89
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

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93

90
2-(4-methoxypyridyl)-1H- benzimidazole-4- (N-2-pyrazinyl)amide

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94

91
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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92

92
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2-pyridyl)amide

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92

93
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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93

94
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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94

95
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

96
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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94

97
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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92

98
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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94

99
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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94

100
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-6-purinyl)amide

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93

101
2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-6-hydroxyl-2- purinyl)amide

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90

102
(L)-2-(6-methoxypyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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91

103
(L)-2-(6-methoxypyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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93

104
2-(6-methoxypyridyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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93

105
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-N′-piperdinyl)amide

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94

106
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2-piperazinyl)amide

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89

107
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2′-benzimidazolyl)amide

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93

108
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-o-aminophenyl)amide

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92

109
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-5-benzimidazolonyl)amide

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90

110
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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89

111
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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93

112
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-(N′-piperazinyl))amide

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93

113
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2-pyrazinyl)amide

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94

114
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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90

115
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-2-pyridyl)amide

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93

116
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4- methyl-5-thiazolyl)amide

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92

117
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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86

118
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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91

119
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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90

120
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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92

121
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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93

122
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

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87

123
2-(6-methoxypyridyl)-1H- benzimidazole-4- (N-6-purinyl)amide

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92

124
2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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88

125
(L)-2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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93

126
(L)-2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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94

127
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

128
2-(4-dimethylaminopyridyl)-1H- benzimidazole-(N-N′- piperidinyl)amide

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94

129
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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92

130
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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94

131
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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94

132
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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93

133
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

134
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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91

135
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

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93

136
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

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93

137
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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88

138
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- pyridyl)amide

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89

139
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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87

140
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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88

141
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

142
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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89

143
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-4,6-dichloro- 5-pyrimidinyl)amide

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93

144
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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93

145
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

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88

146
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4- (N-6-purinyl)amide

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90

147
2-(4-dimethylaminopyridyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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93

148
(L)-2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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92

149
(L)-2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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91

150
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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91

151
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

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93

152
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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92

153
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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93

154
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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90

155
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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92

156
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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87

157
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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93

158
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

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94

159
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

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90

160
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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94

161
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4- (N-2-pyridyl)amide

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92

162
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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94

163
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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94

164
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4,6-dimethoxy- 2-pyrimidinyl)amide

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93

165
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4-chloro- 6-amino-2-pyrimidinyl)amide

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90

166
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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91

167
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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93

168
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-2-hydroxyl-4- pyrimidinyl)amide

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89

169
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4- (N-6-purinyl)amide

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88

170
2-(2,3,4-trimethoxyphenyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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89

171
(L)-2-(3-hydroxyl-4- methoxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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87

172
(L)-2-(3-hydroxyl-4- methoxyphenyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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90

173
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-[N- (1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

174
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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91

175
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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93

176
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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93

177
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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94

178
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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90

179
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

180
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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92

181
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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91

182
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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91

183
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N- 2-pyrimidinyl)amide

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93

184
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4- (N-2-pyridyl)amide

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92

185
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4-methyl- 5-thiazolyl)amide

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93

186
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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89

187
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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92

188
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4-chloro- 6-amino-2-pyrimidinyl)amide

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92

189
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

embedded image

93

190
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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94

191
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

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90

192
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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94

193
2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

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89

194
(L)-2-(2-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethy])]amide

embedded image

94

195
(L)-2-(2-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

196
2-(2-pyridyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

197
2-(2-pyridyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

90

198
2-(2-pyridyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

91

199
2-(2-pyridyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

200
2-(2-pyridyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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89

201
2-(2-pyridyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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88

202
2-(2-pyridyl)-1H-benzimidazole-4- (N-4′-carbonamido-5′- imidazolyl)amide

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86

203
2-(2-pyridyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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87

204
2-(2-pyridyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

embedded image

92

205
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

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90

206
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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91

207
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

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93

208
2-(2-pyridyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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93

209
2-(2-pyridyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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88

210
2-(2-pyridyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

90

211
2-(2-pyridyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

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93

212
2-(2-pyridyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

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92

213
2-(2-pyridyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

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91

214
2-(2-pyridyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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91

215
2-(2-pyridyl)-1H-benzimidazole-4- (N-6-purinyl)amide

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93

216
2-(2-pyridyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

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88

217
(L)-2-(3-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

218
(L)-2-(3-pyridyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

94

219
2-(3-pyridyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

embedded image

92

220
2-(3-pyridyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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92

221
(L)-2-(4-pyridyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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93

222
(L)-2-(4-pyridyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

94

223
2-(4-pyridyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

embedded image

90

224
2-(4-pyridyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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94

225
(L)-2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

226
(L)-2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

227
2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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94

228
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-N′- piperdinyl)amide

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93

229
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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90

230
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

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91

231
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

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93

232
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

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93

233
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

234
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

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89

235
2-(3-pyridazinyl)-1H- benzimidazole-4-(N- (N′-piperazinyl))amide

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87

236
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

92

237
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

90

238
2-(3-pyridazinyl)-1H- benzimidazole-4- (N-2-pyridyl)amide

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91

239
2-(3-pyridazinyl)-1H- benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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93

240
2-(3-pyridazinyl)-1H- benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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89

241
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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94

242
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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90

243
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-4,6-dichloro- 5-pyrimidinyl)amide

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93

244
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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92

245
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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88

246
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-6- purinyl)amide

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91

247
2-(3-pyridazinyl)-1H- benzimidazole-4-(N-6-hydroxyl-2- purinyl)amide

embedded image

87

248
(L)-2-(4-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

249
(L)-2-(4-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

250
2-(4-pyridazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

94

251
2-(4-pyridazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

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92

252
(L)-2-(2-pyrazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethy]-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

253
(L)-2-(2-pyrazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

89

254
2-(2-pyrazinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

94

255
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

90

256
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

94

257
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

92

258
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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90

259
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

94

260
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

87

261
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

90

262
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

91

263
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

264
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

265
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

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88

266
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

89

267
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

268
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

92

269
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

90

270
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

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91

271
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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93

272
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

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89

273
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

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94

274
2-(2-pyrazinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

89

275
(L)-2-(2-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

276
(L)-2-(2-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

277
2-(2-piperazinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

91

278
2-(2-piperazinyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

91

279
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

93

280
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2,-benzimidazolyl)amide

embedded image

92

281
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

93

282
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

94

283
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

89

284
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

92

285
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

92

286
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

92

287
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

288
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

92

289
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

91

290
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

291
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

90

292
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

88

293
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

294
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

94

295
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

89

296
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

90

297
2-(2-piperazinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

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87

298
(L)-2-(N,N′-diethyl-2-piperazinyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

90

299
(L)-2-(N,N′-diethyl-2-piperazinyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

300
2-(N,N′-diethyl-2-piperazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

90

301
2-(N,N′-diethyl-2-piperazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

91

302
(L)-2-(N-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

303
(L)-2-(N-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

304
2-(N-piperazinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

92

305
2-(N-piperazinyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

93

306
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

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91

307
2-(N-piperazinyl)-1H- benzimidazole-4- (N-2′-benzimidazolyl)amide

embedded image

92

308
2-(N-piperazinyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

embedded image

90

309
2-(N-piperazinyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

embedded image

91

310
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′- imidazolyl)amide

embedded image

90

311
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

embedded image

93

312
2-(N-piperazinyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

embedded image

91

313
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

92

314
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

93

315
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2- pyridyl)amide

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94

316
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4- methyl-5-thiazolyl)amide

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94

317
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

embedded image

88

318
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

embedded image

90

319
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4-chloro- 6-amino-2-pyrimidinyl)amide

embedded image

91

320
2-(N-piperazinyl)-1H- benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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93

321
2-(N-piperazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

embedded image

93

322
2-(N-piperazinyl)-1H- benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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88

323
2-(N-piperazinyl)-1H- benzimidazole-4-(N-6- purinyl)amide

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89

324
2-(N-piperazinyl)-1H- benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

embedded image

87

325
(L)-2-(N-ethyl-N′-piperazinyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

326
(L)-2-(N-ethyl-N′-piperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

327
2-(N-ethyl-N′-piperazinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

92

328
2-(N-ethyl-N′-piperazinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

93

329
(L)-2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

330
(L)-2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

331
2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

92

332
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

93

333
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

334
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

335
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

90

336
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

91

337
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

85

338
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

90

339
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

92

340
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

95

341
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

94

342
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

94

343
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

95

344
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

345
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

94

346
2-(2-pyrrolyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino- 2-pyrimidinyl)amide

embedded image

91

347
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

348
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

embedded image

94

349
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

embedded image

86

350
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-6-purinyl)amide

embedded image

92

351
2-(2-pyrrolyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

embedded image

87

352
(L)-2-(4-methyl-5- aminothiazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

353
(L)-2-(4-methyl-5- aminothiazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

354
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

355
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

94

356
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

90

357
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

embedded image

94

358
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

embedded image

93

359
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

embedded image

94

360
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

embedded image

90

361
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N- 4′-pyrazolyl)amide

embedded image

94

362
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-(N'- piperazinyl))amide

embedded image

92

363
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

94

364
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

94

365
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2-pyridyl)amide

embedded image

93

366
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

embedded image

90

367
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

embedded image

91

368
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4,6-dimethoxy- 2-pyrimidinyl)amide

embedded image

93

369
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

embedded image

93

370
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

88

371
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

embedded image

89

372
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-2- hydroxyl-4-pyrimidinyl)amide

embedded image

87

373
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-6-purinyl)amide

embedded image

92

374
2-(4-methyl-5-aminothiazolyl)-1H- benzimidazole-4-(N-6-hydroxyl-2- purinyl)amide

embedded image

90

375
(L)-2-(2-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

91

376
(L)-2-(2-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

377
2-(2-quinolinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

378
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

94

379
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

380
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

381
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

92

382
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

91

383
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

91

384
2-(2-quinolinyl)-lH-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

93

385
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

92

386
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

387
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

94

388
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

92

389
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

92

390
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

391
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

94

392
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

93

393
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

394
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

395
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

88

396
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

90

397
2-(2-quinolinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

85

398
(L)-2-(3-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

399
(L)-2-(3-quinolinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

91

400
2-(3-quinolinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

93

401
2-(3-quinolinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

402
(L)-2-(2-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

91

403
(L)-2-(2-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

89

404
2-(2-piperidinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

91

405
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

92

406
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

407
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

408
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

93

409
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

93

410
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

85

411
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

89

412
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

87

413
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

414
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

92

415
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

91

416
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

93

417
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

88

418
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

93

419
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

89

420
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

421
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

92

422
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

86

423
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

91

424
2-(2-piperidinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

89

425
(L)-2-(3-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

426
(L)-2-(3-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

427
2-(3-piperidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

428
2-(3-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

94

429
(L)-2-(4-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

92

430
(L)-2-(4-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

431
2-(4-piperidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

91

432
2-(4-piperidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

433
(L)-2-(3-indolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

434
(L)-2-(3-indolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

88

435
2-(3-indolyl)-1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

90

436
2-(3-indolyl)-1H-benzimidazole-4- (N-N′-piperidinyl)amide

embedded image

94

437
2-(3-indolyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

embedded image

92

438
2-(3-indolyl)-1H-benzimidazole-4- (N-2′-benzimidazolyl)amide

embedded image

90

439
2-(3-indolyl)-1H-benzimidazole-4- (N-o-aminophenyl)amide

embedded image

91

440
2-(3-indolyl)-1H-benzimidazole-4- (N-5-benzimidazolonyl)amide

embedded image

93

441
2-(3-indolyl)-1H-benzimidazole-4- (N-4′-carbonamido- 5′-imidazolyl)amide

embedded image

93

442
2-(3-indolyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

embedded image

88

443
2-(3-indolyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

embedded image

89

444
2-(3-indolyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

embedded image

94

445
2-(3-indolyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

embedded image

92

446
2-(3-indolyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

embedded image

93

447
2-(3-indolyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

embedded image

91

448
2-(3-indolyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

87

449
2-(3-indoIyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

93

450
2-(3-indolyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

88

451
2-(3-indolyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

92

452
2-(3-indolyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

embedded image

94

453
2-(3-indolyl)-1H-benzimidazole-4- (N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

86

454
2-(3-indolyl)-1H-benzimidazole-4- (N-6-purinyl)amide

embedded image

90

455
2-(3-indolyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

embedded image

86

456
(L)-2-(2′-imidazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

457
(L)-2-(2′-imidazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

458
2-(2′-imidazolyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

88

459
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

93

460
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

90

461
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

94

462
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

86

463
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

90

464
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

86

465
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

93

466
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

93

467
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

94

468
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

93

469
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

90

470
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

94

471
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

86

472
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

94

473
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

86

474
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

475
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

476
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

88

477
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

93

478
2-(2′-imidazolyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

87

479
(L)-2-(3-pyrazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitiophenylhydroxyethyl)]amide

embedded image

94

480
(L)-2-(3-pyrazolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

86

481
2-(3-pyrazolyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

90

482
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

94

483
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

93

484
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

93

485
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

88

486
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

93

487
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

87

488
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

94

489
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

86

490
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

90

491
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

86

492
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

93

493
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

93

494
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

88

495
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

93

496
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

88

497
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

94

498
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

499
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

90

500
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

86

501
2-(3-pyrazolyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

89

502
(L)-2-(2-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

93

503
(L)-2-(2-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

88

504
2-(2-pyrimidinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

93

505
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

embedded image

90

506
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

embedded image

94

507
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

embedded image

92

508
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

embedded image

90

509
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

embedded image

86

510
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

embedded image

87

511
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

embedded image

93

512
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

embedded image

88

513
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

embedded image

93

514
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

embedded image

90

515
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

embedded image

94

516
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

embedded image

93

517
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

embedded image

90

518
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

embedded image

86

519
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

embedded image

93

520
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

93

521
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

embedded image

93

522
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

88

523
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

embedded image

90

524
2-(2-pyrimidinyl)-1H-benzimidazole- 4-(N-6-hydroxyl-2-purinyl)amide

embedded image

86

525
(L)-2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

90

526
(L)-2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

90

527
2-(2-phenyI-5-pyrimidinyl)-1H- benzimidazole-4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

86

528
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

93

529
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2- piperazinyl)amide

embedded image

93

530
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2′- benzimidazolyl)amide

embedded image

88

531
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-o- aminophenyl)amide

embedded image

93

532
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-5- benzimidazolonyl)amide

embedded image

90

533
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

embedded image

94

534
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4′- pyrazolyl)amide

embedded image

90

535
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-(N′- piperazinyl))amide

embedded image

90

536
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2- pyrazinyl)amide

embedded image

86

537
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2- pyrimidinyl)amide

embedded image

93

538
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2-pyridyl)amide

embedded image

93

539
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

embedded image

88

540
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2,4-dihydroxyl- 5-pyrimidinyl)amide

embedded image

93

541
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4,6-dimethoxy- 2-pyrimidinyl)amide

embedded image

90

542
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

embedded image

94

543
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-4,6-dichloro-5- pyrimidinyl)amide

embedded image

94

544
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

embedded image

90

545
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-2-hydroxyl-4- pyrimidinyl)amide

embedded image

86

546
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-6-purinyl)amide

embedded image

93

547
2-(2-phenyl-5-pyrimidinyl)-1H- benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

embedded image

93

548
(L)-2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

embedded image

88

549
(L)-2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

embedded image

93

550
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

embedded image

90

551
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

embedded image

94

552
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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86

553
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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90

554
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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86

555
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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93

556
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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86

557
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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88

558
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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93

559
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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90

560
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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90

561
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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86

562
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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90

563
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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86

564
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

565
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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90

566
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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88

567
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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93

568
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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90

569
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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91

570
2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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93

571
(L)-2-(2-pyrrolidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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94

572
(L)-2-(2-pyrrolidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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90

573
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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94

574
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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92

575
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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94

576
2-( 2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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94

577
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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93

578
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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90

579
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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85

580
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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93

581
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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93

582
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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88

583
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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89

584
2-(2-pyrrolidine-l-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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87

585
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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92

586
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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90

587
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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91

588
2-{ 2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4- chloro-6-amino-2-pyrimidinyl)amide

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93

589
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6-dichloro- 5-pyrimidinyl)amide

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93

590
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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94

591
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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90

592
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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93

593
2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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92

594
(L)-2-(2-piperidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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91

595
(L)-2-(2-piperidine-1-yl-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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91

596
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2- p-chlorophenylhydroxyethyl)]amide

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93

597
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-N′- piperidinyl)amide

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92

598
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- piperazinyl)amide

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93

599
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2′- benzimidazolyl)amide

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94

600
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- aminophenyl)amide

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92

601
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5- benzimidazolonyl)amide

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92

602
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- carbonamido-5′-imidazolyl)amide

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85

603
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4′- pyrazolyl)amide

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94

604
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-(N′- piperazinyl))amide

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90

605
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrazinyl)amide

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94

606
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyrimidinyl)amide

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92

607
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2- pyridyl)amide

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94

608
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5- thiazolyl)amide

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94

609
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4- dihydroxyl-5-pyrimidinyl)amide

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93

610
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dimethoxy-2-pyrimidinyl)amide

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90

611
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-chloro-6- amino-2-pyrimidinyl)amide

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91

612
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6- dichloro-5-pyrimidinyl)amide

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93

613
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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93

614
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl- 4-pyrimidinyl)amide

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88

615
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6- purinyl)amide

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89

616
2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl- 2-purinyl)amide

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87

617
(L)-2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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92

618
(L)-2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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90

619
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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91

620
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

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93

621
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-piperazinyl)amide

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93

622
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

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94

623
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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90

624
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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93

625
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4′-carbonamido- 5′-imidazolyl)amide

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92

626
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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91

627
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

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91

628
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

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93

629
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

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92

630
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2-pyridyl)amide

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93

631
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

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94

632
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

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92

633
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

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92

634
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4-chloro-6-amino-2- pyrimidinyl)amide

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93

635
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

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94

636
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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90

637
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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94

638
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole- 4-(N-6-purinyl)amide

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92

639
2-(2-cyclopropylamino-5- pyrimidinyl)-1H-benzimidazole-4- (N-6-hydroxyl-2-purinyl)amide

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94

640
(L)-2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)] amide

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94

641
(L)-2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- aminophenylhydroxyethyl)]amide

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93

642
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- [N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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90

643
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-N′-piperidinyl)amide

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91

644
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-piperazinyl)amide

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93

645
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2′-benzimidazolyl)amide

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93

646
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-o-aminophenyl)amide

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88

647
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-5-benzimidazolonyl)amide

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89

648
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4′-carbonamido-5′- imidazolyl)amide

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87

649
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4′-pyrazolyl)amide

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92

650
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-(N′-piperazinyl))amide

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90

651
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-pyrazinyl)amide

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91

652
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-pyrimidinyl)amide

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93

653
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-pyridyl)amide

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93

654
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4-methyl-5-thiazolyl)amide

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94

655
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2,4-dihydroxyl-5- pyrimidinyl)amide

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90

656
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4,6-dimethoxy-2- pyrimidinyl)amide

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93

657
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4-chloro-6-amino-2- pyrimidinyl)amide

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92

658
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-4,6-dichloro-5- pyrimidinyl)amide

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91

659
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-o-fluorophenyl)amide

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91

660
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide

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93

661
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-6-purinyl)amide

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92

662
2-(1,3-dimethyl-5-chloro-4- pyrazolyl)-1H-benzimidazole-4- (N-6-hydroxy]-2-purinyl)amide

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93

663
2-(4-hydroxyphenyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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94

664
(L)-2-(3-hydroxyphenyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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92

665
2-(3-hydroxyphenyl)-1H- benzimidazole-4-(N-6- hydroxyl-2-purinyl)amide

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Structure Identification of Product (refer to FIGS. 3-6):

(23) 2-(2-pyridyl)-1H-benzimidazole-4-N-hydroxyethylamide

¹HNMR (DMSO, 400 MHz) δ: 3.64-3.67(t,1H), 3.73-3.75(m,2H), 4.39-4.42(t,2H), 7.32-7.36(t,1H), 7.38-7.40(t,1H), 7.73-7.75(d,1H), 7.80-7.81(d,1H), 7.85-7.86(t,1H), 8.38-8.40(d,1H), 8.59-8.61(d,1H);

(24) 2-(2-pyridyl)-1H-benzimidazole-4-N-o-hydroxyphenylcarboxylamide

¹HNMR (DMSO, 400 MHz) δ: 5.35(s,1H), 7.13(s,1H), 7.15-7.16(d,2H), 7.34-7.36(t,3H), 7.37-7.39(t,1H), 7.83-7.84(d,1H), 7.85-7.86(t,1H), 7.91-7.92(d,1H), 8.11-8.12(d,1H), 8.38-8.40(d,1H), 8.59-8.61(d,1H);

(25) 2-(2-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.35(s,1H), 6.59-6.61(d,1H), 6.63-6.64(t,1H), 6.95-6.97(t,1H), 6.99-7.00(d,1H), 7.01-7.02(d,1H), 7.07-7.09(t,1H), 7.24-7.25(t,1H), 7.37-7.39(t,1H), 7.62-7.63(d,1H), 7.83-7.84(d,1H), 7.91-7.92(d,1H);

(26) (L)-2-(2-hydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.35(s,1H), 7.01-7.02(d,1H), 7.07-7.09(t,1H), 7.24-7.25(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.66-7.67(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(27) 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.46(t,1H), 7.70-7.72(d,1H), 7.89-7.91(d,1H), 7.93-7.95(d,1H), 8.30-8.33(d,1H), 8.57-8.60(d,1H), 11.53(s,1H);

(28) 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (Refer to FIG. 3)

¹HNMR(DMSO, 400 MHz)δ:7.13-7.19(m,1H),7.23-7.27(t,1H),7.36-7.41(t,1H),7.50-7.54(m,2H), 7.85-7.87(d,1H), 7.94-7.95(d,1H), 8.05-8.07(d,1H), 8.57-8.61(t,1H), 12.19-12.20(d,1H), 14.25(s,1H);

(29) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.33(s,1H), 5.35(s,1H), 5.38(s,1H), 6.59-6.61(d,1H), 6.63-6.64(t,1H), 6.71(s,2H), 6.95-6.97(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(30) 2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-hydroxyethyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.33(s,1H), 5.35(s,1H), 5.38(s,1H), 2.84-2.88(m,2H), 3.59-3.62(m,2H), 3.65-3.67(t,1H), 6.71(s,2H), 7.43-7.45(t,1H), 7.89-7.90 (d,1H), 7.93-7.94(d,1H);

(31) 2-(2-piperidinyl)-1H-benzimidazole-4-(4-N′-ethyl-N-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 1.43-1.44(m,1H), 1.45-1.47(m,1H), 1.49-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m1H), 1.91-1.94(m,1H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.04(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(32) 2-(2-pyridyl)-1H-benzimidazole-4-(4-N′-ethyl-N-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 7.36-7.38(t,H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.39(d,1H), 8.59-8.61(d,1H);

(33) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.17-3.18(m,1H), 3.19-3.20(d,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(34) (L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.17-3.18(m,1H), 3.19-3.20(d,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(35) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(36) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.10-3.15(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(37) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 1.91-1.93(m,2H), 2.00-2.06(t,4H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.19-3.20(d,1H), 3.99-4.01(m,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(38) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(39) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(40) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(41) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(42) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

(43) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 1.91-1.95(m,1H), 2.00-2.06(t,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(44) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

(45) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(46) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(47) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 2.45(s,3H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(48) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(49) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 3.82(s,6H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(50) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(51) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(52) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(53) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(54) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(55) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-hydroxy-2-purinyl)amide

(56) (L)-2-(2-thienyl)-1H-benzimidzzole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(57) (L)-2-(2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(58) 2-(2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.17-7.19(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(59) 2-(2-thienyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(60) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(61) 2-(2-thienyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.17-7.19(t,1H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(62) 2-(2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(63) 2-(2-thienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(64) 2-(2-thienyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(65) 2-(2-thienyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(66) 2-(2-thienyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(67) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(68) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.17-7.19(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(69) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(70) 2-(2-thienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(71) 2-(2-thienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.82(s,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(72) 2-(2-thienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(73) 2-(2-thienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.74(s,2H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(74) 2-(2-thienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(75) 2-(2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(76) 2-(2-thienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.82(s,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(77) 2-(2-thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.86(d,1H), 7.87-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(78) 2-(2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(79) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.49-8.51(d,1H);

(80) (L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.49-8.51(d,1H);

(81) 2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,3H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.31(s,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(82) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(83) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,3H), 3.99-4.01(m,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(84) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(85) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(86) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(87) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.49-8.51(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(88) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(89) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(90) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.49-8.51(d,1H);

(91) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.93-6.95(t,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.49-8.51(d,1H);

(92) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.49-8.51(d,1H);

(93) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.49-8.51(d,1H);

(94) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.49-8.51(d,1H), 11.53(s,1H);

(95) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 3.85(s,3H), 5.71(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(96) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.98(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(97) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H), 9.34(s,1H);

(98) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(99) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H);

(100) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.49-8.51(d,1H);

(101) 2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(102) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.80(s,1H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.72-7.74(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(103) (L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.80(s,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.50-6.52(d,1H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(104) 2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.80(s,1H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.29-7.30(d,2H), 7.38-7.39(d,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.72-7.74(t,1H), 7.93-7.94(d,1H);

(105) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(106) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.80(s,1H), 3.99-4.01(m,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(107) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(108) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.50-6.52(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(109) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.35-6.37(d,1H), 6.50-6.52(d,1H), 6.93(s,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(110) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(111) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(112) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.72-7.74(t,1H), 7.93-7.94(d,1H);

(113) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(114) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 6.93-6.95(t,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(115) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(116) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(117) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(118) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 3.82(s,6H), 5.71(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(119) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 5.98(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.72-7.74(t,1H), 7.93-7.94(d,1H);

(120) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(121) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(122) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 5.46-5.48(d,1H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(123) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(124) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(125) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.32-8.35(d,1H);

(126) (L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.65-6.67(d,1H), 6.86(s,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.32-8.35(d,1H);

(127) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 2.68(s,6H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(128) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.68(s,6H), 3.10-3.15(t,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(129) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.68(s,6H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(130) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(131) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.65-6.67(d,1H), 6.75-6.76(d,1H), 6.86(s,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(132) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.35-6.37(d,1H), 6.65-6.67(d,1H), 6.86(s,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(133) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(134) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(135) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.68(s,6H), 2.80-2.83(m,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(136) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(137) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.45-8.46(d,2H);

(138) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.62-6.64(t,1H), 6.65-6.67(d,1H), 6.70-6.72(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.32-8.35(d,1H);

(139) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.32-8.35(d,1H);

(140) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.30(s,1H), 8.32-8.35(d,1H), 11.53(s,1H);

(141) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 3.82(s,6H), 5.71(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(142) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 5.98(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(143) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 9.34(s,1H);

(144) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.60-6.61(d,1H), 6.63-6.64(t,1H), 6.66-6.67(d,1H), 6.86(s,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(145) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 5.46-5.48(d,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H);

(146) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.32-8.35(d,1H);

(147) 2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(148) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(149) (L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.27(s,2H), 6.50-6.52(d,1H), 6.56-6.58(d,2H), 7.11-7.12(d,2H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(150) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(151) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(152) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,9H), 3.99-4.01(m,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(153) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(154) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.27(s,2H), 6.38-6.40(d,1H), 6.50-6.52(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(155) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.35-6.37(d,1H), 6.50-6.52(d,1H), 6.93(s,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(156) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(157) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(158) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(159) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(160) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.93-6.95(t,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(161) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(162) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(163) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(164) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 3.83(s,9H), 5.71(s,1H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(165) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 5.98(s,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(166) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(167) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(168) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 5.46-5.48(d,1H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(169) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(170) 2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(171) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(172) (L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.88-6.90(d,1H), 7.11-7.13(d,2H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(173) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(174) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(175) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.83(s,3H), 3.99-4.01(m,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(176) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.12-7.15(d,2H), 7.21(s,1H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(177) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.88-6.90(d,1H), 7.02-7.04(t,1H), 7.21(s,1H), 7.53-7.55(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(178) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.35-6.37(d,1H), 6.88-6.90(d,1H), 6.93(s,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.49-7.52(d,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(179) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(180) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(181) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(182) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(183) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 6.93-6.95(t,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(184) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.51-7.52(d,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(185) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(186)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(187) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.79(s,6H), 3.83(s,3H), 5.35(s,1H), 5.71(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(188)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 5.98(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(189)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(190) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.88-6.90(d,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(191)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 5.46-5.48(d,1H), 6.88-6.90(d,1H), 7.10-7.11(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(192) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(193) 2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(194) (L)-2-(2-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (Refer to FIG. 4)

¹HMNR(DMSO, 400 MHz)δ:3.57-3.61(m,1H),3.66-3.70(m,1H),4.20-4.22(m,1H),5.08-5.11(q,1H),5.28-5.29(d,1H),6.29-6.30(d,1H), 7.28-7.32(t,1H), 7.57-7.61(m,1H), 7.67-7.73(m,4H), 8.02-8.06(m,3H), 8.57-8.59(m,1H), 8.78-8.80(m,1H), 10.47-10.49(d,1H), 13.62(s,1H);

(195) (L)-2-(2-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(196) 2-(2-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.36-7.38(t,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(197) 2-(2-pyridyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(198) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(199) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(200) 2-(2-pyridyl)-1H-benzimidazole-4(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(201) 2-(2-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(202) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(203) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(204) 2-(2-pyridyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(205) 2(2-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.38-8.41(d,1H), 8.43-8.45(d,1H), 8.59-8.60(d,1H);

(206) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.45-8.46(d,2H), 8.59-8.60(d,1H);

(207) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(208) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(209) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 11.53(s,1H);

(210) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(211) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(212) 2-(2-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 9.34(s,1H);

(213) 2-(2-pyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(214) 2-(2-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(215) 2-(2-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.87-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H);

(216) 2-(2-pyridyl)-1H-benzimidazole-4(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.57-8.59(d,1H), 8.59-8.60(d,1H), 11.53(s,1H);

(217) (L)-2-(3-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.42-8.44(d,1H), 8.70-8.72(d,1H), 9.24(s,1H);

(218) (L)-2-(3-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.42-8.44(d,1H), 8.70-8.72(d,1H), 9.24(s,1H);

(219) 2-(3-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.42-8.44(d,1H), 8.70-8.72(d,1H), 9.24(s,1H);

(220) 2-(3-pyridyl)-1H-benzimidazole-4(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.41-8.43(d,1H), 8.45-8.46(d,2H), 8.70-8.72(d,1H), 9.24(s,1H);

(221) (L)-2-(4-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(222) (L)-2-(4-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);

(223) 2-(4-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);

(224) 2-(4-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.25-8.28(d,2H), 8.45-8.46(d,2H), 8.75-8.77(d,2H);

(225) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.64-7.67(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8.11(d,1H), 8.17-8.20(d,2H), 9.34-9.37(d,1H);

(226) (L)-2-(3-pyridazinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(227) 2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(228) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—N′-piperdinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(229) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(230) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(231) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(232) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(233) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-carbonamido)-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 9.34-9.37(d,1H), 13.00-13.03(d,1H);

(234) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.34-9.37(d,1H), 13.71-13.75(d,1H);

(235) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(236) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.34-9.37(d,1H);

(237) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.45-8.46(d,2H), 9.34-9.37(d,1H);

(238) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.11-8.13(d,1H), 8.59-8.60(d,1H);

(239) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.12(s,1H), 9.34-9.37(d,1H);

(240) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.33(s,1H), 9.34-9.37(d,1H), 11.53(s,1H);

(241) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(242) 2-(3-pyridazinyl)-1H-benzimidazole-4(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(243) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.32(s,1H), 9.34-9.37(d,1H);

(244) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(245) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H);

(246) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.16-8.18(d,1H), 9.34-9.37(d,1H);

(247) 2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.57-8.59(d,1H), 9.34-9.37(d,1H), 11.53(s,1H);

(248) (L)-2-(4-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(249) (L)-2-(4-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.30-9.32(d,1H), 9.46(s,1H);

(250) 2-(4-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.30-9.32(d,1H), 9.46(s,1H);

(251) 2-(4-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.30-9.32(d,1H), 9.46(s,1H);

(252) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(253) (L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(254) 2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(255) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(256) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(257) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(258) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(259) 2-(2-pyrazinyl)-b 1-l H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.931(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(260) 2-(2-pyrazinyl)-1H-benzimidazole-4(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.76-8.79(d,2H), 9.24-9.26(d,1H), 9.34(s,1H), 13.00-13.03(d,1H);

(261) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 13.71-13.75(d,1H);

(262) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(263) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(264) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.76-8.79(d,2H), 9.34(s,1H);

(265) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(266) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(267) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H);

(268) 2-(2-pyrazinyl)1H-benzimidazole-4(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(269) 2-(2-pyrazinyl)1H-benzimidazole-4(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(270) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 9.37(s,1H);

(271) 2-(2-pyrazinyl)1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(272) 2-(2-pyrazinyl)-1H)-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(273) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.76-8.79(d,2H), 9.34(s,1H);

(274) 2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H);

(275) (L)-2-(2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(276) (L)-2-(2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(277) 2-(2-piperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.14-4.17(m,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(278) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.13-3.15(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(279) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,4H), 2.62-2.63(m,2H), 2.65-2.66(m,2H), 2.69-2.70(m,2H), 2.72-2.74(m,2H), 2.77-2.80(m,1H), 2.84-2.86(m,1H), 3.02-3.05(m,1H), 3.09-3.11(m,1H), 3.99-4.01(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(280) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(281) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(282) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(283) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(284) 2(2-piperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(285) 2-(2-piperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 1.94-1.95(m,1H), 2.62-2.63(m,1H), 2.65-2.67(t,5H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.80-2.83(m,4H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(286) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(287) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(288) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(289) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.45(s,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(290) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(291) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 3.82(s,6H), 5.71(s,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(292) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(293) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(294) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(295) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(296) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(297) 2-(2-piperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3.11(m,1H), 4.14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(298) (L)-2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(299) (L)-2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(300) 2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 1.91-1.93(m,2H), 2.40-2.43(m,4H), 2.59-2.60(d,1H), 2.62-2.63(m,1H), 2.64-2.65(t,1H), 2.66-2.67(m,1H), 2.68-2.70(t,2H), 2.72-2.73(m,1H), 2.74-2.75(t,1H), 2.76-2.78(t,1H), 2.77-2.80(m,1H), 2.88-2.90(d,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 4.14-4.16(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(301) 2-(N,N′-diethyl-2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 4.14-4.16(t,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(302) (L)-2-(N-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3.18-3.22(t,4H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(303) (L)-2-(N-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3.18-3.22(t,4H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(304) 2-(N-piperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(305) 2-(N-piperazinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.10-3.15(t,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(306) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.78-2.82(m,5H), 3.02-3.05(m,1H), 3.17-3.22(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(307) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(308) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(309) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(310) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(311) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(312) 2-(N-piperazinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,2H), 2.65-2.67(t,4H), 2.78-2.80(m,4H), 2.81-2.83(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(313) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(314) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(315) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(316) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.45(s,3H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(317) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(318) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(319) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(320) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(321) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(322) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(323) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(324) 2-(N-piperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(325) (L)-2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(326) (L)-2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(327) 2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 1.91-1.93(m,2H), 2.38-2.41(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(328) 2-(N-ethyl-N′-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(329) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(330) (L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.95-6.97(d,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(331) 2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(332) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(333) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(334) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(335) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.27(s,2H), 6.38-6.39(d,1H), 6.40-6.42(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.95-6.97(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(336) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.35-6.37(d,1H), 6.40-6.42(d,1H), 6.93(s,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(337) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(338) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(339) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(340) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(341) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:6.15-6.18(t,1H),6.40-6.42(d,1H),6.93-6.95(t,1H), 6.98-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(342) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(343) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(344) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:6.15-6.18(t,1H),6.40-6.42(d,1H),6.95-6.97(d,1H),7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(345) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:3.82(s,6H), 5.71(s,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(346) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(347) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(348) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.90-6.93(d,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(349) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR(DMSO, 400 MHz)δ:5.46-5.48(d,1H),6.15-6.18(t,1H),6.40-6.42(d,1H),6.95-6.97(d,1H),7.10-7.11(d,1H),7.43-7.45(t,1H),7.82(s,1H),7.89-7.91(d,1H),7.93-7.94(d,1H);

(350) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H),7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(351) 2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(352) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.99(s,2H),7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(353) (L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR(DMSO, 400 MHz)δ: 2.45(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.99(s,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(354) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 2.45(s,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.99(s,2H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(355) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.45(s,3H), 3.10-3.15(t,4H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(356) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.45(s,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(357) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(358) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.99(s,2H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(359) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(360) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(361) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(362) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.45(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.99(s,2H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(363) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(364) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.93-6.95(t,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(365) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(366) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,6H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(367) 2-(4-methyl-5-aminothiazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(368) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 3.82(s,6H), 5.71(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(369) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 5.98(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(370) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(371) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.97(t,1H), 6.99(s,2H), 7.02-7.05(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(372) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 5.46-5.48(d,1H), 6.99(s,2H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(373) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(374) 2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(375) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.64-7.65(d,2H), 7.76-7.77 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.17-8.20(d,2H), 8.44-8.46(d,1H);

(376) (L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.40-8.41(d,1H), 8.44-8.46(d,1H);

(377) 2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.35-7.37(d,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(378) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(379) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(380) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(381) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(382) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(383) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.37(s,2H), 8.44-8.46(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(384) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(385) 2-(2-quinolinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(386) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.44-8.46(d,1H);

(387) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.40-8.43(d,1H), 8.45-8.46(d,2H);

(388) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.04-8.05(d,1H), 8.07-8.09(d,1H), 8.44-8.46(d,1H);

(389) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.12(s,1H), 8.44-8.46(d,1H);

(390) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.33(s,1H), 8.44-8.46(d,1H), 11.53(s,1H);

(391) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(392) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.74(s,2H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(393) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 9.34(s,1H);

(394) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(395) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H);

(396) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.16-8.18(d,1H), 8.44-8.46(d,1H);

(397) 2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 11.53(s,1H);

(398) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.59-7.60(t,1H), 7.62-7.65(d,2H), 7.77-7.79(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.17-8.20(d,2H), 8.22(s,1H), 8.57(s,1H);

(399) (L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.77-7.79(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.57(s,1H);

(400) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.57(s,1H);

(401) 2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.77-7.79(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.45-8.46(d,2H), 8.57(s,1H);

(402) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(403) (L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(404) 2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(405) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.51(m,1H), 1.53-1.55(m,4H), 1.55-1.57(m,1H), 1.59-1.63(m,2H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.10-3.15(t,4H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(406) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.87-1.88(m,1H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.73(m,1H), 2.75-2.76(m,1H), 2.77-2.80(m,1H), 2.82-2.85(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 4.03-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(407) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(408) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(409) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(410) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(411) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(412) 2-(2-piperidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.84-1.89(m,1H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 2.84-2.85(m,4H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(413) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(414) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(415) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(416) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.45(s,3H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(417) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(418) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

(419) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(420) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(421) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(422) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(423) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(424) 2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(425) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.71-2.73(m,1H), 2.74-7.76(m,1H), 2.78-2.80(m,1H), 2.90-2.92(t,1H), 3.12-3.15(t,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(426) (L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.71-2.73(m,1H), 2.74-7.76(m,1H), 2.78-2.80(m,1H), 2.90-2.92(t,1H), 3.12-3.15(t,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(427) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.89-1.90(m,2H), 1.92-1.95(m,1H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.69-2.70(m,1H), 2.71-2.72(m,1H), 2.74-7.76(m,1H), 2.77-2.80(m,1H), 2.82-2.84(m,1H), 2.90-2.92(t,1H), 3.02-3.05(m,1H), 3.15-3.17(t,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(428) 2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

(429) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(430) (L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(431) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.89-1.90(m,2H), 1.92-1.95(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.67-2.68(m,1H), 2.69-2.71(m,2H), 2.72-2.74(m,1H), 2.75-2.76(m,1H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(432) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(433) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.14-8.16(d,1H), 8.17-8.20(d,2H), 8.60-8.62(d,1H);

(434) (L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.01-7.04(t,1H), 7.11-7.13(d,2H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(435) 2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.01-7.04(t,1H), 7.29-7.30(d,2H), 7.31-7.33(t,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(436) 2-(3-indolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(437) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(438) 2-(3-indolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(439) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.06-7.08(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(440) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.50-7.52(d,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(441) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(442) 2-(3-indolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.57-8.59(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(443) 2-(3-indolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(444) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.60-8.62(d,1H);

(445) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.45-8.46(d,2H), 8.60-8.62(d,1H);

(446) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.57-7.58(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(447) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(448) 2-(3-indolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.33(s,1H), 8.60-8.62(d,1H), 11.53(s,1H);

(449) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(450) 2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(451) 2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H), 9.34(s,1H);

(452) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.02-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(453) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.01-7.04(t,1H), 7.10-7.11(d,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H);

(454) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.13-8.15(d,1H), 8.17-8.19(d,1H), 8.60-8.62(d,1H);

(455) 2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.57-8.59(d,1H), 8.60-8.62(d,1H), 11.53(s,1H);

(456) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 13.00-13.03(d,1H);

(457) (L)-2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 13.00-13.03(d,1H);

(458) 2-(2′-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(459) 2-(2′-imidazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(460) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(461) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(462) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.05-7.08(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(463) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(464) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H), 13.05-13.07(d,1H);

(465) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.00-13.03(d,1H), 13.71-13.75(d,1H);

(466) 2-(2-imidazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(467) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 13.00-13.03(d,1H);

(468) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 13.00-13.03(d,1H);

(469) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 13.00-13.03(d,1H);

(470) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 13.00-13.03(d,1H);

(471) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H), 13.00-13.03(d,1H);

(472) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(473) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(474) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H), 13.00-13.03(d,1H);

(475) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.95-6.96(t,1H), 6.97-6.99(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(476) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H);

(477) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 13.00-13.03(d,1H);

(478) 2-(2-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H), 13.00-13.03(d,1H);

(479) (L)-2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.85-7.87(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 12.62-12.64(d,1H);

(480) (L)-2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.48-6.50(d,1H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 12.62-12.64(d,1H);

(481) 2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.48-6.50(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(482) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(483) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(484) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(485) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.48-6.50(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(486) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.48-6.50(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(487) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 12.62-12.64(d,1H), 13.00-13.03(d,1H);

(488) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 12.62-12.64(d,1H), 13.71-13.75(d,1H);

(489) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(490) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 12.62-12.64(d,1H);

(491) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 12.62-12.64(d,1H);

(492) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 12.62-12.64(d,1H);

(493) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 12.62-12.64(d,1H);

(494) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.85-7.87(t,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H), 12.62-12.64(d,1H);

(495) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(496) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(497) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H), 12.62-12.64(d,1H);

(498) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(499) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 6.48-6.50(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H);

(500) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 12.62-12.64(d,1H);

(501) 2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H), 12.62-12.64(d,1H);

(502) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(503) (L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.67-7.70(t,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.08-9.11(d,2H);

(504) 2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(505) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(506) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(507) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(508) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(509) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(510) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.08-9.11(d,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(511) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.08-9.11(d,2H), 13.71-13.75(d,1H);

(512) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(513) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.08-9.11(d,2H);

(514) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.08-9.11(d,2H);

(515) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.08-9.11(d,2H);

(516) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.08-9.11(d,2H);

(517) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.08-9.11(d,2H), 11.53(s,1H);

(518) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.67-7.70(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(519) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(520) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H), 9.34(s,1H);

(521) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(522) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H);

(523) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.08-9.11(d,2H);

(524) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.08-9.11(d,2H), 11.53(s,1H);

(525) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.28-8.31(d,2H), 9.26(s,2H);

(526) (L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(527) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.38-7.39(t,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(528) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(529) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(530) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(531) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(532) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(533) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.37(s,2H), 9.24-9.26(d,1H), 9.29(s,2H)13.00-13.03(d,1H);

(534) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.61(s,1H), 8.63-8.65(d,1H), 9.26(s,2H), 13.71-13.75(d,1H);

(535) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(536) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.26(s,2H);

(537) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.45-8.46(d,2H), 9.26(s,2H);

(538) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(539) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(540) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.33(s,1H), 9.26(s,2H), 11.53(s,1H);

(541) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(542) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(543) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H), 9.34(s,1H);

(544) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(545) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(546) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.28-8.31(d,2H), 9.26(s,2H);

(547) 2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.57-8.59(d,1H), 9.26(s,2H), 11.53(s,1H);

(548) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

(549) (L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.59(s,1H);

(550) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(551) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(552) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(553) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(554) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(555) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(556) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.59(s,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(557) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(558) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.74(s,2H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(559) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.59(s,1H);

(560) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.59(s,1H);

(561) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.59(s,1H);

(562) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.45(s,3H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.59(s,1H);

(563) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.59(s,1H), 11.53(s,1H);

(564) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(565) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,4H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(566) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H), 9.34(s,1H);

(567) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(568) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H);

(569) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.59(s,1H);

(570) 2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 8.62(s,1H), 11.53(s,1H);

(571) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.02(s,2H);

(572) (L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.02(s,2H);

(573) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.92-1.95(m,4H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(574) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.92-1.95(m,4H), 3.10-3.15(t,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(575) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.87-1.89(m,2H), 1.92-1.95(m,4H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.44-3.48(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(576) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(577) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(578) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(579) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(580) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H);

(581) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.87-1.89(m,1H), 1.92-1.95(m,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(582) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H);

(583) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H);

(584) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.02(s,2H);

(585) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 2.45(s,3H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H);

(586) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H);

(587) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(588) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(589) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H);

(590) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(591) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(592) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.02(s,2H);

(593) 2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H);

(594) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.73-3.77(t,4H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.02(s,2H);

(595) (L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.71-3.75(t,4H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.02(s,2H);

(596) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.71-3.75(t,4H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(597) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,8H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(598) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.71-3.75(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(599) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(600) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(601) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(602) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(603) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H);

(604) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N—(N′-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(605) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H);

(606) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H);

(607) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.02(s,2H);

(608) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 2.45(s,3H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H);

(609) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H);

(610) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91 (d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(611) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(612) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H);

(613) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(614) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(615) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.02(s,2H);

(616) 2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H);

(617) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.02(s,2H);

(618) (L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.02(s,2H);

(619) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.12-1.15(d,3H), 1.35-1.37(m,1H),3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(620) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N—N′-piperodinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.52-1.55(m,4H),1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(621) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(622) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(623) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(624) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(625) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(626) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H);

(627) 2-(2-cyclopropylamino-5-pyrimidinyl)1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.91-1.95(m,1H),2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(628) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H);

(629) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H);

(630) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.02(s,2H);

(631) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 2.45(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H);

(632) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H),7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H);

(633) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.82(s,6H),5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(634) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(635) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H);

(636) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(637) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);

(638) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 9.02(s,2H);

(639) 2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H);

(640) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.95(s,3H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(641) (L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H),3.17-3.18(m,1H),3.25-3.28(m,1H),3.50-3.52 (m,1H),3.65-3.68(t,1H),3.70-3.72(d,1H),3.95(s,3H),4.73-4.77(t,1H),6.27(s,2H),6.56-6.58 (d,2H),7.11-7.13(d,2H),7.43-7.45(t,1H),7.89-7.90(d,1H),7.93-7.95(d,1H);

(642) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 2.06(s,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.95(s,3H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(643) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.06(s,3H), 3.10-3.15(t,4H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(644) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide

¹HNMR(DMSO,400 MHz)δ:1.91-1.93(m,2H), 2.06(s,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.95(s,3H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(645) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(646) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(647) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(648) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(649) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(650) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.91-1.95(m,1H), 2.06(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.95(s,3H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(651) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(652) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(653) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(654) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 2.45(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(655) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(656) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.82(s,6H), 3.95(s,3H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(657) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(658) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(659) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H), 3.95(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(660) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H), 3.95(s,3H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(661) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR(DMSO,400 MHz)δ:2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(662) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H);

(663) 2-(4-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (refer to FIG. 5)

¹HNMR(DMSO,400 MHz)δ:7.13-7.19(m,1H),7.23-7.27(t,1H),7.36-7.41(t,1H),7.50-7.54(m,2H), 7.85-7.87(d,1H), 7.94-7.95(d,1H), 8.05-8.07(d,1H), 8.57-8.61(t,1H), 12.19-12.20(d,1H), 14.25(s,1H);

(664) (L)-2-(3-hydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (Refer to FIG. 6)

¹HNMR(DMSO,400 MHz)δ:3.51-3.57(m,1H),3.64-3.72(m,1H),4.22-4.26(m,1H),5.05-5.08(q,1H),5.25-5.27(d,1H),6.16-6.18(d,1H),6.95-6.98(d,1H), 7.23-7.27(t,1H),7.30-7.34(t,1H),7.36-7.40(m,1H),7.65-7.73(m,4H),7.80-7.84(m,1H), 8.03-8.10(m,2H), 9.76(s,1H), 10.43-10.46(d,1H), 13.31(s,1H);

(665) 2-(3-hydroxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 5.35(s,1H), 6.91-6.93(d,1H), 7.04(s,1H), 7.34-7.36(d,1H), 7.43-7.45(t,1H), 7.84-7.86(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H).

EXAMPLES 666-688

1.0 g of 2,3-diaminobenzoic acid is dissolved into 20 ml of glacial acetic acid. Triethyl orthoformate (2.1 eq.) is added into the above mixture at temperature of 0° C.; and to stir it for 2 hours at temperature of 0˜5° C.; and 150 ml of water is added into it, and then to isolate and filter to produce 2-ethoxy-1H-benzimidazole-4-formic acid. The yield is about 89%. 2-ethoxy-1H-benzimidzzole-4-formic acid is added into 15 ml of thionyl chloride, and to react for 60 minutes, and after end of the reaction completely, and (L)-2-amino-1-p-nitrophenyl-1,3-propylene glycol (1.1 eq) is added into the reaction mixture under stirring for 2 hours at the room temperature, and then to filter the inorganic salt, and evaporate the solvent to dry, to obtain the final product of (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide. The yield is about 91%. Using the same process to prepare the compounds in Table 3.

TABLE 3

Field

No.
Compounds
X
Y
%

666
(L)-2-ethoxy-1H-benzimidazole- 4-[N-(1-hydroxymethyl- 2-p-nitrophenylhydroxyethyl)]amide

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94

667
(L)-2-ethoxy-1H-benzimidazole- 4-[N-(1-hydroxymethyl- 2-p-aminophenylhydroxyethyl)]amide

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91

668
2-ethoxy-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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92

669
2-ethoxy-1H-benzimidazole- 4-(N-N′-piperidinyl)amide

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92

670
2-ethoxy-1H-benzimidazole- 4-(N-2-piperazinyl))amide

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93

671
2-ethoxy-1H-benzimidazole- 4-(N-2′-benzimidazolyl)amide

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94

672
2-ethoxy-1H-benzimidazole- 4-(N-o-aminophenyl)amide

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89

673
2-ethoxy-1H-benzimidazole- 4-(N-5-benzimidazolonyl)amide

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91

674
2-ethoxy-1H-benzimidazole- 4-(N-4′-carbonamido-5′- imidazolyl)amide

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86

675
2-ethoxy-1H-benzimidazole- 4-(N-4′-pyrazolyl)amide

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93

676
2-ethoxy-1H-benzimidazole- 4-(N-(N′-piperazinyl))amide

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91

677
2-ethoxy-1H-benzimidazole- 4-(N-2-pyrazinyl)amide

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92

678
2-ethoxy-1H-benzimidazole- 4-(N-2-pyrimidinyl)amide

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92

679
2-ethoxy-1H-benzimidazole- 4-(N-2-pyridyl)amide

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93

680
2-ethoxy-1H-benzimidazole- 4-(N-4-methyl-5-thiazolyl)amide

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94

681
2-ethoxy-1H-benzimidazole- 4-(N-2,4-dihydroxyl-5- pyrimidinyl)amide

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85

682
2-ethoxy-1H-benzimidazole- 4-(N-4,6-dimethoxy-2- pyrimidinyl)amide

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94

683
2-ethoxy-1H-benzimidazole- 4-(N-4-chloro-6-amino- 2-pyrimidinyl)amide

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89

684
2-ethoxy-1H-benzimidazole- 4-(N-4,6-dichloro-5- pyrimidinyl)amide

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685
2-ethoxy-1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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93

686
2-ethoxy-1H-benzimidazole- 4-(N-2-hydroxyl-4- pyrimidinyl)amide

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87

687
2-ethoxy-1H-benzimidazole- 4-(N-6-purinyl)amide

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93

688
2-ethoxy-1H-benzimidzzole- 4-(N-6-hydroxyl-2-purinyl)amide

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Structure Identification of Products:

(666) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H),3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.29-4.33(m,2H), 4.73-4.77(t,1H), 7.43-7.45(t,1H),7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(667) (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H),3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.29-4.33(m,2H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H);

(668) 2-ethoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide

¹HNMR (DMSO, 400 MHz) δ: 1.12-1.15(d,3H), 1.32-1.35(t,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.29-4.33(m,2H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(669) 2-ethoxy-1H-benzimidazole-4-(N—N′-piperidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H),4.29-4.33(m,2H),7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(670) 2-ethoxy-1H-benzimidazole-4-(N-2-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m, 1H), 3.99-4.01(m,1H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(671) 2-ethoxy-1H-benzimidazole-4-(N-2′-benzimidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(672) 2-ethoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(673) 2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(674) 2-ethoxy-1H-benzimidazole-4-(N-4′-carbonamido-5′-imidazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H);

(675) 2-ethoxy-1H-benzimidazole-4-(N-4′-pyrazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H);

(676) 2-ethoxy-1H-benzimidazole-4-(N—(N′-piperazinyl))amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H);

(677) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H);

(678) 2-ethoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H);

(679) 2-ethoxy-1H-benzimidazole-4-(N-2-pyridyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H);

(680) 2-ethoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 2.45(s,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H);

(681) 2-ethoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);

(682) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 3.82(s,6H), 4.29-4.33(m,2H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(683) 2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(684) 2-ethoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H);

(685) 2-ethoxy-1H-benzimidazole-4-(N-o-fluorophenyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(686) 2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H);

(687) 2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H);

(688) 2-ethoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide

¹HNMR (DMSO, 400 MHz) δ: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H).

Measures of Properties:

Measures of Anti-Coxsackie B3 Viruses Activity of the Compounds

The products are applied for measures of antivirus properties of Vero cells. Refer to the results of Table 3: datum of anti-coxsackie B3 viruses activities of some compounds.

TABLE 3

NAME OF

COMPOUNDS
X
Y
IC₅₀(μg/ml)

(L)-2-(2-pyridyl)-1H- benzimidazole-4-[N-(1-hydroxymethyl- 2-p-nitrophenylhydroxyethyl)]amide

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1.76

2-(2-pyridyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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4.115

2-(3-pyridyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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2.37

(L)-2-(2-thienyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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15.90

2-(2-thienyl)-1H-benzimidazole- 4-[N-(1-methyl-2-p- chlorophenylhydroxyethyl)]amide

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5.30

(L)-2-(5-nitro-2-thienyl)- 1H-benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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10.69

2-(5-nitro-2-thienyl)-1H- benzimidazole-4-(N-(1-methyl- 2-p-chlorophenylhydroxyethyl))-amide

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7.12

2-thienyl-1H-benzimidazole-4- (N-(2-fluorophenyl)-amide

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1.06

2-(5-nitro-2-thienyl)-1H- benzimidazole-4-(N-(2-fluorophenyl))- amide

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>9.25

(L)-2-(5-amino-2-thienyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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2.3

2-(5-amino-2-thienyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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3.5

2-(5-amino-2-thienyl)-1H- benzimidazole-4-(N-o- methylphenyl)amide

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8.7

2-(5-amino-2-thienyl)-1H- benzimidazole-4-(N-p- hydroxyphenyl)amide

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6.5

2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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10.2

(L)-2-(4-methoxypyridyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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6.3

2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o- hydroxyphenyl)amide

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16.2

2-(4-methoxypyridyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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13.4

(L)-2-(6-methoxypyridyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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11.2

2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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14.1

2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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15.7

2-(6-methoxypyridyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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16.8

(L)-2-(4-dimethylaminopyridyl)- 1H-benzimidazole- 4-[N-(1-hydroxymethyl- 2-p-nitrophenylhydroxyethyl)]amide

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10.2

2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- (N-o-fluorophenyl)amide

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9.6

2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- (N-o-hydroxyphenyl)amide

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9.8

2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- (N-p-aminophenyl)amide

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10.2

(L)-2-(3-pyridazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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5.8

2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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12.3

2-(3-pyridazinyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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15.2

2-(3-pyridazinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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10.2

(L)-2-(2-N-methyl-4-N- methylpiperazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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9.2

2-(2-N-methyl-4-N- methylpiperazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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8.9

2-(5-methy-2-thienyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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18.5

2-(2-N-methyl-4-N- methylpiperazinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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3.5

(L)-2-(2-pyrazinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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2.3

2-(2-pyrazinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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6.5

2-(2-pyrazinyl)-1H -benzimidazole-4-(N-o- hydroxyphenyl)amide

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3.5

2-(2-pyrazinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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4.2

(L)-2-N-piperazinyl-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-o- nitrophenylhydroxyethyl)]amide

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4.2

2-N-piperazinyl-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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4.8

2-N-piperazinyl-1H- benzimidazole-4-(N-p- aminophenyl)amide

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6.3

(L)-2-(4-methyl-5- aminothiazolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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8.9

2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole- 4-(N-o-fluorophenyl)amide

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10.2

2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole- 4-(N-p-aminophenyl)amide

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9.8

(L)-2-thiazolyl-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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11.2

5-thiazolyl-1H- benzimidazole-4-(N-p- aminophenyl)amide

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13.5

(L)-2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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10.2

2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4- (N-p-hydroxyphenyl)amide

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11.2

(L)-2-(2-pyrimidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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9.8

2-(2-pyrimidinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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8.8

2-(2-pyrimidinyl)-1H- benzimidazole-4-(N-o- hydroxyphenyl)amide

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7.8

2-(2-pyrimidinyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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9.8

(L)-2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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12.0

2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- (N-o-fluorophenyl)amide

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12.6

2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- (N-o-hydroxyphenyl)amide

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13.2

2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4- (N-p-aminophenyl)amide

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15.2

(L)-2-(4-amino-6-chloro- 5-pyrimidinyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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17.2

2-(4-amino-6-chloro-5- pyrimidinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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11.3

2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole- 4-(N-o-hydroxyphenyl)amide

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12.3

2-(4-amino-6-chloro-5- pyrimidinyl)-1H-benzimidazole- 4-(N-p-aminophenyl)amide

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14.1

(L)-2-(2-pyrrolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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5.3

2-(2-pyrrolyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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9.2

(L)-2-(3,5-dimethyl-2- pyrrolyl)-1H-benzimidazole- 4-[N-(1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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8.6

2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4- (N-o-hydroxyphenyl)amide

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10.2

(L)-2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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11.1

2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o- fluorophenyl)amide

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13.2

(L)-2-(2-piperidinyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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17.2

2-(2-quinolinyl)-1H- benzimidazole-4-(N-o- fluorophenyl)amide

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15.3

2-(3-indolyl)-1H- benzimidazole-4-(N-p- aminophenyl)amide

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10.8

(L-)2-(3-indolyl)-1H- benzimidazole-4-[N-(1- hydroxymethyl-2-p- nitrophenylhydroxyethyl)]amide

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9.6

RBV
—
—
353.55

In the above table: “-” indicates that these samples don't have anti-coxsackie B3 viruses activities at the maximum nontoxic dose.

IC₅₀indicates half inhibitory concentration for viruses.

RBV indicates triazole nucleoside, is also called ribavirin, virazole.

It may be seen from the result of test, these compounds have better properties of anti-coxsackie B3 viruses. These compounds of the present invention have better effects on the coxsackie viruses of the picornaviridae and can inhibit coxsackie viruses. Although the present invention has been described in connection with the above embodiments, it should be understood that the present invention is not limited to such preferred embodiments and procedures set forth above. The embodiments and procedures were chosen and described in order to best explain the principles of the invention and its practical application, to thereby enable others skilled in the art to best utilize the invention. It will be apparent to those skilled in the art that various substitution, modifications and changes may be thereto without departing from the scope and spirit of the invention. Therefore, the intention is intended to cover all alternative constructions and equivalents falling within the spirit and scope of the invention as defined only by the appended claims and equivalents thereto.

Number	Date	Country	Kind
2009 1 0045056	Jan 2009	CN	national
2010 1 0000050	Jan 2010	CN	national

Number	Name	Date	Kind
20070112047	Penning et al.	May 2007	A1
20090030016	Gandhi et al.	Jan 2009	A1
20110190351	Ohtani et al.	Aug 2011	A1
20110263566	Matsuo et al.	Oct 2011	A1
20110301146	Matsuo et al.	Dec 2011	A1

Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses

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