Claims
- 1. A method for treating a human host suffering from psychosis, which method comprises administering to such host a therapeutically effective amount of a compound of the formula I ##STR12## wherein, R is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, or C.sub.2-6 alkynyl;
- R.sub.1 is hydrogen;
- R.sub.2 is hydrogen, halogen, or C.sub.1-6 alkoxy;
- Y is oxygen or N-R.sub.3, in which R.sub.3 is hydrogen; and,
- A is a group of the formula ##STR13## wherein R.sub.5 is hydrogen, C.sub.1-6 alkyl, or a group of the formula --CR.sub.6 .dbd.N--R.sub.7 in which R.sub.6 is hydrogen, C.sub.1-4 alkyl or amino and R.sub.7 is hydrogen or C.sub.1-6 alkyl;
- or a pharmaceutically acceptable acid addition salt thereof.
- 2. The method according to claim 1, wherein the pharmaceutically acceptable acid used to form the salt is selected from the group consisting of hydrochloric, hydrobromic, sulfuric, acetic, citric and tartaric acid.
- 3. The method of claim 1, wherein A is endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl; R.sub.1 and R.sub.2 are hydrogen; R is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl, and Y is oxygen or NH.
- 4. The method of claim 1, wherein the compound of formula I is N-(endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxamide or a pharmaceutically acceptable salt thereof.
- 5. The method of claim 1, wherein the compound of formula I is N-(endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-3-methyl-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxamide or a pharmaceutically acceptable salt thereof.
- 6. The method of claim 1, wherein the compound of formula I is N-(endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1H-benzimidazole-1-carboxamide or a pharmaceutically acceptable salt thereof.
- 7. The method of claim 1, wherein the compound of formula I is 3-ethyl-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid (endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl)ester or a pharmaceutically acceptable salt thereof.
Priority Claims (1)
Number |
Date |
Country |
Kind |
21997A/87 |
Sep 1987 |
ITX |
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RELATED APPLICATIONS
This is a continuation of application Ser. No. 08/267,682, filed Jun. 28, 1994, now abandoned, which is a division of application Ser. No. 08/033,675, filed Mar. 16, 1993, now U.S. Pat. No. 5,358,954, which is a division of application Ser. No. 07/845,891, filed Mar. 4, 1992, now U.S. Pat. No. 5,223,511, which is a continuation in part of application Ser. No. 07/768,497, filed Sep. 30, 1991, now abandoned, which is a continuation of application Ser. No. 07/552,353, filed Jul. 12, 1990, now abandoned, which is a continuation of application Ser. No. 07/243,949, filed Sep. 13, 1998, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4871744 |
King et al. |
Oct 1989 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
0223385 |
May 1987 |
EPX |
Divisions (2)
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Number |
Date |
Country |
Parent |
33675 |
Mar 1993 |
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Parent |
845891 |
Mar 1992 |
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Continuations (3)
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Number |
Date |
Country |
Parent |
267682 |
Jun 1994 |
|
Parent |
552353 |
Jul 1990 |
|
Parent |
243949 |
Sep 1988 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
768497 |
Sep 1991 |
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