Claims
- 1. A compound having the name:
- 1-(4-pyridinylcarbonyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidine,i.e., ##STR167## 1-(2-pyridinylcarbonyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidine;
- 1-(3-pyridinylcarbonyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidine;
- 1-(2-pyrazinylcarbonyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine; or
- 1-(4-pyridazinylcarbonyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidine.
- 2. A pharmaceutical composition comprising a compound as defined in claim 1 in combination with a pharmaceutically acceptable carrier.
- 3. A method of treating allergy comprising administering a compound as defined in claim 1 to a mammal in need of such treatment in an amount effective to treat allergy.
- 4. A method of treating inflammation comprising administering to a mammal in need of such treatment an antiinflammatory effective amount of a compound as defined in claim 1.
- 5. A compound having the name:
- 1-(4-pyridinylcarbonyl)-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidine, i.e., ##STR168##
- 6. A pharmaceutical composition comprising a compound as defined in claim 5 in combination with a pharmaceutically acceptable carrier.
- 7. A method of treating allergy comprising administering a compound as defined in claim 5 to a mammal in need of such treatment in an amount effective to treat allergy.
- 8. A method of treating inflammation comprising administering to a mammal in need of such treatment an antiinflammatory effective amount of a compound as defined in claim 5.
Priority Claims (1)
Number |
Date |
Country |
Kind |
87115890 |
Oct 1987 |
EPX |
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Parent Case Info
The present application is a continuation of U.S. application Ser. No. 07/816,777 now abandoned, filed Jan. 2, 1992, which is a division of U.S. application Ser. No. 345,604, filed May 1, 1989 (now U.S. Pat. No. 5,089,496), which is a continuation-in-part of U.S. application Ser. No. 181,860, filed Apr. 15, 1988, now abandoned which in turn is a continuation-in-part of U.S. application Ser. No. 925,342, filed Oct. 31, 1986 (now U.S. Pat. No. 4,826,853); and the benefits of these application is claimed under 35 U.S.C. 120.
US Referenced Citations (19)
Non-Patent Literature Citations (5)
Entry |
Villani et al. "Derivatives of 10, 11-Dihydro-5H-dibenzo [a,d] cycloheptene . . . " J. Med. Chem. vol. 15, No. 7, pp. 750-754 (1972). |
Villani et al., "N-substituted 11-(4-piperidylidene)-5,6 dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridines", Arzneimittel-Forschung/Drug Research, vol. 36 (II), No. 9, 1311-1314 (1986). |
Maurer et al., J. Chromatogr., 382, (1986), 147-165. |
Maurer et al., J. Chromatogr., 430, (1988), 31-41. |
Maurer et al., J. Clin. Chem. Clin. Biochem., 25, No. 9 620, 1987 with translation. |
Divisions (1)
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Number |
Date |
Country |
Parent |
345604 |
May 1989 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
816777 |
Jan 1992 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
181860 |
Apr 1988 |
|
Parent |
925342 |
Oct 1986 |
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