Claims
- 1. A compound of the formula: ##STR8## wherein A is the residue of a fatty acid minus the carboxylic function, and has from 7 to 23 carbon atoms and from 1 to 4 ethylenically unsaturated positions;
- R.sup.2 is a hydrogen atom, halo having an atomic weight of from about 19 to 80, alkoxy having from 1 to 3 carbon atoms, or alkyl having from 1 to 3 carbon atoms,
- R.sup.3 is a hydrogen atom, alkoxy having from 1 to 3 carbon atoms, alkyl having from 1 to 3 carbon atoms, or chloro; and
- j is a whole integer of from 1 to 4.
- 2. A compound of claim 1 in which A is of either the types (A1) having the structure:
- CH.sub.3 --(CH.sub.2).sub.f --(CH.dbd.CH).sub.g --(CH.sub.2).sub.h ;
- or
- (A2) having the structure
- CH.sub.3 --(CH.sub.2).sub.n --(CH.dbd.CH--CH.sub.2).sub.m (CH.sub.2).sub.p
- in which f is a whole integer of from 1 to 10, g is a whole integer of from 1 to 4, and h is a whole integer of from 4 to 9; and
- n is a whole integer of from 1 to 4,
- m is a whole integer of from 2 to 4,
- and p is a whole integer of from 2 to 7.
- 3. A compound of claim 2 in which A is of type (A1).
- 4. A compound of claim 3 in which A is the residue of oleic acid.
- 5. A compound of claim 3 in which A is the residue of palmitoleic acid.
- 6. A compound of claim 2 in which A is of type (A2).
- 7. A compound of claim 6 in which A is the residue of linoleic acid.
- 8. A compound of claim 6 in which A is the residue of linolenic acid.
- 9. A compound of claim 1 of the formula: ##STR9## wherein each of A, R.sup.2, R.sup.3 and j are as defined above.
- 10. A compound of claim 9 in which R.sup.2 is other than a hydrogen atom and R.sup.3 is a hydrogen atom.
- 11. A compound of claim 9 in which both R.sup.2 and R.sup.3 are other than hydrogen atoms.
- 12. A compound of claim 1 in which each unsaturated position of A is in the cis- type isomeric form.
- 13. The compound of claim 7 which is N-(1-indanyl)-cis,cis-9,12-octadecadienamide.
- 14. The compound of claim 4 which is N-(1-indanyl)-cis-9-octadecenylamide.
- 15. A method of reducing the cholesterol ester content of an arterial wall, in a mammal in need of such treatment, comprising administering a cholesterol ester-reducing amount of a compound of claim 1 to said mammal.
- 16. A pharmaceutical composition suitable for reducing the cholesterol ester content of an arterial wall of a mammal comprising a cholesterol ester-reducing effective amount of a compound of claim 1 and a nontoxic pharmaceutically-acceptable carrier.
- 17. A composition of claim 16 in solid form.
- 18. A composition of claim 16, in which the compound is present in an amount of from about 25 to 2,500 milligrams.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2856856 |
Dec 1978 |
DEX |
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Parent Case Info
This is a continuation in part of copending application Ser. No. 867,824 filed Jan. 9, 1978, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3621043 |
Seki et al. |
Nov 1971 |
|
3995059 |
Fukumara et al. |
Nov 1976 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
867824 |
Jan 1978 |
|