Claims
- 1. A compound of the formula ##STR98## wherein: a is 1 or 2;
- b is 0 or 1;
- c is 2, 3 or 4;
- X is oxygen, sulfur, ##STR99## Z is ##STR100## or R.sub.1 is --NR.sub.5 R.sub.6,
- R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, lower alkyl, allyl, wherein aryl is phenyl or substituted phenyl, loweralkoxycarbonyl or lower alkyl substituted by hydroxy, loweralkoxycarbonyl or NR.sub.5 R.sub.6 ;
- R.sub.5 and R.sub.6 are each independently H or alkyl, or both together with the nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, O or S;
- or a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1 wherein a is 1.
- 3. A compound of the formula ##STR101## wherein: b is 0 or 1;
- c is 2, 3 or 4;
- X is oxygen or sulfur;
- Z is ##STR102## R.sub.2, R.sub.3, and R.sub.4 are each independently hydrogen, lower alkyl, allyl, arylloweralkyl, wherein aryl is phenyl or substituted phenyl loweralkoxycarbonyl or lower alkyl substituted by hydroxy, loweralkoxycarbonyl or NR.sub.5 R.sub.6 ;
- R.sub.5 and R.sub.6 are each independently H or alkyl, or both together with the nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, O or S;
- or a pharmaceutically acceptable salt thereof.
- 4. A compound of the formula ##STR103## wherein: b is 0 or 1;
- c is 2, 3 or 4;
- X is oxygen or sulfur;
- Z is ##STR104## R.sub.2, R.sub.3, and R.sub.4 are each independently hydrogen, lower alkyl, allyl, arylloweralkyl, wherein aryl is phenyl or substituted phenyl loweralkoxycarbonyl or lower alkyl substituted by hydroxy, loweralkoxycarbonyl or NR.sub.5 R.sub.6 ;
- R.sub.5 and R.sub.6 are each independently H or alkyl, or both together with the nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, O or S;
- or a pharmaceutically acceptable salt thereof.
- 5. A compound according to claim 4 wherein:
- b is 0;
- X is oxygen;
- R.sub.1 is NR.sub.5 R.sub.6 ; and
- R.sub.3 is hydrogen.
- 6. A compound according to claim 4 wherein:
- b is 0;
- X is oxygen;
- R.sub.1 is NR.sub.5 R.sub.6 ; and
- R.sub.3 is hydrogen.
- 7. A pharmaceutical composition wherein the active ingredient is a compound according to claim 1 in admixture with a pharmaceutical carrier.
- 8. A method for decreasing acid secretion in the gastrointestinal tract of mammals by administering thereto an anti-secretory effective amount of a compound according to claim 1.
- 9. A method for the treatment of gastrointestinal hyperacidity and ulceration in a mammal comprising administering thereto an effective amount of a compound according to claim 1.
- 10. A method for enhancing the gastrointestinal resistance to gastrointestinal irritants in humans and mammals comprising administering thereto an effective cytoprotective amount of a compound of the formula according to claim 1.
Parent Case Info
This is a divisional of copending application Ser. No. 891,197, filed July 28, 1986, now U.S. Pat. No. 4,743,600 which is a divisional of application Ser. No. 798,697, filed Nov. 1, 1985, now U.S. Pat. No. 4,639,442, which is a continuation-in-part of application Ser. No. 664,222, filed Oct. 23, 1984, now U.S. Pat. No. 4,558,719, which is a continuation-in-part of application Ser. No. 604,813, filed Apr. 27, 1984, now U.S. Pat. No. 4,638,001 which is a continuation-in-part of application Ser. No. 489,702, filed Apr. 29, 1983, now U.S. Pat. No. 4,529,723.
Foreign Referenced Citations (1)
Number |
Date |
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106080 |
Apr 1984 |
EPX |
Divisions (2)
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Number |
Date |
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Parent |
891197 |
Jul 1986 |
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Parent |
798697 |
Nov 1985 |
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Continuation in Parts (3)
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Date |
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664222 |
Oct 1984 |
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Parent |
604813 |
Apr 1984 |
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Parent |
489702 |
Apr 1983 |
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