Claims
- 1. A novel benzodiazepine derivative represented by the following formula or a pharmaceutically acceptable salt thereof, ##STR51## wherein R.sup.1 is an aryl group, or an aromatic heterocyclic radical of 5-membered monocyclic, 6-membered monocyclic or 5- and 6-membered bicyclic structure, which may optionally be substituted; and R.sup.2 is an aryl group which may optionally be substituted.
- 2. The novel benzodiazepine derivative or a pharmaceutically acceptable salt thereof as defined in claim 1, wherein R.sup.1 is an aryl group which may optionally be substituted with a lower alkyl group, a lower alkoxy group or a halogen atom.
- 3. The novel benzodiazepine derivative or a pharmaceutically acceptable salt thereof as defined in claim 1, wherein R.sup.1 is a 5-membered heterocyclic radical which may optionally be substituted with a lower alkyl group, a lower alkoxy group or a halogen atom.
- 4. The benzodiazepine derivative of claim 1 which is 1-[2-3-Dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-yl]-3-(3-tolyl)urea or a pharmaceutically acceptable salt thereof.
- 5. The benzodiazepine derivative of claim 1 which is (R)-1-[2,3-Dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-tolyl)urea or a pharmaceutically acceptable salt thereof.
- 6. The benzodiazepine derivative of claim 1 which is 1-[2,3-Dihydro-1-(3-methyl-2-thenoyl)methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-tolyl)urea or a pharmaceutically acceptable salt thereof.
- 7. The benzodiazepine derivative of claim 1 which is (R)-1-[2,3-Dihydro-1-(3-methyl-2-thenoyl)methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-tolyl)urea or a pharmaceutically acceptable salt thereof.
- 8. The benzodiazepine derivative of claim 1 which is (+)-1-[2,3-Dihydro-1-(4'-methylphenacyl)-5-phenyl-1H-1,4-benzodiazepin-2-on-3-yl]-3-(3-methylphenyl)urea or a pharmaceutically acceptable salt thereof.
- 9. The benzodiazepine derivative of claim 1 which is (-)-1-[2,3-Dihydro-1-(4'-methylphenacyl)-5-phenyl-1H-1,4-benzodiazepin-2-on-3-yl]-3-(3-methylphenyl)urea or a pharmaceutically acceptable salt thereof.
- 10. A medicinal composition comprising a novel benzodiazepine derivative or a salt thereof as defined in claim 1 and a pharmaceutically acceptable carrier.
- 11. A benzodiazepine compound represented by the formula: ##STR52## wherein R.sup.1 is an aryl group, or an aromatic heterocyclic radical of a 5-membered monocyclic, a 6-membered monocyclic or a 5- and 6-membered bicyclic structure, which may optionally be substituted; and R.sup.2 is an aryl group which may optionally be substituted.
Priority Claims (3)
Number |
Date |
Country |
Kind |
2-418263 |
Dec 1990 |
JPX |
|
3-111216 |
Feb 1991 |
JPX |
|
3-282056 |
Oct 1991 |
JPX |
|
Parent Case Info
This application is a continuation of application Ser. No. 08/081,250, filed Jun. 6, 1993, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4820834 |
Evans |
Apr 1989 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
0284256 |
Mar 1988 |
EPX |
92-11246 |
Jul 1992 |
WOX |
Non-Patent Literature Citations (1)
Entry |
Noodruff, Neuropeptides 19, Snppl 45-56 (1991). |
Continuations (1)
|
Number |
Date |
Country |
Parent |
81250 |
Dec 1991 |
|