Claims
- 1. A process for preparing a compound having the formula ##STR11## comprising coupling, in an anhydrous solvent and in the presence of, as a reaction catalyst, a transition metal or a complex thereof, a magnesium, lithium or zinc derivative of a compound of the formula ##STR12## with a halogenated naphthalene compound of the formula ##STR13## wherein R.sub.1 represents (i) ##STR14## or (ii) --CH.sub.2 OH, R.sub.6 represents ##STR15## or OR.sub.7 wherein R.sub.7 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl, r' and R" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or a residue of an amino acid or an amino sugar selected from the group consisting of glucosamine, galactosamine and mannosamine, or together form a heterocycle selected from the group consisting of piperidino, piperazino, morpholino and pyrrolidino,
- R.sub.2 represents hydrogen, branched or straight chain alkyl having 1-15 carbon atoms, alkoxy having 1-4 carbon atoms or a cycloaliphatic radical,
- R.sub.3 represents hydrogen, hydroxy, branched or straight chain alkyl having 1-4 carbon atoms, alkoxy having 1-10 carbon atoms, a cycloaliphatic radical selected from the group consisting of 1-methyl cyclohexyl and 1-adamantyl, a thiocycloaliphatic radical, or --O--Si(CH.sub.3).sub.2 --R.sub.8 wherein R.sub.8 represents linear or branched lower alkyl,
- R.sub.4 and R.sub.5, each independently, represent hydrogen, lower alkyl, hydroxy or lower acyloxy, and
- X and Y represent Cl, Br, F or I.
- 2. The process of claim 1 carried out at a temperature ranging from -20.degree. to +30.degree. C.
Priority Claims (1)
Number |
Date |
Country |
Kind |
85849 |
Apr 1985 |
LUX |
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Parent Case Info
This is a division of application Ser. No. 07803,965, filed Dec. 9, 1991, now U.S. Pat. No. 5,183,889 which is a division of Ser. No. 07502/122, filed Mar. 30, 1990, now U.S. Pat. No. 5,098,895, which is a division of Ser. No. 07/120,968, filed Nov. 16, 1987, now U.S. pat. No. 4,861,229, which is a division of Ser. No. 06/850,145, filed Apr. 10, 1986, now U.S. Pat. No. 4,717,720.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4977275 |
Hasegawa et al. |
Dec 1990 |
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Divisions (4)
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Number |
Date |
Country |
Parent |
803965 |
Dec 1991 |
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Parent |
502122 |
Mar 1990 |
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Parent |
120968 |
Nov 1987 |
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Parent |
850145 |
Apr 1986 |
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