Claims
- 1. A compound of formula II ##STR9## wherein R.sup.1a is --H or --OR.sup.7 in which R.sup.7 is a hydroxy protecting group;
- R.sup.2a is --H, --Cl, --F, or --OR.sup.7 in which R.sup.7 is a hydroxy protecting group;
- R.sup.4a is --CO(C.sub.1 -C.sub.4 alkyl) or --(CO)H; and
- R.sup.6 is --H or R.sup.8, wherein R.sup.8 is benzyl.
- 2. A compound according to claim 1 wherein R.sup.1a and R.sup.2a are methoxy.
- 3. A compound according to claim 1 wherein R.sup.4a is --COCH.sub.3.
- 4. A compound of formula VII: ##STR10## wherein R.sup.1a is --H or --OR.sup.7 in which R.sup.7 is a hydroxy protecting group;
- R.sup.2a is --H, --Cl, --F, or --OR.sup.7 in which R.sup.7 is a hydroxy protecting group;
- R.sup.4a is --CO(C.sub.1 -C.sub.4 alkyl) or --(CO)H;
- n is 2 or 3; and
- Q is a leaving group.
- 5. A compound according to claim 4 wherein R.sup.7 is methyl.
- 6. A compound according to claim 4 wherein Q is bromo.
- 7. A process for the synthesis of a compound of claim 1 which comprises:
- reacting a compound of formula III with a compound of formula V ##STR11##
- 8. A process according to claim 7 wherein said catalytic copper (I) salt is selected from the group consisting of Cu.sub.2 O, CuI, and Cu.sub.2 CO.sub.3.
Parent Case Info
This application is a divisional of application Ser. No. 08/933,800, filed Sep. 19, 1997 now U.S. Pat. No. 5,843,563, which claimed benefit of provisional application No. 60/026,556 filed Sep. 24, 1996.
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Foreign Referenced Citations (3)
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062 503 |
Oct 1982 |
EPX |
WO 8902893 |
Apr 1989 |
WOX |
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WOX |
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Divisions (1)
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Number |
Date |
Country |
Parent |
933800 |
Sep 1997 |
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