Claims
- 1. A compound selected from those formula (I): ##STR36## in which: A represents oxygen or sulfur
- X represents a single bond,
- R represents:
- hydrogen or lower alkyl, and in this case p=1 and B represents --CH.sub.2 --CH.sub.2 --NR.sub.1 --CO--R.sub.2 where R.sub.1 represents hydrogen or linear or branched lower alkyl
- and R.sub.2 represents:
- a pyridyl or substituted pyridyl group
- a group of the formula: ##STR37## G representing linear or branched lower alkyl and R.sub.3 and R.sub.4, together with the nitrogen atom to which they are attached, form a piperidine group optionally substituted with one or more lower alkyl or oxo, phenyl phenyl(lower alkyl), or substituted phenyl or substituted phenyl(lower alkyl)
- in the definitions of R.sub.2, R.sub.3 and R.sub.4, the term "substituted" qualifying phenyl and phenyl(lower-alkyl) and pyridyl group meaning that these groups are substituted with one or more radicals chosen from lower alkyl, lower alkoxy, trifluoromethyl and halogen,
- or alternatively R.sub.1, with R.sub.2 and the group N-CO, forms a piperidinone system of formula: ##STR38## or R represents (CH.sub.2).sub.2 --NR.sub.1 --CO--R.sub.2 with R.sub.1 and R.sub.2 having the same definition as given above, and in which case p equals 0 and 1 and B represents lower alkoxy and, its isomers, epimers and diastereoisomers as well as, its addition salts with a pharmaceutically-acceptable acid or base, lower alkyl and lower alkoxy boxing 1 to 6 carbon atoms inclusive and cycloalkyl having 3 to 8 carbon atoms inclusive.
- 2. A compound as claimed in claim 1 in which R represents (CH.sub.2).sub.2 --NR.sub.1 --CO--R.sub.2, B represents methoxy, and p represents 1, its isomers as well as, where appropriate, its addition salts with a pharmaceutically-acceptable acid.
- 3. A compound as claimed in claim 1 which is N-[2-(6-methoxy-3-benzoxazolinoyl)ethyl]isonicotinamide.
- 4. A compound as claimed in claim 1 which is N-[2-(6-methoxy-3-benzothiazolinonyl)ethyl]isonicotinamide.
- 5. A pharmaceutical composition containing as active principle a compound as claimed in claim 1, in combination with a pharmaceutically-acceptable, excipient or vehicle.
- 6. A method for treating a living animal afflicted with a sleep disorder, comprising the step of administering to the said living animal an amount of a compound of claim 1 which in effective for alleviation of the said condition.
Priority Claims (1)
Number |
Date |
Country |
Kind |
91 03538 |
Mar 1991 |
FRX |
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Parent Case Info
The present application is a division of our prior-filed copending application Ser. No. 07/848,373, filed Mar. 9, 1992, now U.S. Pat. No. 5,240,919, issued Aug. 31, 1993.
US Referenced Citations (17)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2667068 |
Mar 1992 |
FRX |
Divisions (1)
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Number |
Date |
Country |
Parent |
848373 |
Mar 1992 |
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