.beta.-[2-(halogenobenzyl)-phenoxy]-ethylamine derivatives

Abstract

This invention is concerned with new .beta.-[2-(halogenobenzyl)-phenoxy]-ylamine derivatives of the general formula ##STR1## wherein R represents a C.sub.1 -C.sub.8 -alkyl group having a linear or branched hydrocarbon chain,R.sub.1 and R.sub.2, which may identical or different, represent each a C.sub.1 -C.sub.4 -alkyl-group, andAr represents a polychlorophenyl group of the formula ##STR2## (in which Y.sub.1 is 4-Cl, Y.sub.2 is H or Cl, and Y.sub.3 is H or Cl, at least one of the Y.sub.2 and Y.sub.3 being Cl); and their addition salts.These new compounds are useful as pharmaceuticals.

Description

This invention relates to .beta.-[2-(halogenobenzyl)-phenoxy]-ethylamine derivatives as new industrial products. It also relates to the method of preparation of said products and their use as pharmaceuticals.

It is known that in the past 2-(halogenobenzyl)-4-alkylphenols (wherein the 4-alkyl group is a branched hydrocarbon radical, in particular an isopropyl, s-butyl, t-butyl, or 1,1,3,3-tetramethylbutyl radical) have been proposed as bacteriostatic substances in U.S. Pat. Nos. 3,830,852; 3,855,317; 3,984,482 and in BUU-HOI et al., J. Org. Chem., 20, pages 1129-1134 (1955).

It is known that 2-(2,4-dichlorobenzyl)-4-(1,1,3,3-tetramethylbutyl)-phenol (which is coded as "B.11" and which is disclosed in the example 1 of U.S. Pat. No. 3,830,852) has been commercialized in France as an anti-infectious drug (International Common Denomination: "CLOFOCTOL"; trademark of the speciality: "OCTOFENE"). This compound, which is particularly effective in the treatment of infectious diseases caused by Gram+ bacteriae, and its analogues of the 2-(halogenobenzyl)-4-alkylphenol type are not naturally water soluble nor water dispersible. The poor affinity for water of said 2-(halogenobenzyl)-4-alkylphenols constitutes a drawback which restricts their use from a galenical point of view.

Moreover it is known that monohalogenated derivatives of .beta.-[2-(halogenobenzyl)-phenoxy]-ethylamine have been disclosed or suggested in the past. In particular the above cited BUU-HOI et al. article discloses as chemical compounds the .beta.-[2-(4-chlorobenzyl)-phenoxy]-N,N-dimethyl-ethylamine and its hydrochloride, and, BE-A-504 409 includes within its general formula acid addition salts of .beta.-[2-(monohalogenobenzyl)-4-(lower)alkyl-phenoxy]-N,N-dialkylethylamine, but the sole compound which is specifically disclosed, the .beta.-[2-(4-bromobenzyl)-phenoxy]-N,N-dimethyl-ethylamine, is not alkylated on the 4-position of the phenoxy group.

On the other hand it is also known from FR-A-2 372 792 that .omega.-[2-(halogenobenzyl)-4-(C.sub.1 -C.sub.5)-alkyl-phenoxy]-N,N-dialkyl-propyl-, butyl- or pentylamines have been proposed as antidepressant agents.

According to the invention are proposed new compounds of the dichloro- and trichlorobenzyl type which are structurally different from the prior art compounds, and which are particularly interesting from a therapeutical point of view on account of (i) their affinity for water and (ii) their anti-infectious and/or antidepressant properties.

The new compounds according to the invention, which are derivatives of .beta.-[2-(halogenobenzyl)-phenoxy]-ethylamine, are characterized in that they are selected from the group consisting of

(i) N,N-dialkyl-.beta.-[2-(polychlorobenzyl)-4-alkylphenoxy]-ethylamines of the general formula ##STR3## wherein R represents a (C.sub.1 -C.sub.8)-alkyl group having a linear or branched hydrocarbon chain;

R.sub.1 and R.sub.2, which may be identical or different, represent each a (C.sub.1 -C.sub.4)-alkyl group, and Ar represents a polychlorophenyl group of the formula ##STR4## (wherein Y.sub.1 is 4-Cl, Y.sub.2 is H or Cl, and Y.sub.3 is H or Cl, at least one of the Y.sub.2 and Y.sub.3 being a chlorine atom); and

(ii) addition salts thereof.

Amongst the R alkyl groups which are suitable according to the invention, one can cite in particlar the CH.sub.3, CH.sub.2 CH.sub.3, CH(CH.sub.3).sub.2, C(CH.sub.3).sub.3, CH(CH.sub.3)CH.sub.2 CH.sub.3, (CH.sub.2).sub.3 CH.sub.3, CH.sub.2 C(CH.sub.3).sub.3, CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3, C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3, C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 and (CH.sub.2).sub.5 CH.sub.3 radicals.

The expression "addition salts" is understood here as meaning firstly the acid addition salts obtained by reacting the free base of formula I with inorganic or organic acids, and secondly the ammonium salts. Hydrochloric, hydrobromic, acetic, formic, propionic, oxalic, fumaric, maleic, succinic, benzoic, cinnamic, mandelic, citric, malic, tartaric, aspartic, glutamic, methanesulfonic and p-toluenesulfonic acids may be mentioned in particular among the acids which can be used to satisfy the said free base. Amongst the compounds useful for obtaining the ammonium salts, one can cite XR.sub.3 compounds (wherein X is F, Cl, Br or I, and, R.sub.3 is a (C.sub.1 -C.sub.10)-alkyl group or a benzyl group).

Thus the invention is concerned with free bases of the formula I and their acid addition salts, on one hand, and with their ammonium salts of the formula ##STR5## (wherein Ar, R, R.sub.1, R.sub.2, R.sub.3 and X are as above defined), on the other hand.

The preferred compounds according to the invention are those wherein R.sub.1 =R.sub.2 =CH or CH.sub.2 CH.sub.3 and Y.sub.1 is 4-Cl, Y.sub.2 is H, and Y.sub.3 is 2-Cl or 3-Cl, and which are represented by the formula ##STR6## wherein R is a (C.sub.1 -C.sub.8)-alkyl group, R' is CH.sub.3 or C.sub.2 H.sub.5 ; their acid addition salts, and, their ammonium salts with XR'.sub.3 (wherein R'.sub.3 is CH.sub.3, CH.sub.2 CH.sub.3 or CH.sub.2 C.sub.6 H.sub.5, and X is F, Cl, Br or I). The preferred ammonium salts cited above can be represented by the formula ##STR7## (wherein X, R, R' and R'.sub.3 are as above defined, X being advantageously Cl, Br or I).

The compounds according to the invention can be prepared by a method known per se by using classical reaction mechanisms. The method which is recommended here comprises reacting a 2-(halogenobenzyl)-4-alkylphenol of the formula ##STR8## wherein Ar and R are as above defined, with a .beta.-N,N-dialkylaminoethyl halide of the formula

Hal--CH.sub.2 --CH.sub.2 --NR.sub.1 R.sub.2 (V) (wherein Hal is Cl or Br, and, R.sub.1 and R.sub.2 are as above defined).

This reaction is advantageously carried out in an inert solvent, in particular dimethylformamid, tetrahydrofuran, for at least 5 hours at a temperature lower than or equal to the refluxing temperature, while using at least 1.1 mol of V for 1 mol of IV, the halide being preferrably the chloride (Hal=Cl).

The free bases of formula I, their acid addition salts and their ammonium salts are useful as pharmaceuticals. They all present antiinfectious properties in the sense that act they according to the doses as bacteriostatic, bactericidal, fungistatic, or, fungicidal agents; in a general manner the ammonium salts are more active as antiinfectious substances than the acid addition salts, these latter being also more active than the free bases.

Moreover the free bases and their acid addition salts exhibit other beneficial effects: they act on the central nervous system as antidepressant agents and are active against enuresia. Some compounds amongst the free bases and their acid addition salts, such as for instance Example compounds 11 (B 795), 12 (B 805), 13 (B 809), 14 (B 785) and 15 (B 751), exhibit moreover beneficial spasmolytic properties. The most interesting compound, as spasmolytic agent, is the compound of Example 12 (B 805).

According to the invention a therapeutical composition is provided which is characterized in that it comprises, in association with a physiologically acceptable excipient, at least a compound of formula I or one of its addition salts, as active ingredient.

Of course in such a composition the active ingredient which is selected from the group consisting of the free bases of formula I, their non-toxic addition salts, and, if needed, mixtures thereof, is present in a pharmaceutically effective amount.

A certain number of compounds according to the invention are given non-restrictively by way of illustration in tables I, II and III hereinafter. The minimal inhibiting concentrations (MIC) of these compounds vis-a-vis a Gram+bacteria (Staphylococcus aureus London) a Gram-bacteria (Escherichia coli) and a fungus (Candida albicans) are given hereinafter in table IV. In table V are tabulated the MIC values of two compounds according to the invention which are particularly interesting [compound B 673 (example 26) and compound B 674 (example 29)] vis-a-vis several strains.

The strains used are those of the catalogues of the "Institut Pasteur" of Paris (abbreviation: CIP), the "Centre International de Distribution de Souches et d'Information sur les Types Microbiens de Lausanne" (abbreviation: La) and the "American Type Culture Collection" (abbreviation: ATCC).

TABLE I__________________________________________________________________________ ##STR9##Product Code No R R.sub.1 R.sub.2 Y.sub.1 Y.sub.2 Y.sub.3 Eb(a) (.degree.C.)__________________________________________________________________________Ex 1 B 715 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl --Ex 2 B 776 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 180-190Ex 3 B 770 CH(CH.sub.3).sub.2 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 200-206Ex 4 B 803 CH(CH.sub.3)CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-CL H 2-CL 172-174Ex 5 B 680 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 195-197Ex 6 B 748 C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-CL H 2-Cl 180-184Ex 7 B 760 (CH.sub.2).sub.3 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 185-190Ex 8 B 750 (CH.sub.2).sub.5 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 210-215Ex 9 B 629 C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl -- Ex 10 -- CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 4-Cl H 3-Cl --__________________________________________________________________________ Note (a): Boiling point under 0.5 mmHg (i.e. about 66.6 pascals) TABLE II__________________________________________________________________________ ##STR10##Product Code No R R.sub.1 R.sub.2 Y.sub.1 Y.sub.2 Y.sub.3 MP(a) (.degree.C.)__________________________________________________________________________Ex 11 B 795 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 155-156Ex 12 B 805 CH(CH.sub.3).sub.2 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 158-159Ex 13 B 809 CH(CH.sub.3)CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 146-147Ex 14 B 785 C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 145-150Ex 15 B 751 C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl 149-150Ex 16 -- C(CH.sub.3).sub.3 CH.sub.3 CH.sub.3 4-Cl H 2-Cl --Ex 17 -- CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 4-Cl H 3-Cl --Ex 18 -- CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 4-Cl H 2-Cl --Ex 19 -- C(CH.sub.3).sub.3 CH.sub.3 CH.sub.3 4-Cl 3-Cl 2-Cl --Ex 20 -- C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 4-Cl H 3-Cl --__________________________________________________________________________ Note (a): instantaneous melting point. TABLE III__________________________________________________________________________ ##STR11##Product Code No R R.sub.1 R.sub.2 R.sub.3 Y.sub.1 Y.sub.2 Y.sub.3 X MP(a) (.degree.C.)__________________________________________________________________________Ex 21 B 794 C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.3 4-Cl H 2-Cl I 138-140Ex 22 B 622 C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.3 4-Cl H 2-Cl I 157-158Ex 23 B 798 C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 (CH.sub.2).sub.3 CH.sub.3 4-Cl H 2-Cl Br 104-108Ex 24 B 808 C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 (CH.sub.2).sub.3 CH.sub.3 4-Cl H 2-Cl Br 167-168Ex 25 B 852 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 (CH.sub.2).sub.3 CH.sub.3 4-Cl H 2-Cl Br 124-125Ex 26 B 673 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 134-136Ex 27 B 791 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 125-130Ex 28 B 774 CH(CH.sub.3).sub.2 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 116-118Ex 29 B 674 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 120-125Ex 30 B 768 C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 132-135Ex 31 B 773 (CH.sub.2).sub.3 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 126-128Ex 32 B 775 (CH.sub.2).sub.5 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 125-127Ex 33 B 617 C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 2-Cl Cl 181-183Ex 34 -- CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3 4-Cl H 2-Cl Cl --Ex 35 -- CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 3-Cl Cl --Ex 36 -- CH(CH.sub.3).sub.2 CH.sub.3 CH.sub.3 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 3-Cl Cl --Ex 37 -- C(CH.sub.3).sub.3 CH.sub.3 CH.sub.3 CH.sub.2 C.sub.6 H.sub.5 4-Cl H 3-Cl Cl --Ex 38 -- C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3 4-Cl H 2-Cl F --Ex 39 -- CH(CH.sub.3)CH.sub.2 CH.sub.3 CH.sub.3 CH.sub.3 CH.sub.2 CH.sub.3 4-Cl H 2-Cl F --Ex 40 -- C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3 C.sub.2 H.sub.5 C.sub.2 H.sub.5 CH.sub.2 CH.sub.3 4-Cl 3-Cl 2-Cl F --__________________________________________________________________________ Note: (a) instantaneous melting point TABLE IV______________________________________ MIC (.mu. g/ml)Product Code No G.sup.+ G.sup.- C______________________________________Ex 1 B 715 12.5 50 --Ex 2 B 776 64 -- 64Ex 3 B 770 16 -- 8Ex 4 B 803 32 -- 16Ex 5 B 680 50 -- --Ex 6 B 748 8 -- 16Ex 7 B 760 64 64 64Ex 8 B 750 64 64 64Ex 9 B 629 25 -- --Ex 10 -- 16 64 --Ex 11 B 795 8 -- 8Ex 12 B 805 4 -- 4Ex 13 B 809 8 -- 0.5Ex 14 B 785 8 64 4Ex 15 B 751 16 -- --Ex 21 B 794 0.125 8 0.5Ex 22 B 622 0.125 64 0.25Ex 23 B 798 0.06 4 0.25Ex 24 B 808 0.015 16 1Ex 26 B 673 0.25 32 4Ex 27 B 791 0.125 8 0.5Ex 28 B 774 0.015 8 0.25Ex 29 B 674 0.015 4 0.125Ex 30 B 768 0.004 4 0.25Ex 31 B 773 0.031 4 0.125Ex 32 B 775 0.125 16 0.5Ex 33 B 617 0.03 -- 1______________________________________ Notes: G.sup.+ = Gram.sup.+ strain: Staphylococcus aureus London CIP A.238 G.sup.- = Gram.sup.- strain: Escherichia coli CIP 54.8 C = fungus strain: Candida albicans CIP 1180 TABLE V______________________________________MIC (in .mu.g/ml) vis-a-vis several strains Example 26 Example 29STRAINS (B 673) (B 674)______________________________________Staphylococcus aureus ATCC 6538 P 0.78 0.78Streptococcus pyogenes la 147 0.78 0.78Streptococcus pyogenes CIP A.241 0.78 0.78Streptococcus pyogenes CIP 56.42 0.78 0.78Streptococcus faecalis CIP 53.152 3.125 0.78Diplococcus pneumoniae la 209 1.56 0.78Bacillus subtilis ATCC 6633 1.56 0.78Corynebacterium diphteriae CIP A.102 25 3.125Branhamella catarrhalis la 987 0.78 0.78Neisseria gonorrhoeae CIP A.52 0.78 0.78Haemophilus influenzae CIP 5293 0.78 0.78Klebsiella pneumoniae la 433 25 6.25Streptococcus pyogenes CIP 5641 0.78 0.78Neisseria meningitidis CIP 7310 0.78 0.78Listeria monocytogenes CIP 54153 1.56 0.78______________________________________

In a general manner, the compounds according to the invention exhibit a low toxicity and are well tolerated by the organism. Table VI given hereinafter shows in particular that the ammonium salts of compounds according to the formula I are less toxic than the ammonium salts previously known as anti-infectious agents.

TABLE VI______________________________________TOXICITY LD-50 miceProduct Code No (mg/kg)______________________________________Ex 23 B 798 >1 000Ex 26 B 673 >1 000Ex 27 B 791 850Ex 29 B 674 >1 000Ex 30 B 768 >1 000Ex 31 B 773 >1 000A-1 (a) -- 550A-2 (b) -- 750______________________________________ Notes: (a): benzalkonium chloride (b): cetrymonium chloride

Further advantages and characteristics of the invention will be understood more clearly on reading the following description of preparative examples which do not imply a limitation but are given by way of illustration.

PREPARATION I

Preparation of .beta.-[2-(2,4-dichlorobenzyl)-4-tertiobutylphenoxy]-N,N-diethyl-ethylamin ##STR12## (example 5; Code No: B 680); alternative nomenclature: 2-(2-diethylaminoethoxy)-5-tertiobutyl-2',4'-dichlorodiphenylmethane.

In a reactor, a mixture consisting of 1 mol (309.18 g) of 2-(2,4-dichlorobenzyl)-4-tertiobutylphenol, 2.4 mols of K.sub.2 CO.sub.3, 2 liters of dimethylformamid and 1.2 mols of 2-chloro-N,N-diethylethylamine hydrochloride, is made to react, under stirring, for 15 hours at 120.degree. C.

The reaction mixture is poured into a saline solution (water saturated with NaCl), extracted with CHCl.sub.3 ; the chloroform phase is washed with water, dried and evaporated under vacuum. By distillation under vacuum of the evaporation residue, B 680 is obtained with a yield of 76.1%.

Eb.sub.0.5 mmHg =195.degree.-197.degree. C.

PREPARATION II

Preparation of N,N-diethyl-N-{2-[2-(2,4-dichlorobenzyl)-tertiobutylphenoxy]-ethyl}-N-benzylammonium chloride ##STR13## (Example 29; Code No 674).

In a reactor 1 mol (408.25 g) of .beta.-[2-(2,4-dichlorobenzyl)-4-tertiobutylphenoxy]-N,N-diethylethylamine is made to react with 1.25 mols of benzyl chloride, for 17 h at 90.degree.-100.degree. C., under stirring. After cooling to room temperature (15.degree.-20.degree. C.), the reaction mixture is washed with diethylether in order to obtain a precipitate which is washed with hexane then acetone at 15.degree.-20.degree. C. By recrystallization B 674 is obtained with a yield of 85.8%.

MP.sub.inst =120.degree.-125.degree. C.

PREPARATION III

Preparation of .beta.-[2-(2,4-dichlorobenzyl)-4-(1,1-dimethylpropyl)-phenoxy]-N,N-diethylethylamine hydrochloride

(Example 14; Code No B 785).

A HCl gas stream is introduced into a solution of 1 mol (422.31 g) of .beta.-[2-(2,4-dichlorobenzyl)-4-(1,1-dimethylpropyl)-phenoxy]-N,N-diethylethylamine (Example 6; Code No B 748) in 800 ml of anhydrous diethylether; After reaction the HCl gas bubbling is stopped and the mixture thus obtained is evaporated to dryness under vacuum, and the evaporation residue is taken up with anhydrous diethylether. A precipitate is formed which is washed with anhydrous diethylether. B 785 is obtained with a yield of 83.3%.

MP.sub.inst =145.degree.-150.degree. C.

PREPARATION IV

Preparation of N,N-diethyl-N-{2-[2-(2,4-dichlorobenzyl)-4-(1,1-dimethylpropyl)-phenoxy]-ethyl}-N-methylammonium iodide

(Example 21; Code No B 794)

A mixture of 1 mol (422.31 g) of .beta.-[2-(2,4-dichlorobenzyl)-4-(1,1-dimethylpropyl)-phenoxy]-N,N-diethylethylamine, 1.25 mols of ICH.sub.3 and 1.2 liters of anhydrous acetone is made to react for 2 h at 45.degree. C. under stirring. After cooling, the reaction mixture is poured into cold (15.degree. C.) CH.sub.3 CO.sub.2 C.sub.2 H.sub.5. A precipitate is obtained. By recrystallization from a CH.sub.3 CO.sub.2 C.sub.2 H.sub.5 --C.sub.2 H.sub.5 OH (98:2) v/v mixture, B 794 is obtained with a yield of 62.4%.

MP.sub.inst =138.degree.-140.degree. C.

PREPARATION V

Preparation of N,N-diethyl-N-{2-[2-(2,4-dichlorobenzyl)-4-(1,1-dimethylpropyl)-phenoxy]-ethyl}-N-butylammonium bromide

(Example 23; Code No B 798)

One mol (422.31 g) of .beta.-[2-(2,4-dichlorobenzyl)-4-(1,1-dimethylpropyl)-phenoxy]-N,N-diethylethylamine is reacted with 1.25 mols of 1-bromobutane, for 15 h at 100.degree. C., under stirring.

After cooling, the reaction mixture is washed with hexane then diethylether to give a precipitate. After washing of this precipitate at 30.degree. C. with CH.sub.3 CO.sub.2 C.sub.2 H.sub.5, B 798 is obtained with a yield of 20.4%

MP.sub.inst =104.degree.-108.degree. C.

Claims

1. A .beta.-[2-(halogenobenzyl)-phenoxy]-ethylamine derivative selected from the group consisting of:

(i) N,N-dialkyl-.beta.-[2-(polychlorobenzyl)-4-alkylphenoxy]-ethylamines of the general formula ##STR14## wherein R represents a C.sub.1 -C.sub.8 -alkyl group having a linear or branched hydrocarbon chain, R.sub.1 and R.sub.2, can be identical or different and each represent a C.sub.1 -C.sub.4 -alkyl group, and Ar represents a polychlorophenyl group of the formula ##STR15## wherein Y.sub.1 is Cl, Y.sub.2 is H or Cl, and Y.sub.3 is H or Cl, and wherein at least one of Y.sub.2 and Y.sub.3 is Cl; and

(ii) addition salts thereof.

2. A compound according to claim 1 in which R is CH.sub.3, CH.sub.2 CH.sub.3, CH(CH.sub.3).sub.2, C(CH.sub.3).sub.3, CH(CH.sub.3)CH.sub.2 CH.sub.3, C(CH.sub.3).sub.2 CH.sub.2 CH.sub.3, (CH.sub.2).sub.3 CH.sub.3, (CH.sub.2).sub.5 CH.sub.3, CH.sub.2 C(CH.sub.3).sub.3, CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 or C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.3.

3. A compound according to claim 1 which is selected from the group consisting of ammonium salts of the formula ##STR16## wherein Ar, R, R.sub.1 and R.sub.2 are defined as indicated in claim 1, R.sub.3 is a C.sub.1 -C.sub.10 -alkyl or benzyl group, and, X is F, Cl, Br or I.

4. A compound according to claim 1, which is selected from the group consisting of

(i) compounds of the formula ##STR17## wherein R' is CH.sub.3 or C.sub.2 H.sub.5 and R is a C.sub.1 -C.sub.8 -alkyl group; and

(ii) acid addition salts thereof.

5. A compound according to claim 1 which is selected from the group consisting of ammonium salts of the formula ##STR18## wherein R' is CH.sub.3 or C.sub.2 H.sub.5, R is a C.sub.1 -C.sub.8 -alkyl group, R'.sub.3 is CH.sub.3, CH.sub.2 CH.sub.3 or CH.sub.2 C.sub.6 H.sub.5, and X is F, Cl, Br or I.

6. .beta.-[2-(2,4-Dichlorobenzyl-4-t-butylphenoxy]-N,N-diethylethylamine and its addition salts.

7. .beta.-[2-(2-(2,4-Dichlorobenzyl)-4-(1,1-dimethylpropyl)-phenoxy]-N,N-diethyl-ethylamine and its addition salts.

8. N,N-Diethyl-N-{2-[2-(2,4-dichlorobenzyl)-4-t-butylphenoxy]-ethyl}-N-benzylammonium chloride.

9. .beta.-[2-(2,4-Dichlorobenzyl)-4-(1,1,3,3-tetramethyl-butyl)-phenoxy]-N,N-diethyl-ethylamine and its addition salts.

10. N,N-Diethyl-N-{2-[2-(2,4-dichlorobenzyl)-4-(1,1,3,3-tetramethylbutyl)-phenoxy]-ethyl}-N-benzylammonium chloride.

11. A therapeutical composition comprising, in association with a physiologically acceptable excipient, a pharmaceutically effective amount of a compound according to claim 1.