Claims
- 1. A compound of the formula (II): ##STR116## wherein R.sub.1 is alkyl of up to 12 carbon atoms, alkenyl of up to 8 carbon atoms, phenyl, benzyl or said alkyl, alkenyl, phenyl or benzyl mono-substituted by lower alkoxyl, lower alkanoyloxyl, halo or nitro; or R.sub.1 is a group of the sub-formula (a) or (b): ##STR117## wherein A.sub.3 is hydrogen or methyl; A.sub.4 is lower alkyl, lower alkoxyl, phenyl, phenoxyl, benzyl or benzyloxyl; A.sub.5 is hydrogen, methyl or methoxyl; and A.sub.6 is hydrogen, methyl or methoxyl; A.sub.1 is hydrogen; and A.sub.2 is a group CR.sub.2 R.sub.3 R.sub.4 wherein R.sub.2 is hydrogen or hydroxyl; and R.sub.4 is joined to R.sub.3 to form part of a 5- to 7- carbon atom carbocyclic ring.
- 2. A compound according to claim 1 which has the cis-configuration about the .beta.-lactam ring.
- 3. A compound according to claim 1 which has the transconfiguration about the .beta.-lactam ring.
- 4. A compound according to claim 1 wherein R.sub.1 is alkyl of up to 12 carbon atoms, alkenyl of up to 8 carbon atoms, phenyl, benzyl or said alkyl, alkenyl, phenyl or benzyl mono-substituted by lower alkoxyl, lower alkanoyloxyl, halo or nitro.
- 5. A compound according to claim 1 wherein R.sub.1 is lower alkyl unsubstituted or mono-substituted by lower alkoxyl.
- 6. A compound according to claim 1 wherein R.sub.1 is benzyl unsubstituted or mono-substituted by lower alkoxyl, nitro or chloro.
- 7. A compound according to claim 1 wherein R.sub.1 is a group of the sub-formula (a) or (b): ##STR118## wherein A.sub.3 is hydrogen or methyl; A.sub.4 is lower alkyl, lower alkoxyl, phenyl, phenoxyl, benzyl or benzyloxyl; A.sub.5 is hydrogen, methyl or methoxyl; and A.sub.6 is hydrogen methyl or methoxyl.
- 8. A compound according to claim 1 wherein R.sub.1 is benzyl.
- 9. A compound according to claim 1 wherein R.sub.1 is p-nitrobenzyl.
- 10. A compound according to claim 1 wherein R.sub.1 is phthalidyl.
- 11. A pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises an antibacterially effective amount of a compound of the formula (II): ##STR119## wherein R.sub.1 is alkyl of up to 12 carbon atoms, alkenyl of up to 8 carbon atoms, phenyl, benzyl or said alkyl, alkenyl, phenyl or benzyl mono-substituted by lower alkoxyl, lower alkanoyloxyl, halo or nitro; or R.sub.1 is a group of the sub-formula (a) or (b): ##STR120## wherein A.sub.3 is hydrogen or methyl; A.sub.4 is lower alkyl, lower alkoxyl, phenyl, phenoxyl, benzyl or benzyloxyl; A.sub.5 is hydrogen, methyl or methoxyl; and A.sub.6 is hydrogen, methyl or methoxyl; A.sub.1 is hydrogen; and A.sub.2 is a group CR.sub.2 R.sub.3 R.sub.4 wherein R.sub.2 is hydrogen or hydroxyl; and R.sub.4 is joined to R.sub.3 to form part of a 5- to 7-carbon atom carbocyclic ring, in combination with a pharmaceutically acceptable carrier.
- 12. A composition according to claim 11 wherein R.sub.1 is alkyl of up to 12 carbon atoms, alkenyl groups of up to 8 carbon atoms, phenyl, benzyl or said alkyl, alkenyl, phenyl or benzyl mono-substituted by lower alkoxyl, lower alkanoyloxyl, halo or nitro.
- 13. A composition according to claim 11 wherein R.sub.1 is lower alkyl unsubstituted or mono-substituted by lower alkoxyl.
- 14. A composition according to claim 11 wherein R.sub.1 is benzyl unsubstituted or mono-substituted by lower alkoxyl, nitro or chloro.
- 15. A composition according to claim 11 wherein R.sub.1 is a group of the sub-formula (a) or (b): ##STR121## wherein A.sub.3 is hydrogen or methyl, A.sub.4 is lower alkyl, lower alkoxyl, phenyl, phenoxyl, benzyl or benzyloxyl; A.sub.5 is hydrogen, methyl or methoxyl; and A.sub.6 is hydrogen, methyl or methoxyl.
- 16. A composition according to claim 11 wherein R.sub.1 is benzyl.
- 17. A composition according to claim 11 wherein R.sub.1 is p-nitrobenzyl.
- 18. A composition according to claim 11 wherein R.sub.1 is phthalidyl.
- 19. A composition according to claim 11 in parenteral administration form.
- 20. A composition according to claim 11 for the treatment of mastitis in cattle in intra-mammary administration form.
Priority Claims (1)
Number |
Date |
Country |
Kind |
11747/77 |
Mar 1977 |
GBX |
|
CROSS-REFERENCE
This is a division of Ser. No. 082,427 filed Oct. 5, 1979 which is a divisional of Ser. No. 887,844 filed Mar. 17, 1978, now both abandoned.
US Referenced Citations (5)
Number |
Name |
Date |
Kind |
4206219 |
Christensen et al. |
Jun 1980 |
|
4223038 |
Smale |
Sep 1980 |
|
4260627 |
Christensen et al. |
Apr 1981 |
|
4262009 |
Christensen et al. |
Apr 1981 |
|
4289696 |
Smale |
Sep 1981 |
|
Non-Patent Literature Citations (1)
Entry |
Bateson et al.; J. Chem. Soc., Chem. Commun., pp. 185-186 (1980). |
Divisions (2)
|
Number |
Date |
Country |
Parent |
82427 |
Oct 1979 |
|
Parent |
887844 |
Mar 1978 |
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