Claims
- 1. A .beta.-lactam compund of the formula: ##STR51## wherein Y is a hydroxyl group, a lower alkanoyloxy group or a lower alkoxycarbonyloxy group;
- W is a group represented by CH.sub.2, NH, ##STR52## A is a phenyl group, a naphthyl group, or a chromonyl group, respectively substituted by (Y).sub.n ;
- R.sub.1 is a hydrogen atom, a hydroxyl group, a methoxy group or a lower alkyl group;
- R.sub.2 is a hydrogen atom, a halogen atom, a methoxy group or a group represented by
- CH.sub.2 R.sub.2 ' wherein R.sub.2 ' is a hydrogen atom, an azido group, a lower alkanoyloxy group, a carbamoyloxy group, a pyridinium group, a substituted pyridinium group wherein the substitutuent is --(CH.sub.2).sub.p --R.sub.A wherein R.sub.A is a carbamoyl group, carboxyl group, cyano group or lower alkoxycarbonyl group having 2 to 5 carbon atoms, and p is 0, 1, 2 or 3; or --R.sub.B --SO.sub.3 --R.sub.C wherein R.sub.B is a lower alkylene group having 1 to 3 carbon atoms, and R.sub.C has the same meaning as R.sub.3, or
- a substituted or unsubstituted heterocyclic thio group wherein the heterocyclic group is a tetrazolyl group, thiadiazolyl group, triazolyl group, triazinyl group or thiazolyl group and wherein the substituent is a lower alkyl group having 1 to 5 carbon atoms, hydroxyl group, oxo group, amino group, nitro group, (CH.sub.2).sub.q CO.sub.2 H, (CH.sub.2).sub.q CO.sub.2 --(alkyl group having 1-4 carbon atoms), (CH.sub.2).sub.q SO.sub.3 H, (CH.sub.2).sub.q --N (alkyl group having 1-4 carbon atoms).sub.2, and q represents an integer of 1 to 3;
- R.sub.3 is a hydrogen atom, an alkali metal, an alkaline earth metal, an ammonium group of a basic amino acid or an ester residue represented by the formula: ##STR53## wherein R.sub.6 represents a hydrogen atom or a lower alkyl group having 1 to 6 carbon atoms, and R.sub.7 represents a lower alkyl group having 1 to 6 carbon atoms, or a phenyl group, or the formula ##STR54## R.sub.4 and R.sub.5 each are hydrogen atom, a lower alkyl group or a cycloalkylidene group with a carbon atom combined therewith; l is 0 or an integer of 1, 2 or 3; m is 0 or 1; and n is an integer of 1, 2, 3, 4 or 5.
- 2. A .beta.-lactam compound according to claim 1 where l is 0.
- 3. A .beta.-lactam compound according to claim 2 wherein R.sub.1 is a hydrogen atom or a hydroxyl group, R.sub.2 is a hydrogen atom, A is a phenyl or chromonyl group respectively substituted by (Y).sub.n, m is 0 or 1, and when m is 1, ##STR55##
- 4. An antimicrobial pharmaceutical composition which comprises an effective antimicrobial amount of a composition of matter according to claim 1 and at least one member of the group consisting of pharmaceutically acceptable diluents, carriers and adjuvants.
- 5. A method for treating bacterial infection in mammals which comprises administering the pharmaceutical composition of claim 1 at a dosage level of between 5 and 350 mg of active ingredient per kilogram of body weight.
Priority Claims (1)
Number |
Date |
Country |
Kind |
56-156752 |
Oct 1981 |
JPX |
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Parent Case Info
This application is a continuation of application Ser. No. 591,254, filed Mar. 20, 1984, now abandoned, which is a continuation of application Ser. No. 424,633, filed Sept. 27, 1982, now abondoned.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
4252952 |
Takano et al. |
Feb 1981 |
|
4275062 |
Breuer et al. |
Jun 1981 |
|
4291164 |
Hirata et al. |
Sep 1981 |
|
4343943 |
Hirata et al. |
Aug 1982 |
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
2353557 |
Dec 1977 |
FRX |
2362856 |
Mar 1978 |
FRX |
2429220 |
Jan 1980 |
FRX |
2025971 |
Jan 1980 |
GBX |
Continuations (2)
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Number |
Date |
Country |
Parent |
591254 |
Mar 1984 |
|
Parent |
424633 |
Sep 1982 |
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