Claims
- 1. Bi-aromatic compounds linked via a heteroethynylene bond, characterized in that they correspond to the general formula (I) below:
- 2. Compounds according to claim 1, characterized in that they are in the form of a salt of an alkali metal or alkaline-earth metal, or alternatively of zinc or of an organic amine.
- 3. Compounds according to either of claims 1 and 2, characterized in that the C1-C10 alkyl radical is chosen from the group consisting of the methyl, ethyl, isopropyl, butyl, tert-butyl, hexyl, 2-ethylhexyl and octyl radicals.
- 4. Compounds according to any one of the preceding claims, characterized in that the linear or branched C1-C20 alkyl radical is chosen from the group consisting of the methyl, ethyl, propyl, 2-ethylhexyl, octyl, dodecyl, hexadecyl and octadecyl radicals.
- 5. Compounds according to any one of the preceding claims, characterized in that the C3-C12 cycloalkyl radical is chosen from the group consisting of the cyclopropyl, cyclopentyl, cyclohexyl, 1-methylcyclohexyl and 1-adamantyl radicals.
- 6. Compounds according to any one of the preceding claims, characterized in that the polyether radical is chosen from the group consisting of the methoxymethoxy, methoxyethoxy and methoxyethoxymethoxy radicals.
- 7. Compounds according to any one of the preceding claims, characterized in that the monohydroxyalkyl radical is chosen from the group consisting of the 2-hydroxyethyl, 2-hydroxypropyl and 3-hydroxypropyl radicals.
- 8. Compounds according to any one of the preceding claims, characterized in that the polyhydroxyalkyl radical is chosen from the group consisting of the 2,3-dihydroxypropyl, 2,3,4-trihydroxybutyl, 2,3,4,5-tetrahydroxypentyl radicals and the pentaerythritol residue.
- 9. Compounds according to any one of the preceding claims, characterized in that the aryl radical is a phenyl radical optionally substituted with at least one halogen atom, a hydroxyl or a nitro function.
- 10. Compounds according to any one of the preceding claims, characterized in that the aralkyl radical is chosen from the group consisting of the benzyl and phenethyl radicals optionally substituted with at least one halogen atom, a hydroxyl or a nitro function.
- 11. Compounds according to any one of the preceding claims, characterized in that the sugar residue is chosen from the group consisting of the glucose, galactose, mannose and glucuronic acid residues.
- 12. Compounds according to any one of the preceding claims, cnaracterized in that the amino acid residue is chosen from the group consisting of the residues derived from lysine, from glycine or from aspartic acid.
- 13. Compounds according to any one of the preceding claims, characterized in that the heterocyclic radical is chosen from the group consisting of the piperidino, morpholino, pyrrolidino and piperazino radicals, optionally substituted in position 4 with a C1-C6 alkyl or a mono- or polyhydroxyalkyl.
- 14. Compounds according to any one of the preceding claims, characterized in that the halogen atom is chosen from the group consisting of fluorine, chlorine and bromine.
- 15. Compounds according to any one of the preceding claims, characterized in that they correspond to the following general formula:
- 16. Compounds according to any one of claims 1 to 14, characterized in that they correspond to the following general formula
- 17. Compounds according to any one of claims 1 to 14, characterized in that they correspond to the following general formula:
- 18. Compounds according to any one of the preceding claims, characterized in that they are taken from the group consisting of:
Methyl 4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphanylethynyl)benzoate, 4-(5,5,8,8,-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphanylethynyl)benzoic acid, Methyl 4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphonylethynyl)benzoate, Methyl 4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthyloxylethynyl)benzoate, 4-(5,5,8,8,-Tetramethyl-5,6,7,8-tetrahydro-2-naphthyloxyethynyl)benzoic acid, Methyl 4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphanylethynyl)benzoate, 4-(5,5,8,8,-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphanylethynyl)benzoic acid, Methyl 4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphonylethynyl)benzoate, 4-(5,5,8,8,-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphonylethynyl)benzoic acid, Methyl 4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphinylethynyl)benzoate, 4-(5,5,8,8,-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylsulphinylethynyl)benzoic acid, Methyl 4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, 4-(5,5,8,8,-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, Methyl 2-hydroxy-4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, 2-Hydroxy-4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, 6-(4-Methoxymethoxyphenylethynylselanyl)-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene, p0 Ethyl 6-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinate, 6-(5,5,8,8,-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinic acid, N-(4-Hydroxyphenyl)-4-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzamide, Methyl 5-(5,5,8,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)-2-pyridine carboxylate, 2-(4-Chlorophenylselanylethynyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene, Methyl 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, 4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, Methyl 2-hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, 2-Hydroxy-4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, Ethyl 6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinate, 6-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinic acid, N-(4-Hydroxyphenyl)-6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinamide, N-Butyl-6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinamide, Morpholin-4-yl-[6-(3,5,5,8,8,-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)-3-pyridyl]methanone, Methyl 5-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)pyridine-2-carboxylate, 5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)pyridine-2-carboxylic acid, [4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)phenyl]methanol, Methyl 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylethynylsulphanyl)benzoate, Methyl 4-(5,5,8,8tetramethyl-5,6,7,8-tetrahydro-2-naphthylethynylsulphonyl)benzoate, Methyl 4-(5,5,8,-tetramethyl-5,6,7,8-tetrahydro-2-naphthylethynylsulphanyl )benzoate, 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylethynylsulphanyl)benzoic acid, 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylethynylsulphonyl)benzoic acid, 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylethynylsulphinyl)benzoic acid, 4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)phenol, Ethyl 4-(4-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, Ethyl 4-(4-methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, 4-(4-Methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, 4-(4-Pentyloxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, Ethyl 4-(3-methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, Ethyl 4-(3-methoxyethoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, 4-(3-Methoxyethoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, 4-(3-Methoxymethoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-napthylselanylethynyl)benzoic acid, Ethyl 4-(3-pentyloxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoate, 4-(3-Pentyloxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)benzoic acid, [4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)phenyl]carbaldehyde, Methyl 4-(4,4-dimethylthiochroman-8-ylselanylethynyl)benzoate, 4-(4,4-Dimethylthiochroman-8-ylselanylethynyl)benzoic acid, Methyl 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-8-naphthylselanylethynyl)benzoate, 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-8-naphthylselanylethynyl)benzoic acid, Methyl 4-[3-(1-adamantyl)-4-methoxyphenyl)-1-ylselanylethynyl]benzoate, 4-[3-(1-Adamantyl)-4-methoxyphenyl)-1-ylselanylethynyl]benzoic acid, Methyl 4-[4-(1-adamantyl)-3-methoxyphenyl)-1-ylselanylethynyl]benzoate, 4-[4-(1-Adamantyl)-3-methoxyphenyl)-1-ylselanylethynyl]benzoic acid, and 4-(6-bromo-4,4-dimethyl-thiochroman-8-ylselanylethynyl)-benzoic acid.
- 19. Compounds according to any one of the preceding claims, for use as a medicinal product.
- 20. Compounds according to claim 19, for use as a medicinal product intended for the treatment of dermatological complaints, dermatological complaints with an inflammatory and/or immunoallergic component of the rheumatic or respiratory type, cardiovascular complaints and opthalmological disorders.
- 21. Use of at least one of the compounds as defined according to any one of claims 1 to 18, for the preparation of a medicinal product intended for the treatment of dermatological complaints, dermatological complaints with an inflammatory and/or immunoallergic component of the rheumatic or respiratory type, cardiovascular complaints and opthalmological disorders.
- 22. Pharmaceutical composition, characterized in that it comprises, in a pharmaceutically acceptable support, at least one compound as defined according to any one of claims 1 to 18.
- 23. Composition according to claim 22, characterized in that the concentration of at least one compound according to one of claims 1 to 18 is between 0.001% and 5% by weight relative to the total weight of the composition.
- 24. Cosmetic composition, characterized in that it contains, in a cosmetically acceptable support, at least one compound as defined according to any one of claims 1 to 18.
- 25. Composition according to claim 24, characterized in that the concentration of at least one compound according to any one of claims 1 to 18 is between 0.001 and 3% by weight relative to the total weight of the composition.
- 26. Use of a cosmetic composition as defined according to either of claims 23 and 25, for body or hair hygiene.
Parent Case Info
[0001] The present application is a continuation-in-part of application Ser. No.09/768,496 filed Jan. 25, 2001, which is a divisional of application Ser. No.09/267,977, filed Apr. 8, 1999 (now U.S. Pat. No. 6,201,019, issued Mar. 13, 2001), which is a 371 U.S. national phase of PCT/FR98/01835, filed Aug. 21, 1998 and claims benefit of FR-97 10554, filed Aug. 21, 1997.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09269997 |
Dec 1999 |
US |
Child |
09768496 |
Jan 2001 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09768496 |
Jan 2001 |
US |
Child |
10215202 |
Aug 2002 |
US |