Claims
- 1. A compound of the formula: ##STR19## wherein: a is 0, 1 or 2;
- b is 0 or 1;
- c is 0, 1-b, 2-b or 3-b;
- d is 0 or 1;
- e is 2, 3 or 4;
- X is oxygen, sulfur, ##STR20## R, R' and R" are each independently H, alkyl, or aryl-alkyl wherein aryl is phenyl or substituted phenyl
- R.sub.1 is ##STR21## R.sub.2 and R.sub.3 are each independently H or alkyl, or both together with the nitrogen to which they are attached form a 5, 6 or 7-membered ring which may include one to three additional hetero atoms of N, O or S; and
- R.sub.4 is H or lower alkyl or R.sub.4 and R.sub.2 together are ethylene or propylene and form a 5- or 6-membered ring together with the nitrogens to which they are attached; or a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1 wherein:
- a is 0;
- b is 0;
- d is 0;
- e is 3; and
- X is oxygen.
- 3. A compound according to claim 1, wherein the carbon atom to which the R.sub.1 --(CH.sub.2).sub.a -- group is attached is in the S(+) configuration.
- 4. A compound according to claim 1, wherein the carbon atom to which the R.sub.1 --(CH.sub.2).sub.a -- group is attached is in the R- configuration.
- 5. A compound according to claim 1, which is the racemic mixture of the base or a pharmaceutically acceptable salt thereof.
- 6. A pharmaceutical composition wherein the active ingredient is a compound according to claim 1 in admixture with a pharmaceutical carrier.
- 7. A method for decreasing acid secretion in the gastrointestinal tract of mammals by administering thereto an anti-secretory effective amount of a compound according to claim 1.
- 8. A method for the treatment of gastrointestinal hyperacidity and ulceration in a mammal comprising administering thereto an effective amount of a compound according to claim 1.
- 9. A method for enhancing the gastrointestinal resistance to gastrointestinal irritants in humans and mammals comprising administering thereto an effective cytoprotective amount of a compound of the formula according to claim 1.
Parent Case Info
This application is a divisional of application Ser. No. 878,284 based on PCT Application Ser. No. PCT/US85/02081, filed Oct. 22, 1985, now U.S. Pat. No. 4,699,906, which is a continuation-in-part of application Ser. No. 664,222, filed Oct. 24, 1984, now U.S. Pat. No. 4,588,719, which is a continuation-in-part of application Ser. No. 604,813, filed Apr. 27, 1984, now U.S. Pat. No. 4,638,001, which is a continuation-in-part of application Ser. No. 489,702, filed Apr. 29, 1983, now U.S. Pat. No. 4,529,723.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4490527 |
Schiehser et al. |
Dec 1984 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
878284 |
Oct 1985 |
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Continuation in Parts (3)
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Number |
Date |
Country |
Parent |
664222 |
Oct 1984 |
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Parent |
604813 |
Apr 1984 |
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Parent |
489702 |
Apr 1983 |
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