Claims
- 1. The process of cleaving double stranded DNA by contact with a compound having the formula: ##STR15## wherein the above formula, R is methyl or ethyl, in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
- 2. The process of cleaving double stranded DNA by contact with distamycin ethylenediamine tetraacetic acid wherein ethylenediamine tetraacetic acid is tethered to the amino terminus of the N-methylpyrrole tripeptide moiety of the distamycin in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
- 3. The process of cleaving double stranded DNA by contact with ethylenediamine tetraacetic acid distamycin wherein ethylenediamine tetraacetic acid is tethered to the carboxy terminus of the N-methylpyrrole tripeptide moiety of the distamycin in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
- 4. The process of cleaving double stranded DNA by contact with penta-N-methylpyrrole-carboxamide ethylenediamine tetraacetic acid in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
- 5. The process of cleaving double stranded DNA by contact with bis(ethylenediamine tetraacetic acid distamycin) in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
- 6. The process of cleaving double stranded DNA by contact with ethylenediamine tetraacetic acid-(bisdistamycin) in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
- 7. The process of cleaving double stranded DNA by contact with methidiumpropyl ethylenediamine tetraacetic acid in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
- 8. The process of cleaving double stranded DNA by contact with ethidiumpropyl ethylenediamine tetraacetic acid in the presence of effective DNA cleavage promoting amounts of ferrous ion and oxygen.
Parent Case Info
This application is a continuation-in-part of Ser. No. 860,604 filed May 7, 1986, now U.S. Pat. No. 4,665,184 issued on May 12, 1987, which was continuation of Ser. No. 540,914, now abandoned, filed Oct. 12, 1983, which was a continuation-in-part of Ser. No. 338,332 filed Jan. 11, 1982, both now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4665184 |
Dervan et al. |
May 1987 |
|
Non-Patent Literature Citations (5)
Entry |
Schultz et al., The Chemical Abstracts, 100: 2875w (1984). |
Hertzberg et al., The Chemical Abstracts, 101: 67951h (1984). |
Taylor et al., The Chemical Abstracts, 101: 3453q (1984). |
Schultz et al., The Chemical Abstracts, 100: 205156k (1984). |
Van Dyke, Science, 225, pp. 1122-1126 (1984). |
Continuations (1)
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Number |
Date |
Country |
Parent |
540914 |
Oct 1983 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
860604 |
May 1986 |
|
Parent |
338327 |
Jan 1982 |
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