Patent Grant
12279874
This application claims priority to PCT Application No. PCT/EP2018/082394, filed on Nov. 23, 2018, which claims priority to European Application No. 17203659.2, filed on Nov. 24, 2017, each of which is incorporated herein by reference in its entirety.
Embodiments of the present invention relate to bio-signal detection. In particular, they relate to improving bio-signal detection.
Bio-signals are signals that provide information about the functioning of a subject's body. There are a very large number of bio-signals.
Bio-signals that relate to the heart and circulation include, for example, systolic blood pressure, diastolic blood pressure, heart rate, electrocardiogram, pulse wave velocity, phonocardiogram, ballistocardiogram, echocardiogram etc.
Detected bio-signals can suffer from noise arising from many different sources.
It is desirable to remove noise from bio-signals.
According to various, but not necessarily all, embodiments of the invention there is provided an apparatus comprising:
a first displacement current sensor comprising a first sensing electrode and a first guard electrode, wherein the first displacement current sensor is configured to measure a first sensed signal dependent upon electrical activity of a subject's heart;
a second displacement current sensor comprising a second sensing electrode and a second guard electrode, wherein the second displacement current sensor is configured to measure a second sensed signal dependent upon electrical activity of a subject's heart; and
circuitry configured to process at least the first sensed signal to compensate for artefacts arising from motion of the subject.
The circuitry may comprise: at least one processor; and at least one memory including computer program code, the at least one memory and the computer program code configured to, with the at least one processor 90, cause the apparatus at least to perform: processing the sensed signal to compensate for artefacts arising from motion of the subject.
According to various, but not necessarily all, embodiments of the invention there is provided examples as claimed in the appended claims.
For a better understanding of various examples that are useful for understanding the detailed description, reference will now be made by way of example only to the accompanying drawings in which:
The apparatus 10 may therefore be, or be a part of, a circulation monitoring system or a health monitoring system that uses the electrocardiogram signal 41 to assess heart function. This may find application for patient monitoring, for personal health monitoring, for fitness assessment, for exercise effectiveness monitoring etc.
The apparatus 10 comprises at least a displacement current sensor 20 and circuitry 40 operatively connected to the displacement current sensor 20. The connection may, for example, be a direct galvanic connection via a lead, as illustrated in
The displacement current sensor 20 is configured to measure one or more sensed electrical signals 21 dependent upon electrical activity of a heart of a subject 30. The sensor 20 detects the one or more sensed electrical signals 21. The sensor 20 may or may not further process the detected electrical signal to produce the one or more sensed electrical signals 21. Measurement does not therefore imply that the one or more sensed electrical signals is quantised, although it may be.
The total current density (defined by curl H) has a galvanic component J and a displacement component dD/dt, where D=ϵE. The displacement current sensor 20 measures a value dependent upon D and its variation over time, dD/dt.
The displacement current sensor 20 comprises at least one electrode 22 in proximity to the skin 32 of the subject 30 but electrically insulated therefrom.
In some examples the displacement current sensor 20 comprises electrical insulation 24 for insulating the at least one electrode 22 from the subject's skin 32.
In some examples, material between the electrode 22 and the subject's skin 30 additionally or alternatively provides electrical insulation of the electrode 22 from the subject's skin 32.
The electrical insulation prevents the displacement current sensor 20 from receiving the galvanic component J of the total current density.
The circuitry 40 is configured to process the one or more sensed electrical signals 21 to compensate for artefacts arising from motion of the subject. The compensation for motion artefacts removes noise from the sensed electrical signal 21 producing a version of the electrical signal 21 that is less affected by noise.
The circuity 40 receives a motion associated signal 50 that is associated with motion of the electrode 22 of the displacement current sensor 20 relative to the user 30.
For example, the motion associated signal 50 may be a motion dependent signal that is dependent upon or responsive to motion of the electrode 22 of the displacement current sensor 20 relative to the user 30. Additionally or alternatively, the motion associated signal 50 may be a force dependent signal that is dependent upon or responsive to force that causes motion of the electrode 22 of the displacement current sensor 20 relative to the user 30.
In some examples, the apparatus 10 comprises one or more motion-associated sensors 52 for producing one or more motion associated signals 50.
For example, a motion-associated sensor 52 may be a motion sensor, a distance sensor; a force sensor, a pressure sensor, a deformation sensor and/or a body wearable motion sensor.
The motion-associated sensor 52 may, for example, be a capacitive sensor, a radio frequency sensor, an ultrasound sensor, an optical sensor; and electromagnetic film sensor, a piezoelectric sensor, a strain gauge sensor, an accelerometer, a gyroscope, and/or a magnetometer.
The circuitry 40 may be any suitable circuitry. It may be an arrangement of discrete components, and/or may comprise programmable gate arrays, and/or may comprise programmed processors, for example.
In some but not necessarily all examples, the circuitry 40 is configured to measure a variable capacitance caused by motion of the electrode 22 of the displacement current sensor 20 relative to the user 30. The circuitry 40 may be configured to measure a variable reactance caused by motion of the electrode 22 of the displacement current sensor 20 relative to the user 30 by measuring, in the Imaginary domain, modulation of a reference signal by the variable reactance. In the examples illustrated in
In the examples of
The circuitry 40 is configured to apply a time-variable voltage V1, as the reference signal 45, to a first electrode 26, for example via a first operational amplifier, and measure a time-variable signal Vout, for example at an output of a second operational amplifier.
In these examples, the first electrode 26 is in proximity to the skin 32 of the subject 30 but electrically insulated therefrom. In some examples, electrical insulation 24 insulates the electrode 26 from the subject's skin 32. In some examples material between the electrode 26 and the subject's skin 30 additionally or alternatively provides electrical insulation of the electrode 26 from the subject's skin 32.
The electrical reference signal 45 has one or more high frequency components, for example, greater than 1 kHz. For example, the electrical reference signal 45 may have a significant component over 100 kHz, for example in the range 100-500 kHz, or in some embodiments may lie entirely within the range over 100 kHz or 100-500 kHz. The electrical reference signal 45 may, for example, be a pure tone (single frequency).
In the example of
The circuitry 40 is configured to apply a time-variable voltage V1 to a first electrode 26 via a first operational amplifier 70, and provide a time-variable signal 43 (voltage Vout) at an output of a second operational amplifier 80.
As illustrated in more detail in
The ECG electrode is centrally located. In these examples it is circular but this is not necessarily essential. The electrode 26/22 is separated from the ECG electrode 601/602, in this example, low relative permittivity gaps are used for separation.
The electrode 26/22 is a circle circumscribing but separated from the ECG electrode 601/602.
Returning to
The ECG signal 412 received at the ECG electrode 602 is applied, via op-amp 92, as a virtual earth at a +ve terminal of a second op-amp 80. A voltage divider may be used in some examples. For example, impedances ZA′ and ZB′ may be connected in series between the output of the op-amp 92 and ground, and an intermediate node between impedances ZA′ and ZB′ may be connected to the +ve terminal of the second op-amp 80.
The first op-amp 70 generates at its output a current and a voltage V1 at the first guard electrode 26. The first op-amp 70 is arranged for closed loop negative feedback via an impedance 72 connected between its output and its −ve terminal. The impedance 72 has a value Z2. The first op-amp 70 is arranged to receive an input at its −ve terminal, via an impedance 74, from a variable voltage source 76. The variable voltage source 76 produces voltage Vin(t). The impedance 74 has a value Z1. The first ECG signal 411 received at the first ECG electrode 601 is applied, after amplification by op-amp 90, as a virtual earth at the +ve terminal of the first op-amp 70.
The second op-amp 80 receives at a −ve terminal a voltage from the second guard electrode 22. The second op-amp 80 is arranged for closed loop negative feedback via an impedance 82 connected between its output and its −ve terminal. The impedance 82 has a value Z3. The second ECG signal 412 received at the second ECG electrode 602 is applied, after amplification by op-amp 92, as a virtual earth at the +ve terminal of the second op-amp 80. The second op-amp 80 generates at its output a voltage Vout which is the motion artefact signal 43. In some examples, an impedance Z4 may be connected between the second guard electrode 22 and the −ve terminal of the second op-amp 80.
The current at the −ve terminal of the second op-amp 80 depends on the voltage (V1) at the first electrode 26 (relative to virtual earth) and an unknown impedance Z associated with the current path between the electrodes 22, 26 and through the subject's body. The impedance Z is comprised of a steady state value and a variable value that may be assumed to arise substantially from relative motion between the electrodes 22, 26 and the subject's body. The output of the op-amp 80 is therefore a variable impedance signal 43 caused by relative motion.
The current at the −ve terminal of the first op-amp 70 is Vin/Z1, where Vin is the variable voltage (relative to virtual earth) applied to a −ve input of the first op-amp 70 via impedance Z1. The first op-amp 70 is arranged for closed loop, negative feedback. The output of the first op-amp 70 is therefore V1=Vin*(1+Z2/Z1). The current at the −ve terminal of the second op-amp 80 is V1/Z where V1 is the variable voltage (relative to virtual earth) applied to a −ve input of the second op-amp 80 via the inter-electrode impedance Z. The second op-amp 80 is arranged for closed loop, negative feedback. The output of the second op-amp 80 is therefore Vout=Z3*V1/Z=Vin*(Z3/Z)*(1+Z2/Z1).
It is possible to separate the part of Vout that arises as a consequence of variation in Z from the part of Vout that arises as a consequence of variation in Vin.
This may, for example, be achieved by removing Vin from Vout in the frequency domain using a demodulator.
If Z1, Z2, Z3 are resistors, then at the higher frequencies of Vin the steady state impedance of the body may be considered to be primarily resistive. The changing impedance arising from the distance between the electrodes 22/26 and the skin surface will be primarily reactive (capacitive).
Changes in the imaginary (reactive) part of the variable impedance signal 43 may therefore be attributed to variation in capacitance arising from the relative motion of the electrodes 22,26 and the body. These represent motion artefacts in the sensed signal 21.
The demodulation circuit may be configured to calculate how the complex transfer function between the input time-variable voltage Vin and the output time-variable voltage Vout varies over time.
The apparatus 10 therefore comprises: a first displacement current sensor 201 comprising a first sensing electrode 601 and a first guard electrode 26 and a second displacement current sensor 202 comprising a second sensing electrode 602 and a second guard electrode 22. The first displacement current sensor 201 is configured to measure a first sensed signal 211 dependent upon electrical activity of a subject's heart. The second displacement current sensor 202 is configured to measure a second sensed signal 212 dependent upon electrical activity of a subject's heart.
The first displacement current sensor 201 comprises electrical insulation for insulating the first sensing electrode 601 from the subject's skin. The second displacement current sensor 202 comprises electrical insulation for insulating the second sensing electrode 602 from the subject's skin.
The first displacement current sensor 201 and the second displacement current sensor 202 are separated in space by at least several centimeters (more than 2 or 3 cm). The first displacement current sensor 201 is movable relative to the subject and is not affixed to the subject. The second displacement current sensor 202 is movable relative to the subject and the first displacement current sensor 201, and is not affixed to the subject. The first displacement current sensor 201 and the second displacement current sensor 202 can be embedded in a bed or other furniture.
The apparatus 10 comprises circuitry configured to process the first sensed signal 211 to compensate for artefacts arising from motion of the subject and to process the second sensed signal 212 to compensate for artefacts arising from motion of the subject.
The circuitry is configured to apply a reference signal 45 to one of the first guard electrode 26 and the second guard electrode 22 and to sense at the other of the first guard electrode 26 and the second guard electrode 22 an additional signal dependent upon motion of the subject and to use the additional signal to estimate artefacts arising from motion of the subject and compensate the first sensed signal and/or the second sensed signal. In the illustrated example, the circuitry is configured to apply a reference signal 45 to the first guard electrode 26 and to sense at the second guard electrode 22 an additional signal dependent upon motion of the subject. The reference signal 45 is a first time-variable voltage and the additional signal is a second time-variable voltage dependent upon the first time-variable voltage and motion of the subject. In this example, the reference signal 45 is continuously applied and the additional signal is sensed continuously and contemporaneously.
The first sensed signal and the second sensed signal are used, as virtual earth, for applying the reference signal 45 and for sensing the additional signal. The circuitry is configured to apply the first time-variable voltage V1 to the first guard electrode 26 via an operational amplifier 70, measure a second time-variable voltage Vout at an output of another operational amplifier 80. An input to the operational amplifier 80 is connected to the second guard electrode 22. An impedance Z3 is connected between the input and the output of the operational amplifier 80. At least a part of the impedance between the first and second guard electrodes 26, 22 is measured using at least the first time-variable voltage and the second time-variable voltage to estimate motion of the subject.
The operational amplifier 80 is virtually earthed by an ECG signal received at the second sensing electrode 602 adjacent the second guard electrode 22 and guarded by the second guard electrode and the operational amplifier 70 is virtually earthed by an ECG signal received at the first sensing electrode 601 adjacent the first guard electrode 26 and guarded by the first guard electrode 26. The apparatus 10 may be configured to use at least a part of the impedance between the first and second guard electrodes as an external reference signal for an adaptive filter for filtering the first sensed signal and/or the first sensed signal.
The circuitry is thus configured to process the first sensed signal to compensate for artefacts arising from motion of the subject, to provide an ECG signal. The circuitry is configured to process the second sensed signal to compensate for artefacts arising from motion of the subject, to provide an ECG signal.
It will be appreciated than in the apparatus 10, the sensed signal 21 is used, as a virtual earth, to compensate for artefacts arising from motion of the subject. The sensed signal 21 is used, as virtual earth, for sensing variations, compared to an applied reference signal 45, used to compensate for artefacts arising from motion of the subject. A first displacement current sensor 201 is configured to apply the reference signal 45, using a first sensed signal as virtual earth. A second displacement current sensor 202 is configured to sense the additional signal using a second sensed signal as virtual earth. The first displacement current sensor 201 is configured to apply the reference signal 45 via first guard electrode 26 and sense the first sensed signal using an adjacent first sensing electrode 601, guarded by the first guard electrode 26. The second displacement current sensor 202 is configured to sense the additional signal via a second guard electrode 22 and sense the second sensed signal using an adjacent second sensing electrode 602, guarded by the second guard electrode 22.
For example, as illustrated in
For example, as illustrated in
For example, as illustrated in
The circuitry 40 illustrated in
The motion-associated sensors 52 may be part of the apparatus 10 or separate to the apparatus 10.
The motion-associated sensor 52 may perform one of more of the sensing functions described with reference to
In the example of
In these examples, but not necessarily all examples, the displacement current sensor 20 is fixed to an article 56 adjacent the subject 30. The article 56 may, for example, be a bed or other furniture.
In the example of
In the example of
In the example of
The motion associated signal 50 may be used to represent artefacts arising from motion of the subject 30. The motion associated signal 50 may be converted 112 to the frequency domain by, for example, using a transform function such as a Fourier Transform (FT). The sensed signal 21 may be converted 112 to the frequency domain by, for example, using a transform function such as a Fourier Transform (FT).
A processor 116 may be used to remove the measured artefacts from the sensed signal in the frequency domain.
For example, it may be determined that the spectral components 50′ of the motion associated signal 50 represent noise in the spectral components of the sensed signal 21. The spectral components of the sensed signal that correspond to the spectral components of the motion associated signal 50 may be adapted to remove motion artefacts. In some examples they may be reduced. In some examples, they may be removed.
In the example of
Implementation of the circuitry 40 may be as a controller 96, for example. The controller 96 may be implemented in hardware alone, have certain aspects in software including firmware alone or can be a combination of hardware and software (including firmware).
As illustrated in
The processor 90 is configured to read from and write to the memory 92. The processor 90 may also comprise an output interface via which data and/or commands are output by the processor 90 and an input interface via which data and/or commands are input to the processor 90.
The memory 92 stores a computer program 94 comprising computer program instructions (computer program code) that controls the operation of the apparatus 10 when loaded into the processor 90. The computer program instructions, of the computer program 94, provide the logic and routines that enables the apparatus to perform the methods illustrated in
The apparatus 10 therefore comprises:
The computer program 94 may arrive at the apparatus 10 via any suitable delivery mechanism. The delivery mechanism may be, for example, a non-transitory computer-readable storage medium, a computer program product, a memory device, a record medium such as a compact disc read-only memory (CD-ROM) or digital versatile disc (DVD), an article of manufacture that tangibly embodies the computer program 94. The delivery mechanism may be a signal configured to reliably transfer the computer program 94. The apparatus 10 may propagate or transmit the computer program 94 as a computer data signal.
Although the memory 92 is illustrated as a single component/circuitry it may be implemented as one or more separate components/circuitry some or all of which may be integrated/removable and/or may provide permanent/semi-permanent/dynamic/cached storage.
Although the processor 90 is illustrated as a single component/circuitry it may be implemented as one or more separate components/circuitry some or all of which may be integrated/removable. The processor 90 may be a single core or multi-core processor.
References to ‘computer-readable storage medium’, ‘computer program product’, ‘tangibly embodied computer program’ etc. or a ‘controller’, ‘computer’, ‘processor’ etc. should be understood to encompass not only computers having different architectures such as single/multi-processor architectures and sequential (Von Neumann)/parallel architectures but also specialized circuits such as field-programmable gate arrays (FPGA), application specific circuits (ASIC), signal processing devices and other processing circuitry. References to computer program, instructions, code etc. should be understood to encompass software for a programmable processor or firmware such as, for example, the programmable content of a hardware device whether instructions for a processor, or configuration settings for a fixed-function device, gate array or programmable logic device etc.
As used in this application, the term ‘circuitry’ refers to all of the following:
This definition of ‘circuitry’ applies to all uses of this term in this application, including in any claims. As a further example, as used in this application, the term “circuitry” would also cover an implementation of merely a processor (or multiple processors) or portion of a processor and its (or their) accompanying software and/or firmware. The term “circuitry” would also cover, for example and if applicable to the particular claim element, a baseband integrated circuit or applications processor integrated circuit for a mobile phone or a similar integrated circuit in a server, a cellular network device, or other network device.
The method, when applied to the apparatus illustrated in
The blocks illustrated in the
Where a structural feature has been described, it may be replaced by means for performing one or more of the functions of the structural feature whether that function or those functions are explicitly or implicitly described.
As used here ‘module’ refers to a unit or apparatus that excludes certain parts/components that would be added by an end manufacturer or a user. The apparatus 10 may be a module.
The term ‘comprise’ is used in this document with an inclusive not an exclusive meaning. That is any reference to X comprising Y indicates that X may comprise only one Y or may comprise more than one Y. If it is intended to use ‘comprise’ with an exclusive meaning then it will be made clear in the context by referring to “comprising only one . . . ” or by using “consisting”.
In this brief description, reference has been made to various examples. The description of features or functions in relation to an example indicates that those features or functions are present in that example. The use of the term ‘example’ or ‘for example’ or ‘may’ in the text denotes, whether explicitly stated or not, that such features or functions are present in at least the described example, whether described as an example or not, and that they can be, but are not necessarily, present in some of or all other examples. Thus ‘example’, ‘for example’ or ‘may’ refers to a particular instance in a class of examples. A property of the instance can be a property of only that instance or a property of the class or a property of a sub-class of the class that includes some but not all of the instances in the class. It is therefore implicitly disclosed that a feature described with reference to one example but not with reference to another example, can where possible be used in that other example but does not necessarily have to be used in that other example.
Although embodiments of the present invention have been described in the preceding paragraphs with reference to various examples, it should be appreciated that modifications to the examples given can be made without departing from the scope of the invention as claimed.
Features described in the preceding description may be used in combinations other than the combinations explicitly described.
Although functions have been described with reference to certain features, those functions may be performable by other features whether described or not.
Although features have been described with reference to certain embodiments, those features may also be present in other embodiments whether described or not.
Whilst endeavoring in the foregoing specification to draw attention to those features of the invention believed to be of particular importance it should be understood that the Applicant claims protection in respect of any patentable feature or combination of features hereinbefore referred to and/or shown in the drawings whether or not particular emphasis has been placed thereon.
| Number | Date | Country | Kind |
|---|---|---|---|
| 17203659 | Nov 2017 | EP | regional |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2018/082394 | 11/23/2018 | WO |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2019/101935 | 5/31/2019 | WO | A |
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| Number | Date | Country | |
|---|---|---|---|
| 20200281498 A1 | Sep 2020 | US |
