Bioabsorbable Polymer-Based Nerve Conduits

Information

• Research Project
• 6338044

• ApplicationId

  6338044

• Core Project Number

  R43NS040625

• Full Project Number

  1R43NS040625-01A1

• Serial Number

  40625

• FOA Number

• Sub Project Id

• Project Start Date

  9/27/2001 - 22 years ago

• Project End Date

  8/31/2002 - 21 years ago

• Program Officer Name

  CHEUNG, GEOFFREY P.

• Budget Start Date

  9/27/2001 - 22 years ago

• Budget End Date

  8/31/2002 - 21 years ago

• Fiscal Year

  2001

• Support Year

  1

• Suffix

  A1

• Award Notice Date

  9/26/2001 - 22 years ago

Organizations

• MicroFab Technologies Inc

DESCRIPTION: We will construct bifurcated (Y-shaped), three-dimensional, biologically active and bioabsorbable polymer-based nerve conduits using ink-jet microdispensing technology for the purpose of facilitating peripheral nerve repair through methods of tissue engineering. These bifurcated, polymer-based nerve conduits will be created under a digitally controlled ink-jet platform to assure direct control of conduit dimensions and construction of B-Nerve Growth Factor (B-NGF) gradients in order to demonstrate selective neurite outgrowth from PC-12 cells based on the abundance of conduit ligated B-NGF in a three-dimensional space. By applying our ink-jet technology we will be able to fabricate nerve conduits containing biomolecule step-gradients that will ultimately enable tissue engineers to selectively control the pathways neurites take to different target areas, and eliminate current barriers associated with current nerve guidance conduits such as non-specific target reinervation. When compared with current mold-based conduit fabrication, ink-jet technology based printing offers a degree of selectivity, specificity, and micro-material deposition otherwise unavailable. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

IC Name

• Activity

  R43

• Administering IC

  NS

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  100000

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  853

• Ed Inst. Type

• Funding ICs

  NINDS:100000\

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  MICROFAB TECHNOLOGIES, INC.

• Organization Department

• Organization DUNS

• Organization City

  PLANO

• Organization State

  TX

• Organization Country

  UNITED STATES

• Organization Zip Code

  75074

• Organization District

  UNITED STATES