Claims
- 1. A composition comprising an isolated bioactive peptide of from 4-39 amino acids in length wherein said peptide comprises an amino acid sequence of any of SEQ ID NOS:1-32, or a fragment of any thereof.
- 2. The composition of claim 1, wherein the peptide comprises an acetyl attached to the N-terminus.
- 3. The composition of claim 1, wherein the peptide comprises an amide attached to the C-terminus.
- 4. The composition of claim 1, comprising one or more peptides with the following amino acid sequences DLNQ, SEQ ID NO:71, SPLGD, SEQ ID NO:111, LGDRL, SEQ ID NO:113, LNVEV, SEQ ID NO:117, AAPTV, SEQ ID NO:127, TAPTV, SEQ ID NO:128, TLRSP, SEQ ID NO:161 RLNVEV, SEQ ID NO:183, VEVDAA, SEQ ID NO:187, VDAAPT, SEQ ID NO:191, VDTAPT, SEQ ID NO:192, DTAPTV, SEQ ID NO:194, AAPTVD, SEQ ID NO:195, TAPTVD, SEQ ID NO:196, DLNRVL, SEQ ID NO:204, EVDAAPT, SEQ ID NO:262, VDTAPTV, SEQ ID NO:265, DAAPTV, SEQ ID NO:266, APTVDLN, SEQ ID NO:270, or a combination thereof.
- 5. The composition of claim 1, wherein the composition is a powder, lotion, hydrogel, oil, emulsion, paste, polish or cream.
- 6. The composition of claim 1, wherein the composition is formulated in a wound dressing.
- 7. The composition of claim 6, wherein the wound dressing is a sheet comprising a keratin derived product.
- 8. The composition of claim 6, wherein the wound dressing is an adhesive bandage.
- 9. The composition of claim 1, wherein the peptide composition is a component of a tissue engineering scaffold.
- 10. The composition of claim 9, wherein the tissue engineering scaffold comprises an insoluble material at least a part of which is obtained from a keratin product.
- 11. The composition of claim 1, wherein the composition is contained in or associated with a hydrogel.
- 12. The composition of claim 11 wherein the hydrogel comprises a keratin derived hydrogel.
- 13. A composition for topical application to skin of a human or animal subject, said composition comprising the composition of claim 1, contained in a lotion, gel, paste, cream, or aqueous solution.
- 14. The composition of claim 13, for topical application to damaged epithelial tissue.
- 15. The composition of claim 14, wherein the damaged epithelial tissue comprises a wound, a rash, diaper rash, a burn, a sunburn, a cut, an abrasion, a puncture, a sore, a bedsore, an ulcer, or wrinkled skin.
- 16. The composition of claim 13, wherein the peptide concentration is from about 100 μg/ml to about 1×10−6,g/ml.
- 17. The composition of claim 1, for cosmetic application to skin.
- 18. The composition of claim 17, wherein the composition is a moisturizer, a deodorant, an anti-aging/skin repair preparation, a cleanser, a toner, an eye care composition, a lip care composition, a fingernail care composition, a toenail care composition, a scalp care composition, a sun care composition, a hand care composition, or a body care composition.
- 19. The composition of claim 17, wherein the composition is an after-care product for a skin insult.
- 20. The composition of claim 19, wherein the skin insult is a chemical peel, sunburn, depilatory irritation, razor-shaving nick, an abrasion, scalp irritation from hair treatment
- 21. The composition of claim 17, wherein the composition is a water based make up.
- 22. The composition of claim 17, wherein the composition is a hair care product.
- 23. The composition of claim 22, wherein the product is a shampoo or hair conditioner.
- 24. A wound dressing comprising the composition of claim 1 contained in, or adhered to a sheet, film or fabric dressing.
- 25. The wound dressing of claim 24, wherein the dressing comprises a keratin derivative.
- 26. The wound dressing of claim 24, wherein said wound dressing is an adhesive bandage.
- 27. The wound dressing of claim 24, wherein the dressing comprises wool or cotton fabric.
- 28. The wound dressing of claim 24, wherein the dressing is a woven keratin sheet.
- 29. The wound dressing of claim 24, wherein the dressing is a non-woven sheet or film comprising a water insoluble keratin.
- 30. The composition of claim 14, wherein the epithelial tissue is skin, nasal, oral, gastro-intestinal, anal, vaginal, ear, eye, lung, or urogenital epithelial tissue.
- 31. A cell growth scaffold comprising a keratin derived sheet material, porous material or hydrogel, and further comprising a composition of claim 1 contained in, or adhered thereto.
- 32. The cell growth scaffold of claim 31, further defined as a spinal implant, a bone growth scaffold, a scaffold for growth of epithelial tissue, a bandage, a non-woven sheet or a woven sheet.
- 33. The cell growth scaffold of claim 32, wherein the non-woven or woven sheets comprise wool pads, woven keratin, keratin bonded to polymer sheets, or cross-linked keratin.
- 34. The cell growth scaffold of claim 31, further comprising an envelope containing the peptides.
- 35. The cell growth scaffold of claim 31, comprising peptides bonded or adhered to the surface of a metal, silicone or polymer implant.
- 36. A composition comprising an isolated bioactive peptide of from 4 to 39 amino acids in length, wherein the peptide comprises the amino acid sequence LGD, DLN, APTV, SEQ ID NO:67, or LNVEV, SEQ ID NO:117.
- 37. The composition of claim 36, wherein the composition is activation of cellular proliferation.
- 38. The composition of claim 36, wherein the cells are skin or bone cells.
- 39. The composition of claim 36, wherein the cells are fibroblasts, keratinocytes, or osteoblasts.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application relies for priority on co-pending U.S. Provisional Application No. 60/352,396, filed Jan. 28, 2002, the disclosure of which is incorporated herein in its entirety by reference.
Provisional Applications (1)
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Number |
Date |
Country |
|
60352396 |
Jan 2002 |
US |