Biocatalyst Platform Technology for Enhancing Cometabolic Biodegradation

Information

  • Research Project
  • 8782296
  • ApplicationId
    8782296
  • Core Project Number
    R43ES024670
  • Full Project Number
    1R43ES024670-01
  • Serial Number
    024670
  • FOA Number
    PA-13-234
  • Sub Project Id
  • Project Start Date
    8/11/2014 - 11 years ago
  • Project End Date
    2/10/2016 - 10 years ago
  • Program Officer Name
    HENRY, HEATHER F
  • Budget Start Date
    8/11/2014 - 11 years ago
  • Budget End Date
    2/10/2016 - 10 years ago
  • Fiscal Year
    2014
  • Support Year
    01
  • Suffix
  • Award Notice Date
    8/11/2014 - 11 years ago
Organizations

Biocatalyst Platform Technology for Enhancing Cometabolic Biodegradation

DESCRIPTION (provided by applicant): Hundreds of different harmful pollutants have contaminated valuable water supplies and resources. Many of these contaminants are recalcitrant (resistant to degradation), and their safe and effective removal from water can be cost prohibitive. For example, chlorinated solvents like trichloroethylene and chloroform are likely human carcinogens with myriad health effects at varying kinds and levels of exposure. The US Environmental Protection Agency (EPA) has established a maximum contaminant level (MCL) for TCE in drinking water of 5 (ug/L). Another recalcitrant compound N-Nitrosodimethylamine (NDMA) is also a probable carcinogen with maximum notification levels of 10 ng/L in many states. Collectively, recalcitrant organic pollutants in water affect hundreds of thousands of sites in the United States and severely confound public and private water treatment efforts. Compared with physical and chemical technologies, biological treatment offers the potential for low-energy, reliable, and eco-friendly degradation of these compounds into innocuous products. Even so, existing methods in applying biological technologies and inducing biodegradation of recalcitrant organics via cometabolism suffer from a number of drawbacks that lead to unreliable performance and high costs. This Phase I feasibility seeks to remedy many of the disadvantages with existing biological treatment technologies through a multidisciplinary approach drawing on materials science, applied microbiology, and environmental engineering. The project will develop, construct, test, and optimize a biocatalyst platform technology that can consolidate the treatment of difficult water quality situations safely and effectively, thereby protecting public health and promoting environmental sustainability. The major outcome of this work will be a proof-of-concept of a novel high performance biocatalytic process for the cometabolic treatment of major contaminants in water. The value proposition of this method includes intensified, targeted performance while limiting waste and reducing capital and operating expenses. Compared with existing methods, the successful outcome of this project has the potential to be a commercial technology-of-choice for water managers and providers, allowing the cost-effective remediation of water supplies and securing significant value for public and private environmental stewardship for future generations.

IC Name
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
  • Activity
    R43
  • Administering IC
    ES
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
    149988
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    143
  • Ed Inst. Type
  • Funding ICs
    NIEHS:149988\
  • Funding Mechanism
    SBIR-STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    MICROVI BIOTECH, INC.
  • Organization Department
  • Organization DUNS
    828139530
  • Organization City
    HAYWARD
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    945453702
  • Organization District
    UNITED STATES