Claims
- 1. A method of preparing a biodegradable active ingredient depot formulation with controlled delivery of a biologically active ingredient which comprises incorporating a biologically active ingredient into a controlled release agent which contains a poly (hydroxyalkyl) amino dicarboxylic acid derivative of the formula I ##STR6## in which n is 1 or 2, m is 2 to 6, x and y are 1 to 400, and z is 0 to 40, and in which the radicals R and R' are identical or, independently of one another, different and denote branched or unbranched, saturated or unsaturated alkyl, cycloalkyl, alkoxy or cycloalkyloxy groups having a total of 1-22 carbon atoms in the alkyl moiety, the alkyl moiety is not interrupted or is interrupted by a carbonyloxy group, or biologically inactive steroid alcohols bonded via their hydroxyl groups, there being random distribution in the polymer of the monomer units placed in square brackets.
- 2. A method according to claim 1 wherein a biologically active substance is encapsulated by said controlled release agent.
- 3. A method according to claim 1 wherein the controlled release agent further contains other biodegradable and/or biocompatible polymers or physiologically acceptable auxiliaries.
- 4. A method according to claim 1 wherein the controlled release agent further contains physiologically acceptable polymer plasticizers.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3700128 |
Jan 1987 |
DEX |
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Parent Case Info
This is a continuation of application Ser. No. 140,132 filed Dec. 31, 1987 now U.S. Pat. No. 4,906,473.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4451452 |
Deibig et al. |
May 1984 |
|
4800085 |
Yoshida et al. |
Jan 1989 |
|
4892733 |
Bichon et al. |
Jan 1990 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
140132 |
Dec 1987 |
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