Claims
- 1. A polymer comprising a plurality of subunits of each of Formula A, Formula B, and Formula C:
Formula A: Formula B: Formula C: 13wherein, as valence and stability permit,
M represents, independently for each occurrence, a substituted or unsubstituted methylene; X is absent or, independently for each occurrence, represents a heteroatom selected from NR, O, and S; R represents, independently for each occurrence, H or lower alkyl; j represents, independently for each occurrence, an integer from 0 to 16; m represents, independently for each occurrence, an integer from 4 to 20; n represents, independently for each occurrence, an integer from 4 to 500; p represents, independently for each occurrence, an integer from 1 to 60; and q represents, independently for each occurrence, an integer from 1 to 20.
- 2. A polymer of claim 1, wherein M represents CH2 for each occurrence, or, for an occurrence of M adjacent to O, CH2 or C═O.
- 3. A polymer of claim 1, wherein the polymer consists essentially of subunits having structures of Formulae A, B, and C.
- 4. A polymer of claim 1, wherein subunits of Formula A make up between 10% and 99% of the polymer, subunits of Formula B make up between 1 and 80% of the polymer, and subunits of Formula C make up between 1% and 80% of the polymer.
- 5. A polymer of claim 4, wherein subunits of Formula A make up between 15% and 95% of the polymer, subunits of Formula B make up between 5 and 60% of the polymer, and subunits of Formula C make up between 5 and 60% of the polymer, by weight.
- 6. A pharmaceutical composition comprising a polymer of claim 1.
- 7. A polymer of claim 1, wherein the polymer is encapsulating a therapeutic agent, a diagnostic agent, an imaging agent, or an adjuvant.
- 8. A polymer of claim 7, wherein the polymer is formulated as microspheres.
- 9. A polymer of claim 8, wherein the polymer is formulated as nanospheres.
- 10. A polymer of claim 8, wherein the microspheres are suitable for administration by inhalation.
- 11. An inhaler comprising microspheres of claim 10.
- 12. A method for treating, preventing, or diagnosing a condition in a patient, comprising administering to the patient a polymer of claim 7.
- 13. Microspheres comprising a polymer comprising a plurality of subunits of each of Formula A and Formula B:
Formula A: Formula B: 14wherein, as valence and stability permit,
M represents, independently for each occurrence, a substituted or unsubstituted methylene; R represents, independently for each occurrence, H or lower alkyl; j represents, independently for each occurrence, an integer from 0 to 16; m represents, independently for each occurrence, an integer from 4 to 20; n represents, independently for each occurrence, an integer from 4 to 500; and p represents, independently for each occurrence, an integer from 1 to 60, wherein the microspheres have a mean diameter between 12 μm and 1 μm.
- 14. Microspheres of claim 13, wherein M represents CH2 for each occurrence, or, for an occurrence of M adjacent to O, CH2 or C═O.
- 15. Microspheres of claim 13, wherein the polymer consists essentially of subunits having structures of Formulae A and B.
- 16. Microspheres of claim 13, wherein subunits of Formula A make up between 10% and 99% of the polymer, and subunits of Formula B make up between 1 and 80% of the polymer.
- 17. Microspheres of claim 16, wherein subunits of Formula A make up between 15% and 95% of the polymer, and subunits of Formula B make up between 5 and 60% of the polymer.
- 18. A pharmaceutical composition comprising microspheres of claim 13.
- 19. Microspheres of claim 13, wherein the polymer encapsulates a therapeutic agent, a diagnostic agent, an imaging agent, or an adjuvant.
- 20. Microspheres of claim 13, wherein the microspheres are suitable for administration by inhalation.
- 21. An inhaler comprising microspheres of claim 20.
- 22. A method for treating, preventing, or diagnosing a condition in a patient, comprising administering to the patient microspheres of claim 19.
- 23. A composition comprising an agent encapsulated by a polymer comprising a plurality of subunits of Formula A and Formula B:
Formula A: Formula B: 15wherein, as valence and stability permit,
M represents, independently for each occurrence, a substituted or unsubstituted methylene; R represents, independently for each occurrence, H or lower alkyl; j represents, independently for each occurrence, an integer from 0 to 16; m represents, independently for each occurrence, an integer from 4 to 20; n represents, independently for each occurrence, an integer from 4 to 500; and p represents, independently for each occurrence, an integer from 1 to 60, wherein, under physiological conditions, the encapsulated agent is released over a period of at least two days.
- 24. A composition of claim 23, wherein M represents CH2 for each occurrence, or, for an occurrence of M adjacent to O, CH2 or C═O.
- 25. A composition of claim 23, wherein the polymer additionally includes subunits of Formula C:
Formula C: 16wherein, as valence and stability permit,
X is absent or, independently for each occurrence, represents a heteroatom selected from NR, O, and S; p represents, independently for each occurrence, an integer from 1 to 60; and q represents, independently for each occurrence, an integer from 1 to 20.
- 26. A composition of claim 23, wherein subunits of Formula A make up between 20% and 99% of the polymer, and subunits of Formula B make up between 1 and 80% of the polymer.
- 27. A composition of claim 25, wherein subunits of Formula A make up between 10% and 99% of the polymer, subunits of Formula B make up between 1 and 80% of the polymer, and subunits of Formula C make up between 1 % and 80% of the polymer.
- 28. A composition of claim 26, wherein subunits of Formula A make up at least 90% of the polymer.
- 29. A pharmaceutical composition comprising a composition of claim 23.
- 30. A composition of claim 23, wherein the agent is a therapeutic agent, a diagnostic agent, an imaging agent, or an adjuvant.
- 31. A composition of claim 23, wherein the composition is formulated as microspheres.
- 32. A composition of claim 31, wherein the composition is formulated as nanospheres.
- 33. A composition of claim 31, wherein the microspheres are suitable for administration by inhalation.
- 34. An inhaler comprising microspheres of claim 33.
- 35. A method for treating, preventing, or diagnosing a condition in a patient, comprising administering to the patient a composition of claim 23.
- 36. A composition of claim 23, wherein the polymer has a Mw of at least 20,000 daltons.
- 37. A composition of claim 28, wherein the polymer has a Mw of at least 20,000 daltons.
- 38. A composition of claim 23, wherein the polymer has a Mw of at least 40,000 daltons.
- 39. A composition of claim 28, wherein the polymer has a Mw of at least 40,000 daltons.
- 40. A composition of claim 23, wherein the subunits of Formula B have a molecular weight of at least 1,000 daltons.
- 41. A composition of claim 28, wherein the subunits of Formula B have a molecular weight of at least 1,000 daltons.
- 42. A composition of claim 36, wherein the subunits of Formula B have a molecular weight of at least 1,000 daltons.
- 43. A composition of claim 37, wherein the subunits of Formula B have a molecular weight of at least 1,000 daltons.
- 44. A method for preparing a polymer, comprising combining monomers of Formula A and of Formula B:
Formula A: Formula B: 17wherein, as valence and stability permit,
M represents, independently for each occurrence, a substituted or unsubstituted methylene; R represents, independently for each occurrence, H or lower alkyl; Z represents a lower alkyl or lower heteroalkyl group; j represents, independently for each occurrence, an integer from 0 to 16; m represents, independently for each occurrence, an integer from 4 to 20; n represents, independently for each occurrence, an integer from 4 to 500; and p represents, independently for each occurrence, an integer from 1 to 60, and reacting the mixture at a temperature between 160 and 200° C. for a time between 15 and 60 minutes.
- 45. A method of claim 44, wherein the temperature is between 170 and 190° C.
- 46. A method of claim 44, wherein the time is between 20 and 60 minutes.
- 47. A method of claim 45, wherein the time is between 20 and 60 minutes.
- 48. A method of claim 45, wherein the time is between 20 and 40 minutes.
- 49. A method of claim 44, wherein the mixture is reacted under a vacuum of less than 1 Torr.
- 50. A method of claim 44, wherein the mixture further includes a Lewis acid catalyst.
- 51. A method of claim 44, wherein the mixture further includes an organic solvent.
- 52. A method of claim 44, wherein the mixture consists essentially of the monomers and, optionally, a catalyst.
- 53. A method for preparing a polymer, comprising combining monomers of Formulae A, B and C:
Formula A: Formula B: Formula C: 18wherein, as valence and stability permit,
M represents, independently for each occurrence, a substituted or unsubstituted methylene; R represents, independently for each occurrence, H or lower alkyl; X is absent or, independently for each occurrence, represents a heteroatom selected from NR, O, and S; Z represents a lower alkyl or lower heteroalkyl group; j represents, independently for each occurrence, an integer from 0 to 16; m represents, independently for each occurrence, an integer from 4 to 20; n represents, independently for each occurrence, an integer from 4 to 500; p represents, independently for each occurrence, an integer from 1 to 60; and q represents, independently for each occurrence, an integer from 1 to 20, and and reacting the mixture at a temperature between 150 and 220° C.
- 54. A method of claim 53, wherein the temperature is between 160 and 200° C.
- 55. A method of claim 53, wherein the time is between 15 and 180 minutes.
- 56. A method of claim 54, wherein the time is between 15 and 180 minutes.
- 57. A method of claim 53, wherein monomers of Formula A make up between 10% and 99% of the mixture, monomers of Formula B make up between 1 and 80% of the mixture, and monomers of Formula C make up between 1% and 80% of the mixture.
- 58. A method of claim 53, wherein the mixture is reacted under a vacuum of less than 1 Torr.
- 59. A method of claim 53, wherein the mixture further includes a Lewis acid catalyst.
- 60. A method of claim 53, wherein the mixture further includes an organic solvent.
- 61. A method of claim 53, wherein the mixture consists essentially of the monomers and, optionally, a catalyst.
RELATED APPLICATION
[0001] This application claims the benefit of, and incorporates by reference, the entire disclsoure of U.S. Provisional Patent Application No. 60/299,729 filed on Jun. 22, 2001.
Provisional Applications (1)
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Number |
Date |
Country |
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60299729 |
Jun 2001 |
US |