Claims
- 1. A method for delivering a bioactive molecule to bone comprising
- making a polymeric composition including as structural and functional components a polyanhydride, and
- bioactive molecules, and
- 2. The method of claim 1 wherein the bioactive molecules are selected from the group consisting of antibiotics, chemotherapeutic agents, bone morphogenic factors, angiogenesis inhibitors, and bone growth factors.
- 3. The method of claim 1 wherein the polyanhydride is selected to degrade over a period of less than approximately a year.
- 4. The method of claim 1 further comprising mixing bioactive molecules with the polyanhydride and implanting the material in bone.
- 5. The method of claim 1 further comprising mixing filler materials with polyanhydride to increase the structural strength of the polyanhydride.
- 6. The method of claim 1 for treatment of tumors comprising removing tumor material and implanting the polyanhydride-bioactive molecules in place thereof.
- 7. The method of claim 1 further comprising mixing the polyanhydride and bioactive material with structural and adhesive materials to form a bond cement.
- 8. A method for delivering a bioactive molecule to bone comprising making a polyanhydride composition including as structural and functional components:
- a polyanhydride and bioactive molecules,
- in a bone cement.
BACKGROUND OF THE INVENTION
This is a continuation of copending application Ser. No. 07/810,324 filed on Dec. 19, 1991, now abandoned, which is a continuation of U.S. Ser. No. 07/690,042 filed Apr. 23, 1991, now abandoned which is a continuation of U.S. Ser. No. 07/361,222 filed Jun. 5, 1989, now abandoned, which is a continuation-in-part of U.S. Ser. No. 613,001 entitled "Bioerodible Polyanhydrides for Controlled Drug Delivery" filed May 21, 1984, now U.S. Pat. No. 4,906,474, by Robert S. Langer, Howard Rosen, Robert J. Linhardt, and Kam Leong, which is a continuation of U.S. Ser. No. 477,710 filed March 22, 1983, now abandoned; Ser. No. 361,222 is a continuation-in-part of U.S. Ser. No. 061,294 entitled "Controlled Drug Delivery High Molecular Weight Polyanhydrides" filed Jun. 12, 1987, now U.S. Pat. No. 4,888,176, by Robert S. Langer, Edith Mathiowitz, Abraham J. Domb, and Cato T. Laurencin, which is a continuation-in-part of U.S. Ser. No. 892,809 filed Aug. 1, 1986, issued as U.S. Pat. No. 4,757,128 Jul. 12, 1988, which is a continuation-in-part of U.S. Ser. No. 613,001, now U.S. Pat. No. 4,906,474, and Ser. No. 361,222 is a continuation-in-part of U.S. Ser. No. 313,953 entitled "Delivery System for Controlled Release of Bioactive Factors" filed Feb. 22, 1989, now abandoned, by Cato T. Laurencin, Paul A. Lucas, Glenn T. Syftestad, Abraham J. Domb, Julia Glowacki, and Robert S. Langer.
US Referenced Citations (11)
Continuations (4)
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Number |
Date |
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810324 |
Dec 1991 |
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Parent |
690042 |
Apr 1991 |
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Parent |
361222 |
Jun 1989 |
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Parent |
477710 |
Mar 1983 |
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Continuation in Parts (5)
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Number |
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Parent |
613001 |
May 1984 |
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Parent |
61294 |
Jun 1987 |
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Parent |
892809 |
Aug 1983 |
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Parent |
613001 |
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Parent |
313953 |
Feb 1989 |
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