The present invention relates to a field of physiological or biometric measurements and, in particular, a measurement configuration for measuring bioimpedance from a human body.
A typical configuration for measuring bioimpedance includes a set of measurement electrodes disposable to contact with skin, a measurement circuitry for measuring bioimpedance from one or more of the electrodes, and a processing circuitry for processing measurement data. There may also be provided a communication circuitry for communicating the processed measurement data in a wired or wireless manner.
The present invention is defined by the subject matter of the independent claim.
Embodiments are defined in the dependent claims.
In the following the invention will be described in greater detail by means of preferred embodiments with reference to the accompanying drawings, in which
The following embodiments are exemplifying. Although the specification may refer to “an”, “one”, or “some” embodiment(s) in several locations of the text, this does not necessarily mean that each reference is made to the same embodiment(s), or that a particular feature only applies to a single embodiment. Single features of different embodiments may also be combined to provide other embodiments.
In another embodiment illustrated in
In an embodiment, the garment is a shirt, a vest, or a harness. The garment may equally be a bra or any other garment designed as an under layer to contact the skin of a human 110 (a user). The garment may be made of one or more of the following materials: nylon, polyamide, elastane, polyester, cotton, and wool.
In the embodiment of
Let us now describe the structure of the measurement circuitry 114 in greater detail with reference to
The bioimpedance measurement may be carried out by arranging signal feed electrodes 210 in the garment and, further arranging measurement the electrodes 212 in the garment. The measurement electrodes 212 may comprise the electrodes 120, 122. The measurement circuitry 114 may be configured to control the signal feed and the measurement, e.g. the following manner. One or more processors 204 may control a current generator 202 to output electric current to the feed electrodes 210. The current generator 202 may be signal synthesizer capable of outputting alternating current one various frequencies. The biompedance measurements may be used for estimating body composition, and multiple frequencies may be output for that purpose.
While the current generator is outputting current to the body, the processor 204 may configure a voltage measurement circuitry 206 to measure voltage between the measurement electrodes 212 and to acquire voltage measurement data from the measurement electrodes. The knowledge of the measured voltage U and the applied current I may then be used to compute the bioimpedance Z according to the well known formula: Z=U/I.
The measurement circuitry 114 may further comprise or have access to at least one memory 220. The memory 220 may store a computer program code comprising instructions readable and executable by the processor(s) 204 and configuring the above-described operation of the processor(s). The memory 220 may further store a configuration database 224 defining parameters for the processor(s), e.g. parameters for the current feed control.
The apparatus may further comprise a communication circuitry configured to transmit measurement data acquired by the measurement circuitry to an external device such as a smart phone or a wrist computer. The external device may be a training computer configured to monitor a physical exercise performed by the user. The communication circuitry may be a wireless communication circuitry supporting a wireless communication protocol such as ANT, ANT+, or Bluetooth®, e.g. Bluetooth Smart®.
As used in this application, the term ‘circuitry’ refers to all of the following: (a) hardware-only circuit implementations, such as implementations in only analog and/or digital circuitry, and (b) combinations of circuits and software (and/or firmware), such as (as applicable): (i) a combination of processor(s) or (ii) portions of processor(s)/software including digital signal processor(s), software, and memory(ies) that work together to cause an apparatus to perform various functions, and (c) circuits, such as a microprocessor(s) or a portion of a microprocessor(s), that require software or firmware for operation, even if the software or firmware is not physically present. This definition of ‘circuitry’ applies to all uses of this term in this application. As a further example, as used in this application, the term ‘circuitry’ would also cover an implementation of merely a processor (or multiple processors) or a portion of a processor and its (or their) accompanying software and/or firmware.
The techniques and methods described herein may be implemented by various means. For example, these techniques may be implemented in hardware (one or more devices), firmware (one or more devices), software (one or more modules), or combinations thereof. For a hardware implementation, the apparatus(es) of embodiments may be implemented within one or more application-specific integrated circuits (ASICs), digital signal processors (DSPs), digital signal processing devices (DSPDs), programmable logic devices (PLDs), field programmable gate arrays (FPGAs), graphics processing units (GPUs), processors, controllers, micro-controllers, microprocessors, other electronic units designed to perform the functions described herein, or a combination thereof. For firmware or software, the implementation can be carried out through modules of at least one chipset (e.g. procedures, functions, and so on) that perform the functions described herein. The software codes may be stored in a memory unit and executed by processors. The memory unit may be implemented within the processor or externally to the processor. In the latter case, it can be communicatively coupled to the processor via various means, as is known in the art. Additionally, the components of the systems described herein may be rearranged and/or complemented by additional components in order to facilitate the achievements of the various aspects, etc., described with regard thereto, and they are not limited to the precise configurations set forth in the given figures, as will be appreciated by one skilled in the art.
From the measured bioimpedance, other physiological characteristics such as a heart stroke volume may be computed. Patent publication US 2002/0193689 discloses one method of computing the stroke volume by using the bioimpedance and the ECG, and the processor 204 may employ such a method in some embodiments.
In the embodiment of
In a further embodiment, one or more of the electrodes 120 and 122 are further configured to measure the ECG. In such a case, the switching mechanism may further control switching of the electrodes to a differential amplifier used as a front-end in the ECG measurements.
In the embodiments of
The garment may have a backside arranged to face a backside of the user and further have a front side arranged to face a front side of the user. In any one of the embodiments of
The electrode(s) 122, 126, 136 disposed below the heart level may be disposed in a chest area of the garment, wherein the garment is arranged to be form-fitting at the location of the second electrode. The form-fitting may be realized by the elastic material of the garment or by a strap in the garment.
In embodiments modified from those described above in connection with
In an embodiment, the feed electrodes may have a different shape than the measurement electrodes. For example, the measurement electrodes may be elongated while the feed electrodes may have a round or point shape. The point shape enables more accurate determination of the current path between the feed electrodes and, thus, simplifies the system configuration. Elongated measurement electrodes provide a better skin contact for the measurements and, thus, improved measurement accuracy.
In an embodiment the switching mechanism 520 switches the function of the measurement electrodes between at least two of the following measurement modes: full ECG mode where all measurement electrodes are used to measure ECG, a full bioimpedance measurement mode where all measurement electrodes are used to measure bioimpedance, and a hybrid measurement mode where a first subset of the measurement electrodes are used to measure ECG and a second subset of the measurement electrodes are used to measure bioimpedance. The switching mechanism may be controlled by the processor 204. The processor 204 may comprise a mode selector circuitry 504 configured to perform a process for selecting a measurement arrangement according to the flow diagram of
Referring to
Upon selecting the full bioimpedance mode in block 600, the process may proceed to block 602 where the mode selector 504 configures the switching mechanism 520 to couple all the electrodes 120 to 132 for bioimpedance measurements. In the full biompedance mode, the switching mechanism 520 may couple at least one pair of the electrodes for current feed and at least one pair of electrodes for voltage measurement. In an embodiment, the current feed electrodes may be coupled to a current generator 202 configured to feed constant current. In an embodiment, the voltage measurement electrodes are coupled to a voltmeter 500 configured to measure voltage between the voltage measurement electrodes while the current generator feeds the current.
In the embodiment using four electrodes, e.g. electrodes 120 to 126, electrodes 120 and 122 may be coupled to the current generator 202 for current feed and electrodes 124, 126 to the voltmeter 500, as described above in connection with
In the embodiment using only two electrodes, the switching mechanism may be configured to alternately switch the electrodes to the current generator 202 and to the voltmeter 500 with a determined frequency. In this manner, only two electrodes may be used when measuring the bioimpedance. The voltmeter may be configured to measure a voltage sample while the electrodes are coupled to the voltmeter and not take samples while the electrodes are coupled to the current generator.
The full bioimpedance mode may be used when measuring body composition, for example. In the full bioimpedance mode, the current generator may be configured to output currency one at least two frequencies, either simultaneously or in a time-multiplexed manner.
Upon selecting the hybrid mode in block 600, the process may proceed to block 606 where the mode selector 504 configures the switching mechanism 520 to couple a subset of the electrodes for the bioimpedance measurements and another subset of electrodes for the ECG measurements. This mode may be employed when measuring the stroke volume and heart rate during a physical exercise or when measuring the body composition and the heart rate simultaneously, for example.
In the hybrid mode, the switching mechanism may couple at least two electrodes to the ECG measurement circuitry 502, at least two electrodes to the current generator 202, and at least two electrodes to the voltmeter 500. In the embodiment of
In the embodiment using a reduced set of electrodes, e.g. four electrodes as in
In the embodiments using the alternating switching, the switching frequency may be higher than 60 Hertz (Hz).
When computing the stroke volume from the bioimpedance, the ECG measurement signal may be used for acquiring a time reference for the stroke volume measurement.
The processor may monitor for a signature in the ECG signal. R peak is a typical strong signature point which may be monitored.
In an embodiment, the processor performs averaging over the bioimpedance sample sets. The averaging may be smoothing where the samples having the same index in the respective sample set are averaged. Referring to
In an embodiment, the processor may further estimate respiratory rate from the signature. The respiratory rate may be computed from a phase of the ECG signal, for example. In another embodiment, the respiratory rate is computed by measuring R-R intervals of the ECG signal. The respiratory rate may be detected from the R-R intervals by using the knowledge that the R-R interval is shorter when the user inhales than when the user exhales. By monitoring this periodicity in the R-R intervals, the respiratory rate may be computed. The processor may compute the respiratory rate by using the measured bioimpedance instead of, or in addition to, the ECG. In an embodiment, the processor(s) 204 may perform motion compensation for the bioimpedance measurements. The garment may comprise one or more motion sensors integrated therein. In an embodiment, the motion sensors are integrated at a locations of the measurement electrodes, e.g. electrodes configured to measure the voltage, for example. In another embodiment, the motion sensor(s) is/are comprised in the same casing as the measurement circuitry.
The motion sensor(s) may be configured to measure motion of the garment at the location(s) of the measurement electrodes, and the measurement circuitry may be configured to perform motion compensation for the measured bioimpedance on the basis of the measured motion.
Referring to
In an embodiment, the cadence is detected by computing a Fourier transform of the motion measurement data and performing peak detection for the transformed data. If a frequency component above a determine threshold has been detected, the processor may determine that cadence has been detected in block 902.
In an embodiment, the motion compensation in block 904 comprises adjustment of averaging window used in the above-described smoothing (block 906). The length of the averaging window, i.e. the number of sample sets to be included in the smoothing, may be determined on the basis of the cadence, for example. For a higher cadence, a larger window may be selected. Instead of cadence, another criterion may be used, e.g. training intensity acquired from a measured heart rate. For a higher intensity, a larger window may be selected. In another embodiment, the size of the window is also or alternatively dependent on an estimate of a signal-to-noise ratio of the bioimpedance measurement signal.
In an embodiment, the motion compensation in block 904 comprises an interference rejection algorithm (block 908). The interference rejection may attempt to detect a signal component having a frequency of the determined cadence and to remove the signal component from the bioimpedance measurement signal.
In yet another embodiment, the motion compensation may include using auxiliary data. For example, when performing stroke volume measurements and detecting cadence, poor signal-to-noise ratio, or another indicator for a need of motion compensation, the processor may use auxiliary data in the stroke volume estimation. For example, the processor may store a mapping table mapping a training intensities or heart rates to stroke volumes. Upon detecting the need for motion compensation, the processor may compute the stroke volume at least partially on the basis of the mapping table. In an embodiment, upon detecting cadence above a determined threshold or a signal quality below another determined threshold, the processor may use only the mapping table for the stroke volume estimation.
Let us now describe some embodiments regarding implementation of the electrodes and electronics in the garment.
In an embodiment, the material of the electrodes is thermoplastic polyurethane (TPU). Properties of TPU include elasticity, transparency, and resistance to oil, grease and abrasion which make them suitable for use in garments. Another option for the electrode material is silver.
In an embodiment, the electrodes are manufactured into the garment through a laminating or a printing process. Through printing, the electrodes may be arranged to form an arbitrary pattern in the garment.
In an embodiment, the electrodes are arranged to have a layered structure.
In another embodiment illustrated in
The signal line 116 or 118 may be sewn in the textile or provided on top of the textile. The signal lines may be formed of a conductive yarn. In an embodiment, EMI shielding is provided for the signal lines 116, 118 of the apparatus. The EMI shielding according to these embodiments may be suitable for any signal lines that conduct electric signals and are susceptible to the EMI. The signal line may comprise an electric conductor that may be formed by an electrically conductive thread or threading in an article of clothing, an apparel or a garment. The electric conductor may be isolated by an isolation layer protecting the electric conductor and isolating the electric conductor. On top of the electric conductor, the EMI shielding may be provided by arranging a conductive threading to cover the electric conductor. The conductive threading may be arranged on top of the electric conductor by stitching or sewing the conductive threading with a sewing machine. The conductive threading may be formed by using zigzag stitching such that the zigzag pattern covers the signal line without penetrating the isolation layer. The conductive threading may be sewn through a substrate in which the signal line is provided, e.g. a textile or a garment. When used in an application where the substrate is in contact with the user's skin, the conductive threading thus engages the user's skin and operates as a skin electrode for grounding the EMI.
In another embodiment, the shielding may be realized by using a coaxial yarn which is basically a yarn having a structure of a coaxial cable. An inner signal line may be surrounded by an isolation layer and a grounding protective layer. The coaxial signal line may be so thin that it can be sewn. The coaxial signal line may comprise two signal lines: one connected to the contact point 1104 and the other to the ground, e.g. the EMI shield 1200. In this manner, shielding for the signal line may be realized.
In yet another embodiment where two or more signal lines are drawn from one location to another, e.g. in the embodiment where the motion sensor is employed at the location of the electrode where the signal lines are drawn from the electrode to the location of the measurement circuitry, the signal lines may be twisted with respect to each other. Accordingly, a twisted pair signal line is formed which provides protection against EMI.
In an embodiment, the signal lines may be covered by a silicone or another protective material.
In an embodiment, the EMI shielding of the signal lines may be provided a conductive paste coating the signal lines.
In an embodiment, a casing housing the electronics including the measurement circuitry 114 is detachable from the garment. The casing may be waterproof and attached mechanically to the garment by using snap fastening, for example. The snap fastening may also align the casing with respect to the garment such that the signal lines in the garment will couple with the corresponding interfaces in the casing.
Referring to
The casing 1320 may comprise the set of connectors 1310, 1312 that are disposed such that the connectors connect to the appropriate connectors of the second set 1304, 1306 when the casing 1320 is attached to the housing. Internal wiring may be provided in the module to connect the connectors to respective components of the measurement circuitry, e.g. to the differential amplifier 502, voltmeter 500, and/or the current generator 202.
In an embodiment, the housing comprises a hole at the location where the casing is to be attached.
Any one of the above-described measurement configurations may be used in the following embodiments for monitoring a physical exercise performed by the user 100.
Computation of the training intensity by using the stroke volume provides several advantages over conventional techniques that determine the training intensity from the heart rate. The heart rate does not yield the whole picture of cardiac output and user's effort level. This may lead for example to inaccurate training load or energy expenditure estimation. A typical example where the heart rate is a sub-optimal measure is high intensity interval training (HIIT) or strength training. After finishing a high-intensity work period, the heart rate drops relatively fast. This results in estimation of a mild training effect for the exercise although the user's muscles become exhausted. Stroke volume behaves differently and provides better correlation with tissue saturation index than the heart rate. The tissue saturation index is a measure of oxygenated haemoglobin in the blood and may be considered to represent true training intensity. The stroke volume may also increase after the heart rate has reached its maximum. It means that the estimation of the training intensity by using the stroke volume enables quantification of the training intensity when the heart rate has saturated. Accordingly, computation of the training intensity by using the stroke volume provides better accuracy in the estimation of the training intensity during and/or after the exercise.
In an embodiment, the training intensity is computed from the stroke volume.
In an embodiment, the processing circuitry computes heart rate from the measured heart activity, and computes the training intensity from cardiac output (CO) defined by a product of the computed stroke volume (SV) and the heart rate (HR) as:
CO(n)=SV(n)×HR(n)
where n represents a time/sample index. As described above, the bioimpedance and the heart activity may be computed synchronously. The CO may thus be computed from samples or sample sets having the same time index or indices.
In an embodiment, the processing circuitry computes the heart rate from the measured heart activity, and further computes the training intensity from oxygen intake (VO2) defined by a product of the computed stroke volume, the heart rate, and a constant factor as:
VO2(n)=SV(n)×HR(n)×avdiff
where avdiff represents arteriovenous oxygen difference. avdiff is an indication of how much oxygen is removed from the blood in capillaries as the blood circulates in the body. In another words, it can be defined as a net difference of oxygen content between aorta and vein in terms of litres of oxygen per litre of blood. For the processing circuitry, this factor may be considered as a constant. It may be a predefiend user-specific parameter.
In an embodiment, the processing circuitry computes the heart rate from the measured heart activity, and further computes the training intensity from energy expenditure (EE) defined by a product of the computed stroke volume, the heart rate, the factor avdiff, and a predetermined user-related parameter as:
EE(n)=SV(n)×HR(n)×avdiff×oec
where oec is an oxygen-to-energy coefficient that represents the user's ability to convert oxygen into energy, e.g. 5 kilocalories per litre of oxygen. EE may be a momentary energy expenditure at timing n.
Any one or a combination of the above-described training intensity measures may be used in block 304. All of them are training intensity metrics based on the stroke volume.
In an embodiment, the processing circuitry may utilize training intensity zones that are mapped to different training intensity ranges by using the stroke volume as a factor for the training intensity. In this embodiment, the processing circuitry may determine a plurality of training intensity zones on the basis of the stroke volume, wherein ranges of each training intensity zone is mapped to a unique range of stroke volume values. Thereafter, the processing circuitry may perform said comparison in blocks 306 and 308 by comparing the training intensity with at least one training intensity zone. In this embodiment, the at least one threshold may comprise at least one limit of the at least one training intensity zone.
The training intensity zones may be created for any one of the above-described training intensity measures, e.g. the SV, CO, VO2 or EE. All of them are based on the stroke volume and, thus represent the training intensity and training effect better than heart rate zones, for example. Another feature that distinguishes the stroke-volume-based training intensity zones from the heart rate zones, for example, is that the processing circuitry may indicate the zones to the user by using a different factor than that on which the zones are based, e.g. the stroke volume. The zone ranges may be mapped to the values of SV, CO, VO2, or EE but the training intensity zones may be indicated to the user by using verbal definitions or by percentages from the maximum value, as illustrated in the middle column of
The heart rate may be a sub-optimal metric for measuring the training intensity and training load of a strength training or HIIT exercise. In a typical HIIT exercise which is an example of interval training, the user performs with high training intensity during work periods and rests or performs with mild training intensity during the rest periods. A general tendency with the TSI is that the TSI drops dramatically shortly after the start of the high-intensity work period and slowly recovers during the rest period. This indicates that the user works out in an anaerobic zone during the work period, which is typical for the HIIT exercise. The heart rate increases during the work period but falls quite quickly during the rest period, depending on the user's heart rate recovery capability. However, the stroke volume rises during the work periods and remains high during the work period. Eventually, the SV starts to drop but at a much slower pace than the heart rate, for example.
HIIT is an efficient exercise to maximize time at maximal SV. The SV has been shown to remain high during rest periods or even surpass SV values measured during the work periods, while VO2 as well as HR decrease quite rapidly during the rest periods. Reducing the training intensity of the rest periods or even resting during the rest periods of the HIIT exercise may therefore prolong the time to exhaustion. It may also allow the accumulation of more time on high-intensity zones, prolong accumulated time spent at maximal SV, maximal CO, maximal VO2, and/or maximal EE and lead to improved training benefit.
In an embodiment, the processing circuitry determines the training guidance such that the SV values are maximized. The processing circuitry may instruct the user to perform to maintain the SV above a determined threshold level. In an embodiment, upon detecting that the SV drops below a determined level, the processing circuitry may instruct the user to increase the training intensity. Figure illustrates an embodiment where the processing circuitry adapts the work periods of the interval exercise to the observations of the measured stroke volume. In this embodiment, the at least one threshold comprises a threshold for triggering the next work interval after a rest period of the physical exercise.
Referring to
In an embodiment, the determined level defined by the threshold is a selected drop of the stroke volume from a reference stroke volume measured at the start of the recovery interval, e.g. a value between 5 and 15 percent. In other words, when the SV has dropped for an amount determined by the value from the start of the rest period, the processing circuitry may trigger the next work period in block 956.
In an embodiment, a similar approach for adapting the length of the work period is utilized by the processing circuitry and, in particular, the end of the work period. In this embodiment, the at least one threshold comprises a threshold indicating a minimum training intensity for a work period of the interval exercise. The processing circuitry accumulates time the stroke volume remains above the threshold during the work period, and outputs the training guidance instruction as an instruction to end the work period. The instruction is triggered by the processing circuitry upon detecting that the stroke volume has remained above the threshold for a determined target time interval T.
Referring to
In an embodiment, the SV-based training intensity monitored in the embodiment of
In an embodiment, the processing circuitry is configured to detect fatigue of the user from the computed stroke volume during the work interval and to output a training guidance instruction for the user to end the interval exercise.
The one or more other indicators indicate that the user' is still performing with high intensity may comprise heart rate or motion intensity. The motion intensity may be measured by using a motion sensor, a force sensor, a cadence sensor, or a combination of these sensors. One or more thresholds may be employed in block 1250, e.g. one for determining the sufficient drop in the SV and another for determining that the training intensity remains sufficiently high for triggering the end of the exercise.
In an embodiment, the fatigue check of block 1250 may be carried out at another instance of the process or in a process parallel with respect to the process of
The training computer may further comprise a user interface 26 comprising a display screen and input means such as buttons or a touch-sensitive display. The processing circuitry 14 may output the instructions regarding the exercise to the user interface 26.
The training computer may further comprise or have access to at least one memory 20. The memory 20 may store a computer program code 24 comprising instructions readable and executable by the processing circuitry 14 and configuring the above-described operation of the processing circuitry 14. The memory 20 may further store a configuration database 22 defining parameters for the processing circuitry, e.g. the thresholds and/or the mapping table of the embodiment of
Some embodiments as described herein may be carried out in the form of a computer process defined by a computer program or portions thereof. Embodiments of the methods described in connection with
In an embodiment, the voltage measurement electrodes may be used for computing the ECG, as described above.
One or more grounding electrodes 2300, 2302 may be integrated into the garment as well. The grounding electrodes may be disposed between the voltage measurement electrodes and between the current feed electrodes, as illustrated in
In an embodiment, at least one of the grounding electrodes couples to an electromagnetic interference (EMI) shield protecting the measurement electrodes against the EMI. While the electrodes 2202, 2204 and the electrodes 2206, 2208 may be disposed very close to one another, the grounding electrodes 2300, 2302 may be more separated from the measurement electrodes 2202 to 2208 to prevent grounding.
SV=Zamp×VET×a
Zamp represents an amplitude of a measured bioimpedance signal according to any one of the above-described embodiments, e.g. an amplitude of a measured change of the bioimpedance. Zamp may be computed from the measured bioimpedance signal by computing a derivative of the measured bioimpedance signal thus acquiring a set of derivative samples, a differential signal. Zamp is thus an amplitude of the set of the differential signal. a represents volume of blood, and it may be considered to be a constant for the user which has been determined before-hand. The process of
In addition to the sensors and measurement circuits describe above, further sensors and measurement circuits may be integrated into the garment. Examples of such sensors include a temperature sensor, a humidity or moisture sensor configured to measure a sweat condition of the user, and an optical heart activity sensor configured to measure blood oximetry or photoplethysmogram (PPG) of the user. Measurement data of such additional sensors may be used in the computation of the above-described metrics such as the stroke volume or bioimpedance. The additional sensors may improve the accuracy of the computation.
It will be obvious to a person skilled in the art that, as the technology advances, the inventive concept can be implemented in various ways. The invention and its embodiments are not limited to the examples described above but may vary within the scope of the claims.
Number | Date | Country | Kind |
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18176972 | Jun 2018 | EP | regional |
This application is a bypass continuation-in-part of international application no. PCT/EP2019/065069 filed Jun. 10, 2019 which claims priority from European Patent Application No. 18176972.0, filed Jun. 11, 2018, which are incorporated by reference herein in their entireties.
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Number | Date | Country | |
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Parent | PCT/EP2019/065069 | Jun 2019 | WO |
Child | 16665363 | US |