The present invention relates to a biological information measuring sensor for measuring biological information in a noninvasive manner by receiving light from a living body.
Measurement of biological information is frequently carried out in the medical field. To measure biological information is very important to know the health conditions of a subject. Here, biological information includes a concentration of a particular component included in a living tissue, temperature information, heart rate, blood pressure, and the like. Particular components included in a living tissue to be measured include, for example, glucose, hemoglobin, oxyhemoglobin, neutral fat, cholesterol, albumin, uric acid, and the like included in the blood.
For example, in an ear thermometer, temperature information is measured by receiving radiation light radiated from the eardrum positioned in the auditory meatus. Furthermore, in a glucometer, a technique has been developed to measure a blood glucose concentration spectroscopically in a noninvasive manner by receiving radiation light radiated from the eardrum positioned in the auditory meatus by separating light of a wavelength in a particular range, and then detecting the spectrum of the received light. In addition, in an apparatus for measuring oxygen saturation, a finger sphygmomanometer, and the like, the technique of measuring biological information optically or spectroscopically in a noninvasive manner by receiving light from a living body has been established.
As described above, in the noninvasive measurement method in which light from a living body is received for optical or spectroscopic measurement in a noninvasive manner, it is not necessary to take a living tissue as represented by blood or humor as a sample from a subject, so that the burden on the subject is greatly reduced and the method is suitable as a method of measuring biological information.
When biological information is measured in a noninvasive manner using the optical or spectroscopic measurement method as described above, a biological information measuring sensor is used which receives radiation light emitted from a living body or transmitted light transmitted through a living body or reflected light reflected on a living body by light-receiving means and photoelectrically converting the same for output. The documents disclosing such a biological information measuring sensor include, for example, Japanese Patent Laying-Open No. 2003-70751 (Patent Document 1), Japanese National Publication No. 2001-503999 (Patent Document 2), and the like.
In order to measure biological information more accurately in the aforementioned biological information measuring sensor, light-receiving efficiency by light-receiving means should be improved. In particular, when biological information is measured by only capturing radiation light emitted from a living body without provision of a separate light source, improvement of light-receiving efficiency is essential, since radiation light radiating from a living body is very weak.
The present invention is therefore made to solve the aforementioned problem. An object of the present invention is to provide a biological information measuring sensor capable of receiving light from a living body efficiently thereby enabling biological information to be measured with high accuracy.
A biological information measuring sensor based on the present invention for measuring biological information in a noninvasive manner by receiving light from a living body includes a light-receiving region and a waveguide. The aforementioned light-receiving region is provided in light-receiving means for receiving light from a living body. The aforementioned waveguide includes an inlet-side opening portion where the light enters and an outlet-side opening portion where the light exits and is provided corresponding to the light-receiving region to introduce the light to the light-receiving region. The aforementioned waveguide includes a first region positioned closer to the inlet-side opening portion and formed to have its opening area gradually increasing from the inlet-side opening portion side toward the outlet-side opening portion side and a second region positioned closer to the outlet-side opening portion and formed to have its opening area gradually reducing from the inlet-side opening portion side toward the outlet-side opening portion side.
Here, “light from a living body” as mentioned above includes radiation light emitted from a living body as well as transmitted light and reflected light of light applied from a light source to a living body.
Because of such a configuration, in the first region of the waveguide, light incident obliquely to the opening surface of the inlet-side opening portion is reflected on the wall surface thereof and thus converted into light traveling in the direction more parallel to the extending direction of the waveguide, while in the second region of the waveguide, its opening area is formed to be gradually narrowed, so that the quantity of light per unit area of light passing through the second region can be increased along its shape. Therefore, the quantity of light incident more vertically to the light-receiving surface can be increased, so that improvement of light-receiving efficiency in the light-receiving region is achieved and biological information can be measured accurately.
In addition, since the opening area is formed to be gradually reduced in the second region of the waveguide, light entering the second region of the waveguide can be condensed at the outlet-side opening portion with the required minimum number of times of reflection on the wall surface of the waveguide. Thus, absorption or scattering of light at the time of reflection is prevented, thereby realizing higher light-receiving efficiency.
Moreover, since the shape of the waveguide closer to the inlet-side opening portion can be tapered, the shape of the tip end of the member forming the waveguide can be tapered accordingly. Therefore, the tip end of the member forming the waveguide can be brought closer to a part to be detected without coming into contact with the surrounding obstruction, and as a result, the inlet-side opening portion can be brought into close proximity to the part to be detected. Therefore, light from a part to be detected can be introduced into the waveguide efficiently. As a result, the light-receiving efficiency in the light-receiving region is improved and biological information can be measured accurately.
In the biological information measuring sensor based on the present invention as described above, preferably, the aforementioned waveguide is formed of an inner circumferential surface of a tubular waveguide formation member. In this case, preferably, an angle between the inner circumferential surface in the first region of the waveguide and a center axis of the waveguide formation member is larger than an angle between the inner circumferential surface in the second region of the waveguide and the center axis of the waveguide formation member.
Here, the angle between the inner circumferential surface of the waveguide formation member and the center axis of the waveguide formation member refers to the narrower angle of the angles between the inner circumferential surface and the center axis.
In order to convert more light into the state closer to a parallel beam in the first region of the waveguide, the inner circumferential surface of the waveguide formation member forming the waveguide needs to be steeper with respect to the center axis. In addition, in order to condense light in the second region of the waveguide without degrading parallelism of light converted into the state closer to a parallel beam, the inner circumferential surface of the waveguide formation member forming the waveguide needs to be gentle. Therefore, by employing the configuration as described above as an example that satisfies these conditions, significant improvement of light-receiving efficiency can be expected.
In the biological information measuring sensor based on the present invention as described above, preferably, the aforementioned waveguide is formed such that an opening shape in the inlet-side opening portion and an opening shape in the outlet-side opening portion are different from each other.
Because of such a configuration, at the inlet-side of the waveguide, the shape of the inlet-side opening portion can be selected so that light enters the waveguide to a maximum extent, while at the outlet-side of the waveguide, the shape of the outlet-side opening portion can be selected according to the shape of the light-receiving region so that the condensed light enters the light-receiving region without loss. Therefore, the higher light-receiving efficiency can be realized.
In accordance with the present invention, a biological information measuring sensor capable of receiving light from a living body efficiently can be provided, so that biological information can be measured more accurately.
In the following, an embodiment of the present invention will be described in detail with reference to the figures. It is noted that in the embodiment illustrated below, a description will be made by way of illustration to a case where the present invention is applied to a glucometer for measuring a blood glucose concentration by putting a probe portion containing a biological information measuring sensor into the auditory meatus, and detecting the spectra of wavelengths in two ranges of mid-infrared radiation radiated from the eardrum using the biological information measuring sensor.
As shown in
As shown in
The above-noted protective casing 12 is formed of a tubular member having a front opening. Dustproof film 13 is attached to protective casing 12 to close the front opening of protective casing 12, and in particular, the part closing the front opening of protective casing 12 functions as a dustproof window 13a. Dustproof film 13 is a film for preventing intrusion of dust into the interior of probe portion 11, and a thin film of, for example, plastic, glass, silicon, or germanium is used for this dustproof film 13. In the present embodiment, a polyethylene film is used so that radiation light radiated from eardrum 30 is transmitted well.
As shown in
Waveguide formation member 14 is arranged such that the front face thereof faces dustproof window 13a. At the back of waveguide formation member 14, the aforementioned light-receiving element 20 is arranged. Waveguide 15 is provided with an inlet-side opening portion 14a on the front face where radiation light radiated from eardrum 30 enters and an outlet-side opening portion 14b on the back face where the aforementioned radiation light passing through waveguide 15 exits.
Waveguide 15 includes a front-side waveguide 15a positioned closer to inlet-side opening portion 14a and a rear-side waveguide 15b positioned closer to outlet-side opening portion 14b. Here, front-side waveguide 15a is a part corresponding to a first region A1 of waveguide 15 and rear-side waveguide 15b is a part corresponding to a second region A2 of waveguide 15. In first region A1 of waveguide 15, an inlet-side inner circumferential surface 14c1 of waveguide formation member 14 is formed in an inclined manner such that the opening area of waveguide 15 gradually increases from inlet-side opening portion 14a toward the outlet-side opening portion 14b side. On the other hand, in second region A2 of waveguide 15, an outlet-side inner circumferential surface 14c2 of waveguide formation member 14 is formed in an inclined manner such that the opening area of waveguide 15 gradually decreases from the inlet-side opening portion 14a side toward outlet-side opening portion 14b.
Light-receiving element 20 arranged at the back of waveguide formation member 14 is an element photoelectrically converting an optical signal received at the light-receiving region as described later into an electrical signal. On the main surface of light-receiving element 20, two light-receiving regions 21, 22 are provided. These light-receiving regions 21, 22 are regions receiving light from a living body. As light-receiving element 20, for example, an element formed of two photodiodes on a single semiconductor substrate may be used or two elements each formed of one photodiode on a single semiconductor substrate may be used.
On the surfaces of light-receiving regions 21, 22, filters 23, 24 are respectively affixed. Filters 23, 24 are spectroscopic means for transmitting only light having a wavelength in a particular range and preventing transmittance of light having a wavelength in the other ranges. In the present embodiment, used as filter 23 is a filter transmitting the mid-infrared radiation with wavelengths of 9 μm-10 μm dependent on a blood glucose concentration, and used as filter 24 is a filter transmitting the mid-infrared radiation with wavelengths of 8 μm-9 μm independent of a blood glucose concentration. Outlet-side opening portion 14b of waveguide 15 formed in the interior of waveguide formation member 14 faces light-receiving regions 21, 22 of light-receiving element 20 with these filters 23, 24 interposed. It is noted that although, in the present embodiment, a filter is used as spectroscopic means by way of illustration, a diffraction grating, a prism, or the like may be used otherwise.
Because of the configuration as described above, radiation light radiated from the eardrum and entering waveguide 15 is condensed inside waveguide 15 to be applied to filters 23, 24. The radiation light applied to filters 23, 24 is separated into mid-infrared radiations of wavelengths in two ranges at filters 23, 24, and then only the separated mid-infrared radiations of wavelengths in the respective ranges enter the respective light-receiving regions 21, 22 of light-receiving element 20. Then, the light received at light-receiving element 20 is photoelectrically converted and output, so that the spectrum is detected based on this output signal in the glucometer main body and the blood glucose concentration is determined.
As shown in
Then, the radiation light entering rear-side waveguide 15b is condensed along the shape of outlet-side inner circumferential surface 14c2 of waveguide formation member 14 defining rear-side waveguide 15b and enters light-receiving regions 21, 22 of light-receiving element 20 through outlet-side opening portion 14b. Here, rear-side waveguide 15b is formed such that its opening area is gradually reduced from the inlet-side opening portion 14a side toward outlet-side opening portion 14b, so that the radiation light entering rear-side waveguide 15b is reflected on outlet-side inner circumferential surface 14c2 with the required minimum number of times. Therefore, absorption or scattering of radiation light at the time of reflection is prevented and reduction of the quantity of light exiting from outlet-side opening portion 14b is prevented.
On the other hand, as shown in
Here, as shown in
As described above, in biological information measuring sensor 10 in the present embodiment, radiation light 40a incident obliquely to the opening surface of inlet-side opening portion 14a of waveguide formation member 14 is also reflected on inlet-side inner circumferential surface 14c1 defining front-side waveguide 15a and thus converted into light traveling in the direction more parallel to the extending direction of waveguide 15. Therefore, the converted radiation light enters light-receiving regions 21, 22 in such a state in which it approaches more parallel to the normal to the light-receiving surfaces of light-receiving regions 21, 22. By contrast, in the biological information measuring sensor according to the conventional example, radiation light 40b incident obliquely to the opening surface of inlet-side opening portion 14a of waveguide formation member 14 enters light-receiving regions 21, 22 with the same angle kept with respect to the normal to the light-receiving surfaces of light-receiving regions 21, 22.
Therefore, as shown in
As explained above, with biological information measuring sensor 10 in the present embodiment, in front-side waveguide 15a, radiation light incident obliquely to the opening surface of inlet-side opening portion 14a is reflected on inlet-side inner circumferential surface 14c1 and thus converted into light traveling in the direction more parallel to the extending direction of waveguide 15, while in rear-side waveguide 15b, its opening area is formed to be gradually narrowed, so that the quantity of light per unit area of radiation light passing through rear-side waveguide 15b can be increased along the shape. Therefore, the quantity of light incident more vertically to light-receiving regions 21, 22 can be increased, so that improvement of light-receiving efficiency in light-receiving regions 21, 22 is achieved and biological information can be measured accurately.
In addition, since the opening area is formed to be gradually reduced in rear-side waveguide 15b, radiation light entering rear-side waveguide 15b can be condensed at outlet-side opening portion 14b with the required minimum number of times of reflection on outlet-side inner circumferential surface 14c2 of rear-side waveguide 15b. Thus, absorption or scattering of light at the time of reflection is prevented, thereby realizing higher light-receiving efficiency.
As one of conditions that satisfy this, it is conceived that the angle between inlet-side inner circumferential surface 14c1 defining front-side waveguide 15a and the center axis of waveguide formation member 14 is formed to be larger than the angle between outlet-side inner circumferential surface 14c2 defining rear-side waveguide 15b and the center axis of waveguide formation member 14. Here, the angles between inlet-side and outlet-side inner circumferential surfaces 14c1, 14c2 and the center axis of waveguide formation member 14 refer to the narrower angles, of the angles between these inlet-side and outlet-side inner circumferential surfaces 14c1, 14c2 and the center axis of waveguide formation member 14.
By satisfying such a condition, more radiation light can be converted into the state closer to a parallel beam in front-side waveguide 15a while the radiation light can be condensed in rear-side waveguide 15b without degrading the parallelism of the light converted into the state closer to a parallel beam in front-side waveguide 15a, so that significant improvement of light-receiving efficiency can be expected.
Because of such a configuration, as compared with the glucometer including the biological information measuring sensor shown in
In the foregoing description, the description has been made by way of illustration to the case where the present invention is applied to the biological information measuring sensor incorporated in a glucometer measuring a blood glucose concentration by detecting the spectra of wavelengths in two ranges of mid-infrared radiation. However, the present invention is also applicable to a biological information measuring sensor incorporated in a measuring apparatus detecting any other biological component or a biological information measuring sensor incorporated in a measuring apparatus measuring temperature information, pulse rate, blood pressure, or the like. In the former case, the present invention is additionally applicable to, for example, one using mid-infrared radiation as well as one using near-infrared radiation or one using visible light. Furthermore, the components to be detected include, in addition to glucose included in the blood as described above, hemoglobin, oxyhemoglobin, neutral fat, cholesterol, albumin, uric acid, and the like.
When objects to be measured are varied, the configuration of the biological information measuring sensor needs to be modified in various manners. When the object to be measured is glucose as described above, the configuration of the biological information measuring sensor is also susceptible to a variety of modifications. In the following, examples of them will be described.
A modification shown in
In this manner, in the case where the waveguide formation member is formed by combining and integrating a plurality of members each having a waveguide formed therein with each other, the effect similar to the effect in the present embodiment as described above is also achieved. The advantage of combining and integrating a plurality of members with each other in this manner is, for example, as follows. When the waveguide formation member is fabricated by cutting a metal or molding a resin, shaping is difficult by such processing, and the employment of this configuration makes fabrication easier even in such a case.
In a modification shown in
Because of such a configuration, the respective shapes of outlet-side opening portions 14b of waveguide formation member 14 can be respectively adopted to the shapes of the light-receiving regions, so that the radiation light introduced into waveguides 15 can be photoelectrically converted by the light-receiving element without loss. Therefore, biological information can be measured with higher accuracy.
In a modification shown in
In this manner, in the case where the inlet-side opening portion and the outlet-side opening portion of the waveguide have different opening shapes, advantageously, at the inlet side of the waveguide, the shape of the inlet-side opening portion can be selected so that light enters the waveguide to a maximum extent, while at the outlet side of the waveguide, the shape of the outlet-side opening portion can be selected according to the shape of the light-receiving region so that the condensed light enters the light-receiving region without loss. Therefore, the higher light-receiving efficiency can be realized.
In the embodiment as described above, the description has been made by way of illustration to the biological information measuring sensor receiving radiation light radiated from a part to be measured of a living body. However, the present invention is also applicable to a biological information measuring sensor receiving transmitted light or reflected light of light applied from a light source to a part to be measured of a living body and photoelectrically converting the same, as a matter of course.
Furthermore, in the embodiment and modifications thereof as described above, the description has been made by way of illustration assuming that a part to be measured of a living body is an eardrum. However, a part to be measured is not limited thereto and may be various parts of a living body.
In this manner, the foregoing embodiment and modifications thereof as disclosed herein are illustrative rather than limitative in all respects. The technical scope of the present invention is defined by the claims, and it is intended that equivalents to the claims and all modifications within the scope are embraced.
Number | Date | Country | Kind |
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2005-166888 | Jul 2005 | JP | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/JP2006/311288 | 6/6/2006 | WO | 00 | 12/3/2007 |