BIOMARKERS FOR RENAL CELL CARCINOMA

TECHNICAL FIELD

The present invention relates to methods for the screening, diagnosis and/or prognosis of renal cell carcinoma. In particular, the methods of the invention allow (i) to predict the presence of a renal mass; (ii) to predict if such renal mass is benign or malignant, (iii) to predict its aggressiveness status and the clinical severity of RCC (stage, grade, and metastasis); (iv) to monitor the progression or regression of RCC in a subject (eg in “watchful waiting” before treatment or surgery or during an oncological therapy to evaluate the effect of the treatment), (v) to monitor the occurrence of RCC in a subject at risk (obese patients, autosomal dominant polycystic kidney disease patients, diabetes, etc), (vi) to detect the recurrence of RCC (eg after partial nephrectomy in the remnant part of the operated kidney or after radical nephrectomy in the contralateral organ or after any type of surgery in other distant organs for metastatic patients), (vii) to distinguish RCC from other renal functional diseases or other malignant diseases (eg, infections, inflammatory or fibrotic systemic diseases or other aetiology of tumors which involve the kidney, eg sarcoma, urothelial cancer, etc).

The methods of the invention are based on the determination of expression profiles of sets of miRNAs representative for renal cell carcinoma compared to a reference and it may be associated with genotype analysis, in particular of uromodulin SNP variants. The invention also refers to a kit to perform such methods.

BACKGROUND ART

Renal Cell Carcinoma

Epidemiology Renal cell carcinoma (RCC) in adults comprehends a heterogeneous group of tumours which derive from renal tubular epithelial cells and represents the most common type of kidney cancer (80%) [Znaor et al., 2015; Chow et al., 2010; Siegel et al., 2017].

Every year more than 350,000 patients have a new diagnosis worldwide, which made it the seventh most common site for tumours [Pantucka et al., 2001]. This cancer is associated with more than 140,000 deaths per year; only in Europe, it was estimated an incidence of 84,400 new cases of RCC and 34,700 kidney cancer-related deaths [Siemer et al., 2006]. RCC has a male-female ratio of 2:17 and occurs most commonly in the fifth to sixth decade, with cancer-specific mortality extremely heterogeneous according to host characteristics [Thompson et al., 2008]. The incidence of RCC has increased since the 1980s by an average of 3% per year, largely related to incidental detection secondary to the more prevalent use of ultrasonography and CT scan [Adams et al., 2008]. The most generally accepted risk factor for RCC is cigarette smoking, although the relative associated risks have been modest, ranging from 1.4 to 2.5 compared with controls [Cumberbatch et al., 2016]. Other established risk factors for RCC include excess body weight and hypertension [Lipworth et al., 2006]. Medical conditions that have been associated with RCC in epidemiological studies include chronic kidney disease, haemodialysis, kidney transplantation, acquired kidney cystic disease, a previous RCC diagnosis and, possibly, diabetes mellitus [Dellavalle et al., 2013].

Histological Classification

Renal cell carcinoma (RCC) classification is based on cytogenetic, genetic and histological studies on both familiar and sporadic tumors [Pantucka et al., 2001]. According to the World Health Organization there are three major histological subtypes of RCC, all differentiated by histological and molecular genetic changes: clear cell (70-80%), papillary (10-15%) and chromophobe (4-5%). The remaining 10-15% of renal tumors include a variety of uncommon, sporadic, familiar carcinomas, and a group of unclassified carcinomas [Cumberbatch et al., 2016].

Among the minor histological subtypes there are oncocytoma and angiomyolipoma which represent renal tumours with a benign prognosis [Ljungberg B et al., 2016].

Clear cell renal cell carcinoma (ccRCC) represents the most common type of RCC. Most ccRCC are composed predominantly of cells containing clear cytoplasm, although eosinophilic cytoplasm predominates in some cells. The growth pattern may be solid, tubular and cystic. Grossly, ccRCC is well circumscribed, capsule is usually absent [D′Avella C et al., 2018]. The cut surface is golden-yellow, often with haemorrhage and necrosis. The indolent variant of ccRCC is multilocular cystic and accounts for approximately 4% of all ccRCC. Up to 95% of ccRCC are sporadic. The most common genetic alteration reported is loss of sequence in the short arm of chromosome 3 [Bex a et al., 2018]. This happens because of a deletion (3p-) or because of a chromosomic translocation (3;6, 3;8, 3;11) that results in the loss of chromosome 3 sequences from 3p12 to 3p26. This is the region where VHL gene is located (3p25.3). Other associated molecular changes may be duplication of the chromosome band 5q22, deletion of chromosome 6q, 8p, 9p and 14q. Sequencing studies have identified other driver genes that are involved in the pathogenesis of renal cell carcinoma, including PBRM1, BAP1, SETD2, TCEB1 and KDM5C32,33. Studies analyzing the effects of these mutations on clinical outcomes, however, are limited by small sample sizes, short-term follow-up, and lack of assessment of multiple markers in the same cohort [Lalani A A, et al., 2018].

Papillary renal cell carcinoma (pRCC) comprehends up to 10-15% of all renal cell carcinomas. Macroscopically, pRCC is well circumscribed with pseudocapsule, yellow or brown in color, and a soft structure. Its growth pattern is typically papillary and it can arise both in a sporadic or familiar way. Pseudocapsules and extensive necrotic changes cause a spherical tumor in the extra renal section [BhindiB et al., 2018]. Tumors with massive necrosis are fragile and vulnerable to spontaneous rupture or rupture resulting from minimal trauma followed by retroperitoneal bleeding. Necrosis cohere with a hypodense central area of tumor on postcontrast CT. This area is surrounded by a vital tumor tissue, seen as a serpiginous contrast-enhancing margin on CT. Papillary renal cell carcinoma is not associated with deletion of chromosome 3p. The most common cytogenetic abnormalities found are trisomies of chromosomes 3q, 7, 8, 12, 16, 17, the loss of Y chromosome in men within the sporadic form and the trisomy of chromosome 7 within the familiar one. Trisomy of chromosome 7, which contains both MET and HGF/SF genes, occurs in 95% of sporadic papillary renal carcinoma. Unlike clear cell RCC, papillary RCC is frequently multifocal from its origin [Wagener N et al., 2018]. Papillary RCCs can be divided into type 1 and type 2 lesions based upon histopathologic features. Type 1 and type 2 papillary carcinomas differ in both clinical features and in their underlying genetic abnormalities:

- Type 1 papillary RCC (p1RCC): p1RCC typically presents with stage I or II disease, and these patients have a relatively favourable prognosis. Although type 1 lesions usually occur in patients with hereditary papillary RCC, most these reports are sporadic. In the hereditary form this disease, activating germline mutations are seen in MET. In non-hereditary forms of the disease, somatic mutations in MET have been identified in approximately 10 to 20 percent of cases. Type 1 tumors are papillary lesions covered by small cells with pale cytoplasm and small oval nuclei with indistinct nucleoli [Pal S K et al., 2018].
- Type 2 papillary RCC (p2RCC): p2RCC is frequently associated with aggressive tumors that are stage III or IV at presentation and are associated with a poor prognosis. These tumors have also been seen in the hereditary leiomyomatosis and renal cell cancer syndrome, which is caused by germline mutation in the gene for fumarate hydratase (FH). Very few patients had alterations in the MET pathway. Type 2 tumors are papillary lesions covered by large cells with abundant eosinophilic cytoplasm. Type 2 cells are typified by pseudo stratification and large, spherical nuclei with distinct nucleoli [Pal S K et al., 2018].

Chromophobe (chRCC): The chromophobe variant of renal cell carcinoma also accounts for 4 percent of all cases of renal cell carcinoma and may have a benign course after surgery, provided that the tumor stage and grade are favorable. The cells of chRCC may have pail or eosinophilic granular cytoplasm. Growth usually occurs in solid sheets. The genetic characteristic of chromophobe RCC is a combination of loss of chromosomes 1, 2, 6, 10, 13 and 17. It is thought to arise from type B intercalated cells of the collecting ducts [Leibovich B C et al, 2018]. Oncocytoma: Oncocytomas, which are benign, account for about 4 percent of nephrectomies performed because renal cell carcinoma is suspected. Oncocytoma is thought to originate from type A intercalated cells of the collecting duct [Valdes Olmos R A et al., 2016].

Diagnosis

The major clinical obstacles in RCC diagnosis and therapy are the unspecific symptoms and the absence of predictive biomarkers for RCC [Heidenreich et al., 2004]. In many cases, RCC remains clinically silent, as the simultaneous presence of haematuria, pain and palpable mass at the side, considered the classic presentation triad, is actually very rare (1%) [Ljungberg et al., 2014]. Symptoms of systemic disease, such as persistent cough, bone pain, cervical lymphadenopathy, constitutional symptoms, weight loss, fever, malaise, lead to a diagnosis in up to 30% of metastatic patients [Hollingsworth et al., 2007].

Historically, survival outcomes for patients with advanced disease have been poor even with oncological treatment. On the contrary, if renal cancer is detected at early stages, surgical treatment remains the unique resolutive therapy with a free survival from metastatic disease around 95% in five years. [Hollingsworth et al., 2007].

RCC is detected mostly by abdominal ultrasound scanning by chance in day to day clinical practice; however, due to its limitations in specificity and accuracy, only CT scan and MRI technologies represent the gold standard tools for renal masses identification [Kutikov et al., 2009]. Unfortunately, both techniques are still unable to distinguish the presence of a benign lesion (e.g. oncocytoma and fat-free angiomyolipoma) from a malignant one (RCC) and this misleading error leads every year up to 20% of unnecessary surgical operations [Linehan et al., 2007]. Percutaneous renal tumor biopsies are increasingly being used for histological diagnosis when the radiological exams are confused and not able to identify clearly a malignant neoplasm; however, due to RCC heterogenicity, renal biopsies do not determine the aggressiveness of cancer [Richard et al., 2015].

Therefore, there is still the need for clinical and molecular strategies capable of stratifying the population according to the risk of developing RCC.

Staging and Grading

RCC tends to spread either by direct invasion through the renal capsule into perinephric fat and adjacent visceral structures or by direct extension into the renal vein. The most common site of distant metastases is the lung [Taneja K et al., 2018] However, liver, bone, adrenal gland, brain, the contralateral kidney and the subcutaneous tissue are potential sites of disease spread. The current International Union Against Cancer (UICC) 2017 TNM (Tumour Node Metastasis) classification is recommended for the staging of RCC (Table 1), where stages I-II represent low risk tumours whereas stages III-IV are high risk neoplasm with a considerable metastatic power dissemination [Brookman-May S D et al., 2015].

TABLE 1

TNM classification system (2017).

T - Primary tumor

TX
Primary tumor cannot be assessed

T0
No evidence of primary tumor

T1
Tumor <7 cm in greatest dimension, limited to the kidney

T1a
Tumor ≤4 cm in greatest dimension, limited to the kidney

T1b
Tumor >4 cm but ≤7 cm in greatest dimension

T2

Tumor >7 cm in greatest dimension, limited to the kidney

T2a
Tumor >7 cm but ≤10 cm in greatest dimension, limited to the kidney

T2b
Tumors >10 cm, limited to the kidney

T3
Tumor extends into major veins or perinephric tissues, but not into the ipsilateral adrenal gland and

not beyond Gerota's fascia

T3a
Tumor extends into the renal vein or its segmental branches, or invades the pelvicalyceal system,

or invades perirenal and/or renal sinus fat but not beyond Gerota's fascia

T3b
Tumor extends into the vena cava below the diaphragm

T3c
Tumor extends into the vena cava above the diaphragm or invades the wall of the vena cava

T4
Tumor invades beyond Gerota's fascia (including contiguous extension into the ipsilateral adrenal gland)

N - Regional lymph nodes

NX
Regional lymph nodes cannot be assessed

N0
No regional lymph node metastasis

N1
Metastasis in regional lymph node(s)

M - Distant metastasis

M0
No distant metastasis

M1
Distant metastasis

TNM stage grouping

Stage I
T1
N0
M0

Stage II
T2
N0
M0

Stage III
T1, T2
N1
M0

T3
Any N
M0

Stage IV
T4
Any N
M0

Any T
Any N
M1

The Fuhrman system was the most frequently used grading system in RCC but should not be applied for chromophobe RCC [Zhang G et al., 2018]. Furthermore, the Fuhrman system has not been validated for most of the new subtypes of renal carcinoma. For these reasons, the four-tiered WHO/ISUP grading system is recommended by the WHO. For grade 1-3 tumours, the system defines tumour grade based on nucleolar prominence. Grade 4 is defined by the presence of pronounced nuclear pleomorphism, tumour giant cells, and/or rhabdoid and/or sarcomatoid differentiation [Nini et al., 2018]. This grading system has been validated for ccRCC and papillary RCC. It has not yet been validated for other tumour types because of the small numbers of reported cases.

Treatment Surgery remains the basis of the curative treatment, despite advances in understanding the biology of RCC. Historically radical nephrectomy was the standard of care for management of renal tumours but the developing of chronic kidney disease and hypertension after the acute nephron mass loss in several patients have led to a more conservative approach with nephron sparing technique [Capitanio et al., 2015].

Uromodulin

Tamm-Horsfall protein was discovered by Igor Tamm and Frank Horsfall in 1950 when they precipitated a protein from the urine that inhibited hemagglutination of viruses [Pennica et al., 1987]. This glycoprotein is exclusively expressed in the kidney, specifically by cells lining the thick ascending limb of the nephron [Muchmore et al., 1985]. The domain composition of uromodulin includes a leader peptide directing its entry in the secretory pathway, four epidermal growth factor (EGF)-like domains (EGF-II and EGF-III predicted to be calcium binding), a central domain of unknown function (named D8C as it contains eight conserved cysteines), a zona pellucida domain, and a glycosylphosphatidylinositol-anchoring site [Rampoldi et al., 2012].

Given its abundance, unique structure and evolutionary conservation through all vertebrate species, a number of physiological and pathological roles have been hypothesized for uromodulin [Bachmann et al., 1985]. These include its role in defence against urinary tract infection, prevention of kidney stone formation, modulation of salt and water retention, hypertension, and more recently its possible role in inflammation and immunomodulation during acute kidney injury as well as in the pathogenesis of CKD [El-achkar et al., 2012]. The potential link between uromodulin and kidney function has been emphasized by some innovative studies that investigated for the first time the role of UMOD variants in regulating UMOD excretion in urine and the possibility that this could affect tubular function and progressive chronic kidney disease [Rampoldi et al., 2003]. Later, several genome-wide association studies revealed that variants in the UMOD gene are strongly associated with markers of renal function and risk of developing CKD in the general population [Bleyer et al., 2010; Trudu et al., 2014]. The biological role of uromodulin in the background of renal cancer occurrence, onset and development has not been clarified yet. The first studies in this field demonstrated the presence of uromodulin in samples of renal cell carcinomas [Kottgen et al., 2010]. Recently, there has been a growing interest in applying proteomics approaches in research on clinical diagnostics and predictive medicine, and uromodulin was one of the investigated proteins in the context of renal cell carcinoma [Eikrem et al., 2016]. The main proteomic goals are to detect quantitative and qualitative differences between normal and pathological samples and to identify these differentially expressed proteins [Eikrem et al., 2016]. The possible role of uromodulin as a specific biomarker of RCC in biological fluids such as urine remains uncertain and demands further investigation.

Micro RNAs

In biology, miRNAs are epigenetic regulators of gene expression able to modulate several cellular processes, from development to disease condition [Krol et al., 2010]. The process of epigenetic regulation is accomplished through binding of miRNAs to their target mRNAs by base-pairing and subsequently inducing either translational repression or mRNA destabilization [Lim et al., 2005]. The human miRNAome is composed of 1,881 precursors and 2,588 mature miRNAs, which regulate at least 60% of protein-coding genes [Bracken et al., 2016]. Because of their broader targeting characteristics, miRNAs are expected to be involved in most biological pathways and cellular processes including cell proliferation, apoptosis, cellular development and cellular signalling [Zhu et al., 2016]. Since 2010, the number of miRNAs included in miRBase has grown by approximately two-thirds owing to the advent of small RNA deep sequencing techniques[Lorenzen et al., 2012].

The majority of miRNAs are located within the tissue's cell, but some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media [Trevisani et al., 2016]. Transcription of miRNAs occurs from individual or clustered genes, although some miRNAs can be encoded from distinct genomic loci. Genes encoding miRNAs are located in non-coding sequences or in introns of either protein-coding genes (miRtrons) or non-coding RNA [Lytle et al., 2007]. Intronic miRNAs are usually co-ordinately expressed with their host gene and most of the time they both affect the same signalling pathway [Baek, D. et al, 2008]. RNA polymerase II transcribes miRNAs in the nucleus as long capped and polyadenylated hairpin transcripts, called primary miRNAs (pri-miRNAs) [Eichhorn et al., 2004]. These are processed into smaller ^˜70 nucleotide stem-looped structures, called precursor miRNAs (pre-miRNAs) by the ribonuclease III-like enzyme Drosha together with the microprocessor complex subunit DGCR8. Pre-miRNAs are then exported to the cytoplasm by exportin-5/GTP-binding nuclear protein Ran, where the ribonuclease Dicer yields 22 nucleotide miRNA duplexes consisting of the guide and passenger strands [Acunzo et al., 2015]. The guide strands are finally assembled into the RNA-induced silencing complex (RISC) and bind through their ‘seed sequence’ (nucleotides 2-8) to fully or partially complementary sites within the 3′ untranslated region of target mRNAs [Yamaguchi et al., 2017].

MiRNAs also have a key role as regulators of cellular crosstalk. They can be actively secreted into the extracellular microenvironment or into body fluids and captured by other cells, thus altering their transcriptional programme [Lampis et al., 2018]. In addition, circulating miRNAs can be derived from apoptotic cells, with the likely purpose of carrying alarm signals from apoptotic cells to other cells [Calin et al., 2004]. miRNAs circulate in blood, urine and other body fluids either packaged into microvesicles and/or exosomes or transported by RNA binding proteins (Argonaute2 complexes) and lipoproteins, which protect them from degradation by ribonucleases [Trionfini et al., 2015]. Given their ease of access, abundance, and stability, circulating miRNAs are novel promising minimally-invasive biomarkers for diagnosis and prognosis of plenty kinds of diseases, such as cancer [Mitchell et al., 2008]. Indeed, there is increasing evidence that miRNAs are involved in oncogenesis and tumour progression [Iorio et al., 2012]. In addition, miRNA signatures in blood are similar in men and women, and independent of patients' age [Mooney et al., 2015; Hunter et al., 2008]. Specific expression profiles of miRNAs have been shown in a variety of cancers, including RCC [Weng et al., 2010; Schaefer et al., 2010]. More importantly, miRNAs are thought to be excellent biomarkers not only for the diagnosis, but also for the prognosis and the classification of cancer [Schaefer et al., 2010]. Differences in the miRNA profiles of tumours versus adjacent renal tissues have been extensively explored [Tang et al., 2015; Li et al., 2015]. However, not always miRNAs deregulated in tissue are also deregulated in blood and vice versa [Keller et al., 2011]. Recently, few studies have assessed circulating levels of miRNA in the blood of RCC patients, but no consistent circulating miRNA signatures of renal cancer have emerged. Authors have often used a candidate miRNA approaches for their investigations [Zhao et al., 2013; Zhang et al., 2013; Zhai et al., 2012; Iwamoto et al., 2014; Hauser et al., 2012; Fedorko et al., 2015; Teixeira et al., 2014] and in the four genome-wide studies performed to date there was no obvious overlap between the miRNA expression profiles obtained [Chanud et et al., 2017; Wulfken et al., 2011; Redova et al., 2012; Wang et al., 2015]. Variability in plasma/serum expression levels of miRNAs in different works could be due to several critical factors: sample collection and processing (es. serum samples could present an altered miRNAs composition due to the coagulation process [Wang et al., 2012]), RNA extraction, and normalization methods. In addition, in three out of four of the genome-wide studies mentioned before, screening was limited to small numbers of samples (6, 15 and 25 RCC patients respectively) [Wulfken et al., 2011; Redova et al., 2012; Wang et al., 2015].

Consequently, lager and deeper research are needed in the novel field of circulating miRNAs in renal cancer.

SUMMARY OF THE INVENTION

In the present invention, the inventors surprisingly found an association of UMOD SNP variants with renal mass presence, malignancy, and aggressiveness in patients. Further specific plasma-circulating miRNAs were found to discriminate renal cancer patients from controls, to discriminate patients with a malignant lesion from those with a benign mass, to determine aggressiveness of RCC.

UMOD genotype may be combined with miRNA profile and optionally together with clinical parameters to provide a screening test and to improve the accuracy and specificity of diagnosis, prognosis, and classification of renal cancer.

In particular, the methods of the invention allow (i) to predict the presence of a renal mass; (ii) to predict if such renal mass is benign or malignant, (iii) to predict its aggressiveness status and the clinical severity of RCC (stage, grade, and metastasis); (iv) to monitor the progression or regression of RCC in a subject (eg in “watchful waiting” before treatment or surgery or during an oncological therapy to evaluate the effect of the treatment), (v) to monitor the occurrence of RCC in a subject at risk (obese patients, autosomal dominant polycystic kidney disease patients, diabetes, etc), (vi) to detect the recurrence of RCC (eg after partial nephrectomy in the remnant part of the operated kidney or after radical nephrectomy in the contralateral organ or after any type of surgery in other distant organs for metastatic patients), (vii) to distinguish RCC from other renal functional diseases or other malignant diseases (eg, infections, inflammatory or fibrotic systemic diseases or other aetiology of tumors which involve the kidney, eg sarcoma, urothelial cancer, etc).

Therefore the invention provides a method to determine if a renal mass present in a subject is a benign or a malignant renal mass or a method to predict if a renal mass present in a subject is a renal cell carcinoma (RCC) or a method to detect the recurrence of a renal mass or a method to identify if a subject is affected by RCC or by other renal functional diseases (diseases that affects the renal parenchyma as a result of a systemic pathological process) or by other malignant diseases (other types of tumours that affect kidneys except RCC) said method comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 11 or Table 21 or is selected from the group consisting of: hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, and hsa-miR-153-3p and wherein said combination is indicated in Table 16 or Table 25.

Preferably the method according further comprises determining the genotype of UMOD SNPs rs71384446, rs9928757, rs11647727, rs28640218, rs7193058, rs76563024, rs11862974, rs13329952, rs7203642, rs7204342, and rs28688991 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNPs are selected from the group consisting of: rs7204775, rs4997081, rs12922822, rs12917707, rs9933330, rs13334589, rs13333226, rs28362063, rs4293393, rs35650857, rs34882080, rs13335818, rs28544423, rs9928003, rs12934320, rs34356953, rs34115067, rs60136849, rs9928936, rs36060036, rs71149134, rs12934455, rs34262842, rs35830321, rs71149135, rs71377648, rs80159442, rs11342813, rs6497476, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs74842838, rs143657120, rs145915865, rs75645968, rs114333799, rs114112267, rs75459600, rs76625281, rs76236484, rs4500734, rs58351658, rs4490010, rs147846395, rs34857077, rs6497475, rs7204210, rs6497474, rs8060932, rs8062123, and rs4238595.

The invention also provides a method to discriminate a subject affected by a low stage RCC from a subject affected by a high stage RCC comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one is indicated in Table 13 or Table 23 or is selected from the group consisting of: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p and wherein said combination is indicated in Table 17 or Table 26.

Preferably said method further comprises determining the genotype of UMOD SNPs rs71384446, rs9928757, rs60136849, rs11647727, rs34356953, rs12934320, rs12934455, rs28640218, rs28544423, rs13335818, rs4293393, rs28362063, rs13333226, rs13329952, rs7203642, rs28688991, and rs12917707 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNPs is selected from the group consisting of: rs12922822, rs9933330, rs13334589, rs34115067, rs9928936, rs71149134, rs7204775, rs71377648, rs9924088, rs9923990, rs9926225, rs111483946, rs112166439, rs113923200, rs554722277, rs111992415, rs544951514, rs113957052, rs111266260, rs192180621, rs12102292, rs116563128, rs145279202, rs9937393, rs150044343, rs7204342, rs80159442, rs11342813, rs11862974, rs6497476, rs76563024, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs8060932, rs8062123, rs4238595, rs7193058, rs34857077, rs6497475, rs6497474, rs181820305, rs117774819, rs528859496, rs149233634, rs147946789, rs181711435, rs184483102, rs183590048, rs187620954, rs191065984, rs182744661, rs185578691, rs182605229, rs191171015, rs185630961, rs192280820, rs182188833, rs186260541, rs185128245, rs77225526, rs74011925, rs78052469, rs75864273, rs150052437, rs74011921, and rs372456426.

The invention also provides a method to discriminate a subject affected by a low grade RCC from a subject affected by a high grade RCC comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 12 or Table 22 or is selected from the group consisting of: hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p and wherein the combination is indicated in Table 18 or Table 27.

Preferably said method further comprises determining the genotype of UMOD SNP rs13333226 or of any other UMOD SNPs in linkage disequilibrium with rs13333226 (preferably with a R²>0.8) in any ethnic background, preferably said other UMOD SNP is selected from the group consisting of: rs7204775, rs7203642, rs4293393, rs4997081, rs28688991, rs28640218, rs13329952, rs13335818, rs34115067, rs60136849, rs9928936, rs35650857, rs34882080, rs71149135, rs34356953, rs11862974, rs6497476, rs11342813, rs7204342, rs76563024, rs80159442, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs28362063, rs13334589, rs9933330, rs12922822, rs12917707, rs28544423, rs9928003, rs12934320, rs36060036, rs71149134, rs12934455, rs34262842, rs35830321, rs71377648, rs9928757, and rs71384446.

The invention also provides a method to determine the presence of clinical metastasis in a RCC patient comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 14 or is selected from the group consisting of: hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, and wherein the combination is indicated in Table 19.

Preferably said method further comprises determining the genotype of UMOD SNPs rs71384446, rs9928757, rs60136849, rs34356953, rs12934320, rs12934455, rs28544423, rs13335818, rs4293393, rs28362063, rs13333226, rs13329952, rs7203642, rs28688991, and rs12917707 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably rs12922822, rs9933330, rs13334589, rs35650857, rs34882080, rs9928003, rs34115067, rs9928936, rs36060036, rs71149135, rs71149134, rs34262842, rs35830321, rs7204775, rs4997081, rs28640218, rs71377648, rs9924088, rs9923990, rs9926225, rs369494277, rs111483946, rs112166439, rs188045848, rs111904030, rs113923200, rs149786037, rs554722277, rs113452476, rs111992415, rs377257136, rs114997829, rs544951514, rs113957052, rs111266260, rs192180621, rs12102292, rs116563128, rs145279202, rs9937393, rs150044343, rs7204342, rs80159442, rs11342813, rs11862974, rs6497476, rs76563024, rs79245268, rs77875418, rs80142672, rs190450490, rs59027126, rs58768874, rs118059635, rs138755971, rs189908977, rs55808501, rs372456426, rs6497475, rs34857077, rs77225526, rs74011925, rs78052469, rs75864273, rs150052437, rs74011921, rs181820305, rs4238595, rs117774819, rs528859496, rs149233634, rs147946789, rs181711435, rs184483102, rs183590048, rs187620954, rs191065984, rs182744661, rs185578691, rs182605229, rs191171015, rs185630961, rs192280820, rs182188833, rs186260541, rs185128245, rs8060932, and rs8062123.

The invention also provides a method for the prognosis of RCC or a method to monitor the effect of a therapy on RCC in a subject comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 12 or Table 13 or Table 14 or Table 22 or Table 23 or is selected from the group consisting of: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, and hsa-miR-15a-5p, hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-3613-3p, hsa-miR-5481, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p and wherein the combination is indicated in Table 17 or Table 18 or Table 19 or Table 26 or Table 27.

Preferably, said method further comprises determining the genotype of UMOD SNPs rs11647727, rs12917707, rs12934320, rs12934455, rs13329952, rs13333226, rs13335818, rs28362063, rs28544423, rs28640218, rs28688991, rs34356953, rs4293393, rs60136849, rs71384446, rs7203642, rs9928757 or of any other UMOD SNPs in linkage disequilibrium with them (preferably with a R²>0.8) in any ethnic background, preferably rs111266260, rs111483946, rs111904030, rs111992415, rs112166439, rs11342813, rs113452476, rs113923200, rs113957052, rs114997829, rs116563128, rs117774819, rs118059635, rs11862974, rs12102292, rs12922822, rs13334589, rs138755971, rs145279202, rs147946789, rs149233634, rs149786037, rs150044343, rs150052437, rs181711435, rs181820305, rs182188833, rs182605229, rs182744661, rs183590048, rs184483102, rs185128245, rs185578691, rs185630961, rs186260541, rs187620954, rs188045848, rs189908977, rs190450490, rs191065984, rs191171015, rs192180621, rs192280820, rs34115067, rs34262842, rs34857077, rs34882080, rs35650857, rs35830321, rs36060036, rs369494277, rs372456426, rs377257136, rs4238595, rs4997081, rs528859496, rs544951514, rs554722277, rs55808501, rs58768874, rs59027126, rs6497474, rs6497475, rs6497476, rs71149134, rs71149135, rs71377648, rs7193058, rs7204342, rs7204775, rs74011921, rs74011925, rs75864273, rs76563024, rs77225526, rs77875418, rs78052469, rs79245268, rs80142672, rs80159442, rs8060932, rs8062123, rs9923990, rs9924088, rs9926225, rs9928003, rs9928936, rs9933330, rs9937393.

The invention also provides a method to predict the presence of a renal mass in a subject comprising measuring the level of at least one miRNA or a combination thereof in a biological sample of the subject and comparing said measured level to a reference level, wherein the at least one miRNA is indicated in Table 10 or Table 20 or is selected from the group consisting of: hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-28-3p, hsa-miR-15b, 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, and hsa-miR-494-3p and wherein the combination is indicated in Table 15 or Table 24.

Preferably in any of herein disclosed methods the subject is affected by obesity, autosomal polycystic kidney disease, multicystic kidney disease, hypertension or diabetes or wherein the subject is a smoker or has a family history of kidney cancer

In a still preferred embodiment any of disclosed herein method further comprises measuring the level of uromodulin in a biological sample of the subject and comparing said measured level to a reference level, preferably the biological sample is selected from the group consisting of: plasma, serum and urine sample.

In a still preferred embodiment any of disclosed herein method further comprises the analysis of a phenotypic characteristic, preferably selected from the group consisting of:

- clinical parameters, such as age at diagnosis/treatment, comorbidity index and specific comorbidities or history of previous renal or non-renal cancer;
- radiological parameters, such as clinical size defined as clinical diameter at axial imaging, tumor volume, clinical tumor stage, clinical nodal stage, PADUA score, RENAL score, ABC score or other nephrometric scores;
- biohumoral parameters, such as hemoglobin, platelets, creatinine, urea, blood electrolytes, total protein serum level and electrophoresis, measured and estimated glomerular filtration rate, proteinuria and urine tests.

In a still preferred embodiment, any of disclosed herein method the biological sample is selected from: blood, blood cells, serum, plasma, urine, saliva, sputum, tears, kidney tissue.

The present invention also provides a kit for use in a method according to any one of previous claim comprising means to quantify said miRNA and control means and optionally comprising means to determine at least one UMOD genotype, preferably said kit comprises an array. Clinical metastasis is revealed by the most common and standard radiological imaging tests (CT, MRI) and is detected before surgery (e.g. renal tumor mass) or after diagnosis of renal tumor. In the present invention the reference level to which the measured miRNA is to be compared with is the value measured in a biological sample of a healthy subject, or the value measured in a biological sample of a subject that does not have a renal mass and/or any previous history of any type of cancer (non-renal mass control). It can also be the value measured in a biological sample of a subject without a renal mass, the value measured in a biological sample of a subject with oncocytoma or other benign renal mass, the value measured in a biological sample of a subject with RCC, the value measured in a biological sample of a subject with low or high grade RCC, the value measured in a biological sample of a subject with low stage or high stage RCC, the value measured in a biological sample of a subject with or without clinical metastasis, the value measured in a biological sample of a subject with RCC before starting a therapy or throughout the course of therapy treatment, the value measured in a biological sample of a subject with RCC in active surveillance, the value measured in a biological sample of a subject with a previous surgery for RCC. The skilled person will choose the appropriate reference value according to the comparison to be made.

Indicated miRNA can be found in the miRbase Version v22.

In the methods of the present invention, the nucleotide sequences of said miRNAs can be found in the miRbase Version v22 and are selected from the group consisting of (i) a nucleotide sequence according to the miRbase Version v22, (ii) a nucleotide sequence that is a fragment of the nucleotide sequence according to (i), preferably, a nucleotide sequence that is a fragment which is between 1 and 12, more preferably between 1 and 8, and most preferably between 1 and 5 or 1 and 3, i.e. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12, nucleotides shorter than the nucleotide sequence according to (i), and (iii) a nucleotide sequence that has at least 80%, preferably at least 85%, more preferably at least 90%, and most preferably at least 95% or 99%, i.e. 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99%, sequence identity to the nucleotide sequence according to (i) or nucleotide sequence fragment according to (ii).

MiRNAs of the present invention may be detected and quantify according to any method known in the art, including methods disclosed herein.

In some aspects, the miRNAs of the present invention are upregulated or overexpressed in renal cell carcinoma or depending on the stage/grade of the carcinoma, the presence or not of clinical metastasis, as well as the histotype of renal mass; In some aspects, the miRNAs of the present invention are downregulated or under-expressed in renal cell carcinoma or depending on the stage/grade of the carcinoma, the presence or not of clinical metastasis, as well as the histotype of renal mass.

The present invention also provides miRNA signatures or “expression signatures”, as indicated in herein tables.

An “expression signature” is a group of two or more genes or gene-related molecules (e.g., DNA, RNA, amino acids and proteins) that exist in a cell, tissue fluid or other sample whose combined expression pattern is characteristic of a particular tissue or is characteristic of a particular condition, or disease state. The expression signature can be used to select or stratify a group of subjects based on, for example, a specific stage of a disease, a risk of developing a particular disease or state of disease or a probability or prediction of a prognosis, with sufficient accuracy to facilitate diagnosis or selection of treatment.

MiRNA is a group of small non-coding RNAs that regulate gene expression during development and differentiation (Bartel 2004). miRNA expression is very tissue-specific (Bartel 2004). Some miRNAs that are stably expressed in certain tissue types might be expressed differently in other tissue types. In some embodiments, the miRNA molecules are present in tissues and/or organs at normal physiological conditions but may be expressed at a much higher or lower level in diseased tissue or cells and are indicative of a change in health status. In other embodiments, the biomarkers may be absent in tissues and/or organs under normal physiological conditions but are specifically expressed in diseased tissue or cells. In other embodiments, the biomarkers may be specifically released to the bloodstream under conditions of RCC, and/or are over- or under-expressed as compared to normal levels. Measurement of miRNA, alone or in combination, in patient samples provides information that may correlate with a diagnosis of the selected disease. Therefore, a set of one or more miRNA molecules may be used in screening, diagnostic and prognostic assays.

As used herein the phrase “diagnostic” or means identifying the presence or nature of a pathologic condition. Diagnostic methods differ in their sensitivity and specificity. The “sensitivity” of a diagnostic assay is the percentage of diseased individuals who test positive (percent of “true positives”). Diseased individuals not detected by the assay are “false negatives.” Subjects who are not diseased and who test negative in the assay may be termed “true negatives.” The “specificity” of a diagnostic assay is 1 minus the false positive rate, where the “false positive” rate is defined as the proportion of those without the disease who test positive. While a particular diagnostic method may not provide a definitive diagnosis of a condition, it suffices if the method provides a positive indication that aids in diagnosis. As used herein the phrase “diagnosing” refers to classifying a disease or a symptom, determining a severity of the disease, monitoring disease progression, forecasting an outcome of a disease and/or prospects of recovery. The term “detecting” may also optionally encompass any of the above.

A “prognosis” may be measured as any outcome of illness. In some embodiments a prognosis is a measurement of or prediction of overall survival, recurrence-free survival, or progression of a disease. A good prognosis indicates, for example, that the disease is less likely to progress, the chance of survival after diagnosis or treatment is high or the length of time a subject is likely to live after diagnosis or after treatment is a relatively long period of time. A poor prognosis indicates, for example, that the disease is more likely to progress, the chance of survival after diagnosis or treatment is low or the length of time a subject is likely to live after diagnosis or after treatment is relatively short.

Alteration of miRNA expression has been shown in malignancies (Michael et al. 2003; Calin et al. 2005; Yanaihara et al. 2006) and plays an important role in tumorigenesis and cancer progression (Esquela-Kerscher & Slack 2006). Studies have shown that certain miRNAs play important roles in various steps of the metastatic cascade, such as the endothelial-mesenchymal transition (EMT), adhesion, migration, invasion, apoptosis and angiogenesis. Because the expression of multiple genes can be regulated by a single miRNA, miRNA expression profiles may be more accurate in determining cancer subtypes than RNA profiles of protein-coding genes (Calin& Croce 2006; Volinia et al. 2006). Expression signatures based on miRNA expression have been shown to aid in diagnosis and prognostication of cancer (Yu et al. 2008; Hiroki et al. 2010).

In the current study, miRNA expression levels in patients affected by a renal mass or RCC were profiled. MiRNA expression levels be profiled using a microarrays or PCR-based assay, as further discussed herein.

miRNA expression may be detected by any suitable method for RNA detection including, but not limited to, microarray, reverse transcriptase polymerase chain reaction (RT-PCR) or other PCR-based assays (e.g. quantitative or real time RT-PCR) or mass spectrometry.

A method for generating a miRNA expression signature may comprises performing a logistic regression analysis to identify a set of one or more miRNAs associated with presence of kidney cancer, presence of adverse phenotypic kidney cancer characteristics or a specific kidney cancer histotype.

A method for generating a miRNA expression signature may also include a step assigning a risk score to each patient with a renal mass by calculating a risk score formula and determining a cut-off risk score to stratify the cohort subjects into one or more risk groups (e.g., high risk, low risk, intermediate risk) as described in further detail in the examples below.

In other embodiments, methods for predicting a presence of kidney cancer, presence of adverse phenotypic kidney cancer characteristics or a specific kidney cancer histotype, hence aiding clinical decision making in the screening, diagnosis and prognostication of the disease, are provided. These methods may include detecting a test expression level of one or more miRNAs as part of a cancer-specific expression signature in a biological sample from a subject having a cancer, assigning a risk score to the test expression level; and predicting a presence of kidney cancer, presence of adverse phenotypic kidney cancer characteristics or specific kidney cancer histotype, hence aiding clinical decision making in the screening, diagnosis and prognostication of the disease.

When the test expression level is assigned a high-risk score, the subject is likely to have kidney cancer, presence of adverse phenotypic kidney cancer characteristics. When the test expression level is assigned a low risk score, the subject is not likely to have kidney cancer, presence of adverse phenotypic kidney cancer characteristics.

In some embodiments, the methods of the present invention provide for utilizing a biological sample of a subject or patient received from a third party; or obtaining a biological sample from a subject or a patient. Examples of suitable biological samples which may optionally be used with the embodiments of the present invention include but are not limited to blood, serum, plasma, blood cells, urine, sputum, saliva, stool, spinal fluid or CSF, lymph fluid, the external secretions of the skin, respiratory, intestinal, and genitourinary tracts, tears, milk, neuronal tissue, lung tissue, any human organ or tissue, including any tumor or normal tissue, any sample obtained by lavage (for example of the bronchial system or of the breast ductal system), and also samples of in vivo cell culture constituents. The sample can optionally be diluted with a suitable eluant before contacting the sample to an antibody and/or performing any other diagnostic assay.

Numerous well-known tissues or fluid collection methods can be utilized to collect a biological sample from the subject in order to genotype and/or sequence DNA regions, determine the level of RNA and/or polypeptide of the variant of interest in the subject. Examples include, but are not limited to, liquid biopsy, fine needle biopsy, needle biopsy, core needle biopsy and surgical biopsy (e.g., brain biopsy), and lavage. Regardless of the procedure employed or where the biopsy or sample is obtained, the level of the variant can be determined, and a diagnosis can thus be made.

The present invention will be illustrated by means of non-limiting examples in reference to the following figures.

FIG. 1. Pairwise r²values among the 22 UMOD SNPs genotyped in this study.

Linkage disequilibrium (LD) map for the 22 UMOD SNPs genotyped in this study. Variants are ordered by chromosomal position. A pairwise r²value is shown in each square. Darker blocks correspond to higher r²values. LD r²values were from 1000 Genomes Phase 3 genotypes for the Tuscan population (TSI, Toscani in Italy).

FIG. 2. Schematic representation of human UMOD gene structure. The position of the 22 UMOD SNP variants is shown.

DETAILED DESCRIPTION OF THE INVENTION

Patients

The study population consisted of 276 patients with a diagnosis of a first episode of renal mass, elected for surgical treatment via nephron sparing surgery or radical nephrectomy, together to 83 non renal mass controls consisted of patients affected by urological functional diseases (kidney stones, benign prostate hypertrophy, etc).

This total cohort of patients was included in the analysis of UMOD genotypes. A subgroup of 120 cases (patients affected by renal masses) together to 78 controls (patients affected by urological benign disfunctions) were included in the analysis of circulating miRNAs. This cohort of patients was composed by a retrospective monocentric phase together with a prospective European multicentric phase.

The prospective cohort was formed by 110 patients (59 case and 51 controls). It is important to underline that each control patient was submitted to an abdominal CT scan to exclude the concomitant presence of a renal mass.

A retrospective cohort refers to patients whose biological samples have been already collected and stored in a biobank and clinical data have been reported in a dataset.

A prospective cohort refers to patients, which are followed over time, whose biological samples and clinical data are collected.

The study population was enrolled from 2011 to 2018 in a single tertiary care institution. From 2019, in addition to this center, other four European centers were involved into the prospectively maintained dataset and specimen collection.

Study Outcomes

The aim of the study was to identify novel biomarkers that can improve the management of patients with RCC at all the stages of clinical decision-making, in particular in 3 specific clinical settings:

1. Screening

The present predictive model based on UMOD genotype and/or circulating miRNAs can predict the presence of a renal mass, defined as a mass either benign or malignant recorded at axial imaging examination (either CT or MRI). In the model, the inventors compared the above-mentioned markers in patients diagnosed with a renal mass relative to controls. The clinical implication of this information is the identification of patients with high risk of a renal mass to axial imaging.

2. Diagnosis of Kidney Cancer

The present predictive model based on UMOD genotype and/or circulating miRNAs can predict the presence of RCC, defined as a renal malignancy. In the model, the inventors compared the above-mentioned markers in patients diagnosed with any RCC histological subtype (ccRCC, p1RCC, p2RCC, chRCC) relative to patients diagnosed with a benign renal mass (oncocytoma, angymyolipoma, benign cyst or other benign histotype). The clinical implication of this information is the selection or identification of patients with high risk of RCC and of patients with low risk of RCC to be inserted in specific treatment or surveillance protocol.

3. Prognostic

The present predictive model based on UMOD genotype and/or circulating miRNAs can predict the prognosis of patients diagnosed with aggressive RCC. Inventors relied on established predictors of RCC prognosis that are direct markers of clinical aggressiveness, namely

- a. tumour stage, defined using the AJCC 2018 staging system and grouped as pT1-pT2 (low stage) vs pT3-pT4 (high stage) [Edge et al., 2010];
- b. pathologic N stage, defined using the AJCC 2018 staging system and grouped as pN0-pNx vs pN1 [Edge et al., 2010];
- c. tumour grade, defined according to the Furhman classification system or WHO/ISUP and grouped as G1-G2 (low grade) vs G3-G4 (high grade) [Delahunt et al., 2013—Delahunt et al., 2016];
- d. presence of clinical metastasis, defined as cM1 stage at systemic clinical staging [Edge et al., 2010].

The clinical implication of this information is the identification of patients with high risk of aggressive RCC for specific treatment. The model allows to spare an aggressive treatment in older and more frail patients. Moreover, the model allows the identification of patients that could benefit from post-treatment follow-up based on the aggressiveness of the disease.

Study Population

Among those with a renal mass, the median age was 64 years old with a male predominance on female patients (65.6% vs 34.4%) as reported in literature. In the final pathology evaluation, the 16.3% of patients demonstrated a benign lesion whereas the 83.7% a malignant one. High stage (pT3-pT4) was diagnosed in the 36.4% while low stage (pT1-pT2) was reported in the 63.6%: in the 59.7% the population displayed low grade tumors (G1-G2) while 40.3% high grade neoplasms (G3-G4). The discrepancy (patients with T1 or T2 staging but G3 or G4 grading and vice versa) between TNM staging and Furman/WHO-ISUP grading was about 24.3%. The 12.3% of patients was affected by a metastatic process.

In the controls group, median age was 58 years old, with a male-female percentage of 62.7% and 37.3%, respectively (Table 2).

TABLE 2

Descriptive analysis of UMOD genotypes total cohort of patients

Renal mass patients
Controls

Number of patients, n
276
83

Age, median (range)
64 (55-72)
58 (50-66)

Gender, n (%)

Male
181 (65.6%)
52 (62.7%)

Female
95 (34.4%)
31 (37.3%)

Malignancy, n (%)

NA

Benign
45 (16.3%)

Malignant
231 (83.7%)

Pathologic T stage, n (%)

NA

pT1-pT2
147 (63.6%)

pT3-pT4
84 (36.4%)

Pathologic grade, n (%)

NA

G1-G2
138 (59.7%)

G3-G4
93 (40.3%)

Clinicalmetastasis, n (%)

NA

cM0
242 (87.7%)

cM1
34 (12.3%)

In the subgroup of patients where miRNAs were analyzed the inventors considered 120 case patients vs 78 controls with the previous same clinical and pathological criteria.

Medium age was 66 years old for renal mass pts while 57 years old for controls. Male/female percentages were 54.2% vs 45.8% for cases and 62.82% vs 37.18% for controls.

Patients affected by a benign lesion were 21.7%. High stage tumours were 28.7% and high-grade neoplasms were 28.7%, with a discrepancy of 15% between stage and grade classifications. Metastatic patients were the 6.7% of the total malignant cancers (Table 3).

TABLE 3

Descriptive analysis of miRNAs total cohort of patients

Renal mass patients
Controls

Number of patients, n
120
78

Age, median (range)
66 (54-73)
57 (49-66)

Gender, n (%)

Male
65 (54.2%)
49 (62.8%)

Female
55 (45.8%)
29 (37.2%)

Malignancy, n (%)

NA

Benign
26 (21.7%)

Malignant
94 (78.3%)

Pathologic T stage, n (%)

NA

pT1-pT2
67 (71.3%)

pT3-pT4
27 (28.7%)

Pathologic grade, n (%)

NA

G1-G2
66 (71.3%)

G3-G4
28 (28.7%)

Clinicalmetastasis, n (%)

NA

cM0
112 (93.3%)

cM1
8 (6.7%)

Then, the inventors decided to consider for the miRNAs analysis also a restricted cohort of patients related to the prospective multicentric study (Table 4).

TABLE 4

Descriptive analysis of miRNAs prospective

multicentric cohort of patients

Renal mass patients
Controls

Number of patients, n
59
51

Age, median (range)
66 (59-75)
59 (53-67)

Gender, n (%)

Male
37 (62.7%)
35 (68.6%)

Female
27 (37.3%)
16 (31.4%)

Malignancy, n (%)

NA

Benign
17 (28.8%)

Malignant
42 (72.2%)

Pathologic T stage, n (%)

NA

pT1-pT2
34 (81%)

pT3-pT4
8 (19%)

Pathologic grade, n (%)

NA

G1-G2
31 (73.8%)

G3-G4
11 (26.2%)

Clinicalmetastasis, n (%)

NA

cM0
58 (98.3%)

cM1
1 (1.7%)

Medium age was 66 years old for renal mass pts while 59 years old for controls. Male/female percentages were 62.7% vs 37.3% for cases and 68.6% vs 31.4% for controls.

Patients affected by a benign lesion were 28.8%. High stage tumours were 19% and high-grade neoplasms were 26.2%, with a discrepancy of 15% between stage and grade classifications. Only one patient was affected by metastasis (1.7%).

Methods

Single Nucleotide Polymorphisms (SNPs) Genotyping in the UMOD Gene

Genomic DNA was extracted from whole blood, leukocytes, or normal kidney tissue (depending on individual sample availability) using the QIAamp DNA Mini Kit (QIAGEN), according to manufacturer's instructions. Purity and concentration of recovered DNA were determined with a NanoDrop spectrophotometer (ND-1000, NanoDrop Technologies, Wilmington, Del., USA). Genotyping of 22 single nucleotide polymorphisms (SNPs) in the UMOD gene (r54293393 (ASSAY ID C_27865986_10), rs13335818 (ASSAY ID C_136431_10), rs28544423 (ASSAY ID C_136432_20), rs11647727 (ASSAY ID C_11844689_10), rs28640218 (ASSAY ID C_27398349_10), rs12934320 (ASSAY ID C_27435435_10), rs12934455 (ASSAY ID C_27435436_10), rs34356953 (ASSAY ID C_27435446_10), rs7193058 (ASSAY ID C_29095382_10), rs4297685 (ASSAY ID C_30368496_10), rs9928757 (ASSAY ID C_30613644_10), rs13333226 (ASSAY ID C_31122293_10), rs11862974 (ASSAY ID C_31122295_10), rs13329952 (ASSAY ID C_31122297_10), rs12917707 (ASSAY ID C_31122302_20), rs28362063 (ASSAY ID C_60216431_10), rs28688991 (ASSAY ID C_60216441_10), rs60136849 (ASSAY ID C_89248696_10), rs71384446 (ASSAY ID C_97852849_10), rs76563024 (ASSAY ID C_102020079_10), rs7203642 (ASSAY ID C_189262956_10), rs7204342 (ASSAY ID C_189263753_10), ThermoFisher, Cat. No.: 4351379) was performed by using the TaqMan Open Array technology (ThermoFisher), following the manufacturer's protocol. DNA was combined with TaqMan OpenArray Genotyping Master Mix, loaded onto the OpenArray™ plates (AccuFill™ system, Cat. No. 4471021) and amplified with the QuantStudio 12K Flex Real-Time PCR System (ThermoFisher, Cat. No. 4472379). All analyses were performed in duplicate to ensure reproducibility of the results. Human gDNA samples from the NHGRI Sample Repository for Human Genetic Research at Coriell Institute for Medical Research were also included as positive controls for each variant, as well as non-template control (NTC), consisting of DNase-free double-distilled water.

Genotype clustering and calling were carried out by using TaqMan Genotyper Software version 1.5 (call rate 99.14%; ThermoFisher).

TaqMan MicroRNA Profiling Using the QuantStudio 12K Flex Real-Time PCR System with OpenArray

Total RNA was isolated from 200 μL of plasma using miRNeasy Serum/Plasma Advanced Kit (QIAGEN, Cat No. 217204) according to manufacturer's instructions, with a little modification. Briefly, during the isolation procedure, 0.001 pmol of synthetic miRNA-39 from Caenorhabditis elegans (cel-miR-39, Accession number MIMAT0000010 miRBase v22, synthesized by ThermoFisher) was added as a spike-in control before the addition of Buffer RPP. In humans, a cel-miR-39-sequence does not exist and thus its quantification enables quality control of the RNA isolation, cDNA synthesis and PCR amplification steps.

cDNA was generated using 2 μl of purified total RNA with the TaqMan Advanced miRNA cDNA Synthesis kit (ThermoFisher, Cat. No. A28007). Expression levels of 668 miRNAs (hsa-let-7a-3p (Assay ID 477861_mir), hsa-let-7a-5p (Assay ID 478575_mir), hsa-let-7b-3p (Assay ID 478221_mir), hsa-let-7b-5p (Assay ID 478576_mir), hsa-let-7c-5p (Assay ID 478577_mir), hsa-let-7d-3p (Assay ID 477848_mir), hsa-let-7d-5p (Assay ID 478439_mir), hsa-let-7e-3p (Assay ID 479281_mir), hsa-let-7e-5p (Assay ID 478579_mir), hsa-let-7f-1-3p (Assay ID 477801_mir), hsa-let-7f-2-3p (Assay ID 477843_mir), hsa-let-7f-5p (Assay ID 478578_mir), hsa-let-7g-3p (Assay ID 477850_mir), hsa-let-7g-5p (Assay ID 478580_mir), hsa-let-7i-3p (Assay ID 477862_mir), hsa-let-7i-5p (Assay ID 478375_mir), hsa-miR-100-3p (Assay ID 478619_mir), hsa-miR-100-5p (Assay ID 478224_mir), hsa-miR-101-3p (Assay ID 477863_mir), hsa-miR-101-5p (Assay ID 478620_mir), hsa-miR-10399-3p (Assay ID 483065_mir), hsa-miR-10399-5p (Assay ID 483087_mir), hsa-miR-103a-2-5p (Assay ID 477864_mir), hsa-miR-103a-3p (Assay ID 478253_mir), hsa-miR-103b (Assay ID 478621_mir), hsa-miR-106a-3p (Assay ID 478623_mir), hsa-miR-106a-5p (Assay ID 478225_mir), hsa-miR-106b-3p (Assay ID 477866_mir), hsa-miR-106b-5p (Assay ID 478412_mir), hsa-miR-107 (Assay ID 478254_mir), hsa-miR-10a-3p (Assay ID 478624_mir), hsa-miR-10a-5p (Assay ID 479241_mir), hsa-miR-10b-3p (Assay ID 477868_mir), hsa-miR-10b-5p (Assay ID 478494_mir), hsa-miR-11400 (Assay ID 483092_mir), hsa-miR-1179 (Assay ID 478626_mir), hsa-miR-1180-3p (Assay ID 477869_mir), hsa-miR-1185-5p (Assay ID 480633_mir), hsa-miR-1197 (Assay ID 478630_mir), hsa-miR-12116 (Assay ID 483094_mir), hsa-miR-12118 (Assay ID 483119_mir), hsa-miR-12135 (Assay ID 483153_mir), hsa-miR-12136 (Assay ID 483118_mir), hsa-miR-122-3p (Assay ID 477874_mir), hsa-miR-122-5p (Assay ID 477855_mir), hsa-miR-1226-5p (Assay ID 478641_mir), hsa-miR-1227-3p (Assay ID 478642_mir), hsa-miR-1228-5p (Assay ID 478644_mir), hsa-miR-122b-3p (Assay ID 479677_mir), hsa-miR-124-3p (Assay ID 480901_mir), hsa-miR-1246 (Assay ID 477881_mir), hsa-miR-1247-5p (Assay ID 477882_mir), hsa-miR-1248 (Assay ID 478653_mir), hsa-miR-1249-3p (Assay ID 478654_mir), hsa-miR-1250-5p (Assay ID 478655_mir), hsa-miR-1255a (Assay ID 478661_mir), hsa-miR-1255b-5p (Assay ID 478662_mir), hsa-miR-1256 (Assay ID 478663_mir), hsa-miR-125a-3p (Assay ID 477883_mir), hsa-miR-125a-5p (Assay ID 477884_mir), hsa-miR-125b-2-3p (Assay ID 478666_mir), hsa-miR-125b-5p (Assay ID 477885_mir), hsa-miR-1260a (Assay ID 478476_mir), hsa-miR-1260b (Assay ID 477886_mir), hsa-miR-126-3p (Assay ID 477887_mir), hsa-miR-126-5p (Assay ID 477888_mir), hsa-miR-1268b (Assay ID 480790_mir), hsa-miR-1270 (Assay ID 478673_mir), hsa-miR-1271-5p (Assay ID 478674_mir), hsa-miR-1273h-3p (Assay ID 479563_mir), hsa-miR-127-3p (Assay ID 477889_mir), hsa-miR-1275 (Assay ID 477890_mir), hsa-miR-127-5p (Assay ID 477891_mir), hsa-miR-1277-3p (Assay ID 478219_mir), hsa-miR-1277-5p (Assay ID 480875_mir), hsa-miR-1283 (Assay ID 478685_mir), hsa-miR-128-3p (Assay ID 477892_mir), hsa-miR-1284 (Assay ID 478686_mir), hsa-miR-1285-3p (Assay ID 478687_mir), hsa-miR-1285-5p (Assay ID 479565_mir), hsa-miR-1287-5p (Assay ID 477894_mir), hsa-miR-1290 (Assay ID 477895_mir), hsa-miR-1291 (Assay ID 478690_mir), hsa-miR-129-1-3p (Assay ID 480873_mir), hsa-miR-129-2-3p (Assay ID 478544_mir), hsa-miR-1292-5p (Assay ID 478691_mir), hsa-miR-1293 (Assay ID 478692_mir), hsa-miR-1294 (Assay ID 478693_mir), hsa-miR-129-5p (Assay ID 477896_mir), hsa-miR-1296-5p (Assay ID 479451_mir), hsa-miR-1298-5p (Assay ID 479452_mir), hsa-miR-1299 (Assay ID 478696_mir), hsa-miR-1301-3p (Assay ID 477897_mir), hsa-miR-1302 (Assay ID 478697_mir), hsa-miR-1303 (Assay ID 478698_mir), hsa-miR-1306-3p (Assay ID 479575_mir), hsa-miR-1306-5p (Assay ID 478701_mir), hsa-miR-1307-3p (Assay ID 483036_mir), hsa-miR-1307-5p (Assay ID 479576_mir), hsa-miR-130a-3p (Assay ID 477851_mir), hsa-miR-130a-5p (Assay ID 483130_mir), hsa-miR-130b-3p (Assay ID 477840_mir), hsa-miR-130b-5p (Assay ID 477899_mir), hsa-miR-132-3p (Assay ID 477900_mir), hsa-miR-132-5p (Assay ID 478705_mir), hsa-miR-133a-3p (Assay ID 478511_mir), hsa-miR-133b (Assay ID 480871_mir), hsa-miR-134-5p (Assay ID 477901_mir), hsa-miR-135a-5p (Assay ID 478581_mir), hsa-miR-136-3p (Assay ID 477902_mir), hsa-miR-136-5p (Assay ID 478307_mir), hsa-miR-137-3p (Assay ID 477904_mir), hsa-miR-138-5p (Assay ID 477905_mir), hsa-miR-139-3p (Assay ID 477906_mir), hsa-miR-139-5p (Assay ID 478312_mir), hsa-miR-1-3p (Assay ID 477820_mir), hsa-miR-140-3p (Assay ID 477908_mir), hsa-miR-140-5p (Assay ID 477909_mir), hsa-miR-141-3p (Assay ID 478501_mir), hsa-miR-142-3p (Assay ID 477910_mir), hsa-miR-142-5p (Assay ID 477911_mir), hsa-miR-143-3p (Assay ID 477912_mir), hsa-miR-143-5p (Assay ID 478713_mir), hsa-miR-144-3p (Assay ID 477913_mir), hsa-miR-144-5p (Assay ID 477914_mir), hsa-miR-145-3p (Assay ID 477915_mir), hsa-miR-145-5p (Assay ID 477916_mir), hsa-miR-146a-3p (Assay ID 478714_mir), hsa-miR-146a-5p (Assay ID 478399_mir), hsa-miR-146b-3p (Assay ID 483103_mir), hsa-miR-146b-5p (Assay ID 483144_mir), hsa-miR-148a-3p (Assay ID 477814_mir), hsa-miR-148a-5p (Assay ID 478718_mir), hsa-miR-148b-3p (Assay ID 477824_mir), hsa-miR-148b-5p (Assay ID 478719_mir), hsa-miR-150-3p (Assay ID 478721_mir), hsa-miR-150-5p (Assay ID 477918_mir), hsa-miR-151a-3p (Assay ID 477919_mir), hsa-miR-151a-5p (Assay ID 478505_mir), hsa-miR-151b (Assay ID 477811_mir), hsa-miR-152-3p (Assay ID 477921_mir), hsa-miR-153-3p (Assay ID 477922_mir), hsa-miR-1537-3p (Assay ID 477923_mir), hsa-miR-154-3p (Assay ID 478725_mir), hsa-miR-154-5p (Assay ID 477925_mir), hsa-miR-155-5p (Assay ID 483064_mir), hsa-miR-15a-3p (Assay ID 477928_mir), hsa-miR-15a-5p (Assay ID 477858_mir), hsa-miR-15b-3p (Assay ID 477929_mir), hsa-miR-15b-5p (Assay ID 478313_mir), hsa-miR-16-1-3p (Assay ID 478727_mir), hsa-miR-16-2-3p (Assay ID 477931_mir), hsa-miR-16-5p (Assay ID 477860_mir), hsa-miR-17-3p (Assay ID 477932_mir), hsa-miR-17-5p (Assay ID 478447_mir), hsa-miR-181a-2-3p (Assay ID 479478_mir), hsa-miR-181a-3p (Assay ID 479405_mir), hsa-miR-181a-5p (Assay ID 477857_mir), hsa-miR-181b-5p (Assay ID 478583_mir), hsa-miR-181c-3p (Assay ID 477933_mir), hsa-miR-181c-5p (Assay ID 477934_mir), hsa-miR-181d-5p (Assay ID 479517_mir), hsa-miR-182-5p (Assay ID 477935_mir), hsa-miR-183-3p (Assay ID 477936_mir), hsa-miR-183-5p (Assay ID 477937_mir), hsa-miR-184 (Assay ID 477938_mir), hsa-miR-1843 (Assay ID 483104_mir), hsa-miR-185-3p (Assay ID 478732_mir), hsa-miR-185-5p (Assay ID 477939_mir), hsa-miR-186-3p (Assay ID 479544_mir), hsa-miR-186-5p (Assay ID 477940_mir), hsa-miR-187-3p (Assay ID 477941_mir), hsa-miR-188-3p (Assay ID 477942_mir), hsa-miR-188-5p (Assay ID 477943_mir), hsa-miR-18a-3p (Assay ID 477944_mir), hsa-miR-18a-5p (Assay ID 478551_mir), hsa-miR-18b-3p (Assay ID 478734_mir), hsa-miR-18b-5p (Assay ID 478584_mir), hsa-miR-1908-5p (Assay ID 478735_mir), hsa-miR-190a-5p (Assay ID 478358_mir), hsa-miR-190b-5p (Assay ID 483105_mir), hsa-miR-191-3p (Assay ID 477951_mir), hsa-miR-191-5p (Assay ID 477952_mir), hsa-miR-192-3p (Assay ID 478741_mir), hsa-miR-192-5p (Assay ID 478262_mir), hsa-miR-193a-3p (Assay ID 478306_mir), hsa-miR-193a-5p (Assay ID 477954_mir), hsa-miR-193b-3p (Assay ID 478314_mir), hsa-miR-193b-5p (Assay ID 478742_mir), hsa-miR-194-5p (Assay ID 477956_mir), hsa-miR-195-3p (Assay ID 478744_mir), hsa-miR-195-5p (Assay ID 477957_mir), hsa-miR-196a-5p (Assay ID 478230_mir), hsa-miR-196b-3p (Assay ID 477958_mir), hsa-miR-196b-5p (Assay ID 478585_mir), hsa-miR-197-3p (Assay ID 477959_mir), hsa-miR-1976 (Assay ID 478365_mir), hsa-miR-199a-3p (Assay ID 477961_mir), hsa-miR-199a-5p (Assay ID 478231_mir), hsa-miR-199b-5p (Assay ID 478486_mir), hsa-miR-19a-3p (Assay ID 479228_mir), hsa-miR-19b-1-5p (Assay ID 477962_mir), hsa-miR-19b-3p (Assay ID 478264_mir), hsa-miR-200a-3p (Assay ID 478490_mir), hsa-miR-200b-3p (Assay ID 477963_mir), hsa-miR-200c-3p (Assay ID 478351_mir), hsa-miR-202-5p (Assay ID 478755_mir), hsa-miR-203a-3p (Assay ID 478316_mir), hsa-miR-203b-3p (Assay ID 478757_mir), hsa-miR-203b-5p (Assay ID 478758_mir), hsa-miR-204-5p (Assay ID 478491_mir), hsa-miR-205-5p (Assay ID 477967_mir), hsa-miR-206 (Assay ID 477968_mir), hsa-miR-208a-3p (Assay ID 477819_mir), hsa-miR-208b-3p (Assay ID 477806_mir), hsa-miR-20a-3p (Assay ID 478317_mir), hsa-miR-20a-5p (Assay ID 478586_mir), hsa-miR-20b-5p (Assay ID 477804_mir), hsa-miR-210-3p (Assay ID 477970_mir), hsa-miR-2110 (Assay ID 477971_mir), hsa-miR-211-5p (Assay ID 478507_mir), hsa-miR-212-3p (Assay ID 478318_mir), hsa-miR-21-3p (Assay ID 477973_mir), hsa-miR-214-3p (Assay ID 477974_mir), hsa-miR-214-5p (Assay ID 478768_mir), hsa-miR-215-5p (Assay ID 478516_mir), hsa-miR-21-5p (Assay ID 477975_mir), hsa-miR-216b-5p (Assay ID 479456_mir), hsa-miR-218-5p (Assay ID 477977_mir), hsa-miR-219a-1-3p (Assay ID 477978_mir), hsa-miR-219a-5p (Assay ID 477980_mir), hsa-miR-219b-3p (Assay ID 478776_mir), hsa-miR-221-3p (Assay ID 477981_mir), hsa-miR-221-5p (Assay ID 478778_mir), hsa-miR-222-3p (Assay ID 477982_mir), hsa-miR-223-3p (Assay ID 477983_mir), hsa-miR-223-5p (Assay ID 477984_mir), hsa-miR-22-3p (Assay ID 477985_mir), hsa-miR-224-3p (Assay ID 478780_mir), hsa-miR-224-5p (Assay ID 483106_mir), hsa-miR-22-5p (Assay ID 477987_mir), hsa-miR-2355-3p (Assay ID 477989_mir), hsa-miR-23a-3p (Assay ID 478532_mir), hsa-miR-23a-5p (Assay ID 478782_mir), hsa-miR-23b-3p (Assay ID 483150_mir), hsa-miR-23b-5p (Assay ID 477991_mir), hsa-miR-24-1-5p (Assay ID 478784_mir), hsa-miR-24-2-5p (Assay ID 478785_mir), hsa-miR-24-3p (Assay ID 477992_mir), hsa-miR-25-3p (Assay ID 477994_mir), hsa-miR-25-5p (Assay ID 478786_mir), hsa-miR-26a-1-3p (Assay ID 478787_mir), hsa-miR-26a-5p (Assay ID 477995_mir), hsa-miR-26b-3p (Assay ID 483077_mir), hsa-miR-26b-5p (Assay ID 478418_mir), hsa-miR-27a-3p (Assay ID 478384_mir), hsa-miR-27a-5p (Assay ID 477998_mir), hsa-miR-27b-3p (Assay ID 478270_mir), hsa-miR-27b-5p (Assay ID 478789_mir), hsa-miR-28-3p (Assay ID 477999_mir), hsa-miR-28-5p (Assay ID 478000_mir), hsa-miR-296-5p (Assay ID 477836_mir), hsa-miR-299-3p (Assay ID 478792_mir), hsa-miR-299-5p (Assay ID 478793_mir), hsa-miR-29a-3p (Assay ID 478587_mir), hsa-miR-29a-5p (Assay ID 478002_mir), hsa-miR-29b-1-5p (Assay ID 478794_mir), hsa-miR-29b-2-5p (Assay ID 478003_mir), hsa-miR-29b-3p (Assay ID 478369_mir), hsa-miR-29c-3p (Assay ID 479229_mir), hsa-miR-29c-5p (Assay ID 478005_mir), hsa-miR-301a-3p (Assay ID 477815_mir), hsa-miR-301b-3p (Assay ID 477825_mir), hsa-miR-302b-3p (Assay ID 478591_mir), hsa-miR-302d-3p (Assay ID 478237_mir), hsa-miR-3065-3p (Assay ID 479605_mir), hsa-miR-3065-5p (Assay ID 478802_mir), hsa-miR-3074-5p (Assay ID 479606_mir), hsa-miR-30a-3p (Assay ID 478273_mir), hsa-miR-30a-5p (Assay ID 479448_mir), hsa-miR-30b-3p (Assay ID 478804_mir), hsa-miR-30b-5p (Assay ID 478007_mir), hsa-miR-30c-1-3p (Assay ID 479412_mir), hsa-miR-30c-5p (Assay ID 478008_mir), hsa-miR-30d-5p (Assay ID 478606_mir), hsa-miR-30e-3p (Assay ID 478388_mir), hsa-miR-30e-5p (Assay ID 479235_mir), hsa-miR-3115 (Assay ID 479607_mir), hsa-miR-3120-3p (Assay ID 478009_mir), hsa-miR-3120-5p (Assay ID 479611_mir), hsa-miR-3130-5p (Assay ID 479621_mir), hsa-miR-31-3p (Assay ID 478012_mir), hsa-miR-3140-3p (Assay ID 479626_mir), hsa-miR-3158-5p (Assay ID 479644_mir), hsa-miR-31-5p (Assay ID 478015_mir), hsa-miR-3173-5p (Assay ID 479656_mir), hsa-miR-3177-3p (Assay ID 479658_mir), hsa-miR-3184-3p (Assay ID 479662_mir), hsa-miR-3184-5p (Assay ID 478817_mir), hsa-miR-3194-5p (Assay ID 479673_mir), hsa-miR-320a-3p (Assay ID 478594_mir), hsa-miR-320b (Assay ID 478588_mir), hsa-miR-320e (Assay ID 478022_mir), hsa-miR-323a-3p (Assay ID 477853_mir), hsa-miR-323b-3p (Assay ID 478825_mir), hsa-miR-323b-5p (Assay ID 478826_mir), hsa-miR-32-3p (Assay ID 478827_mir), hsa-miR-324-3p (Assay ID 483109_mir), hsa-miR-324-5p (Assay ID 483066_mir), hsa-miR-325 (Assay ID 478025_mir), hsa-miR-32-5p (Assay ID 478026_mir), hsa-miR-326 (Assay ID 478027_mir), hsa-miR-328-3p (Assay ID 478028_mir), hsa-miR-329-3p (Assay ID 478029_mir), hsa-miR-330-3p (Assay ID 478030_mir), hsa-miR-330-5p (Assay ID 478830_mir), hsa-miR-331-3p (Assay ID 478323_mir), hsa-miR-331-5p (Assay ID 478032_mir), hsa-miR-335-3p (Assay ID 478033_mir), hsa-miR-335-5p (Assay ID 478324_mir), hsa-miR-337-3p (Assay ID 478035_mir), hsa-miR-337-5p (Assay ID 478036_mir), hsa-miR-338-3p (Assay ID 478037_mir), hsa-miR-338-5p (Assay ID 478038_mir), hsa-miR-339-3p (Assay ID 478325_mir), hsa-miR-339-5p (Assay ID 478040_mir), hsa-miR-33a-3p (Assay ID 478831_mir), hsa-miR-33a-5p (Assay ID 478347_mir), hsa-miR-33b-5p (Assay ID 478479_mir), hsa-miR-340-3p (Assay ID 478041_mir), hsa-miR-340-5p (Assay ID 478042_mir), hsa-miR-342-3p (Assay ID 478043_mir), hsa-miR-342-5p (Assay ID 478044_mir), hsa-miR-345-5p (Assay ID 478366_mir), hsa-miR-346 (Assay ID 478046_mir), hsa-miR-34a-3p (Assay ID 478047_mir), hsa-miR-34a-5p (Assay ID 478048_mir), hsa-miR-34c-3p (Assay ID 478051_mir), hsa-miR-34c-5p (Assay ID 478052_mir), hsa-miR-3529-3p (Assay ID 480652_mir), hsa-miR-3611 (Assay ID 480655_mir), hsa-miR-3613-3p (Assay ID 478434_mir), hsa-miR-3613-5p (Assay ID 479424_mir), hsa-miR-361-3p (Assay ID 478055_mir), hsa-miR-3615 (Assay ID 478837_mir), hsa-miR-361-5p (Assay ID 478056_mir), hsa-miR-362-3p (Assay ID 478058_mir), hsa-miR-362-5p (Assay ID 478059_mir), hsa-miR-363-3p (Assay ID 478060_mir), hsa-miR-363-5p (Assay ID 478840_mir), hsa-miR-365a-3p (Assay ID 478065_mir), hsa-miR-3667-5p (Assay ID 479704_mir), hsa-miR-367-3p (Assay ID 478066_mir), hsa-miR-369-3p (Assay ID 478067_mir), hsa-miR-369-5p (Assay ID 478068_mir), hsa-miR-370-3p (Assay ID 478326_mir), hsa-miR-373-3p (Assay ID 478363_mir), hsa-miR-373-5p (Assay ID 478073_mir), hsa-miR-374a-3p (Assay ID 478855_mir), hsa-miR-374a-5p (Assay ID 478238_mir), hsa-miR-374b-3p (Assay ID 479421_mir), hsa-miR-374b-5p (Assay ID 478389_mir), hsa-miR-374c-3p (Assay ID 478856_mir), hsa-miR-375-3p (Assay ID 478074_mir), hsa-miR-376a-2-5p (Assay ID 478858_mir), hsa-miR-376a-3p (Assay ID 478240_mir), hsa-miR-376a-5p (Assay ID 478859_mir), hsa-miR-376b-3p (Assay ID 478860_mir), hsa-miR-376b-5p (Assay ID 478861_mir), hsa-miR-376c-3p (Assay ID 478459_mir), hsa-miR-377-3p (Assay ID 478075_mir), hsa-miR-377-5p (Assay ID 478863_mir), hsa-miR-378a-3p (Assay ID 478349_mir), hsa-miR-378a-5p (Assay ID 478076_mir), hsa-miR-378c (Assay ID 478864_mir), hsa-miR-3781 (Assay ID 478305_mir), hsa-miR-379-5p (Assay ID 478077_mir), hsa-miR-380-3p (Assay ID 477854_mir), hsa-miR-381-3p (Assay ID 477816_mir), hsa-miR-381-5p (Assay ID 478866_mir), hsa-miR-382-3p (Assay ID 479458_mir), hsa-miR-382-5p (Assay ID 478078_mir), hsa-miR-3913-3p (Assay ID 479734_mir), hsa-miR-3913-5p (Assay ID 479735_mir), hsa-miR-3928-3p (Assay ID 479749_mir), hsa-miR-3940-3p (Assay ID 479759_mir), hsa-miR-409-3p (Assay ID 478084_mir), hsa-miR-409-5p (Assay ID 478872_mir), hsa-miR-410-3p (Assay ID 478085_mir), hsa-miR-411-3p (Assay ID 479526_mir), hsa-miR-411-5p (Assay ID 478086_mir), hsa-miR-421 (Assay ID 478088_mir), hsa-miR-422a (Assay ID 478481_mir), hsa-miR-423-3p (Assay ID 478327_mir), hsa-miR-423-5p (Assay ID 478090_mir), hsa-miR-424-3p (Assay ID 478091_mir), hsa-miR-424-5p (Assay ID 478092_mir), hsa-miR-4253 (Assay ID 480774_mir), hsa-miR-425-3p (Assay ID 478093_mir), hsa-miR-425-5p (Assay ID 478094_mir), hsa-miR-4286 (Assay ID 478096_mir), hsa-miR-429 (Assay ID 477849_mir), hsa-miR-4306 (Assay ID 478392_mir), hsa-miR-431-3p (Assay ID 478888_mir), hsa-miR-431-5p (Assay ID 478889_mir), hsa-miR-432-3p (Assay ID 478892_mir), hsa-miR-432-5p (Assay ID 478101_mir), hsa-miR-433-3p (Assay ID 478102_mir), hsa-miR-4429 (Assay ID 480852_mir), hsa-miR-4433a-3p (Assay ID 478897_mir), hsa-miR-4433a-5p (Assay ID 479801_mir), hsa-miR-4433b-3p (Assay ID 479802_mir), hsa-miR-4433b-5p (Assay ID 479803_mir), hsa-miR-4444 (Assay ID 479810_mir), hsa-miR-4446-3p (Assay ID 479812_mir), hsa-miR-4448 (Assay ID 480683_mir), hsa-miR-4454 (Assay ID 478104_mir), hsa-miR-4466 (Assay ID 483160_mir), hsa-miR-448 (Assay ID 478105_mir), hsa-miR-4488 (Assay ID 478906_mir), hsa-miR-449a (Assay ID 478561_mir), hsa-miR-450a-5p (Assay ID 478106_mir), hsa-miR-450b-3p (Assay ID 478913_mir), hsa-miR-450b-5p (Assay ID 478914_mir), hsa-miR-4516 (Assay ID 478303_mir), hsa-miR-451a (Assay ID 478107_mir), hsa-miR-4523 (Assay ID 479852_mir), hsa-miR-452-3p (Assay ID 478917_mir), hsa-miR-452-5p (Assay ID 478109_mir), hsa-miR-4537 (Assay ID 480691_mir), hsa-miR-4538 (Assay ID 478110_mir), hsa-miR-454-3p (Assay ID 478329_mir), hsa-miR-454-5p (Assay ID 478919_mir), hsa-miR-455-3p (Assay ID 478112_mir), hsa-miR-455-5p (Assay ID 478113_mir), hsa-miR-4662a-5p (Assay ID 479896_mir), hsa-miR-4669 (Assay ID 478925_mir), hsa-miR-4684-5p (Assay ID 479920_mir), hsa-miR-4685-3p (Assay ID 479921_mir), hsa-miR-4689 (Assay ID 478117_mir), hsa-miR-4690-3p (Assay ID 480702_mir), hsa-miR-4732-3p (Assay ID 478118_mir), hsa-miR-4732-5p (Assay ID 478119_mir), hsa-miR-4747-5p (Assay ID 480001_mir), hsa-miR-483-3p (Assay ID 478122_mir), hsa-miR-483-5p (Assay ID 478432_mir), hsa-miR-484 (Assay ID 478308_mir), hsa-miR-485-3p (Assay ID 478125_mir), hsa-miR-485-5p (Assay ID 478126_mir), hsa-miR-486-3p (Assay ID 478422_mir), hsa-miR-486-5p (Assay ID 478128_mir), hsa-miR-487a-3p (Assay ID 477826_mir), hsa-miR-487b-3p (Assay ID 477835_mir), hsa-miR-489-3p (Assay ID 478130_mir), hsa-miR-490-3p (Assay ID 478131_mir), hsa-miR-491-5p (Assay ID 478132_mir), hsa-miR-493-3p (Assay ID 478134_mir), hsa-miR-493-5p (Assay ID 478943_mir), hsa-miR-494-3p (Assay ID 478135_mir), hsa-miR-495-3p (Assay ID 478136_mir), hsa-miR-496 (Assay ID 478335_mir), hsa-miR-497-5p (Assay ID 478138_mir), hsa-miR-499a-5p (Assay ID 478139_mir), hsa-miR-499b-3p (Assay ID 478949_mir), hsa-miR-500a-3p (Assay ID 478951_mir), hsa-miR-500a-5p (Assay ID 478309_mir), hsa-miR-5010-3p (Assay ID 480086_mir), hsa-miR-501-3p (Assay ID 478350_mir), hsa-miR-501-5p (Assay ID 478142_mir), hsa-miR-502-3p (Assay ID 478348_mir), hsa-miR-502-5p (Assay ID 478954_mir), hsa-miR-503-5p (Assay ID 478143_mir), hsa-miR-504-5p (Assay ID 478144_mir), hsa-miR-505-3p (Assay ID 478145_mir), hsa-miR-505-5p (Assay ID 478957_mir), hsa-miR-509-3-5p (Assay ID 478963_mir), hsa-miR-5100 (Assay ID 480099_mir), hsa-miR-513b-5p (Assay ID 479297_mir), hsa-miR-513c-5p (Assay ID 479349_mir), hsa-miR-515-3p (Assay ID 478976_mir), hsa-miR-516a-5p (Assay ID 478978_mir), hsa-miR-516b-5p (Assay ID 478979_mir), hsa-miR-517a-3p (Assay ID 479485_mir), hsa-miR-517c-3p (Assay ID 479487_mir), hsa-miR-5187-5p (Assay ID 480101_mir), hsa-miR-518c-3p (Assay ID 478982_mir), hsa-miR-518d-3p (Assay ID 479393_mir), hsa-miR-518d-5p (Assay ID 479530_mir), hsa-miR-518e-3p (Assay ID 479408_mir), hsa-miR-518f-3p (Assay ID 478984_mir), hsa-miR-519a-3p (Assay ID 479534_mir), hsa-miR-519d-3p (Assay ID 478986_mir), hsa-miR-520d-3p (Assay ID 478990_mir), hsa-miR-520d-5p (Assay ID 478616_mir), hsa-miR-523-3p (Assay ID 478994_mir), hsa-miR-524-3p (Assay ID 479338_mir), hsa-miR-525-3p (Assay ID 478995_mir), hsa-miR-532-3p (Assay ID 478336_mir), hsa-miR-532-5p (Assay ID 478151_mir), hsa-miR-539-5p (Assay ID 478152_mir), hsa-miR-541-3p (Assay ID 478999_mir), hsa-miR-542-3p (Assay ID 478153_mir), hsa-miR-542-5p (Assay ID 478337_mir), hsa-miR-543 (Assay ID 478155_mir), hsa-miR-544a (Assay ID 478156_mir), hsa-miR-545-3p (Assay ID 479002_mir), hsa-miR-545-5p (Assay ID 479003_mir), hsa-miR-548a-3p (Assay ID 478157_mir), hsa-miR-548a-5p (Assay ID 479501_mir), hsa-miR-548aa (Assay ID 479004_mir), hsa-miR-548aj-5p (Assay ID 479009_mir), hsa-miR-548 am-5p (Assay ID 480872_mir), hsa-miR-548b-3p (Assay ID 479018_mir), hsa-miR-548b-5p (Assay ID 478589_mir), hsa-miR-548c-3p (Assay ID 479537_mir), hsa-miR-548d-3p (Assay ID 477833_mir), hsa-miR-548d-5p (Assay ID 480870_mir), hsa-miR-548e-3p (Assay ID 478362_mir), hsa-miR-548g-3p (Assay ID 479020_mir), hsa-miR-548h-5p (Assay ID 479503_mir), hsa-miR-5481 (Assay ID 480874_mir), hsa-miR-548j-5p (Assay ID 479022_mir), hsa-miR-548k (Assay ID 479374_mir), hsa-miR-5481 (Assay ID 479391_mir), hsa-miR-548m (Assay ID 479023_mir), hsa-miR-548n (Assay ID 479024_mir), hsa-miR-548p (Assay ID 479025_mir), hsa-miR-550a-3-5p (Assay ID 479031_mir), hsa-miR-550a-3p (Assay ID 479032_mir), hsa-miR-550a-5p (Assay ID 477852_mir), hsa-miR-550b-2-5p (Assay ID 479033_mir), hsa-miR-551a (Assay ID 478158_mir), hsa-miR-551b-3p (Assay ID 478159_mir), hsa-miR-552-3p (Assay ID 479036_mir), hsa-miR-553 (Assay ID 479038_mir), hsa-miR-556-3p (Assay ID 479041_mir), hsa-miR-5582-3p (Assay ID 480123_mir), hsa-miR-5588-5p (Assay ID 480135_mir), hsa-miR-562 (Assay ID 479047_mir), hsa-miR-570-3p (Assay ID 479053_mir), hsa-miR-574-3p (Assay ID 478163_mir), hsa-miR-574-5p (Assay ID 479357_mir), hsa-miR-576-3p (Assay ID 478164_mir), hsa-miR-576-5p (Assay ID 478165_mir), hsa-miR-579-3p (Assay ID 479059_mir), hsa-miR-580-3p (Assay ID 479061_mir), hsa-miR-582-5p (Assay ID 478166_mir), hsa-miR-583 (Assay ID 479065_mir), hsa-miR-584-5p (Assay ID 478167_mir), hsa-miR-585-3p (Assay ID 479067_mir), hsa-miR-589-3p (Assay ID 479072_mir), hsa-miR-589-5p (Assay ID 479073_mir), hsa-miR-590-3p (Assay ID 478168_mir), hsa-miR-590-5p (Assay ID 478367_mir), hsa-miR-592 (Assay ID 479075_mir), hsa-miR-593-3p (Assay ID 479076_mir), hsa-miR-597-5p (Assay ID 478339_mir), hsa-miR-598-3p (Assay ID 478172_mir), hsa-miR-605-5p (Assay ID 478174_mir), hsa-miR-606 (Assay ID 479087_mir), hsa-miR-608 (Assay ID 479089_mir), hsa-miR-615-3p (Assay ID 478175_mir), hsa-miR-616-5p (Assay ID 479099_mir), hsa-miR-618 (Assay ID 479101_mir), hsa-miR-619-5p (Assay ID 479103_mir), hsa-miR-624-3p (Assay ID 479108_mir), hsa-miR-624-5p (Assay ID 478178_mir), hsa-miR-625-3p (Assay ID 478179_mir), hsa-miR-625-5p (Assay ID 479469_mir), hsa-miR-627-3p (Assay ID 479111_mir), hsa-miR-627-5p (Assay ID 478427_mir), hsa-miR-628-3p (Assay ID 478181_mir), hsa-miR-628-5p (Assay ID 479112_mir), hsa-miR-629-3p (Assay ID 478182_mir), hsa-miR-629-5p (Assay ID 478183_mir), hsa-miR-633 (Assay ID 479115_mir), hsa-miR-636 (Assay ID 478185_mir), hsa-miR-641 (Assay ID 479120_mir), hsa-miR-642a-5p (Assay ID 479121_mir), hsa-miR-643 (Assay ID 479123_mir), hsa-miR-6501-5p (Assay ID 480194_mir), hsa-miR-6503-5p (Assay ID 480197_mir), hsa-miR-6513-5p (Assay ID 480213_mir), hsa-miR-651-5p (Assay ID 479131_mir), hsa-miR-652-3p (Assay ID 478189_mir), hsa-miR-652-5p (Assay ID 479132_mir), hsa-miR-653-5p (Assay ID 479134_mir), hsa-miR-654-3p (Assay ID 479135_mir), hsa-miR-654-5p (Assay ID 478368_mir), hsa-miR-655-3p (Assay ID 478191_mir), hsa-miR-656-3p (Assay ID 479137_mir), hsa-miR-660-3p (Assay ID 479143_mir), hsa-miR-660-5p (Assay ID 478192_mir), hsa-miR-663b (Assay ID 479146_mir), hsa-miR-664a-3p (Assay ID 478193_mir), hsa-miR-665 (Assay ID 479150_mir), hsa-miR-668-3p (Assay ID 479151_mir), hsa-miR-671-3p (Assay ID 478194_mir), hsa-miR-671-5p (Assay ID 483035_mir), hsa-miR-6727-5p (Assay ID 480235_mir), hsa-miR-6729-3p (Assay ID 480238_mir), hsa-miR-6734-5p (Assay ID 480247_mir), hsa-miR-6741-5p (Assay ID 480260_mir), hsa-miR-6748-3p (Assay ID 480270_mir), hsa-miR-675-5p (Assay ID 478196_mir), hsa-miR-6757-5p (Assay ID 480286_mir), hsa-miR-6765-5p (Assay ID 480300_mir), hsa-miR-6803-3p (Assay ID 480372_mir), hsa-miR-6852-5p (Assay ID 480461_mir), hsa-miR-6881-5p (Assay ID 480513_mir), hsa-miR-6882-5p (Assay ID 480515_mir), hsa-miR-708-3p (Assay ID 479162_mir), hsa-miR-708-5p (Assay ID 478197_mir), hsa-miR-7114-3p (Assay ID 480554_mir), hsa-miR-7-1-3p (Assay ID 478198_mir), hsa-miR-744-3p (Assay ID 479165_mir), hsa-miR-744-5p (Assay ID 478200_mir), hsa-miR-758-3p (Assay ID 479166_mir), hsa-miR-7-5p (Assay ID 483061_mir), hsa-miR-766-3p (Assay ID 478342_mir), hsa-miR-766-5p (Assay ID 479174_mir), hsa-miR-769-3p (Assay ID 479177_mir), hsa-miR-769-5p (Assay ID 478203_mir), hsa-miR-7704 (Assay ID 480576_mir), hsa-miR-770-5p (Assay ID 479178_mir), hsa-miR-7706 (Assay ID 480578_mir), hsa-miR-7847-3p (Assay ID 480584_mir), hsa-miR-7976 (Assay ID 480595_mir), hsa-miR-7977 (Assay ID 479180_mir), hsa-miR-8077 (Assay ID 480619_mir), hsa-miR-873-5p (Assay ID 478204_mir), hsa-miR-874-3p (Assay ID 478205_mir), hsa-miR-876-3p (Assay ID 479186_mir), hsa-miR-877-3p (Assay ID 477856_mir), hsa-miR-877-5p (Assay ID 478206_mir), hsa-miR-885-3p (Assay ID 479188_mir), hsa-miR-885-5p (Assay ID 478207_mir), hsa-miR-887-3p (Assay ID 479189_mir), hsa-miR-888-5p (Assay ID 479192_mir), hsa-miR-889-3p (Assay ID 478208_mir), hsa-miR-891a-5p (Assay ID 479196_mir), hsa-miR-92a-1-5p (Assay ID 479205_mir), hsa-miR-92a-3p (Assay ID 477827_mir), hsa-miR-92b-3p (Assay ID 477823_mir), hsa-miR-92b-5p (Assay ID 479207_mir), hsa-miR-933 (Assay ID 479208_mir), hsa-miR-93-3p (Assay ID 478209_mir), hsa-miR-935 (Assay ID 479210_mir), hsa-miR-93-5p (Assay ID 478210_mir), hsa-miR-937-3p (Assay ID 479212_mir), hsa-miR-939-5p (Assay ID 478245_mir), hsa-miR-9-3p (Assay ID 478211_mir), hsa-miR-941 (Assay ID 479217_mir), hsa-miR-942-5p (Assay ID 478212_mir), hsa-miR-943 (Assay ID 479219_mir), hsa-miR-944 (Assay ID 479220_mir), hsa-miR-95-3p (Assay ID 478213_mir), hsa-miR-9-5p (Assay ID 478214_mir), hsa-miR-96-5p (Assay ID 478215_mir), hsa-miR-98-3p (Assay ID 479223_mir), hsa-miR-98-5p (Assay ID 478590_mir), hsa-miR-99a-3p (Assay ID 479224_mir), hsa-miR-99a-5p (Assay ID 478519_mir), hsa-miR-99b-3p (Assay ID 478216_mir), hsa-miR-99b-5p (Assay ID 478343_mir), hsa-miR-199a-3p (Assay ID 477961_mir), hsa-miR-365a-3p (Assay ID 478065_mir), ThermoFisher, Cat. No. A25576), including cel-miR-39-3p (Assay ID 478293_mir, ThermoFisher, Cat. No. A25576), were quantified using the TaqMan Open Array technology (ThermoFisher), as per the manufacturer's instructions. cDNA was diluted 1:20 in 0.1×TE (pH 8.0), combined with TaqMan OpenArray Real-TimePCR Master Mix, loaded onto the OpenArray™ plates (AccuFill™ system, Cat. No. 4471021) and amplified with the QuantStudio 12K Flex Real-Time PCR System (ThermoFisher, Cat. No. 4472379). Technical duplicates were performed in each OpenArray™ plates. OpenArray® microRNA profiling data were processed and filtered using Python scripts. Briefly, QuantStudio 12K Flex Software assigns a Cq value and an Amplification score (Amp Score) and a Cq Confidence (Cq Conf.) value to each reaction for rapid assessment of data reliability. Data were filtered to exclude reactions with Amp Score <1.00, Cq Conf. <0.8, and Cq below 10 or above 28. In addition, a miRNA was considered as detected only if passes that criteria in at least 70% of the samples.

The concentrations from plasma samples were normalized using the global mean normalization method: the value of ΔCq was calculated by subtracting the mean of Cq values of all analyzed miRNAs from the mean of Cq values of each miRNA, in each patient sample. Statistical analysis was performed on the ΔCq values. In order to assess the change in gene expression, the values of ΔΔCq were then calculated by subtracting the mean of ΔCq of a group of samples from the mean of ΔCq of the comparison group of samples. The fold changes were calculated as 2^−ΔΔCq.

Statistical Analysis

As regarding the analysis of UMOD genotype, the chi-square test was used to determine significant differences in genotype frequencies in the UMOD gene between different patients' groups, defined on the basis of the different outcomes (screening, diagnosis, and prognosis). As regarding the analysis of circulating plasma miRNAs, the Mann-Whitney test was used for the identification of statistically differentially regulated miRNAs between different patients' groups, defined on the basis of the different outcomes (screening, diagnosis, and prognosis). Any miRNA with Amp Score <1.00 and/or Cq Conf. <0.8 and/or Cq below 10 or above 28 in >30% of the samples were filtered out, resulting in 274 miRNAs, including cel-miR-39-3p. miRNAs which exhibit high percentage of missing values were removed only after checking through statistical test that the missingness pattern is not associated with the outcome.

The small percentage (1.68%) of missing values were imputed through an iterative procedure based on Bayesian Linear Regression. All statistical tests were two-sided with a significance level set at p<0.05 and were performed using python version 3.7.

In addition to this single biomarker analysis, a machine learning supervised classification of samples for the various forecasting tasks was performed by using Support Vector Machines (SVM) as implemented in the Scikit-Learn package for the python programming languages (python, version 3.7). As parameters, a linear kernel together with I1/I2 penalties and a cost parameter sampled from 0.01 to 10 was evaluated. As subset selection technique, a bootstrap simulation based on recursive feature elimination was used. This allowed to rank by importance the variables in analysis. A further reduction of the dimensionality of the obtained features was achieved by means of Bayesian optimisation. The most performing subsets were used to train the SVM and to carry out the prediction of the test samples in a 10-fold cross validation procedure (stratifying by outcome in order to account for class imbalances). To test for overfitting, permutation simulations were performed.

In order to evaluate the performances of each classification models the inventors investigated three different metrics: accuracy, recall, Receiver Operating Characteristic Area Under the Curve (ROC AUC). Accuracy is the ratio between the actual correctly predicted population on the total population. Recall is the ratio between the actual positive predicted population on all the positive predicted population. The ROC AUC is the area under the Receiver Operating Characteristic curve, created by plotting the recall against 1—specificity.

EXAMPLES
Example 1: Variants in the UMOD Gene Associated with High Risk of RCC and High Risk of Aggressive RCC

The inventors have previously demonstrated in a cohort of 211 patients diagnosed with a renal mass and treated with surgery that the TT-rs4293393 variant in the UMOD gene is associated with a more aggressive clinical and pathological RCC phenotype and, in particular, with clinical metastasis, and high stage. [Trevisani et al., 2017].

The inventors extended their analysis to other 21 UMOD SNP variants: 15 (r512917707, rs12934320, rs12934455, rs13329952, rs13333226, rs13335818, rs28362063, rs28544423, rs28640218, rs28688991, rs34356953, rs60136849, rs71384446, rs7203642, r59928757) and 3 (r511647727, rs4297685, r57193058) SNPs in linkage disequilibrium (LD) with rs4293393 with a r²>0.8 and a 0.5≤r≤0.7, respectively; and 3 SNPs (r511862974, rs7204342, r576563024) not in LD with rs4293393 in the European/Caucasoid population.

Pairwise r²values for those SNPs are reported in FIG. 1.

Those SNPs have a different location in the UMOD locus: 1 SNPs is upstream of UMOD gene promoter; 9 SNPs are in the UMOD gene promoter; 9 SNPs are intron variants, located in introns 1, 4, 5, and 7; and 3 SNPs are synonymous variant, two of them in the exon 3 and the other in the exon 4 (FIG. 2).

All those variants are important for different reasons: variants located in the UMOD gene promoter could be associated with an effect on gene expression [Trudu et al., 2013]; intronic variants can lead to pseudo-exon inclusion, due to activation of non-canonical splice sites or changes in splicing regulatory elements, or disrupt transcription regulatory motifs and non-coding RNA genes [Vaz-Drago et al., 2017]; synonymous variants could affect protein function altering RNA secondary structures, affecting RNA stability, and subsequently reducing protein expression [Nackley et al., 2006] and possibly affecting protein folding and function [Kimchi-Sarfaty et al. 2007]; synonymous variants could also affect splicing regulatory sequences as enhancers or silencers of splicing.

A total of 276 renal mass patients and 83 controls were genotyped for the 22 SNPs listed above. Minor allele frequencies (MAF), ranging from 0.03 to 0.3 (MAF observed), were similar to those reported in the literature (MAF (100Genome, EUR) (Table 4).

TABLE 4

Minor allele frequency (MAF) among

the overall population (n = 359).

bp

Minor
MAF
MAF

position
SNP
Allele
(1000Genome, EUR)
(observed)

20339137
rs71384446
G
0.25
0.23

20341541
rs9928757
G
0.23
0.20

20342493
rs60136849
G
0.20
0.18

20344843
rs11647727
T
0.28
0.30

20345004
rs34356953
A
0.20
0.18

20345933
rs12934320
A
0.20
0.18

20345959
rs12934455
A
0.19
0.15

20347945
rs28640218
A
0.21
0.20

20348311
rs28544423
A
0.20
0.18

20348509
rs13335818
A
0.20
0.18

20348779
rs7193058
C
0.28
0.30

20352517
rs76563024
C
0.01
0.03

20353266
rs4293393
C
0.20
0.18

20353690
rs28362063
G
0.20
0.18

20354332
rs13333226
C
0.20
0.19

20354903
rs11862974
T
0.01
0.03

20355185
rs13329952
G
0.22
0.21

20355808
rs7203642
C
0.22
0.20

20355917
rs7204342
A
0.01
0.04

20356228
rs28688991
A
0.22
0.22

20356368
rs12917707
A
0.20
0.18

20357242
rs4297685
G
0.33
0.30

* Information available at: http://www.ncbi.nlm.nih.gov/projects/SNP/.

For statistical analysis of the SNPs with a MAF between 0.03 and 0.23, the inventors grouped patients carrying one or two copies of the minor allele variant and compared them with patients homozygous for the major allele variant. For statistical analysis of rs11647727, rs7193058, and rs4297685 the inventors maintained the three genotypic classes.

As shown in Table 5, rs4293393 as well as 14 SNPs having strong or perfect LD (linkage disequilibrium) with rs4293393 (r513333226, rs12917707, rs13335818, rs28362063, rs28544423, rs34356953, rs60136849, rs12934320, rs13329952, rs28688991, rs7203642, rs9928757, rs12934455, r528640218) were significantly associated with pT3-pT4 stage, most of them showing a very similar or identical p value, as expected, ranging from 0.001 and 0.01. Only rs71384446, even if in LD with rs4293393 with a r²>0.8, were not significantly associated with pT3-pT4 stage with a p value of 0.06, which could reach statistical significance by increasing the study cohort.

On the other hand, none of the SNPs having a weak or no LD with rs4293393 were significantly associated with pT3-pT4 stage. Only rs11647727 showed a p value of 0.05, at the limits of significance.

TABLE 5

Association between UMOD SNP variants and higher pathologic T stage (pT3-pT4).

RCC patients

p

SNP
Variable
(n = 231)
Genotypic frequencies (%)
value

rs71384446

0.06

pT3-pT4
84

GG + GT
30.95
TT
68.05

pT1-pT2
147

GG + GT
43.54
TT
56.46

rs9928757

0.009

pT3-pT4
84

GG + CG
22.62
CC
77.38

pT1-pT2
147

GG + CG
39.46
CC
60.54

rs63136849

0.004

pT3-pT4
84

GG + GA
19.05
AA
80.95

pT1-pT2
147

GG + GA
37.41
AA
62.59

rs11647727

0.05

pT3-pT4
84
TT
2.38
CT
34.52
CC
63.10

pT1-pT2
147
TT
6.80
CT
45.58
CC
47.62

rs34356953

0.003

pT3-pT4
84

AA + AC
19.05
CC
80.95

pT1-pT2
147

AA + AC
38.10
CC
61.90

rs12934320

0.005

pT3-pT4
84

AA + AG
19.05
GG
80.95

pT1-pT2
147

AA + AG
36.73
GG
63.27

rs12934455

0.01

pT3-pT4
84

AA + AG
16.67
GG
83.33

pT1-pT2
147

AA + AG
31.97
GG
68.03

rs2 text missing or illegible when filed

218

0.01

pT3-pT4
84

AA + AC
22.62
CC
77.38

pT1-pT2
147

AA + AC
38.78
CC
61.22

rs28544423

0.003

pT3-pT4
84

AA + AG
19.05
GG
80.95

pT1-pT2
147

AA + AG
38.10
GG
61.90

rs13335818

0.003

pT3-pT4
84

AA + AG
19.05
GG
80.95

pT1-pT2
147

AA + AG
38.10
GG
61.90

rs7193058

0.2

pT3-pT4
84
CC
3.57
CT
34.52
TT
61.90

pT1-pT2
147
CC
7.48
CT
42.86
TT
49.66

rs76563024

0.6

pT3-pT4
84

CC + CT
4.76
TT
95.24

pT1-pT2
147

CC + CT
3.40
TT
96. text missing or illegible when filed

rs429

0.003

pT3-pT4
84

CC + CT
19.05
TT
80.95

pT1-pT2
147

CC + CT
38.10
TT
61.90

rs28362063

0.003

pT3-pT4
84

GG + AG
19.05
AA
80.95

pT1-pT2
147

GG + AG
38.10
AA
61.90

rs13333226

0.001

pT3-pT4
84

CC + CT
19.05
TT
80.95

pT1-pT2
147

CC + CT
39.46
TT
80.54

rs11862974

0.8

pT3-pT4
84

TT + GT
4.76
GG
95.24

pT1-pT2
147

TT + GT
5.44
GG
94.56

rs13329952

0.005

pT3-pT4
84

GG + AG
23.81
AA
76.19

pT1-pT2
147

GG + AG
42.18
AA
57.82

rs7203642

0.007

pT3-pT4
84

CC + CT
23.81
TT
76.19

pT1-pT2
147

CC + CT
41.50
TT
58.50

rs7204342

0.8

pT3-pT4
84

AA + AC
4.76
CC
95.24

pT1-pT2
147

AA + AC
5.44
CC
94.56

rs28688891

0.005

pT3-pT4
84

AA + AG
23.81
GG
76.19

pT1-pT2
147

AA + AG
42.18
GG
57.82

rs12917707

0.003

pT3-pT4
84

AA + AC
19.05
CC
80.95

pT1-pT2
147

AA + AC
38.10
CC
61.90

rs4297685

0.1

pT3-pT4
84
GG
9.52
AG
33.33
AA
57.14

pT1-pT2
147
GG
9.52
AG
46.26
AA
44.22

text missing or illegible when filed

indicates data missing or illegible when filed

Similarly, as shown in Table 6, rs4293393 as well as 14 SNPs having strong or perfect LD with rs4293393 (r59928757, rs13333226, rs12917707, rs13335818, rs28362063, rs28544423, rs34356953, rs60136849, rs12934320, rs71384446,rs13329952,rs28688991,rs7203642, r512934455) were significantly associated with clinical metastasis, most of them showing a very similar or identical p value, as expected, ranging from 0.005 and 0.03.

Only rs12934455 and rs28640218, even if in LD with rs4293393 with a r²>0.8, were not significantly associated with clinical metastasis, with a p value of 0.06 and 0.1, respectively. However, rs12934455 only marginally failed to meet statistical significance. On the other hand, none of the SNPs having a weak or no LD with rs4293393 were significantly associated with clinical metastasis.

TABLE 6

Association between UMOD SNP variants and presence of clinical metastasis (cM1).

Renal mass patients

p

SNP
Variable
(n = 276)
Genotypic frequencies (%)
value

rs71384446

0.02

cM1
34

GG + GT
23.53
TT
76.47

cM0
242

GG + GT
43.80
TT
56.20

rs9928757

0.005

cM1
34

GG + CG
14.71
CC
85.29

cM0
242

GG + CG
3 text missing or illegible when filed

.67
CC

text missing or illegible when filed

0.33

rs text missing or illegible when filed

136849

0.02

cM1
34

GG + GA
14.71
AA
85.29

cM0
242

GG + GA
34.71
AA
65.29

rs11647727

0.3

cM1
34
TT
2.94
CT
35.29
CC
61.76

cM0
242
TT
7.44
CT
42.98
CC
4 text missing or illegible when filed

.59

rs3435 text missing or illegible when filed

53

0.02

cM1
34

AA + AC
14.71
CC
85.29

cM0
242

AA + AC
35.12
CC
64.88

rs12934320

0.02

cM1
34

AA + AG
14.71
GG
85.29

cM0
242

AA + AG
35.12
GG
65.70

rs129 text missing or illegible when filed

4455

0.06

cM1
34

AA + AG
14.71
GG
85.29

cM0
242

AA + AG
30.17
GG
68.83

rs2864 text missing or illegible when filed

218

0.1

cM1
34

AA + AC
23.53
CC
76.47

cM0
242

AA + AC
37.19
CC
62.81

rs28544423

0.02

cM1
34

AA + AG
14.71
GG
85.29

cM0
242

AA + AG
35.12
GG
64.88

rs13335818

0.02

cM1
34

AA + AG
14.71
GG
85.29

cM0
242

AA + AG
35.12
GG
64.88

rs7193058

0.3

cM1
34
CC
5.88
CT
29.41
TT
64.71

cM0
242
CC
8.26
CT
41.74
TT
50.00

rs76563024

0.9

cM1
34

CC + CT
5.88
TT
94.12

cM0
242

CC + CT
5.37
TT
94.63

rs42 text missing or illegible when filed

9

0.02

cM1
34

CC + CT
14.71
TT
85.29

cM0
242

CC + CT
35.12
TT
64.88

rs2 text missing or illegible when filed

3

0.02

cM1
34

GG + AG
14.71
AA
85.29

cM0
242

GG + AG
35.12
AA
64.88

rs13333226

0.01

cM1
34

CC + CT
14.71
TT
85.29

cM0
242

CC + CT
35.95
TT
64.05

rs11862974

0.9

cM1
34

TT + GT
5.88
GG
94.12

cM0
242

TT + GT
6.61
GG
93.39

rs13329952

0.03

cM1
34

GG + AG
20.59
AA
79.41

cM0
242

GG + AG
40.08
AA
58.92

rs720 text missing or illegible when filed

642

0.03

cM1
34

CC + CT
20.59
TT
79.41

cM0
242

CC + CT
39.67
TT
60.33

rs7204342

0.9

cM1
34

AA + AC
5.88
CC
94.12

cM0
242

AA + AC
6.81
CC
93.39

rs28688991

0.03

cM1
34

AA + AG
20.59
GG
79.41

cM0
242

AA + AG
40.08
GG
59.92

rs12917707

0.2

cM1
34

AA + AC
14.71
CC
85.29

cM0
242

AA + AC
35.12
CC
64.88

rs4297 text missing or illegible when filed

5

0.7

cM1
34
GG
5.88
AG
41.18
AA
52.94

cM0
242
GG
10.33
AG
42.15
AA
47.52

text missing or illegible when filed

indicates data missing or illegible when filed

No SNP showed a significant association with high grade (Table 7). However, rs13333226 variant showed a p value of 0.096, on the very limits of significance.

TABLE 7

Association between UMOD SNP variant and higher pathologic grade (G3-G4).

RCC patients

p

SNP
Variable
(n = 231)
Genotypic frequencies (%)
value

rs71384446

0.5

G3-G4
93

GG + GT
36.56
TT
63.44

G1-G2
138

GG + GT
40.58
TT
59.42

rs9928757

0.3

G3-G4
93

GG + CG
29.03
CC
70.97

G1-G2
138

GG + CG
36.23
CC
63.77

rs60136849

0.2

G3-G4
93

GG + GA
25.81
AA
74.19

G1-G2
138

GG + GA
34.06
AA
65.94

rs11647727

0.3

G3-G4
93
TT
4.30
CT
36.56
CC
59.14

G1-G2
138
TT
5.80
CT
44.93
CC
49.28

rs34356953

0.1

G3-G4
93

AA + AC
25.81
CC
74.19

G1-G2
138

AA + AC
34.78
CC
65.22

rs12934320

0.2

G3-G4
93

AA + AG
25.81
GG
74.19

G1-G2
138

AA + AG
33.33
GG
66.67

rs12934455

0.6

G3-G4
93

AA + AG
24.73
GG
75.27

G1-G2
138

AA + AG
27.54
GG
72.46

rs28640218

0.6

G3-G4
93

AA + AC
31.18
CC
68.82

G1-G2
138

AA + AC
34.06
CC
65.94

rs28544423

0.1

G3-G4
93

AA + AG
25.81
GG
74.19

G1-G2
138

AA + AG
34.78
GG
65.22

rs13335818

0.1

G3-G4
93

AA + A6
25.81
GG
74.19

G1-G2
138

AA + AG
34.78
GG
65.22

rs7193058

0.2

G3-G4
93
CC
5.38
CT
33.33
TT
61.29

G1-G2
138
CC
6.52
CT
44.20
TT
49.28

rs76563024

0.8

G3-G4
93

CC + CT
4.30
TT
95.70

G1-G2
138

CC + CT
3.62
TT
96.38

rs4293393

0.1

G3-G4
93

CC + CT
25.81
TT
74.19

G1-G2
138

CC + CT
34.78
TT
65.22

rs28362063

0.1

G3-G4
93

GG + AG
25.81
AA
74.19

G1-G2
138

GG + AG
34.78
AA
65.22

rs13333226

0.096

G3-G4
93

CC + CT
25.81
TT
74.19

G1-G2
138

CC + CT
36.23
TT
63.77

rs11862974

0.9

G3-G4
93

TT + GT
5.38
GG
94.62

G1-G2
138

TT + GT
5.07
GG
94.93

rs13329952

0.3

G3-G4
93

GG + AG
31.18
AA
68.82

G1-G2
138

GG + AG
38.41
AA
61.59

rs7203642

0.3

G3-G4
93

CC + CT
31.18
TT
68.82

G1-G2
138

CC + CT
37.68
TT
62.32

rs7204342

0.9

G3-G4
93

AA + AC
5.38
CC
94.62

G1-G2
138

AA + AC
5.07
CC
94.93

rs28688991

0.3

G3-G4
93

AA + AG
31.18
GG
68.82

G1-G2
138

AA + AG
38.41
GG
61.59

rs12917707

0.1

G3-G4
93

AA + AC
25.81
CC
74.19

G1-G2
138

AA + AC
34.78
CC
65.22

rs429768S

0.8

G3-G4
93
GG
10.75
AG
41.94
AA
47.31

G1-G2
138
GG
8.70
AG
4130
AA
50.00

As shown in Table 8, there are 7 SNPs, rs76563024, rs9928757, rs7193058, rs11862974, rs7204342, rs28640218, and rs11647727, which showed a statistically significant association with patients with a malignant lesion (kidney cancer), with respect to patients with a benign mass. rs76563024, rs11862974, and rs7204342 were in strong LD among each other, as well as rs7193058 was in strong LD with rs11647727, as shown in FIG. 1.

On the other hand, rs71384446, rs7203642, rs13329952, rs28688991, showed a similar association with malignant histotypes with a p value between 0.07 and 0.09 (Table 8). This suggest a trend for association that could become significant by increasing the study cohort.

TABLE 8

Association between UMOD SNP variants and risk of RCC.

Renal mass patients

p

SNP
Variable
(n = 276)
Genotypic frequencies (%)
value

rs71384446

0.07

Malignant lesion
231

GT + GG
38.96
TT
61.04

Benign mass
45

GT + GG
53.33
TT
46.67

rs9928757

0.01

Malignant lesion
231

CG + GG
33.33
CC
66.67

Benign mass
45

CG + GG
53.33
CC
46.67

rs text missing or illegible when filed

0.2

Malignant lesion
231

GA + GG
30.74
AA
6 text missing or illegible when filed

.26

Benign mass
45

GA + GG
40.00
AA
60.00

rs11647727

0.03

Malignant lesion
231
TT
5.19
CT
41.56
CC
53.25

Benign mass
45
TT
15.56
CT
4.44
CC
40.00

rs34356953

0.2

Malignant lesion
231

AC + AA
31.17
CC
68.83

Benign mass
45

AC + AA
40.00
CC
80.00

rs12934320

0.2

Malignant lesion
231

AG + AA
30.30
GG
69.70

Benign mass
45

AG + AA
40.00
GG
60.00

rs12934455

0.1

Malignant lesion
231

AG + AA
26.41
GG
73.58

Benign mass
45

AG + AA
37.78
GG
62.22

rs28640218

0.04

Malignant lesion
231

AC + AA
32.90
CC
67.10

Benign mass
45

AC + AA
48.89
CC
51.11

rs28544423

0.2

Malignant lesion
231

AG + AA
31.17
GG

text missing or illegible when filed

8.83

Benign mass
45

AG + AA
40.00
GG
60.00

rs13335818

0.2

Malignant lesion
231

AG + AA
31.17
GG
68.83

Benign mass
45

AG + AA
40.00
GG
60.00

rs7193058

0.02

Malignant lesion
231
CC
6.06
CT
3 text missing or illegible when filed

.83
TT
54.11

Benign mass
45
CC
17.78
CT
42.22
TT
40.00

rs76563024

0.01

Malignant lesion
231

CT + CC
3.90
TT
96.10

Benign mass
45

CT + CC
13.33
TT
86.67

rs4293393

0.2

Malignant lesion
231

CT + CC
31.17
TT
68.83

Benign mass
45

CT + CC
40.00
TT
60.00

rs28362053

0.2

Malignant lesion
231

AG + GG
31.17
AA
68.83

Benign mass
45

AG + GG
40.00
AA
60.00

rs13333226

0.3

Malignant lesion
231

CT + CC
32.03
TT
67.97

Benign mass
45

CT + CC
40.00
TT
60.00

rs11862974

0.04

Malignant lesion
231

GT + TT
5.19
GG
94.81

Benign mass
45

GT + TT
13.33
GG
86.67

rs13329952

0.09

Malignant lesion
231

AG + GG
35.50
AA
64.50

Benign mass
45

AG + GG
48.89
AA
51.11

rs7204342

0.08

Malignant lesion
231

CT + CC
35.06
TT
64.94

Benign mass
45

CT + CC
48.89
TT
51.11

rs7204342

0.04

Malignant lesion
231

AC + AA
5.19
CC
94.81

Benign mass
45

AC + AA
13.33
CC
86.67

rs28688991

0.09

Malignant lesion
231

AG + AA
35.50
GG
64.50

Benign mass
45

AG + AA
48.89
GG
51.11

rs12917707

0.2

Malignant lesion
231

AC + AA
31.17
CC
68.83

Benign mass
45

AC + AA
40.00
CC
60.00

rs4297685

0.8

Malignant lesion
231
GG
9.52
AG
41.56
AA
48.92

Benign mass
45
GG
11.11
AG
44.44
AA
44.44

text missing or illegible when filed

indicates data missing or illegible when filed

As showed in Table 9, rs7193058 and rs11647727 variants showed a statistically significant association with renal mass patients with respect to controls, with a p value of 0.03 and 0.04, respectively. Of note, most of the controls are patients with kidney stones and it is known that some UMOD variants, especially those located in the UMOD gene promoter, are associated with reduced risk of kidney stones [Gudbjartsson et al., 2010]. Since the UMOD promoter top variant rs4293393 shows a higher p value of 0.2, the inventors believe that the association of rs11647727 and rs7193058 variants is not driven by an enrichment of renal lithiasis-related variants in the control population.

TABLE 9

Association between UMOD SNP variants and risk of renal mass.

Overall population

p

SNP
Variable
(n = text missing or illegible when filed

)
Genotypic frequencies (%)
value

rs text missing or illegible when filed

0.4

Renal mass patients
276

GT + GG
41.30
TT
58.70

Controls
83

GT + GG
4#z,899.99
TT

text missing or illegible when filed

0.5

Renal mass patients
276

CG + GG

text missing or illegible when filed

CC
65.41

Controls
83

CG + GG
40.95
CC
5 text missing or illegible when filed

.04

rs text missing or illegible when filed

0.1

Renal mass patients
276

GA + GG
32.25
AA
67.75

Controls
83

GA + GG
40.96
AA
5 text missing or illegible when filed

.04

rs text missing or illegible when filed

0.04

Renal mass patients
276
TT

text missing or illegible when filed

CT
42.03
CC
51.09

Controls
83
TT

text missing or illegible when filed

.02
CT
57.83
CC
36.14

rs text missing or illegible when filed

0.2

Renal mass patients
276

AC + AA
32.61
CC
67.39

Controls
83

AC + AA
40. text missing or illegible when filed

CC
5 text missing or illegible when filed

.04

rs text missing or illegible when filed

0.1

Renal mass patients
276

AG + AA
31.88
GG
68.12

Controls
83

AG + AA
40.95
GG
59.04

rs text missing or illegible when filed

0.5

Renal mass patients
276

AG + AA
28.25
GG
71.74

Controls
83

AG + AA

text missing or illegible when filed

.55
GG
57.47

rs text missing or illegible when filed

0.2

Renal mass patients
276

AC + AA
35.51
CC

text missing or illegible when filed

4.49

Controls
83

AC + AA
43.37
CC

text missing or illegible when filed

0.2

Renal mass patients
276

AG + AA
37.61
GG
67.39

Controls
83

AG + AA
40.96
GG
59.04

rs text missing or illegible when filed

0.2

Renal mass patients
276

AG + AA
32.61
GG
87.38

Controls
83

AG + AA
39.76
GG
60.24

rs text missing or illegible when filed

0.03

Renal mass patients
276
CC
7.97
CT
40.22
TT
51.81

Controls
83
CC
5.02
CT
56.63
TT
37.35

rs text missing or illegible when filed

0.5

Renal mass patients
276

CT + CC
5.43
TT
94.57

Controls
83

CT + CC
7.23
TT
92.77

rs text missing or illegible when filed

0.2

Renal mass patients
276

CT + CC

text missing or illegible when filed

TT
67.39

Controls
83

CT + CC
42.95
TT
59.04

rs text missing or illegible when filed

0.2

Renal mass patients
276

AG + GG
32.61
AA
67.39

Controls
83

AG + GG
39.76
AA
50.24

rs text missing or illegible when filed

0.1

Renal mass patients
276

CT + CC
33.33
TT
56.67

Controls
83

CT + CC
42.17
TT
57.83

rs text missing or illegible when filed

0.3

Renal mass patients
276

GT + TT
6.52
GG
95.48

Controls
83

GT + TT
8.43
GG

text missing or illegible when filed

0.3

Renal mass patients
276

AG + GG
37.68
AA
62.32

Controls
83

AG + GG
44.58
AA
55.42

rs7208642

0.2

Renal mass patients
276

CT + CC
57.32
TT
62.68

Controls
83

CT + CC
45.78
TT
55.42

rs7204342

0.3

Renal mass patients
276

AC + AA
6.52
CC

text missing or illegible when filed

Controls
83

AC + AA
9.64
CC
90.56

rs text missing or illegible when filed

0.2

Renal mass patients
276

AG + AA
37.68
GG

text missing or illegible when filed

.32

Controls
83

AG + AA
45.78
GG

text missing or illegible when filed

.22

rs12917707

0.2

Renal mass patients
276

AC + AA
32.61
CC
67.39

Controls
83

AC + AA
39.76
CC
60.24

rs4297685

0.4

Renal mass patients
276
GG
9.78
AG
42.05
AA
48.19

Controls
83
GG
4.82
AG
43.37
AA

text missing or illegible when filed

indicates data missing or illegible when filed

Example 2: Circulating Plasma miRNAs Profiling in the Total Study Population

To develop specific miRNA signatures for RCC screening, diagnosis, and prognosis, a TaqMan-based high-throughput screen of 668 miRNAs was performed in plasma samples of 120 patients with a renal mass (either benign or malignant) and 78 controls.

MiRNAs previously described as readily detectable in human plasma samples—including hsa-miR-16-5p, and hsa-miR-21-3p—were detected in all samples. Following the inventors' filtering criteria, a total of 273 miRNAs were subjected to differential expression analyses. The inventors found a set of 54 miRNAs that was significantly differentially expressed (p value <0.05) in plasma of patients with a renal mass (n=115) compared with controls (n=78). In addition, 18 miRNAs, even if did not reach statistical significance, showed a trend that could become significant by increasing the study cohort (0.05<p value <0.1) (Table 10).

TABLE 10

Differentially expressed miRNAs in patients with a renal mass

(n = 115) compared with controls (n = 78).

miRNA
FC*
p value

hsa-miR-423-5p
1.28
0.0001

hsa-miR-186-5p
1.18
0.0002

hsa-miR-877-5p
1.46
0.0004

hsa-miR-378a-3p
1.28
0.0004

hsa-miR-320e
1.27
0.001

hsa-miR-652-3p
1.26
0.001

hsa-miR-598-3p
1.19
0.002

hsa-miR-197-3p
0.65
0.002

hsa-miR-500a-5p
1.39
0.003

hsa-miR-205-5p
0.71
0.003

hsa-miR-6803-3p
0.73
0.003

hsa-miR-125a-5p
0.86
0.003

hsa-miR-320a-3p
1.18
0.006

hsa-let-7e-5p
0.87
0.007

hsa-miR-362-5p
1.28
0.007

hsa-miR-21-5p
1.14
0.008

hsa-miR-132-3p
0.79
0.008

hsa-miR-375-3p
0.71
0.009

hsa-miR-1260a
0.73
0.01

hsa-miR-331-3p
0.85
0.01

hsa-miR-128-3p
1.12
0.01

hsa-miR-532-5p
1.23
0.01

hsa-miR-29c-5p
1.16
0.01

hsa-miR-378a-5p
0.82
0.01

hsa-miR-28-3p
1.24
0.01

hsa-miR-145-5p
0.85
0.01

hsa-miR-151b
0.91
0.01

hsa-miR-361-5p
1.22
0.02

hsa-miR-501-5p
1.26
0.02

hsa-miR-369-3p
0.84
0.02

hsa-miR-4286
0.89
0.02

hsa-miR-505-3p
1.15
0.02

hsa-miR-10a-5p
0.86
0.02

hsa-miR-2110
1.24
0.02

hsa-miR-193b-3p
0.83
0.02

hsa-miR-224-5p
0.80
0.02

hsa-miR-214-3p
0.77
0.02

hsa-miR-181a-5p
1.28
0.02

hsa-miR-628-3p
0.76
0.02

hsa-miR-550a-3-5p
1.57
0.03

hsa-miR-339-3p
1.18
0.03

hsa-miR-323a-3p
1.41
0.03

hsa-miR-500a-3p
1.15
0.03

hsa-miR-125b-5p
0.84
0.03

hsa-miR-483-3p
0.81
0.03

hsa-miR-151a-3p
1.20
0.04

hsa-miR-499a-5p
1.29
0.04

hsa-miR-21-3p
1.15
0.04

hsa-miR-3940-3p
0.89
0.04

hsa-miR-10b-5p
0.75
0.04

hsa-miR-769-5p
1.26
0.04

hsa-miR-30d-5p
1.09
0.04

hsa-miR-181b-5p
1.16
0.04

hsa-miR-448
0.83
0.049

hsa-miR-377-3p
0.86
0.05

hsa-miR-4306
1.16
0.05

hsa-miR-22-5p
1.08
0.05

hsa-miR-380-3p
0.84
0.05

hsa-miR-103a-2-5p
0.91
0.06

hsa-miR-130b-5p
0.81
0.06

hsa-miR-146a-5p
1.19
0.06

hsa-miR-188-5p
1.18
0.06

hsa-miR-210-3p
1.13
0.07

hsa-miR-885-5p
0.68
0.07

hsa-miR-320b
1.12
0.07

hsa-miR-26b-3p
0.88
0.07

hsa-miR-421
0.89
0.08

hsa-miR-7-5p
0.85
0.08

hsa-miR-579-3p
0.78
0.08

hsa-miR-17-3p
1.08
0.08

hsa-miR-24-3p
1.16
0.09

hsa-miR-660-5p
1.18
0.09

*FC: fold changes (>1 increased; <1 decreased expression in in patients with a renal mass)

Then, the inventors investigated whether patients with a benign mass were associated with a specific miRNA signature that significantly differs (p value <0.05) from patients with a malignant lesion (RCC). The inventors observed 6 miRNAs significantly differentially expressed in patients with a benign mass (n=24) compared with RCC patients (n=91). In addition, 12 miRNAs showed a trend towards statistical significance (0.05<p value <0.1) (Table 11).

TABLE 11

Differentially expressed miRNAs in patients with a benign mass

(n = 24) compared with RCC patients (n = 91).

miRNA
FC*
p value*

hsa-miR-337-5p
1.23
0.01

hsa-miR-99a-3p
1.68
0.02

hsa-miR-331-5p
1.52
0.02

hsa-miR-221-5p
1.26
0.03

hsa-miR-1290
1.35
0.04

hsa-miR-196b-5p
1.36
0.048

hsa-miR-550a-3-5p
1.49
0.06

hsa-miR-548l
1.35
0.06

hsa-miR-152-3p
1.09
0.06

hsa-miR-501-5p
1.23
0.06

hsa-miR-125b-5p
0.79
0.08

hsa-miR-34a-3p
0.60
0.08

hsa-miR-410-3p
1.28
0.08

hsa-miR-485-3p
0.59
0.08

hsa-miR-192-5p
0.80
0.08

hsa-miR-361-3p
0.85
0.098

hsa-miR-877-5p
1.16
0.098

hsa-miR-215-5p
0.79
0.099

*fold changes (>1 increased; <1 decreased expression in RCC patients)

The inventors also analyzed whether specific miRNA expression patterns were correlated to established predictors of RCC prognosis that are direct markers of clinical aggressiveness, namely tumour stage, tumour grade, and presence of clinical metastasis (cM1).

A panel of 43miRNAs was found to be significantly differentially expressed between low grade RCC patients (n=64) and high grade cases (27). 36 miRNAs, even if did not reach statistical significance, showed a trend that could become significant by increasing the study cohort (Table 12).

TABLE 12

Differentially expressed miRNAs (p value ≤ 0.05) in

low grade RCC patients (n = 64) compared with high

grade RCC patients (n = 27).

miRNA
FC*
p value

hsa-miR-382-5p
2.50
0.0004

hsa-miR-18a-5p
0.73
0.0006

hsa-miR-125b-5p
0.57
0.0009

hsa-miR-20a-5p
0.71
0.002

hsa-miR-429
0.55
0.002

hsa-miR-17-5p
0.70
0.002

hsa-miR-369-3p
1.41
0.002

hsa-miR-21-3p
1.44
0.002

hsa-miR-382-3p
1.80
0.003

hsa-miR-134-5p
1.81
0.004

hsa-miR-433-3p
1.81
0.004

hsa-miR-100-5p
0.50
0.005

hsa-miR-125a-5p
0.79
0.006

hsa-miR-584-5p
1.24
0.006

hsa-miR-93-5p
0.79
0.006

hsa-miR-20b-5p
0.77
0.007

hsa-miR-18a-3p
0.80
0.008

hsa-miR-374a-3p
0.64
0.009

hsa-miR-410-3p
1.42
0.01

hsa-let-7b-5p
0.71
0.01

hsa-miR-424-3p
1.43
0.01

hsa-miR-101-3p
0.69
0.01

hsa-miR-32-3p
1.19
0.02

hsa-miR-154-5p
1.87
0.02

hsa-miR-409-3p
2.18
0.02

hsa-miR-130b-3p
1.10
0.02

hsa-miR-193b-3p
0.66
0.02

hsa-miR-484
0.80
0.02

hsa-miR-3613-3p
0.81
0.02

hsa-miR-629-5p
1.35
0.02

hsa-miR-151a-3p
1.25
0.02

hsa-miR-493-5p
1.67
0.02

hsa-let-7d-3p
1.15
0.03

hsa-miR-144-3p
0.59
0.03

hsa-miR-885-5p
0.54
0.03

hsa-miR-655-3p
1.32
0.03

hsa-miR-106b-3p
0.85
0.03

hsa-miR-942-5p
1.23
0.04

hsa-miR-374a-5p
0.72
0.04

hsa-miR-148a-3p
0.83
0.04

hsa-let-7e-3p
0.74
0.04

hsa-miR-127-3p
1.79
0.04

hsa-miR-103a-3p
0.77
0.046

hsa-miR-323b-3p
1.79
0.05

hsa-miR-337-5p
1.18
0.05

hsa-miR-376c-3p
1.54
0.05

hsa-miR-195-5p
0.83
0.06

hsa-miR-181a-3p
1.17
0.06

hsa-miR-483-5p
1.54
0.06

hsa-miR-590-3p
0.85
0.06

hsa-let-7d-5p
0.68
0.06

hsa-miR-151a-5p
1.22
0.06

hsa-miR-324-5p
0.83
0.06

hsa-miR-500a-5p
0.70
0.06

hsa-miR-331-3p
0.84
0.06

hsa-miR-7-l-3p
1.18
0.06

hsa-miR-154-3p
1.21
0.06

hsa-miR-10a-5p
0.78
0.07

hsa-miR-194-5p
0.71
0.07

hsa-miR-22-5p
1.11
0.07

hsa-miR-423-5p
1.25
0.07

hsa-miR-142-3p
0.79
0.07

hsa-miR-30b-5p
0.85
0.07

hsa-miR-548a-3p
1.32
0.07

hsa-miR-1537-3p
1.17
0.07

hsa-miR-221-3p
1.19
0.07

hsa-miR-495-3p
1.66
0.07

hsa-miR-1290
1.44
0.08

hsa-miR-455-3p
0.64
0.08

hsa-miR-377-3p
1.30
0.08

hsa-miR-451a
0.70
0.08

hsa-miR-16-5p
0.78
0.08

hsa-miR-301a-3p
0.81
0.08

hsa-miR-376a-3p
1.43
0.09

hsa-miR-122-5p
0.57
0.09

hsa-miR-1301-3p
1.12
0.09

hsa-miR-374b-5p
0.81
0.09

hsa-let-7g-5p
0.83
0.098

hsa-miR-144-5p
0.74
0.098

*fold changes (>1 increased; <1 decreased expression in high grade RCC patients)

Similarly, the inventors found that 38 miRNAs can significantly distinguish (p value <0.05) between low stage RCC patients (n=65) and high stage RCC patients (n=26), while 20 miRNAs showed a trend towards statistical significance (0.05<p value <0.1)(Table 13).

TABLE 13

Differentially expressed miRNAs in low stage RCC patients (n =

65) compared with high stage RCC patients (n = 26).

miRNA
FC*
p value

hsa-miR-629-5p
1.55
0.0004

hsa-miR-320a-3p
1.38
0.001

hsa-miR-423-5p
1.43
0.002

hsa-miR-30b-5p
0.78
0.002

hsa-miR-320e
1.44
0.003

hsa-miR-374a-5p
0.67
0.004

hsa-miR-100-5p
0.47
0.005

hsa-miR-374a-3p
0.60
0.006

hsa-miR-30c-5p
0.81
0.007

hsa-miR-2110
1.37
0.007

hsa-miR-27b-3p
0.74
0.008

hsa-miR-664a-3p
0.69
0.008

hsa-let-7d-3p
1.17
0.01

hsa-miR-548k
1.29
0.01

hsa-miR-26b-5p
0.75
0.01

hsa-miR-374b-5p
0.76
0.01

hsa-miR-483-5p
1.71
0.01

hsa-miR-378a-3p
1.31
0.01

hsa-miR-769-5p
1.54
0.02

hsa-miR-34a-3p
1.72
0.02

hsa-miR-125a-5p
0.83
0.02

hsa-miR-224-5p
0.70
0.02

hsa-miR-320b
1.29
0.02

hsa-miR-27a-3p
0.77
0.02

hsa-miR-545-3p
0.79
0.02

hsa-miR-335-5p
0.84
0.03

hsa-miR-140-3p
1.21
0.03

hsa-miR-126-3p
0.82
0.03

hsa-miR-382-5p
1.77
0.03

hsa-miR-484
0.81
0.03

hsa-miR-18a-5p
0.85
0.03

hsa-miR-29c-3p
1.09
0.04

hsa-miR-26a-5p
0.74
0.04

hsa-miR-339-3p
1.33
0.04

hsa-miR-202-5p
1.38
0.04

hsa-miR-133b
0.55
0.045

hsa-miR-590-3p
0.83
0.048

hsa-miR-15a-3p
0.83
0.049

hsa-miR-324-3p
0.87
0.05

hsa-miR-628-3p
1.28
0.06

hsa-miR-17-5p
0.80
0.06

hsa-miR-1290
1.33
0.06

hsa-miR-502-3p
1.26
0.07

hsa-miR-424-3p
1.28
0.07

hsa-miR-301a-3p
0.83
0.07

hsa-miR-139-5p
0.80
0.08

hsa-miR-148b-3p
0.88
0.08

hsa-miR-142-3p
0.78
0.08

hsa-miR-133a-3p
0.73
0.08

hsa-miR-20a-5p
0.83
0.08

hsa-miR-942-5p
1.19
0.08

hsa-miR-190a-5p
0.85
0.09

hsa-miR-1307-5p
0.73
0.09

hsa-miR-885-5p
0.64
0.09

hsa-miR-1180-3p
1.59
0.09

hsa-miR-29c-5p
1.10
0.09

hsa-miR-4306
1.30
0.09

hsa-miR-1249-3p
0.77
0.098

*fold changes (>1 increased; <1 decreased expression in high stage RCC patients)

Finally, 15 miRNAs were found to be significantly differentially expressed between cM0 RCC patients (n=84) and cM1 RCC patients (n=7), while 21 miRNAs show a p value between 0.05 and 0.098, indicating a trend towards statistical significance (Table 14).

TABLE 14

Differentially expressed miRNAs in cM0 RCC patients (n =

84) compared with cM1 RCC patients (n = 7).

miRNA
FC*
p value

hsa-miR-337-5p
1.44
0.006

hsa-miR-410-3p
1.72
0.008

hsa-miR-374a-3p
0.52
0.01

hsa-miR-590-3p
0.71
0.01

hsa-miR-377-3p
1.92
0.02

hsa-miR-548k
1.49
0.02

hsa-miR-382-5p
2.68
0.03

hsa-miR-655-3p
1.49
0.03

hsa-miR-378a-5p
1.50
0.03

hsa-let-7d-3p
1.19
0.04

hsa-miR-1290
2.05
0.04

hsa-miR-483-5p
1.75
0.04

hsa-miR-323b-3p
2.76
0.047

hsa-miR-376c-3p
2.00
0.048

hsa-miR-590-5p
0.75
0.048

hsa-miR-374a-5p
0.57
0.05

hsa-let-7g-3p
0.67
0.05

hsa-miR-18a-5p
0.81
0.06

hsa-miR-142-3p
0.66
0.06

hsa-miR-125a-5p
0.79
0.07

hsa-miR-130b-3p
1.22
0.07

hsa-miR-429
0.53
0.07

hsa-miR-15a-3p
0.73
0.08

hsa-miR-20a-5p
0.72
0.08

hsa-miR-134-5p
1.67
0.08

hsa-miR-369-3p
1.31
0.08

hsa-miR-548l
1.61
0.08

hsa-miR-127-3p
2.18
0.08

hsa-miR-196b-5p
1.41
0.08

hsa-miR-877-5p
1.60
0.08

hsa-miR-671-5p
1.47
0.09

hsa-miR-17-5p
0.75
0.09

hsa-miR-532-3p
0.76
0.09

hsa-miR-409-3p
2.40
0.09

hsa-miR-484
0.78
0.09

hsa-miR-376a-3p
1.81
0.098

*fold changes (>1 increased; <1 decreased expression in cM1 RCC patients)

Since in most cases it is very difficult to reach high accuracy, specificity and sensitivity for discrimination between two clinical conditions (i.e. renal mass patients vs controls, patients with a benign mass vs patients with a malignant lesion, patients with high grade RCC vs patients with low grade RCC, patients with high stage RCC vs patients with low stage RCC, patients with clinical metastasis (cM1) vs patients without clinical metastasis (cM0)) using a single miRNA biomarker, no simple threshold method can be used. Therefore, in addition to single biomarker analysis, the inventors identified unique sets of miRNAs (miRNA signatures), leading to a significant increase in sensitivity, specificity, accuracy and predictive power for screening, diagnosing and prognosing of RCC patients by using machine learning algorithms.

The inventors investigated also clinical parameters in association with miRNAs biomarkers, using the feature selection algorithm, and the variable age resulted predictive in association with some miRNAs in screening, and clinical metastasis.

It is important to underline that the single variable age, using the same evaluation metric, performed significantly less than the presented combinations with an accuracy of 52.10%, recall of 48.69%, and ROC AUC of 54.13% for screening and an accuracy of 74.44%, recall of 20%, and ROC AUC of 22.78% for clinical metastasis.

In addition, the inventors combined some of the identified miRNAs signatures (together or not with age) with SNPs, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for screening, diagnosing and prognosing of RCC patients by using machine learning algorithms (Table 15, 16, 17, 18, 19).

This is the list of the best 29 mRNAs selected by the algorithm sorted by importance for screening outcome: hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-28-3p, hsa-miR-15b, 3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p, hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5, hsa-miR-423-5p, hsa-miR-29a-3p, and hsa-miR-7-5p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for screening (Table 15).

TABLE 15

Combinations that allow higher sensitivity, specificity, accuracy and predictive power for screening.

N
Combinations
Accuracy
ROC AUC
Recall

1
hsa-miR-197-3p
63.42
63.58
86.89

2
hsa-miR-197-3p, hsa-miR-378a-3p
67.53
71.47
84.24

3
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136
68.58
72.54
81.74

4
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
72.29
78.01
82.5

28-3p

5
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
75.42
78.52
81.67

28-3p, hsa-miR-15b-3p

6
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
74.37
78.5
80.0

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p

7
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
75.95
80.29
83.41

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p

8
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
73.87
79.82
81.67

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p

9
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
75.97
80.63
84.32

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age

10
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
74.89
81.16
84.32

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p

11
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
76.5
80.78
85.15

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p

12
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
74.95
81.94
83.33

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326

13
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
74.39
80.91
83.41

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p

14
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
75.95
82.08
81.67

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p

15
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
75.95
81.96
80.83

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p

16
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
77.00
84.11
84.24

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p

17
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
76.47
83.69
83.33

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b

18
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
79.61
84.79
83.33

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306

19
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
82.24
85.88
83.41

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p

20
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
81.16
85.09
81.67

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p

21
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
81.16
85.21
85.15

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p

22
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
81.18
85.55
85.15

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p

23
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
81.18
85.70
82.65

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p

24
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
82.21
86.38
82.65

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p

25
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
81.71
88.13
84.32

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p

26
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
81.71
88.26
84.32

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p

27
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
81.71
87.57
85.15

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p

28
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
80.11
87.19
83.41

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-423-5p

29
hsa-miR-197-3p, hsa-miR-378a-3p, hsa-miR-12136, hsa-miR-
80.16
87.40
86.97

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p, hsa-miR-30b-5p,

hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p

30
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
81.76
85.90
86.06

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-

423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

31
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
81.74
85.94
86.21

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-

miR-323b-3p,

32
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
81.71
85.52
84.39

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

33
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
81.18
83.44
83.64

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-

3p,

34
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
80.68
83.34
81.89

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

35
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
80.68
84.57
83.56

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

36
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
80.68
85.08
85.3

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

37
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
80.68
84.63
85.3

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, age,

38
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
80.68
85.56
82.8

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-

423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

39
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
80.68
84.00
85.38

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

40
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
80.68
85.17
84.47

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-

323b-3p,

41
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
80.66
86.09
82.73

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

42
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
80.66
84.60
82.58

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-

3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-

miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

43
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
80.66
84.33
87.05

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

44
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
80.66
85.02
83.64

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, age, hsa-miR-323b-3p,

45
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
80.66
86.31
82.8

4306, hsa-miR-1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

46
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
80.63
85.41
86.14

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age,

47
hsa-miR-326, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-
80.63
84.69
85.38

5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-

miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

48
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
80.18
85.15
81.89

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

49
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-195-5p,
80.16
86.05
84.55

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

50
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
80.16
85.47
81.89

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

51
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-
80.16
81.61
82.58

5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, age, hsa-miR-323b-3p,

52
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
80.13
84.73
83.48

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

53
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21-
80.13
84.75
84.47

5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-

550a-3-5p, age, hsa-miR-323b-3p,

54
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
80.13
82.8
85.3

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age, hsa-miR-323b-3p,

55
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
80.13
84.05
81.74

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

56
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
80.13
83.98
85.3

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

57
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
80.13
84.72
84.39

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, age,

58
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
80.13
85.77
83.56

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

59
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
80.11
83.35
85.3

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

60
hsa-miR-326, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-
80.11
84.36
83.64

5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-

miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

61
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
80.11
82.77
84.47

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

62
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
80.11
83.37
85.23

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

63
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.66
83.89
81.89

1301-3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

64
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.66
82.6
81.82

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, hsa-miR-323b-3p,

65
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
79.66
86.6
81.89

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-

423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-

miR-323b-3p,

66
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-
79.66
85.2
83.56

3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

67
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21-
79.66
83.25
84.55

5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, age, hsa-miR-323b-3p,

68
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-
79.63
82.73
81.89

1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

69
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
79.63
86.36
82.05

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age, hsa-miR-323b-3p,

70
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-
79.63
84.26
81.97

5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, age, hsa-miR-323b-3p,

71
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
79.63
84.74
81.06

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-

3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

72
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
79.63
84.51
83.48

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-

miR-323b-3p,

73
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
79.63
84.83
83.56

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

age, hsa-miR-323b-3p,

74
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
79.63
85.26
83.71

4306, hsa-miR-1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age,

75
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
79.63
85.8
84.47

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age,

76
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
79.63
85.88
80.15

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

77
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
79.63
85.66
83.56

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

78
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.63
84.77
82.8

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

79
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
79.63
84.19
83.48

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-

miR-323b-3p,

80
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
79.61
83.47
84.39

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

81
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
79.61
83.84
84.39

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

82
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
79.61
81.07
83.64

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

83
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
79.61
85.09
84.55

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

84
hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
79.61
83.51
85.3

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

85
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
79.61
81
85.38

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, age, hsa-miR-323b-3p,

86
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
79.61
84.89
83.56

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

87
hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-
79.61
84.46
85.38

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

hsa-miR-323b-3p,

88
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
79.58
83.01
84.55

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age, hsa-miR-323b-3p,

89
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
79.58
84.99
84.39

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-

550a-3-5p, age, hsa-miR-323b-3p,

90
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.58
84.53
84.24

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-

28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

91
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-195-
79.16
85.87
83.79

5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-

miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-

3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

92
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
79.16
82.77
81.89

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

93
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
79.13
84.56
84.55

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

94
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.13
85.02
85.3

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

95
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.13
84.27
83.56

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, age, hsa-miR-323b-3p,

96
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
79.11
85.8
83.71

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

97
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
79.11
84.98
82.73

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

98
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
79.11
84.75
82.65

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

99
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-
79.11
84.37
84.39

1260b, hsa-miR-1301-3p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

100
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
79.11
84.37
85.98

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p,

hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-323a-3p, hsa-miR-

550a-3-5p, hsa-miR-323b-3p,

101
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.11
85.45
83.48

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-

423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-

323b-3p,

102
hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306,
79.11
84.14
82.73

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-

3p,

103
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
79.08
82.82
82.65

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age,

104
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
79.08
84.41
83.48

1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

105
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
79.08
81.54
83.64

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-29a-3p,

hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-

miR-323b-3p,

106
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.08
85.14
83.56

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

hsa-miR-323b-3p,

107
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
79.08
83.49
84.55

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

108
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.08
85.37
84.39

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-

5p, age, hsa-miR-323b-3p,

109
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.08
84.07
83.56

4306, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-

5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

110
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
79.08
84.77
80.98

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

111
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
79.08
84.99
85.38

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

112
hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
79.08
84.37
84.39

4306, hsa-miR-1301-3p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

113
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
79.08
81.09
83.56

21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-101-3p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

hsa-miR-323b-3p,

114
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.08
84.61
86.06

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

115
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
79.08
83.48
82.88

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

hsa-miR-323b-3p,

116
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
79.08
83.31
83.71

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

117
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
79.08
84.69
82.65

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

118
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
79.08
82.03
82.65

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

119
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
79.08
83.1
84.32

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

120
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
79.08
84.6
81.74

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

121
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
79.08
80.71
83.64

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-29a-3p,

hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, age, hsa-miR-323b-3p,

122
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
79.05
84.67
83.48

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

123
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
79.05
84.18
86.06

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-

3p,

124
hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
79.05
84.75
82.73

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

125
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
79.05
82.92
85.15

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age, hsa-miR-323b-3p,

126
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
78.63
83.14
81.06

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age,

127
hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.63
83.52
80.98

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

128
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
78.61
85.42
83.56

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

129
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
78.61
83.65
82.65

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, age, hsa-miR-323b-3p,

130
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.61
83.28
84.55

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-323a-3p, age,

hsa-miR-323b-3p,

131
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
78.61
86.04
84.62

hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

132
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
78.61
84.62
83.48

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

133
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
78.61
86.2
82.8

hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

134
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
78.61
85.22
82.8

hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-

3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

135
hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-
78.61
84.25
81.89

1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

136
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
78.61
84.27
83.48

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

137
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
78.58
82.64
84.47

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, age,

138
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
78.58
86.71
83.56

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-

423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

139
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
78.58
83.41
83.64

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

140
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
78.58
86
82.58

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age, hsa-miR-323b-3p,

141
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-
78.58
84.13
81.06

5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-323b-3p,

142
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.58
84.42
80.83

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

143
hsa-miR-142-5p, hsa-miR-1260b, hsa-miR-21-5p, hsa-miR-377-
78.58
81.07
85.98

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-

miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

144
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.58
84.58
81.89

4306, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-

miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

hsa-miR-323b-3p,

145
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
78.58
82.71
81.97

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-374a-

5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

146
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
78.58
84.47
83.56

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

147
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.58
85.35
83.64

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

148
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
78.58
83.55
80.83

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p,

hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

149
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-
78.55
84.62
82.73

1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

150
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.55
84.55
83.56

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

151
hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306,
78.55
85.2
83.56

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-

3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

152
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
78.55
86.36
82.73

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age, hsa-miR-323b-3p,

153
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
78.55
85.55
82.8

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-423-

5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

154
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
78.55
85.3
83.64

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, age, hsa-miR-323b-3p,

155
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.55
84.2
83.56

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-

550a-3-5p, age, hsa-miR-323b-3p,

156
hsa-miR-326, hsa-miR-142-5p, hsa-miR-92b-3p, hsa-miR-
78.55
84.2
83.41

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-

5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age, hsa-miR-323b-3p,

157
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
78.55
82.4
81.82

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, age,

158
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
78.11
83
81.89

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, age,

159
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
78.11
81.18
84.7

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, age, hsa-miR-323b-3p,

160
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.11
84.64
82.73

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, age,

161
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.11
83.96
82.8

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, age,

162
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
78.11
83.02
81.74

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-

5p, hsa-miR-323b-3p,

163
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.08
84.56
81.89

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

age, hsa-miR-323b-3p,

164
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.08
85.91
83.64

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

165
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
78.08
85.23
82.88

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

hsa-miR-323b-3p,

166
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.08
82.82
83.56

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

167
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-195-5p,
78.08
85.99
81.89

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p,

hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, hsa-miR-550a-3-5p, age,

168
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
78.08
81.83
81.74

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p,

hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

169
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
78.08
83.22
83.56

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-

5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, age,

170
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
78.08
84.46
81.89

hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

171
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
78.08
84.22
83.64

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

172
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
78.08
84.94
80.08

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

173
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21-
78.05
85.03
81.89

5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-

miR-323b-3p,

174
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.05
84.83
82.8

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age, hsa-miR-323b-3p,

175
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
78.05
84.14
83.71

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-423-5p,

hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

176
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
78.05
82.7
84.47

377-3p, hsa-miR-483-5p, hsa-miR-423-5p, hsa-miR-29a-3p,

hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, hsa-miR-550a-3-5p, age,

177
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
78.05
85.44
80.98

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p,

178
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.05
84.96
83.56

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age,

179
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.05
84.97
84.55

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

180
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
78.05
84.83
80.15

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-

3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age, hsa-miR-323b-3p,

181
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
78.05
85.93
82.73

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

182
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-
78.05
83.66
80.76

5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

183
hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
78.05
83.56
81.82

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p,

hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

184
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
78.05
85.64
80.83

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p,

hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

185
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
78.05
84.2
82.65

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

186
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
78.03
84.38
82.73

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-

550a-3-5p, age, hsa-miR-323b-3p,

187
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21-5p,
78.03
84.61
80.98

hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-

181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p,

hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

hsa-miR-323b-3p,

188
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
78.03
81.71
82.65

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

189
hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
78.03
85.03
80.76

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

190
hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306,
78.03
85.73
79.17

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

191
hsa-miR-326, hsa-miR-142-5p, hsa-miR-4306, hsa-miR-1301-
78.03
82.66
82.58

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-

3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

192
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
78.03
81.43
81.74

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age,

193
hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-377-
77.58
80.76
82.58

3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-

miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p,

hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-

323b-3p,

194
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-195-
77.58
79.56
81.97

5p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, hsa-miR-323b-3p,

195
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
77.58
81.72
80.83

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-

miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

196
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-21-
77.58
85.14
82.73

5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-

3p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

197
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
77.58
83.11
80.98

1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, age,

198
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
77.58
84.61
82.73

1260b, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-

423-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

199
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
77.55
85
81.89

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

200
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-
77.55
83.38
82.73

3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-

miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-

323b-3p,

201
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
77.55
81.7
81.89

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

202
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
77.55
84.81
80.98

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

203
hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306,
77.55
85.01
81.82

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

204
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
77.55
84.94
85.23

130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-21-5p,

hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-29a-3p, hsa-miR-7-5p,

hsa-miR-15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-

miR-323b-3p,

205
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
77.55
83.36
80.98

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, age,

206
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
77.55
84.67
80.91

4306, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-

323b-3p,

207
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
77.55
81.54
79.92

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

hsa-miR-323b-3p,

208
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
77.55
84.74
80.23

3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-

miR-181c-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-

3p, hsa-miR-323a-3p,

209
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
77.53
81.83
84.32

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

210
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-
77.53
85.09
81.67

5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-

195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, age, hsa-miR-323b-3p,

211
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-
77.53
82.44
82.8

3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, age,

212
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-
77.53
82.71
79.24

1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

213
hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
77.5
84.91
80.76

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-

miR-323b-3p,

214
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
77.5
83.41
83.64

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

215
hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
77.5
82.7
82.73

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

216
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
77.5
83.3
82.65

4306, hsa-miR-1301-3p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

217
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
77.5
83.51
81.82

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-

3p, hsa-miR-101-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

218
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
77.5
86.62
80.98

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

219
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-
77.5
82.39
82.73

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

220
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
77.5
84.6
81.67

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

221
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
77.5
84.28
81.74

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

222
hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
77.47
83.49
80.91

21-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

223
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
77.08
80.19
83.64

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-374a-

5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age,

224
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-195-
77.05
82.15
81.89

5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-

miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

225
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
77.05
84.49
82.65

130a-3p, hsa-miR-1260b, hsa-miR-21-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

226
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
77.05
82.85
80.91

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, age,

227
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
77.05
82.19
81.82

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

age,

228
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
77.05
84.64
80.15

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

229
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-
77.03
82.41
82.65

3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-423-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, age,

230
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
77.03
83.45
80.15

1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

231
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
77.03
82.72
82.5

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-328-

3p, hsa-miR-550a-3-5p,

232
hsa-miR-326, hsa-miR-142-5p, hsa-miR-1260b, hsa-miR-4306,
77.03
83.56
81.89

hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-

3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

233
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
77.03
84.13
81.06

hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

234
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
77.03
82.35
80.91

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, age,

235
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
77.03
78.58
79.02

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p,

hsa-miR-550a-3-5p, hsa-miR-323b-3p,

236
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
77.03
82.22
81.89

hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-

3p, age, hsa-miR-323b-3p,

237
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
77.03
82.8
81.82

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, age, hsa-

miR-323b-3p,

238
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
77.03
84.3
80.98

21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

239
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
77.03
84.79
81.74

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

240
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
77.00
83.30
82.65

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

241
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
77.00
82.07
81.67

1260b, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p,

hsa-miR-15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-

miR-323b-3p,

242
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
76.97
83.16
84.39

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

243
hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306,
76.97
84.41
80.83

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

244
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
76.97
84.74
81.06

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p,

hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-

3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

245
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
76.97
84.57
82.65

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

246
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-
76.97
81.69
84.17

3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-

5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age,

247
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
76.95
84.4
79.92

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

248
hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306,
76.95
85.22
82.73

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-

3p, hsa-miR-550a-3-5p, age,

249
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
76.55
84.65
80.15

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-

miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p,

hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

250
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
76.53
85.34
81.82

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

251
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-1260b, hsa-miR-
76.53
82.56
81.59

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

252
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-
76.53
82.83
81.97

3p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p,

253
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
76.53
83.43
79.32

1301-3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR-

15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p,

254
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
76.5
85.53
81.21

3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-28-3p, hsa-miR-15b-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

255
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
76.5
83.58
83.56

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p,

hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-

miR-323b-3p,

256
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
76.5
82.09
81.74

21-5p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p,

hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

257
hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
76.5
83.47
82.8

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

258
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
76.5
82.57
81.89

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age,

259
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
76.47
82.33
83.56

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

260
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-4306, hsa-miR-
76.47
83.33
80.15

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

261
hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
76.47
83.18
79.24

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age,

262
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
76.47
84.77
80.91

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

263
hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306,
76.47
83.55
80.91

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-

3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

264
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
76.47
79.71
81.82

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

265
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
76.45
79.86
79.85

21-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

hsa-miR-323b-3p,

266
hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
76.45
84.64
80.91

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

267
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
76.45
78.29
80.83

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p,

hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

268
hsa-miR-326, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-4306,
76.42
84.16
81.97

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-423-5p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

hsa-miR-323b-3p,

269
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
76.03
79.86
78.26

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

270
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
76
80.16
79.09

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

hsa-miR-323b-3p,

271
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-
76
83.5
79.17

5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-

3p,

272
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
75.97
84.22
78.33

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age,

273
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
75.97
84.25
81.74

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-181c-3p, hsa-

miR-101-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, age, hsa-miR-323b-3p,

274
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
75.97
84.16
80.08

1260b, hsa-miR-4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

275
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
75.97
83.38
80.08

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

276
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
75.97
83.61
81.74

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, age,

277
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
75.97
79.33
82.58

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-323a-3p, age,

278
hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
75.95
82.4
80.76

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

279
hsa-miR-30b-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
75.95
81
83.33

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-

miR-550a-3-5p, age,

280
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
75.92
83.11
81.97

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

281
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-
75.92
80.55
81.82

1301-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-3p,

hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, age,

282
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
75.89
81.9
80.91

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

283
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
75.47
84.86
80

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age,

284
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
75.47
79.79
77.27

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-

3p,

285
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
75.47
80.85
81.82

1260b, hsa-miR-4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-

5p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-323a-3p, age, hsa-

miR-323b-3p,

286
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
75.47
79.28
78.18

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p,

hsa-miR-550a-3-5p,

287
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-
75.45
86.11
79.24

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age, hsa-miR-323b-3p,

288
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
75.45
81.38
81.89

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, hsa-miR-323b-3p,

289
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
75.45
82.33
80

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

hsa-miR-323b-3p,

290
hsa-miR-30b-5p, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-
75.45
82.6
80

5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-

miR-181c-3p, hsa-miR-101-3p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-550a-3-5p, hsa-

miR-323b-3p,

291
hsa-miR-326, hsa-miR-1260b, hsa-miR-4306, hsa-miR-195-5p,
75.42
84.63
79.17

hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-

3-5p, age,

292
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
75.42
83.22
79.17

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

293
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
75.42
80.4
79.24

1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-101-3p,

hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-550a-

3-5p, hsa-miR-323b-3p,

294
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
75.42
81.62
79.77

21-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

hsa-miR-323b-3p,

295
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-4306,
75.42
82.24
78.33

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-

28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-323b-3p,

296
hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-
75.39
83.93
77.27

195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, age, hsa-miR-323b-3p,

297
hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-195-5p, hsa-miR-
75.39
82.98
81.06

377-3p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p,

hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

298
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
75.39
82.11
81.21

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-

3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

299
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
74.97
81.08
81.74

3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-

miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

300
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-195-
74.97
80.05
80.98

5p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-

miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-550a-3-5p, hsa-miR-323b-3p,

301
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
74.97
81.39
80.15

1301-3p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

302
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
74.97
81.58
79.17

1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

hsa-miR-323b-3p,

303
hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306,
74.95
81.24
81.21

hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-28-3p, hsa-miR-

15b-3p, hsa-miR-328-3p, age, hsa-miR-323b-3p,

304
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
74.95
84.63
81.06

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-

miR-328-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

305
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-1301-
74.92
84.45
77.58

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-7-5p,

hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-

550a-3-5p, age,

306
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
74.92
83.27
80.08

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

307
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
74.92
83.38
80.08

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

308
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
74.92
84.13
81.59

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p,

hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-

3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

309
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
74.92
79.02
78.18

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-

5p, hsa-miR-323b-3p,

310
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
74.92
84.55
80.15

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-550a-3-5p, age,

311
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
74.89
82.61
80

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p, age,

312
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
74.89
81.47
79.02

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-

5p, age, hsa-miR-323b-3p,

313
hsa-miR-326, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306,
74.89
82.58
79.92

hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-

550a-3-5p,

314
hsa-miR-30b-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
74.87
80.22
78.11

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age, hsa-miR-

323b-3p,

315
hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
74.87
81.69
78.11

1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

328-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

316
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
74.45
79.57
80

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-

181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p,

hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-miR-328-

3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

317
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
74.42
80.83
79.09

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-

miR-328-3p, hsa-miR-323b-3p,

318
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
74.42
79.78
79.92

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-

miR-550a-3-5p,

319
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
74.42
82.89
77.27

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-28-3p,

hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

320
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
74.42
81.51
79.47

4306, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

age,

321
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
74.42
82.19
78.33

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p,

hsa-miR-323a-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

322
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
74.42
79.07
80

1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-323a-3p, hsa-miR-550a-3-5p,

323
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
74.42
82.46
80.68

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-15b-3p, hsa-miR-328-

3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

324
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
74.42
82.34
79.17

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

325
hsa-miR-142-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
74.39
81.12
79.09

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-

3p, hsa-miR-550a-3-5p, age,

326
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
74.39
81.78
81.67

3p, hsa-miR-195-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-

miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-15b-

3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

327
hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
74.37
83.35
79.92

1260b, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-

miR-423-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p,

hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-

323b-3p,

328
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-181a-
73.89
80.88
78.18

5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-

miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-

15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-

3p,

329
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-142-5p, hsa-miR-92b-
73.87
81.85
80.08

3p, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-423-5p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-

323a-3p, hsa-miR-323b-3p,

330
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
73.87
80.9
80.08

1301-3p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

28-3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-323b-3p,

331
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-92b-3p, hsa-miR-
73.87
80.45
80.15

195-5p, hsa-miR-483-5p, hsa-miR-28-3p, hsa-miR-15b-3p, hsa-

miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age, hsa-

miR-323b-3p,

332
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
73.84
84.07
77.5

1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-

miR-550a-3-5p, age,

333
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
73.84
82.21
77.42

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-

328-3p, hsa-miR-323a-3p, age, hsa-miR-323b-3p,

334
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
73.82
80.7
79.24

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-

miR-6803-3p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p,

age,

335
hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
73.42
78.81
78.26

195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

336
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
73.39
83.36
76.52

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-

miR-423-5p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-328-3p,

hsa-miR-550a-3-5p, hsa-miR-323b-3p,

337
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
73.37
78.46
76.29

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-

miR-550a-3-5p, hsa-miR-323b-3p,

338
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
73.37
78.99
78.26

1260b, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-

3p,

339
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
73.37
81.54
76.36

21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

340
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
73.34
80.92
78.11

130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-323b-3p,

341
hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
73.34
79.57
76.52

195-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-15b-3p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

hsa-miR-323b-3p,

342
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-
73.32
80.36
78.11

1260b, hsa-miR-4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-

miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, age,

343
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-4306, hsa-miR-21-
73.32
81.65
78.41

5p, hsa-miR-483-5p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-

miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-323a-3p,

hsa-miR-550a-3-5p, age,

344
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
73.32
81.51
77.95

1260b, hsa-miR-1301-3p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

328-3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

345
hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-
73.29
81.76
80.91

1301-3p, hsa-miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-101-3p, hsa-miR-29a-3p, hsa-miR-28-3p, hsa-miR-

328-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

346
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
72.87
77.4
79.02

6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-

550a-3-5p, hsa-miR-323b-3p,

347
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
72.87
80.77
79.09

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-377-3p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-

miR-423-5p, hsa-miR-29a-3p, hsa-miR-15b-3p, hsa-miR-328-

3p, hsa-miR-550a-3-5p, hsa-miR-323b-3p,

348
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
72.84
80.24
78.11

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

374a-5p, hsa-miR-423-5p, hsa-miR-29a-3p, hsa-miR-328-3p,

hsa-miR-550a-3-5p, hsa-miR-323b-3p,

349
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
72.84
81.71
77.35

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

age,

350
hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-1260b, hsa-miR-
72.82
82.27
78.33

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-101-

3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-miR-328-3p, hsa-miR-

323a-3p, hsa-miR-550a-3-5p, age,

351
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
72.82
83.55
75.91

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-28-

3p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age,

352
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-181a-5p, hsa-miR-
72.82
81.54
78.18

1260b, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-

miR-423-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-550a-

3-5p, age, hsa-miR-323b-3p,

353
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
72.79
82.57
77.35

1301-3p, hsa-miR-21-5p, hsa-miR-483-5p, hsa-miR-6803-3p,

hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-

29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-550a-3-5p,

age,

354
hsa-miR-30b-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
72.76
81.94
76.44

4306, hsa-miR-1301-3p, hsa-miR-195-5p, hsa-miR-377-3p,

hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-

101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-

miR-328-3p, hsa-miR-550a-3-5p, age, hsa-miR-323b-3p,

355
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
72.32
81.14
79.02

3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-377-3p, hsa-miR-

6803-3p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p,

hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-

550a-3-5p, age, hsa-miR-323b-3p,

356
hsa-miR-142-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
72.29
79.72
78.11

130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-1301-3p,

hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-423-5p, hsa-miR-

29a-3p, hsa-miR-15b-3p, hsa-miR-550a-3-5p, hsa-miR-323b-

3p,

357
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
72.26
80.78
77.2

1301-3p, hsa-miR-21-5p, hsa-miR-6803-3p, hsa-miR-181c-3p,

hsa-miR-101-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-

7-5p, hsa-miR-328-3p, hsa-miR-550a-3-5p, age,

358
hsa-miR-142-5p, hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-
72.26
80.69
77.2

4306, hsa-miR-1301-3p, hsa-miR-377-3p, hsa-miR-483-5p,

hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p, hsa-miR-

374a-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, age,

hsa-miR-323b-3p,

359
hsa-miR-326, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
71.82
76.62
77.27

1260b, hsa-miR-4306, hsa-miR-21-5p, hsa-miR-377-3p, hsa-

miR-6803-3p, hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-7-

5p, hsa-miR-328-3p, hsa-miR-323a-3p,

360
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-1260b, hsa-miR-
71.79
80.96
77.35

4306, hsa-miR-1301-3p, hsa-miR-21-5p, hsa-miR-195-5p, hsa-

miR-377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-

3p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-

550a-3-5p, age,

361
hsa-miR-30b-5p, hsa-miR-142-5p, hsa-miR-1260b, hsa-miR-
71.76
79.54
78.11

377-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-423-5p,

hsa-miR-7-5p, hsa-miR-15b-3p, age,

362
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-130a-3p, hsa-miR-
71.76
81.31
79.17

21-5p, hsa-miR-29a-3p, hsa-miR-7-5p, hsa-miR-28-3p, hsa-

miR-15b-3p, hsa-miR-323a-3p, hsa-miR-550a-3-5p, age,

363
hsa-miR-30b-5p, hsa-miR-181a-5p, hsa-miR-92b-3p, hsa-miR-
71.18
77.92
74.77

4306, hsa-miR-21-5p, hsa-miR-195-5p, hsa-miR-374a-5p, hsa-

miR-550a-3-5p, age,

364
hsa-miR-30b-5p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-483-
70.76
76.96
78.33

5p, hsa-miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-

miR-29a-3p, hsa-miR-7-5p, hsa-miR-323a-3p, age,

365
hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-195-5p, hsa-miR-
70.71
76.37
80.91

377-3p, hsa-miR-483-5p, hsa-miR-6803-3p, hsa-miR-423-5p,

hsa-miR-7-5p, hsa-miR-323a-3p, hsa-miR-323b-3p,

366
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-1301-3p, hsa-miR-
70.21
77.87
76.36

483-5p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p,

hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-

550a-3-5p, hsa-miR-323b-3p,

367
hsa-miR-130a-3p, hsa-miR-1260b, hsa-miR-4306, hsa-miR-
70.16
80.7
74.77

1301-3p, hsa-miR-6803-3p, hsa-miR-181c-3p, hsa-miR-101-3p,

hsa-miR-374a-5p, hsa-miR-29a-3p, hsa-miR-328-3p, hsa-miR-

550a-3-5p, age, hsa-miR-323b-3p,

368
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-1260b, hsa-miR-1301-
66.55
76.16
76.36

3p, hsa-miR-21-5p, hsa-miR-377-3p, hsa-miR-6803-3p, hsa-

miR-181c-3p, hsa-miR-374a-5p, hsa-miR-423-5p, hsa-miR-29a-

3p, hsa-miR-7-5p, hsa-miR-328-3p, hsa-miR-323b-3p,

369
combination 1 + rs11862974
67.11
64.36
87.8

370
combination 1 + rs7193058
74.89
79.03
86.97

371
combination 2 + rs12917707
69.63
70.47
70.15

372
combination 2 + rs11647727
68.58
71.76
83.56

373
combination 3 + rs7204342
69.13
73.18
83.48

374
combination 3 + rs7193058
69.11
72.14
83.23

375
combination 4 + rs12917707
73.84
77.37
80.3

376
combination 4 + rs11647727
72.79
77.42
83.4

377
combination 8 + rs76563024
74.92
81.29
83.56

378
combination 8 + rs7193058
74.89
79.03
80.7

379
combination 29 + rs76563024
80.18
87.08
87.08

380
combination 149 + rs76563024
78.57
85.51
84.51

381
combination 150 + rs76563024
77.3
85.51
86.71

382
combination 151 + rs76563024
75.3
85.01
84.17

383
combination 152 + rs76563024
75.3
84.7
84.20

384
combination 153 + rs76563024
74.4
83.51
85.17

385
combination 154 + rs76563024
74.3
82.5
86.18

386
combination 155 + rs76563024
74
82
84.20

This is the list of the best 30 mRNAs selected by the algorithm sorted by importance for diagnosis outcome: hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-3p, and hsa-miR-337-5p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for diagnosis (Table 16).

TABLE 16

Combinations that allow higher sensitivity, specificity, accuracy and predictive power for diagnosis.

N
Combinations
Accuracy
ROC AUC
Recall

387
hsa-miR-99a-3p
78.26
65.53
100.0

388
hsa-miR-99a-3p, hsa-miR-1180-3p
79.13
71.54
100.0

389
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p
78.26
75.95
100.0

390
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
79.13
77.85
100.0

4286

391
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
79.13
82.04
100.0

4286, hsa-miR-103a-2-5p

392
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
80
82.18
95.56

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p

393
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
80.87
82.62
94.44

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p

394
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
82.1
84.26
93.33

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

395
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
84.5
81.67
92.22

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p

396
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
83.8
80.16
93.33

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p

397
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
84.5
89.17
94.44

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p

398
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
84.5
90.42
94.44

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p

399
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
83.8
91.45
93.33

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l

400
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
86.09
90.52
94.44

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p

401
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
87.83
90.38
94.44

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p

402
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
87.83
91.71
93.33

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p

403
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
86.09
90.82
94.44

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p

404
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
86.96
92.99
95.56

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p

405
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
89.7
95.25
92.22

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p

406
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
88.7
92.32
93.33

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p

407
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
90.3
95.96
93.33

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p

408
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
89.7
95.25
93.33

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a

409
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
90.3
95.29
90.0

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p

410
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
89.7
95.29
90.0

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p

411
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
90.3
93.33
90.0

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p

412
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
90.3
92.85
91.11

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-485-3p

413
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
88.7
93.78
88.89

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-485-3p, hsa-miR-335-5p

414
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
88.7
93.17
90.0

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290

415
hsa-miR-99a-3p, hsa-miR-1180-3p, hsa-miR-192-5p, hsa-miR-
88.7
93.21
91.11

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p, hsa-miR-

30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-

miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290,

hsa-miR-132-3p

416
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
95.8
95.93
97.89

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

417
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
94.02
96.35
95.89

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

382-5p

418
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
94.02
94.56
95.89

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

419
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.94
94.93
96.78

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

420
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.11
96.72
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

421
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.11
96.35
95.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

335-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

422
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.03
96.67
95.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-335-

5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-382-5p

423
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.03
93.76
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

424
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.03
95.3
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

425
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.03
95.3
94.78

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-382-5p

426
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.03
94.93
94.67

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

427
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
93.03
93.81
94.67

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

428
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
92.95
97.28
94.56

5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-

miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-

215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

429
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.5
94.74
94.89

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-

491-5p, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-337-5p,

hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-

590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

430
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.5
98.52
95.78

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-

335-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

431
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.5
95.24
94.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

432
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.27
95.06
95.78

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

433
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.27
96.67
93.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-

491-5p, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

434
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.27
97.59
94.67

450a-5p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

435
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.2
94.93
94.78

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

436
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.2
96.85
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-

491-5p, hsa-miR-501-5p, hsa-miR-335-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

437
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
92.2
94.74
94.67

450a-5p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

438
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.2
94.93
95.78

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

439
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.2
93.57
94.56

450a-5p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-

2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-590-5p

440
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.2
96.22
95.78

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

441
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
92.2
95
93.67

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

442
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
92.2
93.57
93.67

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

443
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.2
94.5
95.78

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

444
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
92.2
95.61
94.67

433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-

miR-491-5p, hsa-miR-501-5p, hsa-miR-335-5p, hsa-miR-4286,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-382-5p

445
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.2
95.06
93.67

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

446
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.12
94.5
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

447
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.12
94.69
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-590-5p, hsa-miR-382-

5p

448
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.12
94.19
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-

5p

449
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
92.12
94.31
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

450
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
92.05
97.28
94.56

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

451
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.4
94.5
94.78

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

452
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
91.6
95.56
92.56

5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-

miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-382-5p

453
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.6
94.87
94.78

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

454
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.6
94.74
93.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

455
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.6
93.94
93.67

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

456
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
91.6
94.37
93.67

450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

457
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.6
94.19
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-

3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

458
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-450a-5p, hsa-miR-
91.6
92.52
93.67

331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-

5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

459
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
91.6
96.48
93.67

450a-5p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

460
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-450a-5p, hsa-miR-
91.6
95.48
93.67

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

461
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.6
93.07
93.56

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

462
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
91.6
93.63
93.67

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-382-5p

463
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.6
96.48
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

464
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
91.6
94.56
93.67

450a-5p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

465
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.29
95.24
92.33

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-590-5p, hsa-miR-382-5p

466
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
91.29
94.74
94.56

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

467
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
91.29
94.56
93.44

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

468
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
91.29
95.48
93.44

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-4286,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-382-5p

469
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.29
95.85
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-

3p, hsa-miR-500a-5p, hsa-miR-382-5p

470
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.29
96.35
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

471
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
91.21
93.94
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p,

hsa-miR-590-5p, hsa-miR-382-5p

472
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
90.1
91.7
93.78

181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-

miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-4286,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-382-5p

473
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.1
93.81
94.67

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-500a-5p, hsa-miR-382-5p

474
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
90.1
94.87
94.56

5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-

miR-501-5p, hsa-miR-4732-5p, hsa-miR-132-3p, hsa-miR-4286,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-590-5p

475
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.1
94.87
92.44

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-382-5p

476
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.1
92.63
92.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

477
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
96.54
92.56

450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

478
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
95.8
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-

miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-

3p, hsa-miR-500a-5p, hsa-miR-382-5p

479
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
90.85
92.33

193b-3p, hsa-miR-450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-

5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-

215-5p, hsa-miR-590-3p, hsa-miR-590-5p, hsa-miR-382-5p

480
hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-
90.3
95.43
93.67

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

481
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
93.94
93.67

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

482
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
94
92.56

193b-3p, hsa-miR-450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-

3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

483
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
95.85
92.33

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

484
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
90.3
93.07
93.67

5p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-

miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-

215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

485
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
90.3
95.98
92.56

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

486
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
94
94.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p,

hsa-miR-382-5p

487
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.3
93.44
92.44

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-590-5p

488
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
90.3
94.31
94.56

433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-

miR-491-5p, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

489
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
90.5
93.31
92.56

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

490
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.5
94
94.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-

3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

491
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
90.5
96.11
92.44

5p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-

miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-

5p, hsa-miR-382-5p

492
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-
90.5
94.5
94.56

193b-3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

493
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.5
92.94
92.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

494
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.5
96.48
92.44

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-335-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

495
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.5
93.81
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-

3p, hsa-miR-500a-5p

496
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.5
94.19
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-

5p, hsa-miR-382-5p

497
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
90.5
94.44
93.56

5p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-

590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

498
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.8
94.5
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-382-5p

499
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
90.8
94.06
93.56

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

500
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
90.8
94
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-

miR-590-5p, hsa-miR-382-5p

501
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
90.8
95.17
93.56

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

502
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
89.77
95.98
94.56

410-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

503
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.7
95.43
94.56

450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-382-5p

504
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.7
92.94
93.67

193b-3p, hsa-miR-450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

505
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.7
91.59
93.44

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-221-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-

485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-

3p

506
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
89.7
95.37
95.56

5p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-

miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-4732-

5p, hsa-miR-132-3p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-590-5p

507
hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-
89.7
94.93
93.67

433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

508
hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-410-3p, hsa-miR-
89.7
88.81
93.44

221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-335-5p, hsa-miR-4286, hsa-miR-

590-5p, hsa-miR-382-5p

509
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.2
96.72
92.56

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

510
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
89.2
93.63
93.67

450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

511
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.2
95.56
94.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-

491-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

512
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.2
92.46
92.33

450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-335-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

513
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.2
93.44
92.44

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

514
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.2
95.61
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-221-5p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

515
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.2
92.94
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-335-5p, hsa-miR-

1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

516
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.2
92.07
92.67

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

517
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.5
94
93.56

450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

518
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.5
91.78
94.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

590-5p, hsa-miR-382-5p

519
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.5
94.87
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-590-5p, hsa-miR-

382-5p

520
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
89.5
96.41
94.56

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-382-5p

521
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.5
94.69
92.33

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-335-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

522
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
89.5
94.61
93.44

miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-

3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-485-3p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

523
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.5
94.5
92.33

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-335-

5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

524
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
89.7
93.13
92.33

450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-590-5p

525
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.7
92.76
92.44

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p,

hsa-miR-382-5p

526
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
89.9
94.37
92.33

miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-

3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

527
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
89.9
93.13
92.33

miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-

3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-4732-5p, hsa-

miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-

5p, hsa-miR-590-3p, hsa-miR-500a-5p

528
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
89.9
93.94
91.22

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

335-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-590-3p, hsa-miR-590-5p, hsa-miR-382-5p

529
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
89.9
94.06
92.33

miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-

3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

530
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
89.9
92.37
93.33

miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-

5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-

3p, hsa-miR-500a-5p, hsa-miR-382-5p

531
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.86
95.43
93.56

450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

532
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.86
93.61
93.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

533
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.86
95.43
93.44

450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

534
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.86
92.57
92.56

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-221-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-

485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-

3p, hsa-miR-500a-5p

535
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.86
96.35
93.56

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

536
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.86
94.69
91.56

450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

537
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.86
94.37
93.44

450a-5p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

538
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.79
90.3
92.33

193b-3p, hsa-miR-450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-

3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-590-5p

539
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.79
92.2
94.67

193b-3p, hsa-miR-433-3p, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

540
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.79
94.19
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

335-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

541
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.79
93.69
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

485-3p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

542
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.79
94.24
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

543
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.79
94.06
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-335-5p, hsa-miR-132-3p, hsa-miR-337-5p,

hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-382-5p

544
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
88.79
93.69
93.44

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

545
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
88.79
88.98
92.44

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-382-5p

546
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.71
92.02
95.67

miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-

3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

547
hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.71
92.94
91.33

miR-221-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

548
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
88.71
93.37
91.56

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

549
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.71
92.39
93.67

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-3p, hsa-miR-590-5p, hsa-miR-382-5p

550
hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.71
93.44
93.44

miR-433-3p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-382-5p

551
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
88.71
93.81
92.44

450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

552
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.4
94.56
92.33

miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

553
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.4
94.67
92.44

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-132-3p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

554
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.4
92.15
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-

3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p

555
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.6
95.3
91.33

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

556
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.6
93.39
91.22

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

335-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-

382-5p

557
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.6
94.3
92.33

miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

558
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
88.8
90.89
92.22

miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-

5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-132-3p, hsa-

miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-

5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

559
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.03
94.5
92.56

450a-5p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

560
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.03
92.26
92.67

193b-3p, hsa-miR-450a-5p, hsa-miR-331-5p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

561
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
88.03
94
91.44

450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

562
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.95
91.17
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-

501-5p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

563
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.95
93.19
92.67

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-500a-5p

564
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.95
94.31
92.33

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-590-5p

565
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
87.88
89.28
90.11

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

566
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.88
92.41
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p,

hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-

501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

567
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.88
92.31
90.33

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-

miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-382-5p

568
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
87.88
92.74
93.44

miR-433-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-

3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

569
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.88
91.7
92.56

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-500a-

5p

570
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.88
92.31
90.33

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-491-5p,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-590-5p, hsa-miR-382-5p

571
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
87.8
91.57
91.33

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-335-5p, hsa-miR-132-3p, hsa-miR-337-5p,

hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

572
hsa-miR-30e-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-
87.8
93.76
91.33

331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-501-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-

5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

573
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
87.73
92.31
91.22

miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

574
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.73
88.44
90.11

193b-3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p

575
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-193b-3p, hsa-miR-
87.73
89.24
92.22

450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-4732-5p, hsa-miR-215-5p, hsa-miR-

590-3p

576
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.73
91.28
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p,

hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-

215-5p, hsa-miR-500a-5p

577
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
87.73
91.26
91.22

miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-132-3p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

578
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
87.73
90.22
94.56

miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

579
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
87.5
92.2
92.22

miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-

5p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-335-5p, hsa-

miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-

5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

580
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
87.27
90.48
90.22

221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-501-5p,

hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-590-

5p, hsa-miR-382-5p

581
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.2
86.22
91.33

450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-5p

582
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.12
92.44
91.56

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

583
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-331-5p, hsa-miR-
87.12
90.11
91.44

181c-3p, hsa-miR-501-5p, hsa-miR-1290, hsa-miR-4286, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-

382-5p

584
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.12
93.33
92.56

193b-3p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-335-5p, hsa-miR-

337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-

5p, hsa-miR-382-5p

585
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.12
92.44
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-382-5p

586
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
87.05
90.35
91.22

5p, hsa-miR-410-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-

miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-590-5p

587
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
87.05
90.28
92.44

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p

588
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.05
94.06
90.22

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-

5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-

215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

589
hsa-miR-193b-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-
87.05
90.78
93.44

331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-

miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-4286,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-590-5p

590
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
87.05
92.7
94.56

410-3p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-335-5p, hsa-miR-132-3p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-590-5p

591
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.05
92.83
88.11

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-335-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p,

hsa-miR-590-5p, hsa-miR-382-5p

592
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
87.05
90.33
92.44

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

593
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
87.05
92.57
90.33

5p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p, hsa-

miR-485-3p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-

2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

594
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
87.05
92.2
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

595
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
86.97
90.2
91.22

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

596
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
86.97
90.46
91.22

miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-132-3p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p

597
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.97
92.94
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-3p, hsa-miR-590-5p, hsa-miR-382-5p

598
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.97
89.72
90.22

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-

501-5p, hsa-miR-335-5p, hsa-miR-132-3p, hsa-miR-337-5p,

hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

599
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.97
92.2
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-

miR-590-5p, hsa-miR-382-5p

600
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.97
91.65
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-

miR-500a-5p, hsa-miR-590-5p

601
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
86.97
92.93
91.22

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-

4732-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

602
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.97
89.19
94.67

193b-3p, hsa-miR-450a-5p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

603
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
86.97
87.63
91.33

450a-5p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p,

hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-

215-5p, hsa-miR-500a-5p

604
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
86.97
88.19
91.33

450a-5p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p,

hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-

500a-5p

605
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410-
86.97
86.09
91.33

3p, hsa-miR-433-3p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-

miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-5p

606
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.89
90.3
91.33

193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p

607
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
86.89
92.2
91.33

5p, hsa-miR-193b-3p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-

miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

608
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-221-5p, hsa-miR-
86.82
94.06
92.44

4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-103a-2-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

609
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
86.6
90.3
93.44

5p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-

miR-181c-3p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-335-

5p, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-

590-3p, hsa-miR-590-5p, hsa-miR-382-5p

610
hsa-miR-30e-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-
86.29
90.28
90.22

221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-501-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-382-5p

611
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.29
89.56
90.22

450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-5p, hsa-miR-382-5p

612
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
86.29
93.56
90.33

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-

5p

613
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
86.29
91.04
91.22

450a-5p, hsa-miR-221-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-590-5p

614
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.21
92.81
91.33

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-335-5p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-

miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

615
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.21
94.06
90.33

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

616
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
86.21
94.5
91.33

5p, hsa-miR-193b-3p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-

miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

617
hsa-miR-20b-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-
86.21
86.96
90.22

331-5p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-

590-5p

618
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.21
90.06
92.44

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p,

hsa-miR-382-5p

619
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-450a-5p, hsa-miR-
86.21
88.93
92.44

433-3p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-132-3p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-

590-3p, hsa-miR-500a-5p

620
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-450a-5p, hsa-miR-
86.21
92.89
91.33

410-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-491-5p, hsa-miR-1290, hsa-miR-4286, hsa-miR-215-

5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

621
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
86.21
90.46
92.44

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

622
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.21
89.56
93.44

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-

382-5p

623
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
86.21
94.13
91.33

5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-

miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-501-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

624
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.21
88.74
95.78

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-

miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

625
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.14
92.2
91.44

193b-3p, hsa-miR-450a-5p, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-

miR-590-5p

626
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
86.14
89.19
92.33

410-3p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-

miR-501-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-4286,

hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-590-5p

627
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
86.14
92.2
91.33

5p, hsa-miR-193b-3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-

miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-

5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-

215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

628
hsa-miR-30e-3p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
86.14
89.91
91.33

miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

629
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.06
92.94
90.22

193b-3p, hsa-miR-450a-5p, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-590-5p

630
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
86.06
89.24
90.22

193b-3p, hsa-miR-410-3p, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p

631
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
85.98
89.3
90.22

5p, hsa-miR-193b-3p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-

miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-500a-5p

632
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-433-3p, hsa-miR-
85.98
91.2
90.22

181c-3p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-103a-

2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-590-5p

633
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410-
85.3
90.41
91.22

3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-

miR-501-5p, hsa-miR-4732-5p, hsa-miR-132-3p, hsa-miR-4286,

hsa-miR-590-3p, hsa-miR-590-5p

634
hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-
85.5
88.61
93.56

miR-451a, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p,

hsa-miR-335-5p, hsa-miR-1290, hsa-miR-590-5p, hsa-miR-382-

5p

635
hsa-miR-30e-3p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
85.5
90.48
91.33

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-

1290, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-215-5p, hsa-

miR-590-3p, hsa-miR-500a-5p

636
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-
85.5
89.67
90.22

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-221-5p,

hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-

485-3p, hsa-miR-335-5p, hsa-miR-132-3p, hsa-miR-4286, hsa-

miR-590-3p, hsa-miR-590-5p

637
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410-3p, hsa-miR-221-
85.5
88.13
90.33

5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-

miR-1290, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-382-5p

638
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-
85.8
88.19
90.33

410-3p, hsa-miR-221-5p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-4286, hsa-miR-590-5p, hsa-miR-382-5p

639
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
85.8
93.31
90.33

193b-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

335-5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

640
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
85.8
87.7
90.33

5p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-

miR-181c-3p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-

5p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-590-5p, hsa-miR-382-5p

641
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
85.8
92.22
92.44

410-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

642
hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
85.
86.89
90.22

410-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-501-5p,

hsa-miR-4732-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-

337-5p, hsa-miR-4286, hsa-miR-103a-2-5p

643
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-450a-5p, hsa-miR-
85.
91.57
91.33

331-5p, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-4732-5p,

hsa-miR-335-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-590-3p, hsa-miR-382-5p

644
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
85.
88.5
91.33

450a-5p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-132-3p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-

590-3p, hsa-miR-500a-5p

645
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-450a-5p, hsa-miR-
85.
88.74
91.33

433-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p, hsa-

miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-

5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

646
hsa-miR-548l, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-
85.
84.74
92.44

181c-3p, hsa-miR-1290, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p

647
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-
85.
88.81
89.11

450a-5p, hsa-miR-331-5p, hsa-miR-501-5p, hsa-miR-335-5p,

hsa-miR-1290, hsa-miR-4286, hsa-miR-590-3p, hsa-miR-590-

5p

648
hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p, hsa-
85.
88.93
92.44

miR-451a, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-215-5p, hsa-miR-590-5p

649
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
85.23
90.67
89.22

5p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-

miR-491-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-

2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

650
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
85.23
84.93
91.11

193b-3p, hsa-miR-450a-5p, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-590-3p, hsa-miR-590-5p, hsa-miR-382-5p

651
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
85.23
93.89
90.22

5p, hsa-miR-193b-3p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-

miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-335-5p,

hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-500a-5p, hsa-miR-382-5p

652
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
85.15
89.06
89.11

193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-590-5p

653
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.5
87.81
90.33

193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

654
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.5
90.17
93.56

450a-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-

1290, hsa-miR-4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p

655
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.5
93.19
88.22

193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-590-5p, hsa-miR-382-5p

656
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.7
91.02
89.22

193b-3p, hsa-miR-450a-5p, hsa-miR-491-5p, hsa-miR-501-5p,

hsa-miR-485-3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-590-3p, hsa-miR-

500a-5p

657
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.7
91.96
91.33

450a-5p, hsa-miR-410-3p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

658
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.7
87.39
92.44

193b-3p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-500a-5p

659
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.9
86.83
90.22

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-491-5p,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

660
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.9
93.81
89.11

193b-3p, hsa-miR-450a-5p, hsa-miR-433-3p, hsa-miR-181c-3p,

hsa-miR-451a, hsa-miR-491-5p, hsa-miR-501-5p, hsa-miR-485-

3p, hsa-miR-335-5p, hsa-miR-1290, hsa-miR-337-5p, hsa-miR-

4286, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

661
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.9
85.85
90.11

193b-3p, hsa-miR-410-3p, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-590-5p

662
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
84.9
89.11
89.11

5p, hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-491-5p, hsa-

miR-485-3p, hsa-miR-335-5p, hsa-miR-500a-5p, hsa-miR-590-

5p, hsa-miR-382-5p

663
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.9
86.83
90.22

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

664
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.9
92.04
92.33

450a-5p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-

132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-382-5p

665
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.9
89
90.22

450a-5p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a, hsa-

miR-491-5p, hsa-miR-132-3p, hsa-miR-103a-2-5p, hsa-miR-

215-5p, hsa-miR-590-3p, hsa-miR-500a-5p

666
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.9
90.56
91.33

193b-3p, hsa-miR-410-3p, hsa-miR-433-3p, hsa-miR-331-5p,

hsa-miR-181c-3p, hsa-miR-491-5p, hsa-miR-335-5p, hsa-miR-

337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-

5p, hsa-miR-382-5p

667
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.2
88.63
89.11

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-433-3p,

hsa-miR-331-5p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-500a-5p, hsa-miR-382-5p

668
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-491-5p, hsa-miR-
84.2
88
92.33

4732-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p,

hsa-miR-103a-2-5p, hsa-miR-590-3p, hsa-miR-382-5p

669
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.24
86.72
94.44

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-491-5p,

hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-

miR-215-5p, hsa-miR-382-5p

670
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
84.24
89.5
89

193b-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-

590-5p

671
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-
84.17
91.96
89.11

433-3p, hsa-miR-181c-3p, hsa-miR-501-5p, hsa-miR-4732-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-

4286, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-590-5p

672
hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
83.4
85.96
92.44

450a-5p, hsa-miR-221-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p,

hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-

miR-500a-5p

673
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
83.4
87.39
90.22

193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

674
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
83.4
86.09
90.33

193b-3p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-500a-5p

675
hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-193b-3p, hsa-miR-
83.6
85.41
89.11

410-3p, hsa-miR-433-3p, hsa-miR-221-5p, hsa-miR-181c-3p,

hsa-miR-491-5p, hsa-miR-4732-5p, hsa-miR-1290, hsa-miR-

132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p

676
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-20b-5p, hsa-miR-
83.8
87.33
90

450a-5p, hsa-miR-331-5p, hsa-miR-451a, hsa-miR-491-5p, hsa-

miR-4732-5p, hsa-miR-485-3p, hsa-miR-103a-2-5p, hsa-miR-

215-5p, hsa-miR-590-5p, hsa-miR-382-5p

677
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
83.8
89.43
89

193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-590-5p, hsa-

miR-382-5p

678
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
83.8
90.06
89

193b-3p, hsa-miR-410-3p, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-590-5p

679
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
83.8
85.41
92.44

193b-3p, hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-

miR-500a-5p, hsa-miR-590-5p

680
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
83.1
86.41
93.44

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-335-5p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

681
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
83.1
87.7
87.89

193b-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-590-5p

682
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
82.88
90.28
88.22

193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-miR-221-5p,

hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-

485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-590-3p, hsa-miR-

500a-5p

683
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
82.8
86.09
91.22

193b-3p, hsa-miR-410-3p, hsa-miR-181c-3p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-

3p, hsa-miR-337-5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-

miR-382-5p

684
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410-
82.73
83.69
92.44

3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p,

hsa-miR-382-5p

685
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410-
82.5
85.35
91.33

3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-501-5p, hsa-miR-

485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-

miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-

382-5p

686
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
82.5
87.02
89.11

193b-3p, hsa-miR-451a, hsa-miR-491-5p, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-382-5p

687
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-
82.5
89.11
91.44

5p, hsa-miR-193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-

miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p,

hsa-miR-103a-2-5p, hsa-miR-500a-5p, hsa-miR-382-5p

688
hsa-miR-30e-3p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
82.8
88.44
90.11

193b-3p, hsa-miR-433-3p, hsa-miR-331-5p, hsa-miR-451a,

hsa-miR-491-5p, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-590-

5p, hsa-miR-382-5p

689
hsa-miR-30e-3p, hsa-miR-450a-5p, hsa-miR-181c-3p, hsa-miR-
82.00
89.59
85.67

451a, hsa-miR-501-5p, hsa-miR-4732-5p, hsa-miR-335-5p, hsa-

miR-1290, hsa-miR-337-5p, hsa-miR-215-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-590-5p, hsa-miR-382-5p

690
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
81.89
84.48
89.11

193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-485-3p,

hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-

103a-2-5p

691
hsa-miR-331-5p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-
81.89
83.93
91.33

491-5p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-335-5p,

hsa-miR-1290, hsa-miR-337-5p, hsa-miR-590-3p, hsa-miR-

500a-5p, hsa-miR-590-5p, hsa-miR-382-5p

692
hsa-miR-193b-3p, hsa-miR-450a-5p, hsa-miR-410-3p, hsa-
81.89
84.3
94.67

miR-181c-3p, hsa-miR-501-5p, hsa-miR-485-3p, hsa-miR-1290,

hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-4286, hsa-miR-

103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p

693
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-
81.82
83.74
89.11

193b-3p, hsa-miR-410-3p, hsa-miR-451a, hsa-miR-491-5p,

hsa-miR-485-3p, hsa-miR-1290, hsa-miR-132-3p, hsa-miR-337-

5p, hsa-miR-103a-2-5p, hsa-miR-215-5p, hsa-miR-500a-5p

694
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-20b-5p, hsa-miR-410-
81.82
85.85
91.22

3p, hsa-miR-181c-3p, hsa-miR-451a, hsa-miR-485-3p, hsa-miR-

1290, hsa-miR-132-3p, hsa-miR-337-5p, hsa-miR-103a-2-5p,

hsa-miR-215-5p, hsa-miR-500a-5p, hsa-miR-382-5p

695
hsa-miR-545-5p, hsa-miR-548l, hsa-miR-450a-5p, hsa-miR-
80.98
83.74
93.44

181c-3p, hsa-miR-491-5p, hsa-miR-335-5p, hsa-miR-132-3p,

hsa-miR-337-5p, hsa-miR-590-3p, hsa-miR-500a-5p

696
hsa-miR-548l, hsa-miR-193b-3p, hsa-miR-501-5p, hsa-miR-
80.91
85.54
94.56

132-3p, hsa-miR-4286, hsa-miR-103a-2-5p, hsa-miR-215-5p

697
combination 387 + rs13335818
79.13
45.13
98.89

698
combination 388 + rs76563024
80
75.1
98.89

699
combination 389 + rs76563024
80.87
78.71
100.0

700
combination 390 + rs76563024
80.87
80.31
98.89

701
combination 392 + rs76563024
81.74
79.08
97.78

702
combination 393 + rs12934455
85.22
84.73
96.67

703
combination 395 + rs12934455
85.22
79.65
95.56

704
combination 397 + rs71384446
86.09
87.88
97.78

705
combiantion 399 + rs7203642
86.96
87.09
95.56

706
combination 400 + rs28688991
86.96
85.75
94.44

707
combination 652 + rs7203642
85.22
92.38
94.44

708
combination 653 + rs7203642
85.22
92.38
92.38

709
combination 654 + rs7203642
85.22
92.38
92.38

This is the list of the best 30 mRNAs selected by the algorithm sorted by importance for tumour stage: hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3, hsa-miR-140-3p, hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, and hsa-miR-15a-5p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour stage (Table 17).

TABLE 17

Combinations that allow higher sensitivity, specificity,

accuracy and predictive power for tumour stage.

N
Combinations
Accuracy
ROCAUC
Recall

710
hsa-miR-769-5p
72.57
66.51
0.0

711
hsa-miR-769-5p, hsa-miR-27b-3p
74.74
80.82
23.00

712
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p
78.19
83.28
50.67

713
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
78.13
86.31
58.00

629-5p

714
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
79.24
87.54
62.67

629-5p, hsa-miR-100-5p

715
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
80.23
87.59
66.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p

716
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
85.85
89.38
70.0

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p

717
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
86.9
90.46
69.33

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p

718
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
88.01
91.23
72.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

719
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
89.12
93.03
72.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p

720
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
88.01
93.23
76.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-5p

721
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
89.12
92.92
69.33

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p

722
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
90.06
95.64
81.33

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p

723
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
85.85
95.18
73.33

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p

724
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
89.12
94.87
65.33

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p

725
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
86.96
94.05
68.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p

726
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
85.85
92.26
68.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p

727
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
84.8
93.95
80.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p

728
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
85.73
94.05
72.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136

729
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
86.84
94.67
72.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p

730
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
86.9
94.1
72.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p

731
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
88.01
95.59
68.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p

732
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
86.9
94.92
68.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p, hsa-miR-337-5p

733
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
86.9
94.92
76.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p, hsa-miR-337-5p, hsa-miR-188-5p

734
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
86.9
94.72
76.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p

735
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
88.01
92.62
76.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p,

hsa-miR-4306

736
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
90.12
94.97
76.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p,

hsa-miR-4306, hsa-miR-27a-3p

737
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
87.95
95.18
80.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p,

hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p

738
hsa-miR-769-5p, hsa-miR-27b-3p, hsa-miR-320a-3p, hsa-miR-
90.12
95.38
80.67

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p, hsa-miR-22-

5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-

miR-744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-

5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-

455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p,

hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

1296-5p

739
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
95.67
98.33
91.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

740
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
92.56
97.86
86.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-miR-652-3p

741
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-10b-5p, hsa-miR-
92.56
97.38
90.00

12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-

3p, hsa-miR-224-5p, hsa-miR-652-3p

742
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
92.44
98.81
88.33

195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p,

hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-

652-3p

743
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
92.44
96.03
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-miR-652-3p

744
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
92.33
95.32
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

745
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.44
96.98
86.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p

746
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.44
97.86
86.67

12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-

miR-652-3p

747
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.44
97.62
80.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-

3p

748
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.44
96.19
86.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

749
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
95.32
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

750
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
95.32
81.67

485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

751
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
91.33
96.75
81.67

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-miR-652-3p

752
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
96.9
85.00

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-

3p

753
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
97.14
83.33

485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

754
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
95.71
83.33

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-miR-140-3p

755
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
94.21
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-miR-652-3p

756
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
96.03
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-miR-652-3p

757
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.33
96.27
78.33

195-5p, hsa-miR-485-3p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-miR-652-3p

758
hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-
91.33
93.41
78.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

759
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
91.22
94.21
81.67

485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

760
hsa-miR-22-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-
90.44
94.52
85.00

3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-miR-652-3p

761
hsa-miR-22-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-
90.44
96.35
85.00

3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-15a-5p, hsa-

miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-

5p, hsa-miR-652-3p

762
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
90.33
96.43
81.67

339-3p, hsa-miR-744-5p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-

140-3p

763
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.33
96.35
81.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

764
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.33
97.06
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-

3p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p

765
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
95.56
81.67

485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-miR-652-3p

766
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
90.22
92.94
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-1296-

5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-

miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p

767
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
96.75
78.33

195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

768
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
90.22
94.44
76.67

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-4306, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-

miR-140-3p

769
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
96.03
85.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

770
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
90.22
95.08
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-

miR-652-3p, hsa-miR-140-3p

771
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
90.22
91.11
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p,

hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-

224-5p, hsa-miR-652-3p, hsa-miR-140-3p

772
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
93.49
78.33

195-5p, hsa-miR-485-3p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

773
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
96.51
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-

3p

774
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
94.76
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-miR-652-3p

775
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
96.67
81.67

195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-

5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-

miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-

3p

776
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
97.78
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-

3p, hsa-miR-652-3p

777
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
96.98
90.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p

778
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.22
95.56
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p

779
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
90.22
91.75
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-1296-

5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-

miR-652-3p, hsa-miR-140-3p

780
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
90.22
96.75
81.67

12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-134-5p,

hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-

224-5p, hsa-let-7i-3p, hsa-miR-652-3p

781
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.11
94.13
73.33

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-140-3p

782
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
90.11
92.7
73.33

744-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-miR-140-3p

783
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.33
95.4
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-188-5p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

784
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.33
93.02
78.33

744-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p

785
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.33
94.37
81.67

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-miR-652-3p

786
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.22
92.94
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

787
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.22
95.71
86.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-

3p

788
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.22
93.97
86.67

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p,

hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-

224-5p, hsa-miR-652-3p

789
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
89.22
95.71
85.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

790
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.22
94.37
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-miR-652-3p

791
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-195-5p, hsa-miR-
89.22
93.49
76.67

12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-

140-3p

792
hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-
89.22
91.59
73.33

10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-181c-5p, hsa-

miR-4306, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-miR-652-3p, hsa-miR-140-3p

793
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
89.22
92.3
73.33

195-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-1296-

5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-

miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p

794
hsa-miR-22-5p, hsa-miR-485-3p, hsa-miR-12136, hsa-miR-34a-
89.22
91.9
76.67

3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-

3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140-3p

795
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
89.22
95.79
85.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

796
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.22
92.78
86.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p

797
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
89.22
96.51
81.67

339-3p, hsa-miR-744-5p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-652-3p, hsa-miR-140-3p

798
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
93.65
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p

799
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-744-5p, hsa-miR-
89.11
94.84
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-

miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p

800
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
89.11
91.98
73.33

195-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-1296-5p, hsa-miR-15a-

5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

801
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-10b-5p, hsa-miR-
89.11
94.6
73.33

12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-

miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-

5p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p

802
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-195-5p, hsa-miR-
89.11
92.14
70.00

10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-

140-3p

803
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
94.05
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

804
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
94.05
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

805
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
89.11
96.11
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-652-3p, hsa-miR-140-3p

806
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
89.11
89.76
73.33

195-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-

5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa-miR-

652-3p, hsa-miR-140-3p

807
hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-485-3p, hsa-miR-
89.11
95.63
73.33

10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-1296-5p,

hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-

224-5p, hsa-miR-652-3p, hsa-miR-140-3p

808
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
93.25
76.67

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p,

hsa-miR-652-3p

809
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
89.11
92.54
78.33

339-3p, hsa-miR-744-5p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-140-3p

810
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
89.11
97.3
78.33

339-3p, hsa-miR-744-5p, hsa-miR-485-3p, hsa-miR-10b-5p,

hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140-3p

811
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
94.05
81.67

485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-224-5p, hsa-miR-652-3p

812
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
89.11
95.00
81.67

12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

813
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
93.97
81.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140-

3p

814
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
89.11
92.46
78.33

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p,

hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-

224-5p, hsa-miR-652-3p

815
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
94.05
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

816
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
92.94
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

817
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
89.11
95.56
78.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

818
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
94.68
81.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-

3p

819
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
89.11
92.46
68.33

744-5p, hsa-miR-195-5p, hsa-miR-10b-5p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p,

hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-224-5p, hsa-miR-

652-3p, hsa-miR-140-3p

820
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
89.11
94.52
81.67

339-3p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-

5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

821
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
89.11
93.65
73.33

744-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-183-3p, hsa-miR-652-3p, hsa-miR-140-3p

822
hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-
89.11
94.05
76.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-

7i-3p, hsa-miR-652-3p, hsa-miR-140-3p

823
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.11
95.95
78.33

195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-

5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-

miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p,

hsa-miR-652-3p

824
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
89.00
96.59
80.00

195-5p, hsa-miR-485-3p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p,

hsa-miR-140-3p

825
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
89.00
93.57
70.00

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-miR-140-3p

826
hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-
89.00
92.06
76.67

10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-181c-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-

5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-

652-3p, hsa-miR-140-3p

827
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.22
93.33
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-224-5p, hsa-miR-652-3p

828
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR-
88.22
93.02
70.00

12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-miR-652-3p

829
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.22
95.08
81.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-miR-652-3p

830
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
88.11
95.24
85.00

10b-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-27a-3p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-miR-652-3p

831
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
93.57
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-224-5p, hsa-miR-652-3p

832
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
92.94
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

833
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
95.24
81.67

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

834
hsa-miR-22-5p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-
88.11
89.84
73.33

34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-181c-5p, hsa-

miR-27a-3p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-224-

5p, hsa-let-7i-3p, hsa-miR-140-3p

835
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
95.56
81.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p

836
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
97.06
80.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-let-7i-3p, hsa-miR-652-3p

837
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR-
88.11
93.49
76.67

12136, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-

miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-

5p, hsa-miR-652-3p

838
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
88.11
95.79
81.67

339-3p, hsa-miR-744-5p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-4306, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-miR-652-3p, hsa-miR-140-

3p

839
hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
93.81
86.67

485-3p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-

miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-

5p, hsa-miR-652-3p, hsa-miR-140-3p

840
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
88.11
92.78
80.00

744-5p, hsa-miR-195-5p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-4306, hsa-miR-134-

5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-

miR-224-5p, hsa-miR-652-3p

841
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
93.73
70.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p,

hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-

3p, hsa-miR-140-3p

842
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR-
88.11
96.03
81.67

12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

843
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
92.78
76.67

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

844
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
92.94
81.67

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p

845
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
92.86
78.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p

846
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.11
92.38
78.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-183-3p, hsa-miR-224-5p

847
hsa-miR-22-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-
88.00
92.78
73.33

3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-181c-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-

5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-

140-3p

848
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
88.00
94.29
81.67

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p

849
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
88.00
93.97
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-27a-

3p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-652-3p, hsa-miR-140-3p

850
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.00
95.48
76.67

195-5p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p, hsa-miR-140-3p

851
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
88.00
92.7
81.67

12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

224-5p, hsa-let-7i-3p, hsa-miR-652-3p

852
hsa-miR-22-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-
88.00
91.35
76.67

3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-181c-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-

5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p

853
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
88.00
93.81
81.67

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p

854
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
88.00
93.65
85.00

10b-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-224-5p, hsa-miR-652-3p

855
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.00
94.29
78.33

485-3p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

856
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
88.00
94.68
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-

miR-652-3p

857
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
88.00
93.73
70.00

195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-

181c-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-miR-140-3p

858
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.00
94.13
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-let-7i-3p, hsa-miR-652-3p

859
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
88.00
93.25
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-let-7i-3p

860
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.89
93.57
76.67

485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

861
hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-
87.89
92.22
76.67

10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-181c-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-

5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-140-3p

862
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
87.89
94.68
78.33

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140-3p

863
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.89
93.25
73.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140-3p

864
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-744-5p, hsa-miR-
87.89
94.6
73.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-

15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-140-3p

865
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
87.89
95.63
81.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-4306, hsa-miR-134-

5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-

miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140-3p

866
hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-
87.11
93.33
78.33

12136, hsa-miR-188-5p, hsa-miR-134-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-

652-3p

867
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.11
95.24
76.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p

868
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
87.11
89.37
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-1296-

5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-

miR-652-3p

869
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.11
91.9
76.67

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

870
hsa-miR-1307-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-
87.11
90.87
75.00

337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-

miR-1296-5p, hsa-miR-15a-5p, hsa-miR-183-3p, hsa-miR-224-

5p

871
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.11
93.17
76.67

10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p,

hsa-miR-652-3p

872
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.11
92.62
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

873
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.00
94.13
81.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p

874
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-744-5p, hsa-miR-
87.00
93.49
78.33

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

875
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.00
92.7
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-

miR-100-5p, hsa-miR-224-5p

876
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
87.00
92.94
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-27a-

3p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-

miR-652-3p

877
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
87.00
90.95
85.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa-miR-652-3p

878
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.00
93.81
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-

3p

879
hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-
87.00
93.97
76.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-

183-3p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p

880
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
87.00
93.49
70.00

10b-5p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-

miR-4306, hsa-miR-27a-3p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-

652-3p, hsa-miR-140-3p

881
hsa-miR-22-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-
87.00
93.97
78.33

12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-181c-5p, hsa-miR-4306, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

882
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
87.00
95.16
85.00

10b-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-27a-3p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

883
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
87.00
93.65
73.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-let-7i-3p

884
hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-
87.00
93.41
81.67

12136, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-134-5p,

hsa-miR-629-5p, hsa-miR-224-5p, hsa-miR-652-3p

885
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
87.00
93.81
73.33

744-5p, hsa-miR-195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR-

4306, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-

miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p

886
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
87.00
93.41
85.00

10b-5p, hsa-miR-12136, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-4306, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-

224-5p, hsa-let-7i-3p

887
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
87.00
91.43
76.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-miR-652-3p

888
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
87.00
90.87
75.00

744-5p, hsa-miR-10b-5p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p,

hsa-miR-1296-5p, hsa-miR-183-3p, hsa-miR-652-3p

889
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-195-5p, hsa-miR-
87.00
93.65
70.00

10b-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-181c-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

890
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
87.00
94.21
70.00

744-5p, hsa-miR-195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR-

4306, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-

miR-100-5p, hsa-miR-652-3p, hsa-miR-140-3p

891
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
93.17
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-188-5p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-652-3p

892
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
93.1
78.33

485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-

miR-652-3p

893
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
86.89
93.81
85.00

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-4306, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-100-5p, hsa-miR-652-3p

894
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
86.89
94.13
85.00

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR-

4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-

miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140-

3p

895
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
93.1
78.33

485-3p, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

896
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
93.57
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-miR-652-3p

897
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
86.89
95.24
73.33

339-3p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-

5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140-3p

898
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
93.1
78.33

485-3p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-224-5p, hsa-miR-652-3p

899
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
93.1
78.33

485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

900
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
92.3
73.33

485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-

652-3p

901
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
92.46
81.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-let-7i-3p

902
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
86.89
93.73
75.00

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-miR-652-3p

903
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
86.89
90.24
78.33

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

904
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
89.05
76.67

195-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-

5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-

miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-

5p

905
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
96.11
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-224-5p,

hsa-miR-652-3p

906
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
94.29
76.67

195-5p, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

907
hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
86.89
92.38
68.33

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-4306, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-224-5p, hsa-miR-652-3p

908
hsa-miR-22-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-
86.89
93.73
66.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-

140-3p

909
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
86.89
91.51
76.67

34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-

miR-181c-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-

miR-224-5p, hsa-let-7i-3p, hsa-miR-140-3p

910
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.89
93.02
76.67

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

911
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
86.78
93.49
76.67

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p,

hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-

224-5p, hsa-miR-652-3p, hsa-miR-140-3p

912
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
86.00
93.33
85.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

913
hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.00
91.03
63.33

744-5p, hsa-miR-195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-

5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-224-5p, hsa-

miR-652-3p, hsa-miR-140-3p

914
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
86.00
90.4
66.67

744-5p, hsa-miR-195-5p, hsa-miR-10b-5p, hsa-let-7d-3p, hsa-

miR-181c-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR-15a-

5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

915
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.00
94.29
71.67

34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

916
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
86.00
91.83
73.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p

917
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
86.00
92.54
71.67

339-3p, hsa-miR-12136, hsa-let-7d-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-

5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-

miR-652-3p, hsa-miR-140-3p

918
hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-
86.00
91.67
75.00

12136, hsa-miR-188-5p, hsa-miR-134-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

919
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-
85.89
92.14
81.67

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-652-3p

920
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.89
94.84
81.67

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p

921
hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
85.89
91.35
73.33

195-5p, hsa-miR-10b-5p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-

miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-134-5p,

hsa-miR-1296-5p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-

140-3p

922
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.89
93.81
70.00

744-5p, hsa-miR-485-3p, hsa-miR-10b-5p, hsa-miR-12136,

hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-652-3p

923
hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-
85.89
92.7
63.33

10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-181c-5p, hsa-

miR-4306, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140-3p

924
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
85.89
93.89
78.33

339-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-140-3p

925
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.89
93.25
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

926
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.89
97.7
80.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p,

hsa-miR-100-5p, hsa-miR-652-3p

927
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
85.89
90.00
76.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-miR-652-3p

928
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
85.89
93.17
85.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p

929
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
85.89
95.00
80.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p,

hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

930
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
85.89
91.98
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-miR-652-3p

931
hsa-miR-22-5p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-
85.89
94.52
65.00

188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-

miR-15a-5p, hsa-miR-629-5p, hsa-miR-183-3p, hsa-miR-652-

3p, hsa-miR-140-3p

932
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
85.78
94.29
73.33

195-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-455-3p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-let-7i-3p, hsa-

miR-652-3p, hsa-miR-140-3p

933
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.78
94.05
71.67

485-3p, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-miR-652-3p

934
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
85.78
91.9
73.33

195-5p, hsa-miR-485-3p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-455-3p, hsa-miR-337-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-let-7i-3p, hsa-miR-140-3p

935
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-485-3p, hsa-miR-
85.78
91.19
68.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140-3p

936
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
85.78
91.43
76.67

12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-

652-3p

937
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.78
93.33
76.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

938
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.78
91.67
76.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p,

hsa-miR-224-5p, hsa-miR-652-3p

939
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
85.78
89.92
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-15a-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-652-3p

940
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.78
93.33
76.67

485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-

7i-3p, hsa-miR-652-3p

941
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-195-5p, hsa-miR-
85.78
92.94
68.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-652-3p, hsa-miR-140-3p

942
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
85.78
90.08
68.33

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-27a-3p,

hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-

140-3p

943
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.00
93.25
78.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-

miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p

944
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
85.00
93.89
73.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p,

hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-

3p, hsa-miR-652-3p

945
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR-
85.00
94.44
70.00

12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-188-5p, hsa-

miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-

miR-224-5p, hsa-miR-652-3p

946
hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-195-5p, hsa-miR-
84.89
87.22
66.67

12136, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-4306, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-183-3p, hsa-miR-140-3p

947
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR-
84.89
91.35
70.00

12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

629-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

948
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.78
93.49
68.33

12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-

miR-652-3p

949
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
84.78
92.38
75.00

10b-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p

950
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
84.78
90.87
85.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p

951
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
84.78
92.14
71.67

485-3p, hsa-miR-455-3p, hsa-miR-181c-5p, hsa-miR-4306, hsa-

miR-27a-3p, hsa-miR-134-5p, hsa-miR-1296-5p, hsa-miR-183-

3p, hsa-miR-224-5p

952
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.78
92.22
70.00

195-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-

miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-27a-

3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

953
hsa-miR-22-5p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
84.78
94.13
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa-

miR-652-3p

954
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-485-3p, hsa-miR-
84.78
90.4
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-652-3p

955
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
84.78
92.3
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p,

hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

956
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-10b-5p, hsa-miR-
84.78
92.46
81.67

12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-4306, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-652-3p

957
hsa-miR-1307-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-
84.78
88.57
73.33

134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-140-3p

958
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.78
90.71
68.33

10b-5p, hsa-miR-12136, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

183-3p, hsa-miR-224-5p, hsa-miR-652-3p

959
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
84.78
91.35
71.67

10b-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

629-5p, hsa-miR-224-5p, hsa-miR-652-3p

960
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-
84.78
91.83
68.33

744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p,

hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-337-5p, hsa-miR-

181c-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-1296-5p,

hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-140-3p

961
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
84.78
92.62
75.00

10b-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-27a-3p,

hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-

224-5p, hsa-let-7i-3p, hsa-miR-652-3p

962
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.78
91.35
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p

963
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
84.78
92.54
68.33

195-5p, hsa-miR-485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-

miR-337-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR-15a-5p,

hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-

652-3p, hsa-miR-140-3p

964
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.78
91.11
71.67

34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p,

hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-

183-3p, hsa-miR-224-5p, hsa-miR-652-3p

965
hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-
84.78
92.78
75.00

10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-

miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-1296-

5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-

miR-140-3p

966
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-485-3p, hsa-miR-
84.78
92.22
76.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-27a-3p, hsa-miR-15a-

5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p

967
hsa-miR-548a-3p, hsa-miR-339-3p, hsa-miR-744-5p, hsa-miR-
84.78
94.37
70.00

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-miR-455-3p,

hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-

1296-5p, hsa-miR-15a-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-224-5p, hsa-miR-652-3p, hsa-miR-140-3p

968
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.78
90.79
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-miR-652-3p

969
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
84.78
89.44
71.67

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140-3p

970
hsa-miR-22-5p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-
84.78
94.29
81.67

3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p,

hsa-miR-652-3p

971
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.78
91.27
68.33

12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-183-3p, hsa-miR-224-5p, hsa-miR-652-3p

972
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
84.78
92.06
68.33

339-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-4306, hsa-miR-27a-

3p, hsa-miR-1296-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-

miR-183-3p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-140-3p

973
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
84.78
91.59
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

974
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR-
84.67
91.51
78.33

12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

183-3p, hsa-miR-224-5p, hsa-miR-652-3p

975
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
84.67
96.11
75.00

339-3p, hsa-miR-744-5p, hsa-miR-485-3p, hsa-miR-10b-5p,

hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-

4306, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-15a-5p, hsa-

miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140-

3p

976
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
84.67
92.94
71.67

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-miR-652-3p, hsa-

miR-140-3p

977
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-10b-5p, hsa-miR-
84.67
92.46
68.33

12136, hsa-miR-34a-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-4306, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-183-3p, hsa-miR-652-3p, hsa-miR-140-3p

978
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
84.67
95.4
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

979
hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-195-5p, hsa-miR-
83.78
89.76
68.33

10b-5p, hsa-let-7d-3p, hsa-miR-181c-5p, hsa-miR-4306, hsa-

miR-1296-5p, hsa-miR-100-5p, hsa-miR-652-3p, hsa-miR-140-

3p

980
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-miR-
83.78
90.16
71.67

455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p,

hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-

183-3p, hsa-miR-224-5p, hsa-miR-652-3p

981
hsa-miR-1307-5p, hsa-miR-744-5p, hsa-miR-10b-5p, hsa-miR-
83.78
88.97
76.67

34a-3p, hsa-let-7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-

miR-188-5p, hsa-miR-4306, hsa-miR-134-5p, hsa-miR-1296-5p,

hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-

652-3p

982
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-485-3p, hsa-miR-
83.67
87.14
73.33

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-652-3p

983
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
83.67
90.63
78.33

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

15a-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa-

miR-652-3p

984
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
83.67
90.16
70.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-100-5p,

hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

985
hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
83.56
88.49
73.33

485-3p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-

miR-181c-5p, hsa-miR-27a-3p, hsa-miR-1296-5p, hsa-miR-15a-

5p, hsa-miR-100-5p, hsa-let-7i-3p, hsa-miR-652-3p, hsa-miR-

140-3p

986
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-10b-5p, hsa-let-
83.56
88.89
70.00

7d-3p, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-

miR-181c-5p, hsa-miR-27a-3p, hsa-miR-629-5p, hsa-miR-183-

3p, hsa-let-7i-3p

987
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
83.56
90.87
70.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

988
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
83.56
91.43
75.00

10b-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

629-5p, hsa-miR-100-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

989
hsa-miR-22-5p, hsa-miR-1307-5p, hsa-miR-744-5p, hsa-miR-
83.44
86.83
68.33

10b-5p, hsa-miR-34a-3p, hsa-miR-188-5p, hsa-miR-4306, hsa-

miR-134-5p, hsa-miR-15a-5p, hsa-miR-629-5p, hsa-miR-224-

5p, hsa-let-7i-3p, hsa-miR-140-3p

990
hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
82.67
86.03
61.67

12136, hsa-miR-455-3p, hsa-miR-337-5p, hsa-miR-188-5p,

hsa-miR-181c-5p, hsa-miR-27a-3p, hsa-let-7i-3p, hsa-miR-652-

3p, hsa-miR-140-3p

991
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-195-5p, hsa-miR-
82.56
91.35
65.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-4306, hsa-miR-15a-5p, hsa-miR-629-

5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-652-3p

992
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
82.56
87.86
66.67

195-5p, hsa-miR-10b-5p, hsa-miR-34a-3p, hsa-let-7d-3p, hsa-

miR-337-5p, hsa-miR-181c-5p, hsa-miR-4306, hsa-miR-1296-

5p, hsa-miR-652-3p, hsa-miR-140-3p

993
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-
82.56
92.14
68.33

744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-10b-5p,

hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p, hsa-miR-

4306, hsa-miR-27a-3p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-

let-7i-3p, hsa-miR-652-3p, hsa-miR-140-3p

994
hsa-miR-1307-5p, hsa-miR-485-3p, hsa-miR-12136, hsa-miR-
82.56
90.48
75.00

455-3p, hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-134-5p,

hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-

3p

995
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
82.56
90.4
71.67

10b-5p, hsa-miR-12136, hsa-miR-455-3p, hsa-miR-337-5p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-134-5p, hsa-miR-

629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-miR-652-3p

996
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
82.56
89.05
65.00

10b-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-27a-3p,

hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-100-5p, hsa-miR-

224-5p, hsa-miR-652-3p

997
hsa-miR-22-5p, hsa-miR-548a-3p, hsa-miR-744-5p, hsa-miR-
82.44
92.14
65.00

485-3p, hsa-miR-10b-5p, hsa-miR-12136, hsa-miR-34a-3p,

hsa-miR-337-5p, hsa-miR-4306, hsa-miR-1296-5p, hsa-miR-

15a-5p, hsa-miR-100-5p, hsa-miR-183-3p, hsa-miR-140-3p

998
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
82.44
90.4
70.00

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-

134-5p, hsa-miR-629-5p, hsa-miR-224-5p, hsa-let-7i-3p, hsa-

miR-652-3p

999
hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-485-3p, hsa-miR-
81.33
91.43
71.67

10b-5p, hsa-miR-12136, hsa-miR-34a-3p, hsa-miR-455-3p,

hsa-miR-337-5p, hsa-miR-188-5p, hsa-miR-181c-5p, hsa-miR-

27a-3p, hsa-miR-134-5p, hsa-miR-629-5p, hsa-miR-224-5p,

hsa-let-7i-3p, hsa-miR-652-3p

1000
hsa-miR-1307-5p, hsa-miR-12136, hsa-miR-188-5p, hsa-miR-
80.56
86.43
70.00

27a-3p, hsa-miR-1296-5p, hsa-miR-629-5p, hsa-miR-100-5p

1001
hsa-miR-548a-3p, hsa-miR-1307-5p, hsa-miR-339-3p, hsa-miR-
76.00
80.95
51.67

744-5p, hsa-miR-195-5p, hsa-miR-485-3p, hsa-miR-34a-3p,

hsa-miR-188-5p, hsa-miR-27a-3p, hsa-miR-1296-5p, hsa-let-7i-

3p

1002
combination 710 + rs28544423
80.23
79.59
70.53

1003
combination 712 + rs28544423
80.35
83.95
73.96

1004
combination 713 + rs28544423
80.29
85.44
82.76

1005
combination 714 + rs28544423
81.46
86.51
83.77

1006
combination 715 + rs28544423
84.68
87.85
88.02

1007
combination 718 + rs71384446
89.12
91.13
91.93

1008
combination 719 + rs28544423
91.29
94.21
89.92

1009
combination 724 + rs11647727
89.12
92.92
92.43

1010
combination 725 + rs11647727
89.18
94.91
92.12

1011
combination 726 + rs28544423
90.18
93.13
92.71

1012
combination 727 + rs7193058
86.96
93.13
92.46

1013
combination 728 + rs13333226
86.96
92.92
93.04

1014
combination 729 + rs4297685
88.01
94.72
92.43

1015
combination 730 + rs11647727
88.01
94.41
92.37

1016
combination 737 + rs11862974
88.01
94.26
92.98

1017
combination 738 + rs28544423
91.35
96.21
92.06

1018
combination 711 + rs4293393
72.63
73.03
91.44

1019
combination 712 + rs4293393
80.35
83.95
95.14

1020
combination 713 + rs4293393
80.35
85.59
93.88

1021
combination 714 + rs4293393
82.46
86.72
94.49

1022
combination 715 + rs4293393
84.68
87.85
93.57

1023
combination 718 + rs4293393
88.07
94.1
94.1

1024
combination 719 + rs4293393
87.95
94.21
94.21

1025
combination 725 + rs4293393
90.18
93.13
92.52

1026
combination 726 + rs4293393
89.06
93.13
92.71

1027
combination 727 + rs4293393
89.06
93.13
92.46

1028
combination 728 + rs4293393
86.96
93.74
93.24

1029
combination 729 + rs4293393
89.12
94.36
92.63

1030
combination 737 + rs4293393
89.18
96.56
92.72

This is the list of the best 30 mRNAs selected by the algorithm sorted by importance for tumour grade: hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p, hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3, hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548 am-5p, hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour grade. (Table 18).

TABLE 18

Combinations that allow higher sensitivity, specificity,

accuracy and predictive power for tumour grade.

N
Combinations
Accuracy
ROC AUC
Recall

1031
hsa-miR-33a-5p
73.57
60.35
60.00

1032
hsa-miR-33a-5p, hsa-miR-125a-5p
73.57
77.19
75.10

1033
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p
73.51
73.95
70.0

1034
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
82.4
88.59
80.52

hsa-miR-744-5p

1035
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
81.29
85.55
79.5

hsa-miR-744-5p, hsa-miR-125b-5p

1036
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
81.35
88.35
82.3

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1037
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
82.4
92.5
85.5

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p

1038
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
82.4
91.92
84.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p

1039
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
84.62
90.74
88.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p

1040
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
85.67
88.27
86.5

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p

1041
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
86.73
94.14
87.31

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p

1042
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
86.73
91.09
86.5

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p

1043
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.89
94.39
88.9

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p

1044
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.89
97.72
90.0

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p

1045
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.95
97.38
88.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p

1046
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.95
96.82
96.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p

1047
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
90.06
96.76
92.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p

1048
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.95
96.48
92.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p

1049
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.95
96.43
92.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p

1050
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
86.73
95.2
88.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p

1051
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
86.73
95.47
92.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p

1052
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
87.84
95.78
92.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p

1053
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
87.84
95.47
85.33

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p

1054
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.95
96.34
85.33

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p

1055
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
87.84
94.83
85.33

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p

1056
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
86.73
95.38
92.0

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p

1057
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
88.95
95.69
92.0

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p

1058
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
86.73
95.41
88.0

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p

1059
hsa-miR-33a-5p, hsa-miR-125a-5p, hsa-miR-424-3p,
87.89
95.82
96.67

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p, hsa-miR-545-5p, hsa-miR-134-5p,

hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p

1060
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
97.89
100.00
100.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1061
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
97.89
100.00
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1062
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
97.78
100.00
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1063
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
96.67
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1064
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.78
100.00
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1065
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
98.25
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1066
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
97.78
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1067
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
98.33
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1068
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
100.00
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1069
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
100.00
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1070
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
97.78
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1071
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
98.33
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1072
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.67
100.00
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1073
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
95.56
95.95
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p

1074
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.78
100.00
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-31-5p

1075
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
94.56
98.33
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1076
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
97.78
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1077
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1078
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
97.62
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-31-5p

1079
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
94.56
98.89
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1080
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
98.89
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1081
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
99.44
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1082
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1083
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
98.33
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1084
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.56
98.33
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1085
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.44
96.67
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1086
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
94.44
98.89
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1087
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
94.44
96.11
90.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1088
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
94.44
95.56
90.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1089
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.67
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1090
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.56
98.33
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1091
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.56
98.89
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1092
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.56
98.89
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-31-5p

1093
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
93.56
98.33
86.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1094
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
93.56
99.44
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1095
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.56
97.3
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1096
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
93.44
97.22
88.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1097
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.44
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1098
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.44
98.33
85.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1099
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
93.44
98.33
88.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p,

hsa-miR-31-5p

1100
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
93.44
98.33
88.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1101
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
93.44
99.44
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1102
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
93.44
97.06
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-31-5p

1103
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
93.44
98.89
86.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-31-5p

1104
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
93.44
97.22
80.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1105
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
93.33
96.11
86.67

hsa-miR-652-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1106
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
97.78
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-31-5p

1107
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
97.62
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p,

hsa-miR-31-5p

1108
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.44
98.33
81.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1109
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-128-3p, hsa-miR-31-5p

1110
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1111
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
100.00
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1112
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
98.33
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1113
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
97.78
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1114
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.44
98.33
88.33

hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p

1115
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
98.89
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1116
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
97.78
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p

1117
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.44
99.44
90.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1118
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.44
98.33
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-31-5p

1119
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
97.22
90.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1120
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
97.06
93.33

hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1121
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
98.33
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1122
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
97.3
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1123
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
96.51
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p

1124
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
92.33
95.63
90.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1125
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
92.33
98.33
93.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-31-5p

1126
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
98.89
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p

1127
hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
92.33
97.78
93.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p

1128
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
92.33
96.11
90.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1129
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
92.33
96.67
90.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p,

hsa-miR-31-5p

1130
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
96.67
88.33

hsa-miR-652-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1131
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
96.67
90.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1132
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
96.35
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p

1133
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
96.67
85.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1134
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
96.51
80.00

hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p

1135
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
92.33
97.78
85.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1136
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
96.75
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1137
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.33
98.17
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1138
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
97.22
85.00

hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1139
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
97.22
85.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1140
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
92.33
97.22
83.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1141
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.33
97.22
85.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1142
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
92.22
95.95
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1143
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
92.22
98.33
83.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1144
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.44
98.89
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1145
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-128-3p, hsa-miR-31-5p

1146
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
98.33
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p,

hsa-miR-31-5p

1147
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
98.89
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p,

hsa-miR-31-5p

1148
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
97.78
90.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1149
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
97.22
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-31-5p

1150
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
99.44
96.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1151
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
97.22
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1152
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
97.78
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-31-5p

1153
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
96.11
88.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1154
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
97.22
88.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1155
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
98.89
86.67

hsa-miR-103a-2-5p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-31-5p

1156
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
98.89
85.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p,

hsa-miR-31-5p

1157
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
96.35
85.00

hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1158
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
96.59
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1159
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
97.22
85.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-7-1-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1160
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
98.89
85.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1161
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
95.00
90.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p

1162
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
96.11
88.33

hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p

1163
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.33
97.22
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-31-5p

1164
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.33
98.89
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-31-5p

1165
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.22
98.33
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1166
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.22
98.17
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p

1167
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.22
95.24
93.33

hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-128-3p, hsa-miR-31-5p

1168
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
91.22
97.06
81.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1169
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
91.22
97.22
80.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1170
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
91.22
98.33
85.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1171
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
91.22
95.4
73.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-31-5p

1172
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.22
97.22
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p

1173
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
91.22
96.75
90.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p,

hsa-miR-31-5p

1174
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.22
97.06
91.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1175
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.22
97.78
88.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1176
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.22
95.95
86.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1177
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
91.22
96.51
76.67

hsa-miR-339-3p, hsa-miR-151a-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p

1178
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.11
97.22
86.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1179
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.11
95.08
83.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1180
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.11
94.68
78.33

hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-125b-5p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1181
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
91.11
96.11
93.33

hsa-miR-652-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p,

hsa-miR-31-5p

1182
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
91.11
95.24
76.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-31-5p

1183
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
91.11
95.79
76.67

hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1184
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.44
100.00
90.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1185
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.33
98.89
93.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1186
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.22
96.75
90.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1187
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.22
96.75
80.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1188
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p,
90.22
96.11
83.33

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1189
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
90.22
98.89
85.00

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p

1190
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.22
97.22
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p

1191
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.22
96.75
83.33

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1192
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
90.22
97.22
83.33

hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1193
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p,
90.22
95.00
90.00

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1194
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.22
97.78
85.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1195
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.22
96.03
93.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-21-3p,

hsa-miR-31-5p

1196
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.22
94.84
86.67

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1197
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
90.22
97.06
81.67

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-21-3p,

hsa-miR-31-5p

1198
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.22
99.44
85.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1199
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
90.11
97.78
73.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1200
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.11
96.19
86.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p

1201
hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
90.11
93.89
86.67

hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1202
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p,
90.11
88.89
85.00

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-21-3p

1203
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.11
95.56
86.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1204
hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
90.11
95.00
83.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1205
hsa-miR-545-5p, hsa-miR-222-3p, hsa-miR-151a-5p,
90.11
92.3
71.67

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p

1206
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
90.11
97.22
80.00

hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p

1207
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.11
98.89
85.00

hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-31-5p

1208
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.00
91.43
75.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-7-1-3p,

hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p

1209
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.00
95.08
80.00

hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-579-3p,

hsa-miR-144-3p, hsa-miR-502-3p, hsa-miR-21-3p,

hsa-miR-31-5p

1210
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
90.00
96.51
75.00

hsa-miR-652-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1211
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
90.00
92.7
75.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-629-5p

1212
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p,
90.00
96.51
80.00

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-31-5p

1213
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p,
89.22
95.00
86.67

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-31-5p

1214
hsa-miR-545-5p, hsa-miR-483-5p, hsa-miR-664a-3p,
89.22
96.67
81.67

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p

1215
hsa-miR-545-5p, hsa-miR-483-5p, hsa-miR-548am-5p,
89.11
96.51
86.67

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1216
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p,
89.11
96.11
86.67

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1217
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p,
89.11
92.7
75.00

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p,

hsa-miR-664a-3p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p

1218
hsa-miR-545-5p, hsa-miR-652-3p, hsa-miR-483-5p,
89.11
97.22
80.00

hsa-miR-548am-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p

1219
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
89.11
98.17
81.67

hsa-miR-103a-2-5p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p,

hsa-miR-31-5p

1220
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
89.11
96.19
81.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-501-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p

1221
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
89.11
97.22
80.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p

1222
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
89.11
95.95
80.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1223
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
89.11
95.79
81.67

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-31-5p

1224
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p,
89.11
93.25
83.33

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p

1225
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
89.11
96.75
86.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p,

hsa-miR-31-5p

1226
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
89.00
97.62
80.00

hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-483-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1227
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
89.00
98.17
85.00

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-31-5p

1228
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
89.00
96.67
70.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1229
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
89.00
95.4
76.67

hsa-miR-103a-2-5p, hsa-miR-339-3p, hsa-miR-7-1-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1230
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
89.00
97.22
90.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-222-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-21-3p, hsa-miR-31-5p

1231
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p,
89.00
88.17
78.33

hsa-miR-369-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-21-3p

1232
hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
89.00
95.63
83.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1233
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
89.00
97.22
78.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-31-5p

1234
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
88.89
97.22
80.00

hsa-miR-652-3p, hsa-miR-222-3p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-31-5p

1235
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p,
88.11
94.44
86.67

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1236
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
88.11
94.6
86.67

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1237
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
88.11
96.11
88.33

hsa-miR-652-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-31-5p

1238
hsa-miR-545-5p, hsa-miR-483-5p, hsa-miR-548am-5p,
88.11
96.11
81.67

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1239
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p,
88.00
96.19
75.00

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-424-5p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p

1240
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
88.00
93.41
81.67

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p

1241
hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-7-1-3p,
88.00
93.97
83.33

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-128-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1242
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p,
88.00
92.14
80.00

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p

1243
hsa-miR-545-5p, hsa-miR-652-3p, hsa-miR-483-5p,
88.00
97.22
80.00

hsa-miR-548am-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1244
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p,
88.00
95.4
71.67

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-31-5p

1245
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
88.00
95.56
80.00

hsa-miR-339-3p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-21-3p

1246
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
88.00
93.1
81.67

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p

1247
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
88.00
95.4
80.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p

1248
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p,
88.00
95.95
83.33

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1249
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
87.89
97.78
83.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-579-3p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1250
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p,
87.89
93.02
76.67

hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-31-5p

1251
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
87.89
95.79
85.00

hsa-miR-652-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-502-3p, hsa-miR-31-5p

1252
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
87.89
97.22
73.33

hsa-miR-483-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1253
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
87.89
95.24
70.00

hsa-miR-652-3p, hsa-miR-222-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p

1254
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
87.78
92.3
76.67

hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-151a-5p,

hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-miR-744-5p, hsa-miR-502-3p

1255
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-652-3p,
87.00
98.17
83.33

hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1256
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
86.89
94.84
80.00

hsa-miR-103a-2-5p, hsa-miR-369-3p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-21-3p

1257
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p,
86.89
95.00
71.67

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p

1258
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p,
86.89
94.13
76.67

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-31-5p

1259
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
86.89
94.68
88.33

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-31-5p

1260
hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-369-3p,
86.89
94.21
78.33

hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-629-5p, hsa-miR-128-3p, hsa-miR-31-5p

1261
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
86.89
96.75
78.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-579-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-125b-5p, hsa-miR-21-3p, hsa-miR-31-5p

1262
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
86.89
93.57
76.67

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p

1263
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
86.89
96.51
71.67

hsa-miR-339-3p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p

1264
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
86.89
95.56
80.00

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-483-5p,

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-21-3p, hsa-miR-31-5p

1265
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
86.89
96.9
80.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-31-5p

1266
hsa-miR-195-5p, hsa-miR-339-3p, hsa-miR-483-5p,
86.89
94.13
80.00

hsa-miR-222-3p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-31-5p

1267
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-339-3p,
86.89
95.56
75.00

hsa-miR-483-5p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-502-3p

1268
hsa-miR-195-5p, hsa-miR-339-3p, hsa-miR-483-5p,
86.89
93.65
80.00

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-21-3p

1269
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-7-1-3p,
86.89
95.08
73.33

hsa-miR-126-5p, hsa-miR-125b-5p, hsa-miR-502-3p,

hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p

1270
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
86.89
93.25
78.33

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p

1271
hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
86.78
95.24
71.67

hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p,

hsa-miR-128-3p

1272
hsa-miR-545-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
86.67
94.13
71.67

hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-126-5p,

hsa-miR-664a-3p, hsa-miR-501-5p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-744-5p

1273
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p,
86.67
91.75
71.67

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-501-5p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-629-5p, hsa-miR-31-5p

1274
hsa-miR-545-5p, hsa-miR-652-3p, hsa-miR-369-3p,
85.89
96.67
76.67

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-501-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-629-5p

1275
hsa-miR-195-5p, hsa-miR-339-3p, hsa-miR-483-5p,
85.78
89.44
73.33

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-125b-5p, hsa-miR-21-3p

1276
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
85.78
92.22
71.67

hsa-miR-339-3p, hsa-miR-222-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-125b-5p,

hsa-miR-21-3p, hsa-miR-31-5p

1277
hsa-miR-195-5p, hsa-miR-103a-2-5p, hsa-miR-652-3p,
85.78
94.05
75.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-125b-5p, hsa-miR-21-3p,

hsa-miR-31-5p

1278
hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,
85.78
89.68
76.67

hsa-miR-548am-5p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-21-3p, hsa-miR-31-5p

1279
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
85.78
96.67
80.00

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-579-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p,

hsa-miR-21-3p, hsa-miR-31-5p

1280
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
85.78
95.79
80.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-21-3p, hsa-miR-31-5p

1281
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-339-3p,
85.78
95.00
75.00

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-548am-5p,

hsa-miR-664a-3p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-502-3p

1282
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
85.78
93.1
75.00

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-151a-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p

1283
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
85.78
95.63
81.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-151a-5p,

hsa-miR-126-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p,

hsa-miR-31-5p

1284
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
85.78
93.25
75.00

hsa-miR-339-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p

1285
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-339-3p,
85.67
86.59
75.00

hsa-miR-7-1-3p, hsa-miR-222-3p, hsa-miR-151a-5p,

hsa-miR-579-3p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-502-3p, hsa-miR-128-3p

1286
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-103a-2-5p,
85.56
91.98
68.33

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p,

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-144-3p,

hsa-miR-629-5p

1287
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
85.56
95.63
76.67

hsa-miR-7-1-3p, hsa-miR-151a-5p, hsa-miR-126-5p,

hsa-miR-501-5p, hsa-miR-144-3p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1288
hsa-miR-339-3p, hsa-miR-7-1-3p, hsa-miR-548am-5p,
85.56
92.22
66.67

hsa-miR-579-3p, hsa-miR-501-5p, hsa-miR-424-5p,

hsa-let-7d-3p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-21-3p, hsa-miR-31-5p

1289
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
85.56
89.6
73.33

hsa-miR-369-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-let-7d-3p, hsa-miR-21-3p, hsa-miR-31-5p

1290
hsa-miR-545-5p, hsa-miR-151a-5p, hsa-miR-126-5p,
84.78
91.51
73.33

hsa-miR-501-5p, hsa-miR-424-5p, hsa-let-7d-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-629-5p,

hsa-miR-128-3p

1291
hsa-miR-134-5p, hsa-miR-103a-2-5p, hsa-miR-339-3p,
84.78
92.7
80.00

hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-222-3p,

hsa-miR-548am-5p, hsa-miR-126-5p, hsa-miR-664a-3p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-744-5p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-629-5p,

hsa-miR-128-3p, hsa-miR-21-3p, hsa-miR-31-5p

1292
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-483-5p,
84.67
88.41
66.67

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-151a-5p,

hsa-miR-664a-3p, hsa-miR-27b-3p, hsa-miR-744-5p,

hsa-miR-125b-5p

1293
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-103a-2-5p,
84.67
95.79
71.67

hsa-miR-652-3p, hsa-miR-369-3p, hsa-miR-483-5p,

hsa-miR-151a-5p, hsa-miR-579-3p, hsa-miR-664a-3p,

hsa-miR-27b-3p, hsa-miR-744-5p, hsa-miR-125b-5p,

hsa-miR-502-3p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-31-5p

1294
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p,
84.56
91.67
80.00

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-222-3p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-501-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-31-5p

1295
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
83.56
93.33
76.67

hsa-miR-103a-2-5p, hsa-miR-652-3p, hsa-miR-339-3p,

hsa-miR-7-1-3p, hsa-miR-126-5p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-502-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1296
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-339-3p,
83.56
90.32
68.33

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-548am-5p,

hsa-miR-126-5p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-744-5p, hsa-miR-125b-5p, hsa-miR-21-3p,

hsa-miR-31-5p

1297
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
83.44
90.63
81.67

hsa-miR-652-3p, hsa-miR-339-3p, hsa-miR-369-3p,

hsa-miR-7-1-3p, hsa-miR-483-5p, hsa-miR-151a-5p,

hsa-miR-579-3p, hsa-miR-664a-3p, hsa-miR-424-5p,

hsa-miR-128-3p, hsa-miR-31-5p

1298
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-652-3p,
83.44
83.65
78.33

hsa-miR-369-3p, hsa-miR-7-1-3p, hsa-miR-126-5p,

hsa-miR-144-3p, hsa-let-7d-3p, hsa-miR-27b-3p,

hsa-miR-125b-5p, hsa-miR-629-5p, hsa-miR-128-3p,

hsa-miR-21-3p, hsa-miR-31-5p

1299
hsa-miR-134-5p, hsa-miR-195-5p, hsa-miR-339-3p,
82.44
87.78
66.67

hsa-miR-483-5p, hsa-miR-222-3p, hsa-miR-126-5p,

hsa-miR-424-5p, hsa-miR-144-3p, hsa-let-7d-3p,

hsa-miR-125b-5p, hsa-miR-502-3p, hsa-miR-21-3p

1300
hsa-miR-545-5p, hsa-miR-134-5p, hsa-miR-195-5p,
82.33
88.1
61.67

hsa-miR-339-3p, hsa-miR-369-3p, hsa-miR-7-1-3p,

hsa-miR-222-3p, hsa-miR-501-5p, hsa-miR-144-3p,

hsa-let-7d-3p, hsa-miR-27b-3p, hsa-miR-21-3p,

hsa-miR-31-5p

1301
hsa-miR-545-5p, hsa-miR-369-3p, hsa-miR-483-5p,
82.33
91.35
75.00

hsa-miR-222-3p, hsa-miR-548am-5p, hsa-miR-126-5p,

hsa-miR-501-5p, hsa-miR-424-5p, hsa-miR-144-3p,

hsa-miR-27b-3p, hsa-miR-629-5p, hsa-miR-31-5p

1302
combination 1031 + rs11647727
74.68
59.34
75.65

1303
combination 1034 + rs11862974
82.46
90.46
74.46

1304
combination 1035 + rs4297685
81.35
88.02
85.85

1305
combination 10346 + rs4297685
82.46
88.88
87.82

1306
combination 1037 + rs4297685
85.73
91.06
89.18

1307
combination 1038 + rs4297685
85.73
90.75
89.06

1308
combination 1039 + rs11862974
85.79
92.77
92.51

1309
combination 1040 + rs76563024
86.78
92.5
91.06

1310
combination 1041 + rs76563024
87.95
95.69
93.0,

1311
combination 1044 + rs76563024
89.01
95.67
92.08

1312
combination 1045 + rs76563024
90.12
95.62
98.24

1313
combination 1046 + rs76563024
89.01
95.34
99.69

1314
combination 1047 + rs4297685
91.17
97.12
99.38

1315
combination 1049 + rs76563024
89.01
96.7
99.08

1316
combination 1050 + rs76563024
87.89
96.08
98.8

1317
combination 1051 + rs7204342
88.89
96
96.65

1318
combination 1052 + rs11647727
91.11
96.31
95.23

1319
combination 1054 + rsl2934455
89.01
95.74
95.53

1320
combination 1055 + rs9928757
89.01
95.19
95.5

1321
combination 1056 + rs76563024
90
96
92.51

1322
combination 1057 + rs28544423
90
95.72
91.06

1323
combination 1058 + rs34356953
90
94.8
93.0

1324
combination 1059 + rs28544423
88.95
96.05
92.08

1325
combination 1226 + rs11647727
89.00
90.32
92.51

1326
combination 1227 + rs11647727
89.00
90.63
91.06

1327
combination 1037 + rs4293393
82.46
91.67
93.0

1328
combination 1038 + rs4293393
83.51
91.64
92.08

1329
combination 1040 + rs4293393
84.68
92.26
98.24

1330
combination 1045 + rs4293393
90.18
99.08
99.69

1331
combination 1046 + rs4293393
93.45
97.69
99.38

1332
combination 1050 + rs4293393
91.23
98.18
99.08

1333
combination 1056 + rs4293393
92.28
97.34
95.23

List of the best 29 mRNAs selected by the algorithm sorted by importance for clinical metastasis: hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-129, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for clinical metastasis (Table 19).

TABLE 19

Combinations that allow higher sensitivity, specificity,

accuracy and predictive power for clinical metastasis.

N
Combinations
Accuracy
ROC AUC
Recall

1334
hsa-miR-3613-3p
92.34
58.01
70.0

1335
hsa-miR-3613-3p, hsa-miR-548l
92.34
73.27
70.0

1336
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k
92.34
82.65
80.0

1337
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
92.46
94.67
80.0

3p

1338
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
93.51
92.9
70.0

3p, hsa-miR-153-3p

1339
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
95.56
97.02
70.0

3p, hsa-miR-153-3p, hsa-miR-590-3p

1340
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
95.67
98.2
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p

1341
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
94.5
97.61
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290

1342
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
95.61
96.47
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p

1343
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
96.67
96.47
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1344
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
96.67
96.47
100.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484

1345
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
95.61
97.65
100.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p

1346
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
97.84
96.47
100.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p

1347
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
98.89
97.65
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p

1348
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
100.00
100.00
100.00

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p

1349
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
100.00
100.00
100.00

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p

1350
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
100.00
100.00
100.00

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p

1351
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
100.00
100.00
100.00

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p

1352
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
98.89
100.00
100.00

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p

1353
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
97.78
99.38
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p

1354
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
97.78
99.38
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p

1355
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
97.78
99.38
80.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age

1356
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
96.67
100.00
100.00

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p

1357
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
96.67
98.75
70.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-342-3p

1358
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
96.67
97.57
70.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p

1359
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
95.56
95.22
70.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-

3p

1360
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
95.56
97.57
70.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-

3p, hsa-miR-126-3p

1361
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
96.67
96.4
70.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-miR-150-5p

1362
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-548k, hsa-miR-377-
96.67
98.75
70.0

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p, hsa-miR-484, hsa-

miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p

1363
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p,

hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-590-3p

1364
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p

1365
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1366
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-455-3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290

1367
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382-

5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-582-5p, hsa-miR-1290

1368
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382-

5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290

1369
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p

1370
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1371
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
100.00
100.00
100.00

3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-126-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-

3p

1372
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-455-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532-

5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290,

hsa-let-7g-3p

1373
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-455-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532-

5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1374
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p

1375
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-455-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-

5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1376
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-

miR-410-3p

1377
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
100.00
100.00
100.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-

miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p

1378
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p

1379
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
100.00
100.00
100.00

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1380
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1381
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p

1382
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
100.00
100.00
100.00

3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-410-3p

1383
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
100.00
100.00
100.00

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1384
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382-

5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1385
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290, hsa-miR-410-3p

1386
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
100.00
100.00
100.00

hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p,

hsa-miR-1290, hsa-miR-410-3p

1387
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1-
100.00
100.00
100.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-

miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-590-3p

1388
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p

1389
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p,

hsa-miR-410-3p

1390
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p,

hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-590-3p

1391
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-

410-3p

1392
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p

1393
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1394
hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-
100.00
100.00
100.00

3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-582-5p, hsa-miR-410-3p

1395
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p

1396
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
100.00
100.00
100.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

582-5p, hsa-miR-1290, hsa-miR-410-3p

1397
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p,

hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-

miR-582-5p

1398
hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-
100.00
100.00
100.00

671-5p, age, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-

1290, hsa-miR-410-3p

1399
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-

miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-

5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p

1400
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
100.00
100.00
100.00

miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-582-5p, hsa-miR-1290

1401
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p,

hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1402
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
100.00
100.00
100.00

miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290

1403
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290

1404
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
100.00
100.00
100.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-

5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-

153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-

miR-410-3p

1405
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1406
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
100.00
100.00
100.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p

1407
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
100.00
100.00
100.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-

410-3p

1408
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
100.00
100.00
100.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-

3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-

590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1409
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290

1410
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290

1411
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
100.00
100.00
100.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-

3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-

590-3p, hsa-miR-582-5p, hsa-miR-1290

1412
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
100.00
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-410-3p

1413
hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-miR-
100.00
100.00
100.00

382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

582-5p, hsa-miR-1290

1414
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
100.00
100.00
100.00

miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1415
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR-7-1-
100.00
100.00
100.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-590-3p, hsa-miR-410-3p

1416
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
100.00
100.00
100.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-590-3p

1417
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
100.00
100.00
100.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-1290

1418
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
98.95
99.41
100.00

hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-

126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1419
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.95
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290

1420
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.95
100.00
90.00

590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-

3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1421
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.95
99.41
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1422
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.95
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1423
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.95
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-1290

1424
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.95
100.00
90.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1425
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.95
100.00
90.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290

1426
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.95
100.00
90.00

590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532-

5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1427
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-miR-7-1-
98.95
100.00
90.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-197-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-

3p

1428
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.95
100.00
100.00

590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-

miR-671-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-590-3p

1429
hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-
98.95
99.41
90.00

598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-

5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p

1430
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.95
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290

1431
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.95
100.00
90.00

590-5p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-

5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1432
hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-
98.95
100.00
100.00

3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-miR-532-5p,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-

3p, hsa-miR-582-5p, hsa-miR-410-3p, hsa-let-7g-3p

1433
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.95
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1434
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
100.00
90.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR-

197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1435
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
96.88
90.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p,

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-

3p

1436
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
98.13
90.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p,

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1437
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
99.38
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-

532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-410-3p

1438
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1-
98.89
99.38
90.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-

3p, hsa-miR-410-3p

1439
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
98.89
100.00
100.00

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-

3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1440
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.89
98.75
90.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1441
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.89
100.00
100.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1442
hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
98.89
98.75
90.00

7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-

5p, hsa-miR-1290

1443
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
100.00
90.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-let-7g-3p

1444
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
80.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1445
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
100.00
100.00

miR-455-3p, hsa-miR-382-5p, hsa-miR-532-5p, hsa-miR-197-

3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1446
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
100.00
100.00

miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-

410-3p

1447
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
98.89
100.00
90.00

7d-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-582-5p, hsa-miR-1290

1448
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1449
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
80.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1450
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let-7d-
98.89
99.38
90.00

3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-590-3p, hsa-miR-410-3p

1451
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
98.89
91.76
80.00

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-

410-3p, hsa-let-7g-3p

1452
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
98.89
100.00
90.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p

1453
hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-
98.89
100.00
90.00

455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-

miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-

5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-

582-5p

1454
hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-miR-
98.89
100.00
100.00

382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

582-5p, hsa-miR-1290, hsa-miR-410-3p

1455
hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-
98.89
98.82
100.00

671-5p, age, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-

3p

1456
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1-
98.89
99.38
90.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-

miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p

1457
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.89
100.00
90.00

590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-

miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

582-5p, hsa-miR-1290, hsa-miR-410-3p

1458
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290

1459
hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
98.89
98.75
90.00

7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p,

hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-

582-5p, hsa-miR-1290

1460
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
99.38
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1461
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
100.00

6803-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p,

hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p,

hsa-miR-1290

1462
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
98.89
100.00
100.00

miR-671-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

582-5p, hsa-miR-1290

1463
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
98.89
95.29
80.00

7d-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1464
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290

1465
hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-
98.89
98.13
90.00

miR-342-3p, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-582-5p

1466
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
100.00
100.00

miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1467
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
98.89
99.38
90.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-

miR-410-3p

1468
hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-
98.89
100.00
90.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-342-3p,

hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-

590-3p

1469
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
98.13
90.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p,

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p

1470
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let-7d-
98.89
97.65
80.00

3p, hsa-miR-7-1-3p, age, hsa-miR-342-3p, hsa-miR-126-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-410-3p

1471
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
98.89
99.38
100.00

3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-590-3p, hsa-miR-410-3p

1472
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
98.89
100.00
100.00

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p,

hsa-miR-1290, hsa-miR-410-3p

1473
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
98.89
100.00
80.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342-

3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-

5p, hsa-miR-1290

1474
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
99.38
90.00

miR-455-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-

153-3p, hsa-miR-582-5p, hsa-miR-1290

1475
hsa-miR-376c-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-
98.89
98.82
100.00

miR-382-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p

1476
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
97.65
80.00

545-5p, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p

1477
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
98.13
90.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p,

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-let-7g-3p

1478
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
98.89
100.00
100.00

3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-197-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-

3p, hsa-miR-590-3p, hsa-miR-410-3p

1479
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-

150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290

1480
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
100.00
90.00

miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-582-5p, hsa-miR-1290

1481
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
100.00
100.00

miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1482
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-miR-7-1-
98.89
100.00
100.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-590-3p

1483
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
97.5
90.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-

7g-3p

1484
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
99.38
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382-

5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-1290, hsa-miR-410-3p

1485
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
98.89
100.00
100.00

miR-671-5p, age, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-

126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1486
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1487
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
98.89
100.00
100.00

hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p,

hsa-miR-1290, hsa-miR-410-3p

1488
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
100.00
90.00

miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-

532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290

1489
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
98.89
100.00
90.00

miR-671-5p, age, hsa-miR-342-3p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290

1490
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
100.00
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-1290

1491
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
98.89
100.00
80.00

7d-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-

3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1492
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
98.89
100.00
100.00

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-

410-3p

1493
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
98.89
100.00
100.00

hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1494
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
98.89
100.00
90.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290, hsa-miR-410-3p

1495
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
98.89
98.75
90.00

6803-3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1496
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
98.89
98.75
90.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-

miR-410-3p

1497
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
98.89
98.75
90.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1498
hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
98.89
100.00
80.00

hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-410-3p

1499
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
98.82
80.00

miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-

532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-

3p

1500
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
98.89
96.88
90.00

miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-miR-342-3p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-

5p

1501
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let-7d-
98.89
100.00
100.00

3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-410-3p

1502
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
98.89
99.38
90.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1503
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-
97.89
99.41
90.00

miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, age, hsa-miR-

532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290,

hsa-miR-410-3p

1504
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-miR-7-1-
97.89
100.00
80.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-590-3p

1505
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
97.89
100.00
80.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-590-3p

1506
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
97.84
100.00
80.00

miR-590-5p, hsa-miR-455-3p, hsa-miR-671-5p, hsa-miR-382-

5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p,

hsa-miR-582-5p

1507
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.84
100.00
80.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-

miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-1290

1508
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.84
99.38
80.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-

miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

1290, hsa-miR-410-3p

1509
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
97.84
99.38
90.00

3p, hsa-miR-671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-3p

1510
hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671-
97.84
98.75
90.00

5p, age, hsa-miR-342-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-590-3p, hsa-miR-582-5p

1511
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
97.84
100.00
80.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p

1512
hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-
97.84
100.00
80.00

382-5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p,

hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-

582-5p, hsa-miR-410-3p

1513
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.84
100.00
80.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-

miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1514
hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-
97.84
96.25
80.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-

miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-1290

1515
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
97.84
100.00
80.00

miR-590-5p, hsa-miR-455-3p, hsa-miR-598-3p, hsa-miR-671-

5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p,

hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-

590-3p, hsa-miR-1290

1516
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
97.84
96.47
80.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p

1517
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
97.84
96.47
80.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-let-7g-3p

1518
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR-
97.84
98.82
70.00

598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1519
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
97.84
100.00
100.00

miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1520
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
97.84
100.00
100.00

miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-

197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1521
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.84
100.00
90.00

590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, age, hsa-miR-382-

5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-1290

1522
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
97.84
100.00
90.00

miR-455-3p, age, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1523
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.84
98.82
70.00

590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-

miR-671-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-

3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-

590-3p, hsa-let-7g-3p

1524
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
97.84
96.47
80.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p,

hsa-miR-410-3p, hsa-let-7g-3p

1525
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
96.95
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-1290, hsa-miR-410-3p

1526
hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-382-5p, hsa-miR-
97.78
98.75
100.00

197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p,

hsa-miR-410-3p

1527
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
97.57
70.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-

3p

1528
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
99.38
90.00

hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-miR-377-3p, hsa-miR-582-5p

1529
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
98.82
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-7-1-3p, age, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1530
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
98.13
70.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p,

hsa-miR-410-3p, hsa-let-7g-3p

1531
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
97.02
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-

let-7g-3p

1532
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-let-
97.78
98.13
90.00

7d-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa-miR-342-3p,

hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-

410-3p

1533
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
95.77
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p

1534
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
100.00
80.00

7d-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1535
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
98.82
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-7-1-3p, age, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1536
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
96.95
70.00

7d-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-

3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1537
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
98.75
90.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-410-3p

1538
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
93.97
70.00

6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p,

age, hsa-miR-532-5p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-590-3p

1539
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
98.75
90.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-590-3p, hsa-miR-410-3p

1540
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-
97.78
100.00
80.00

598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-1290

1541
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
97.78
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p

1542
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-590-
97.78
98.75
90.00

5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-

671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-590-3p

1543
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
97.78
99.38
70.00

3p, age, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-150-5p,

hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p

1544
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
97.78
100.00
100.00

hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-410-3p

1545
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
96.88
70.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-342-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-590-

3p, hsa-let-7g-3p

1546
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
97.57
70.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

342-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-590-3p

1547
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
99.38
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382-

5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-miR-410-3p

1548
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
97.78
98.75
70.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-410-3p

1549
hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
98.75
90.00

7d-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-let-7i-3p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-

5p, hsa-miR-1290

1550
hsa-miR-484, hsa-miR-7-1-3p, hsa-miR-598-3p, age, hsa-miR-
97.78
98.82
60.00

382-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-410-3p

1551
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
99.38
70.00

6803-3p, hsa-miR-455-3p, age, hsa-miR-342-3p, hsa-miR-197-

3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-582-5p, hsa-miR-1290

1552
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
91.69
70.00

7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p

1553
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
95.29
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-671-5p, age, hsa-miR-342-

3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1554
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
84.26
70.00

6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-382-

5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p

1555
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
99.38
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-miR-410-3p

1556
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
98.82
70.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-342-

3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-410-3p

1557
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
95.29
80.00

590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-

7g-3p

1558
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
91.69
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382-

5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1559
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-miR-7-1-
97.78
99.38
70.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p

1560
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
97.57
70.00

7d-3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p,

hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-

590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1561
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
97.57
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-671-5p,

age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-410-3p, hsa-let-7g-3p

1562
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-590-
97.78
98.75
70.00

5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-

671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p

1563
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
97.78
98.82
90.00

miR-455-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1564
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
97.78
98.75
90.00

hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-410-3p

1565
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-455-3p, hsa-let-
97.78
97.65
70.00

7d-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-miR-126-3p,

hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-

5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1566
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
99.38
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-miR-410-3p, hsa-let-7g-3p

1567
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
98.13
70.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p,

hsa-let-7g-3p

1568
hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-
97.78
98.13
90.00

miR-342-3p, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p

1569
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
100.00
70.00

6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1570
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
94.45
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1571
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
98.75
70.00

7d-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-

3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1572
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
89.96
70.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-

3p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1573
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
97.78
99.38
90.00

miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, age, hsa-miR-

342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290

1574
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
98.75
70.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-let-7g-3p

1575
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
90.92
70.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p,

hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-532-5p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-7g-3p

1576
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
98.13
90.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p

1577
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
97.78
98.75
90.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-590-3p,

hsa-miR-410-3p

1578
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-
97.78
90.37
70.00

miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-150-5p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-410-3p, hsa-let-7g-3p

1579
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
98.2
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1580
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
97.57
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1581
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-
97.78
94.12
80.00

7-1-3p, age, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-let-7g-3p

1582
hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-671-5p, age, hsa-
97.78
99.38
70.00

miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-

410-3p, hsa-let-7g-3p

1583
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
97.78
98.2
70.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1584
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
98.75
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1585
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
97.78
98.75
70.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-342-3p,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-

410-3p

1586
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
97.78
99.38
70.00

6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p,

hsa-miR-342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290

1587
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
98.13
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-miR-410-3p

1588
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
97.78
99.38
70.00

7d-3p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1589
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
97.78
100.00
90.00

miR-598-3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-

126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-

410-3p

1590
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
97.78
93.49
70.00

590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-

miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-miR-410-3p, hsa-let-7g-3p

1591
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
96.95
70.00

6803-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-miR-410-3p, hsa-let-7g-3p

1592
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-
97.78
92.32
70.00

miR-455-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-

197-3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-

3p

1593
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
97.78
92.32
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, age, hsa-miR-382-

5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-

miR-150-5p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1594
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
97.78
95.29
80.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-410-3p

1595
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.78
99.38
70.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-

miR-532-5p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p

1596
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.78
99.41
90.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-410-3p

1597
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
96.78
99.38
70.00

3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p,

hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-590-3p, hsa-miR-410-3p

1598
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.78
100.00
70.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-410-3p

1599
hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p,
96.73
97.57
100.00

hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-410-3p

1600
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
96.73
100.00
80.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-410-3p

1601
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
96.73
97.02
60.00

590-5p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-miR-410-3p

1602
hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.73
100.00
90.00

hsa-miR-598-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-410-3p

1603
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
96.73
98.2
60.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290

1604
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
96.73
99.38
100.00

3p, age, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-126-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-

3p

1605
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
96.73
97.5
60.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-1290, hsa-miR-410-3p

1606
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.73
99.38
60.00

6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1607
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-
96.73
100.00
60.00

598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-

5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1608
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.73
97.57
60.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290, hsa-let-7g-3p

1609
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
96.73
98.13
60.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-1290, hsa-miR-410-3p

1610
hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-342-3p, hsa-
96.73
96.99
70.00

miR-532-5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-

3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p

1611
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
96.73
97.02
60.00

590-5p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-1290, hsa-miR-410-3p

1612
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
96.73
95.29
60.00

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-

miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-

1290, hsa-let-7g-3p

1613
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.73
98.79
100.00

hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-410-3p

1614
hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-
96.73
97.54
90.00

342-3p, hsa-miR-126-3p, hsa-miR-377-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-410-3p

1615
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-6803-3p, hsa-miR-
96.73
92.32
70.00

455-3p, hsa-miR-671-5p, hsa-miR-382-5p, hsa-let-7i-3p, hsa-

miR-222-3p, hsa-miR-582-5p

1616
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
96.73
98.82
60.00

miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p

1617
hsa-miR-545-5p, hsa-miR-7-1-3p, hsa-miR-342-3p, hsa-miR-
96.73
92.87
90.00

532-5p, hsa-miR-126-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-582-5p, hsa-miR-1290

1618
hsa-miR-484, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.73
99.38
90.00

hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p,

hsa-miR-410-3p

1619
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
96.73
95.81
70.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-532-5p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-

7g-3p

1620
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-
96.73
91.91
80.00

3p, hsa-miR-598-3p, age, hsa-miR-342-3p, hsa-miR-150-5p,

hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-

410-3p

1621
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.73
95.7
60.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-1290,

hsa-miR-410-3p, hsa-let-7g-3p

1622
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.73
99.38
60.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-410-3p, hsa-let-7g-3p

1623
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
96.67
95.85
50.00

598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1624
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, age,
96.67
92.94
70.00

hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-

222-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p,

hsa-miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1625
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
96.67
98.13
70.00

6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-

miR-1290

1626
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-let-7d-
96.67
94.52
50.00

3p, hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p,

hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-

153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1627
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
96.67
98.2
80.00

miR-455-3p, hsa-let-7d-3p, hsa-miR-671-5p, hsa-miR-382-5p,

hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p,

hsa-miR-1290, hsa-miR-410-3p

1628
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
96.67
97.57
50.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-

miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-

410-3p

1629
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
96.67
97.57
50.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-

miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290

1630
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
96.67
88.79
70.00

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-

3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p, hsa-let-7g-3p

1631
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-7d-
96.67
97.65
70.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-532-5p, hsa-

miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-582-5p, hsa-miR-410-3p, hsa-let-7g-3p

1632
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
96.67
97.65
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-

5p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-let-7g-3p

1633
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
96.67
98.82
50.00

6803-3p, hsa-miR-590-5p, hsa-miR-7-1-3p, age, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-

let-7i-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290,

hsa-miR-410-3p

1634
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
96.67
95.7
70.00

7d-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p,

hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-

582-5p, hsa-miR-1290, hsa-miR-410-3p

1635
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-7-1-3p, hsa-miR-598-
96.67
96.47
40.00

3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-

3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1636
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
96.67
93.42
70.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-

miR-342-3p, hsa-miR-150-5p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-410-3p

1637
hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-let-7d-
96.67
92.87
50.00

3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-153-3p, hsa-miR-

590-3p, hsa-miR-582-5p, hsa-miR-410-3p, hsa-let-7g-3p

1638
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
96.67
97.65
60.00

590-5p, hsa-miR-7-1-3p, age, hsa-miR-342-3p, hsa-miR-197-

3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

222-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-1290

1639
hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p, age, hsa-
96.67
98.75
70.00

miR-382-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-582-5p

1640
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.67
98.75
50.00

545-5p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-

miR-598-3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-miR-

150-5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-

7g-3p

1641
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
96.67
95.63
70.00

6803-3p, hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p,

hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-

126-3p, hsa-miR-222-3p, hsa-miR-153-3p, hsa-miR-582-5p,

hsa-miR-1290, hsa-let-7g-3p

1642
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.67
98.13
70.00

590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-

miR-671-5p, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-150-

5p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-let-7g-3p

1643
hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-
96.67
97.57
60.00

3p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-

let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p

1644
hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.67
99.38
80.00

hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-

miR-222-3p, hsa-miR-377-3p

1645
hsa-miR-484, hsa-miR-545-5p, hsa-let-7d-3p, hsa-miR-7-1-3p,
96.67
97.57
80.00

hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-

miR-222-3p, hsa-miR-410-3p

1646
hsa-miR-484, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-
96.67
100.00
60.00

671-5p, age, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-

410-3p

1647
hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-
96.67
96.4
80.00

382-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-222-3p,

hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p

1648
hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa-
96.67
97.57
100.00

miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-

5p, hsa-miR-410-3p

1649
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.67
95.77
70.00

590-5p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p, age,

hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-590-3p, hsa-miR-410-3p, hsa-let-7g-3p

1650
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-
96.67
98.13
50.00

545-5p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p,

hsa-miR-598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-

miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p, hsa-let-

7g-3p

1651
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-
96.67
91.88
70.00

6803-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa-

miR-153-3p, hsa-miR-582-5p, hsa-let-7g-3p

1652
hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-
95.73
96.43
80.00

671-5p, age, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-126-

3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-

590-3p, hsa-miR-582-5p

1653
hsa-miR-376c-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-
95.67
98.24
70.00

miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p

1654
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
95.67
99.41
60.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-

miR-377-3p

1655
hsa-miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-
95.67
98.75
70.00

3p, hsa-miR-671-5p, age, hsa-miR-532-5p, hsa-miR-126-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-582-

5p, hsa-miR-410-3p

1656
hsa-miR-30e-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-
95.67
97.57
60.00

miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-410-3p

1657
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-
95.67
98.2
50.00

590-5p, hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p,

hsa-miR-382-5p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p

1658
hsa-miR-590-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-
95.67
94.6
50.00

671-5p, hsa-miR-532-5p, hsa-miR-197-3p, hsa-miR-150-5p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-

3p

1659
hsa-miR-484, hsa-miR-30e-3p, hsa-miR-590-5p, hsa-let-7d-3p,
95.67
95.7
50.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-

miR-532-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p,

hsa-miR-410-3p, hsa-let-7g-3p

1660
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR-7-1-
95.67
98.2
80.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-342-3p,

hsa-miR-197-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-410-3p

1661
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-590-5p, hsa-
95.61
98.13
50.00

miR-455-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-342-

3p, hsa-miR-197-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-

miR-377-3p, hsa-miR-153-3p, hsa-miR-410-3p

1662
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
95.61
97.57
40.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p, age,

hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-

410-3p

1663
hsa-miR-30e-3p, hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-
95.61
98.2
60.00

1-3p, age, hsa-miR-197-3p, hsa-let-7i-3p, hsa-miR-590-3p,

hsa-miR-582-5p, hsa-miR-1290, hsa-let-7g-3p

1664
hsa-miR-484, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-
95.61
87.32
50.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-382-5p, hsa-

miR-342-3p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222-

3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-let-

7g-3p

1665
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
95.61
96.29
90.00

miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p, hsa-miR-671-5p,

age, hsa-miR-342-3p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-

377-3p, hsa-miR-590-3p, hsa-miR-582-5p

1666
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-
95.61
94.45
50.00

miR-455-3p, hsa-let-7d-3p, age, hsa-miR-342-3p, hsa-miR-

532-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-

410-3p

1667
hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, age, hsa-miR-
95.61
95.74
80.00

382-5p, hsa-miR-532-5p, hsa-miR-126-3p, hsa-miR-222-3p,

hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p

1668
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-
95.61
95.85
60.00

miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-582-5p, hsa-

miR-1290, hsa-miR-410-3p

1669
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-598-3p, hsa-
95.61
99.41
50.00

miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-590-3p, hsa-

miR-1290

1670
hsa-miR-6803-3p, hsa-miR-590-5p, hsa-miR-598-3p, hsa-miR-
95.61
96.32
80.00

671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-let-7i-3p, hsa-

miR-377-3p, hsa-miR-1290, hsa-miR-410-3p

1671
hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
95.61
95.7
60.00

7d-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-126-

3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p, hsa-miR-

582-5p, hsa-miR-1290

1672
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-671-
95.61
95.29
50.00

5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-197-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-410-3p, hsa-let-7g-3p

1673
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
95.61
99.38
60.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p

1674
hsa-miR-376c-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-
95.61
95.77
60.00

671-5p, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-150-5p,

hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-let-7g-

3p

1675
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
95.61
100.00
40.00

miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p,

age, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-410-3p, hsa-

let-7g-3p

1676
hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-
95.61
98.75
60.00

382-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-3p,

hsa-miR-582-5p

1677
hsa-miR-6803-3p, hsa-miR-590-5p, hsa-let-7d-3p, hsa-miR-7-
95.61
89.89
50.00

1-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-222-3p, hsa-miR-377-3p,

hsa-miR-153-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-

410-3p, hsa-let-7g-3p

1678
hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-
95.61
98.13
60.00

miR-382-5p, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p

1679
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-590-5p, hsa-miR-7-1-
95.61
96.47
40.00

3p, age, hsa-miR-342-3p, hsa-miR-197-3p, hsa-miR-126-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-

3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1680
hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p,
95.61
97.57
80.00

age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-

miR-377-3p, hsa-miR-410-3p

1681
hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa-
95.56
97.57
90.00

miR-342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-

3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p

1682
hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671-
95.56
97.57
50.00

5p, hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-

590-3p, hsa-miR-582-5p

1683
hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-382-5p, hsa-miR-
95.56
97.57
90.00

342-3p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p

1684
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-let-7d-
95.56
97.5
40.00

3p, hsa-miR-598-3p, hsa-miR-671-5p, age, hsa-miR-382-5p,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-

3p, hsa-miR-590-3p, hsa-miR-410-3p

1685
hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-miR-382-5p, hsa-
95.56
96.95
60.00

miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-582-5p, hsa-miR-410-3p

1686
hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p,
95.56
93.9
40.00

age, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-

590-3p, hsa-miR-1290, hsa-miR-410-3p

1687
hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-
95.56
97.57
50.00

3p, hsa-miR-671-5p, age, hsa-miR-126-3p, hsa-let-7i-3p, hsa-

miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p

1688
hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-671-
94.62
98.82
60.00

5p, age, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-3p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-

5p, hsa-miR-410-3p

1689
hsa-miR-376c-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-
94.62
98.82
60.00

1-3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-532-5p,

hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-590-

3p, hsa-miR-582-5p

1690
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
94.56
95.22
30.00

598-3p, age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-

5p, hsa-miR-197-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-153-3p, hsa-miR-590-3p, hsa-miR-1290, hsa-miR-410-3p

1691
hsa-miR-545-5p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-
94.56
95.85
30.00

miR-382-5p, hsa-miR-197-3p, hsa-miR-126-3p, hsa-miR-222-

3p, hsa-miR-377-3p, hsa-miR-590-3p, hsa-miR-582-5p, hsa-

miR-410-3p

1692
hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-532-
94.56
90.96
80.00

5p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-582-5p, hsa-miR-410-3p

1693
hsa-miR-30e-3p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-
94.56
94.67
80.00

3p, hsa-miR-671-5p, age, hsa-miR-382-5p, hsa-miR-532-5p,

hsa-miR-126-3p, hsa-let-7i-3p, hsa-miR-590-3p, hsa-miR-582-

5p, hsa-let-7g-3p

1694
hsa-miR-484, hsa-miR-590-5p, hsa-miR-7-1-3p, hsa-miR-598-
94.56
95.77
40.00

3p, hsa-miR-671-5p, age, hsa-miR-342-3p, hsa-miR-197-3p,

hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-410-

3p

1695
hsa-miR-484, hsa-miR-545-5p, hsa-miR-590-5p, hsa-let-7d-3p,
94.5
96.95
20.00

hsa-miR-7-1-3p, hsa-miR-598-3p, hsa-miR-671-5p, hsa-miR-

126-3p, hsa-miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-

miR-410-3p, hsa-let-7g-3p

1696
hsa-miR-30e-3p, hsa-miR-455-3p, hsa-miR-7-1-3p, age, hsa-
94.5
96.43
50.00

miR-197-3p, hsa-miR-222-3p, hsa-miR-590-3p, hsa-miR-582-

5p, hsa-miR-410-3p, hsa-let-7g-3p

1697
hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-
94.5
93.42
40.00

3p, age, hsa-miR-382-5p, hsa-miR-126-3p, hsa-miR-222-3p,

hsa-miR-377-3p, hsa-miR-582-5p

1698
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-455-3p, age, hsa-
94.5
98.75
60.00

miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-miR-126-

3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-582-5p, hsa-miR-410-3p

1699
hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, age, hsa-miR-
94.5
96.32
80.00

382-5p, hsa-miR-342-3p, hsa-miR-126-3p, hsa-miR-222-3p,

hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p

1700
hsa-miR-484, hsa-miR-376c-3p, hsa-miR-6803-3p, hsa-miR-
94.5
97.57
60.00

590-5p, hsa-let-7d-3p, hsa-miR-598-3p, age, hsa-miR-382-5p,

hsa-miR-126-3p, hsa-miR-150-5p, hsa-miR-222-3p, hsa-miR-

377-3p, hsa-miR-153-3p, hsa-miR-1290, hsa-miR-410-3p

1701
hsa-miR-545-5p, hsa-miR-6803-3p, hsa-miR-455-3p, hsa-let-
94.5
91.99
70.00

7d-3p, hsa-miR-671-5p, hsa-miR-342-3p, hsa-miR-126-3p,

hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-582-5p

1702
hsa-miR-484, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-598-3p,
94.5
97.02
40.00

age, hsa-miR-382-5p, hsa-miR-342-3p, hsa-miR-532-5p, hsa-

miR-150-5p, hsa-let-7i-3p, hsa-miR-377-3p, hsa-miR-153-3p,

hsa-miR-590-3p

1703
hsa-miR-545-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-
94.44
96.4
50.00

3p, hsa-miR-382-5p, hsa-miR-222-3p, hsa-miR-377-3p, hsa-

miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p

1704
hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-382-5p, hsa-miR-
93.45
93.97
60.00

197-3p, hsa-miR-126-3p, hsa-miR-222-3p, hsa-miR-377-3p,

hsa-miR-590-3p, hsa-miR-582-5p, hsa-miR-410-3p

1705
hsa-miR-30e-3p, hsa-miR-376c-3p, hsa-miR-455-3p, hsa-miR-
93.45
96.4
20.00

7-1-3p, hsa-miR-598-3p, hsa-miR-197-3p, hsa-miR-126-3p,

hsa-let-7i-3p, hsa-miR-582-5p, hsa-miR-410-3p

1706
hsa-miR-376c-3p, hsa-miR-545-5p, hsa-miR-6803-3p, hsa-
93.33
97.57
50.00

miR-590-5p, hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-598-3p,

hsa-miR-671-5p, hsa-miR-126-3p, hsa-miR-150-5p, hsa-let-7i-

3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-1290, hsa-miR-

410-3p

1707
hsa-miR-455-3p, hsa-miR-7-1-3p, hsa-miR-197-3p, hsa-miR-
92.34
92.79
0.00

222-3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p

1708
hsa-miR-455-3p, hsa-let-7d-3p, hsa-miR-7-1-3p, hsa-miR-222-
92.34
92.79
0.00

3p, hsa-miR-377-3p, hsa-miR-582-5p, hsa-miR-410-3p

1709
combination 1337 + rs11647727
93.51
94.71
86.62

1710
combination 1338 + rs11647727
94.56
86.36
85.99

1711
combination 1339 + rs13329952
96.67
93.42
94.12

1712
combination 1340 + rs9928757
96.73
96.36
94.12

1713
combination 1341 + rs11647727
94.5
94.04
94.12

1714
combination 1344 + rs4297685
96.73
85.88
91.76

1715
combination 1345 + rs4297685
95.67
85.88
92.94

1716
combination 1353 + rs4293393
97.78
95.29
88.2

1717
combination 1354 + rs4293393
97.78
92.94
87.3

1718
combination 1356 + rs13335818
96.67
90.59
95.1

1719
combination 1359 + rs13335818
95.61
90.44
97.1

1720
combination 1360 + rs13335818
95.61
88.64
92.94

1721
combination 1681 + rs11647727
95.61
89.12
91.76

1722
combination 1682 + rs11647727
95.61
89.12
94.12

Example 3: Circulating Plasma miRNAs Profiling in the Prospective Multicentric Cohort

Then, the inventors repeat the same type of statistical analysis restricted to the prospective multicentric cohort only, consisting of 59 patients with a renal mass (either benign or malignant) and 51 controls.

The inventors found a set of 6 miRNAs that was significantly differentially expressed (p value <0.05) in plasma of patients with a renal mass (n=59) compared with controls (n=51). In addition, 12 miRNAs, even if did not reach statistical significance, showed a trend that could become significant by increasing the study cohort (0.05<p value <0.1)(Table 20).

TABLE 20

Differentially expressed miRNAs in patients with a renal mass

(n = 59) compared with controls (n = 51).

miRNA
FC*
p value

hsa-miR-423-5p
1.21
0.006

hsa-miR-378a-3p
1.22
0.02

hsa-miR-877-5p
1.32
0.03

hsa-miR-505-3p
1.18
0.03

hsa-miR-2110
1.31
0.03

hsa-miR-500a-3p
1.15
0.047

hsa-miR-4306
1.16
0.05

hsa-miR-499a-5p
1.36
0.05

hsa-miR-483-5p
1.31
0.06

hsa-miR-376c-3p
0.76
0.06

hsa-miR-361-5p
1.17
0.07

hsa-miR-494-3p
0.69
0.08

hsa-miR-28-3p
1.21
0.08

hsa-miR-377-3p
0.84
0.08

hsa-miR-154-3p
0.86
0.08

hsa-miR-320e
1.17
0.08

hsa-miR-331-3p
0.88
0.09

hsa-miR-30b-5p
0.90
0.09

*fold changes (>1 increased; <1 decreased expression in patients with a renal mass)

Then, the inventors investigated whether patients with a benign mass were associated with a specific miRNA signature that significantly differs from patients with a malignant lesion (RCC). The inventors observed 26 miRNAs significantly differentially expressed in patients with a benign mass (n=17) compared with RCC patients (n=42),In addition, 17 miRNAs showed a trend towards statistical significance (0.05<p value <0.1)(Table 21).

TABLE 21

Differentially expressed miRNAs in patients with a benign mass

(n = 17) compared with RCC patients (n = 42).

miRNA
FC
p value*

hsa-miR-337-5p
1.40
0.002

hsa-miR-550a-3-5p
1.85
0.003

hsa-miR-574-5p
1.71
0.01

hsa-miR-130b-5p
1.45
0.01

hsa-miR-132-3p
1.49
0.01

hsa-miR-103a-2-5p
1.18
0.01

hsa-miR-99a-3p
1.78
0.02

hsa-miR-1249-3p
1.35
0.02

hsa-miR-375-3p
1.43
0.02

hsa-miR-1290
1.45
0.02

hsa-miR-1180-3p
0.55
0.02

hsa-miR-29c-5p
0.81
0.03

hsa-miR-214-3p
1.38
0.03

hsa-miR-362-3p
1.27
0.03

hsa-miR-223-3p
0.82
0.03

hsa-miR-181a-5p
0.77
0.03

hsa-miR-205-5p
1.44
0.03

hsa-miR-582-5p
1.33
0.03

hsa-miR-196b-5p
1.46
0.03

hsa-miR-497-5p
1.14
0.04

hsa-miR-151a-3p
0.77
0.04

hsa-miR-361-3p
0.76
0.04

hsa-miR-450a-5p
1.43
0.04

hsa-miR-532-3p
1.28
0.04

hsa-miR-410-3p
1.49
0.047

hsa-miR-6803-3p
1.28
0.047

hsa-let-7d-5p
0.76
0.053

hsa-miR-1277-3p
1.38
0.053

hsa-miR-1260a
1.28
0.059

hsa-miR-96-5p
1.16
0.059

hsa-miR-31-5p
1.29
0.061

hsa-miR-942-5p
1.28
0.061

hsa-miR-1260b
1.21
0.074

hsa-miR-26a-5p
0.88
0.074

hsa-miR-30d-5p
0.88
0.074

hsa-miR-181c-5p
0.75
0.076

hsa-miR-7-l-3p
1.22
0.079

hsa-miR-590-3p
1.16
0.082

hsa-miR-590-5p
1.19
0.085

hsa-miR-421
1.22
0.088

hsa-miR-32-3p
1.31
0.091

hsa-miR-326
0.76
0.098

hsa-miR-3613-3p
0.79
0.098

*fold changes (>1 increased; <1 decreased expression in patients with a benign mass)

A panel of 11 miRNAs was found to be significantly differentially expressed between low grade RCC patients (n=31) and high grade cases (n=11), while 8 miRNAs showed a trend towards statistical significance (0.05<p value <0.1) (Table 22).

TABLE 22

Differentially expressed miRNAs (p value ≤ 0.05) in

low grade RCC patients (n = 31) compared with high

grade RCC patients (n = 11).

miRNA
FC*
p value

hsa-miR-103a-2-5p
1.23
0.03

hsa-miR-150-5p
0.61
0.03

hsa-miR-629-5p
1.38
0.03

hsa-miR-433-3p
1.89
0.04

hsa-miR-148a-3p
0.74
0.04

hsa-miR-29a-3p
0.72
0.04

hsa-miR-29b-3p
0.73
0.04

hsa-miR-29c-5p
0.76
0.04

hsa-let-7e-5p
1.17
0.0497

hsa-miR-27a-3p
0.76
0.0497

hsa-miR-342-3p
0.73
0.0497

hsa-miR-382-5p
2.17
0.060

hsa-miR-151a-3p
1.29
0.068

hsa-miR-10a-5p
0.73
0.087

hsa-miR-202-5p
0.79
0.087

hsa-miR-4306
1.32
0.087

hsa-miR-34a-5p
0.74
0.098

hsa-miR-369-3p
1.37
0.098

hsa-miR-584-5p
1.22
0.098

*fold changes (>1 increased; <1 decreased expression in high grade RCC patients)

Similarly, the inventors found that 7 miRNAs can significantly distinguish between low stage RCC patients (n=34) and high stage RCC patients (n=8), while 6 miRNAs showed a p value between 0.06 and 0.09, indicating a trend towards statistical significance (Table 23).

TABLE 23

Differentially expressed miRNAs in low stage RCC patients (n =

34) compared with high stage RCC patients (n = 8).

miRNA
FC
p value*

hsa-miR-324-3p
0.64
0.01

hsa-miR-215-5p
0.54
0.01

hsa-miR-769-5p
2.06
0.01

hsa-miR-598-3p
1.67
0.03

hsa-miR-320a-3p
1.32
0.04

hsa-miR-548a-3p
1.55
0.04

hsa-miR-190a-5p
0.70
0.04

hsa-miR-491-5p
1.34
0.06

hsa-miR-335-5p
0.83
0.07

hsa-miR-423-3p
1.32
0.09

hsa-miR-100-5p
0.60
0.09

hsa-miR-224-5p
0.61
0.09

hsa-miR-421
0.72
0.09

*fold changes (>1 increased; <1 decreased expression in high stage RCC patients)

No analysis regarding miRNAs' signatures related to metastatic outcome were performed in the prospectic multicentic phase because only one patient was affected by a metastatic process.

Similarly to the total study cohort analysis reported above, in addition to single biomarker analysis, the inventors identified unique sets of miRNAs (miRNA signatures) leading to a significant increase in sensitivity, specificity, accuracy and predictive power for screening, diagnosing and prognosing of RCC patients by using machine learning algorithms.

Again, the inventors investigated clinical parameters in association with miRNAs biomarkers, using the feature selection algorithm, and the variable age resulted predictive in association with some miRNAs in screening, and diagnosis. It is important to underline that the single variable age, using the same evaluation metric, performed significantly less than the presented combinations with an accuracy of 52.72%, recall of 38.33%, and ROC AUC of 57.82% for screening and an accuracy of 38.78%, recall of 62.5%, and ROC AUC of 56.64% for diagnosis.

This is the list of the best 29 mRNA selected by the algorithm sorted by importance for screening outcome: hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, and hsa-miR-494-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for screening (Table 24).

TABLE 24

Combinations that allow higher sensitivity, specificity,

accuracy and predictive power for screening.

N
Combinations
Accuracy
ROC AUC
Recall

1723
hsa-miR-378a-3p
60.61
64.57
86.8

1724
hsa-miR-378a-3p, hsa-miR-328-3p
59.7
62.72
80.71

1725
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p
69.74
69.33
81.66

1726
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age
68.83
75.54
85.14

1727
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
68.83
74.94
82.37

hsa-miR-361-5p

1728
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
70.69
75.89
84.15

hsa-miR-361-5p, hsa-miR-1260b

1729
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
72.55
81.78
79.84

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p

1730
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
75.24
82.96
81.5

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p

1731
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
74.37
83.15
83.28

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p

1732
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
78.92
85
83.28

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1733
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
79.87
85.67
79.84

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p

1734
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
77.14
86.35
81.58

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p

1735
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
74.24
86.59
81.66

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p

1736
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
79.83
87.87
79.80

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p

1737
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
82.64
88.87
82.45

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p

1738
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
81.65
88.35
79.76

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p

1739
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
77.92
88.43
80.67

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p

1740
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
81.65
90.81
77.94

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326

1741
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
81.65
90.31
78.02

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110

1742
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
82.6
92.35
78.02

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p

1743
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
81.69
91.35
81.54

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p

1744
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
80.82
89.56
80.67

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p

1745
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
80.65
89.8
81.54

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p

1746
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
78.92
90.35
80.63

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306

1747
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
79.74
90.67
82.37

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-423-3p

1748
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
80.69
90.67
80.59

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p

1749
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
81.65
91.17
81.5

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p

1750
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
82.6
91.48
81.5

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p

1751
hsa-miR-378a-3p, hsa-miR-328-3p, hsa-miR-28-3p, age,
83.46
91.07
80.63

hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p, hsa-miR-

550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-

202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-

5p, hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-128-3p

1752
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
85.41
91.3
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1753
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
85.41
89.93
90

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1754
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
85.41
89.8
90

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1755
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
85.32
89.94
86.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1756
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
84.5
89.78
88.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-532-3p, hsa-miR-

15b-3p

1757
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
84.46
89.76
86.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-532-3p, hsa-miR-15b-3p

1758
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
84.46
90.43
88.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1759
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
84.46
90.41
86.67

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

2110, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-miR-6803-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1760
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
84.46
86.39
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p

1761
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
84.46
90.61
86.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1762
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
84.42
88.52
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1763
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
84.42
86.15
86.67

hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-

miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-

miR-361-5p, hsa-miR-532-3p

1764
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
84.42
89.94
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-532-3p, hsa-miR-15b-3p

1765
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-423-5p,
84.42
91.78
83.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1766
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
84.37
93.67
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p, hsa-miR-7-5p

1767
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
84.37
93.31
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1768
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
83.59
86.39
86.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-494-3p, hsa-miR-1260b, hsa-miR-532-

3p, hsa-miR-15b-3p

1769
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
83.59
90.43
86.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1770
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
83.59
90.09
86.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1771
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
83.55
89.74
86.67

miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1772
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
83.55
90.91
85

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-15b-3p

1773
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
83.55
91.8
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age,

hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-

miR-15b-3p, hsa-miR-7-5p

1774
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
83.55
88.33
86.67

miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1775
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
83.55
90.3
88.33

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1776
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa-
83.55
91
86.67

miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1777
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
83.55
87.87
83.33

hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-15b-3p

1778
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
83.51
89.91
86.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1779
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
83.51
90.74
85

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

101-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1780
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
83.51
85.46
85

hsa-miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-

miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p

1781
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p,
82.68
84.63
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p, hsa-miR-15b-3p

1782
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
82.64
85.94
83.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p,

hsa-miR-532-3p, hsa-miR-15b-3p

1783
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
82.64
90.28
83.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1784
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
82.64
90.24
86.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

101-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1785
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
82.64
89.15
85

miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1786
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
82.64
88.43
83.33

hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-

miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age,

hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-

miR-15b-3p

1787
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
82.64
88.07
81.67

hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-

miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age,

hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p

1788
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p,
82.64
89.76
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1789
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
82.6
89.39
85

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

101-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p,

hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p,

age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p,

hsa-miR-15b-3p

1790
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
82.6
92.11
83.33

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p, hsa-miR-7-5p

1791
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
82.6
88.93
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-

18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1792
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
82.6
89.65
85

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-6803-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1793
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
82.51
92.37
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1794
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
82.51
92
80

hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1795
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-326, hsa-
81.73
83.63
83.33

miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-

15b-3p

1796
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
81.73
90.63
80

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p,

age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-532-3p,

hsa-miR-15b-3p

1797
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
81.73
92.13
83.33

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1798
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
81.73
88.72
80

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-323b-

3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-532-3p

1799
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
81.73
87.48
83.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-6803-3p, hsa-miR-323b-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1800
hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-
81.73
87.28
83.33

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1801
hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa-
81.73
87.04
83.33

miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1802
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
81.69
91.19
81.67

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423-

3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p,

age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p,

hsa-miR-15b-3p, hsa-miR-7-5p

1803
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
81.69
86.39
83.33

197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p,

age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p,

hsa-miR-15b-3p

1804
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
81.69
89.93
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-532-3p

1805
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
81.69
89.28
81.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1806
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
81.69
87.5
83.33

miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1807
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
81.69
89.22
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p

1808
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-197-3p,
81.69
85.89
85

hsa-miR-101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age,

hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p

1809
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
81.65
87.69
80

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age,

hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p

1810
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-197-3p,
81.65
86.17
86.67

hsa-miR-101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-

miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p, hsa-miR-15b-3p

1811
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
81.65
86.7
81.67

hsa-miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-

miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p

1812
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
81.65
92
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1813
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
81.65
90.15
83.33

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1814
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
81.65
88.15
83.33

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-323b-

3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1815
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-423-5p,
81.65
88.93
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1816
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
81.65
88.5
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-

3p, hsa-miR-15b-3p, hsa-miR-7-5p

1817
hsa-miR-181c-3p, hsa-miR-202-5p, hsa-miR-1301-3p,
81.6
86.13
81.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-323b-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1818
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
81.6
91.35
81.67

miR-197-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1819
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
81.6
88.22
81.67

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

128-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-7-5p

1820
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p,
80.87
83.78
80

hsa-miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p

1821
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
80.82
86.56
81.67

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1822
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
80.82
88.09
78.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

15b-3p

1823
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p,
80.82
85.43
83.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p,

hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-15b-3p

1824
hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-
80.78
87.11
81.67

miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1825
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
80.78
86
83.33

hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa-

miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p

1826
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa-
80.78
90.46
85

miR-197-3p, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1827
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
80.78
83.74
83.33

hsa-miR-1301-3p, hsa-miR-326, hsa-miR-197-3p, hsa-

miR-4306, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, age, hsa-miR-

361-5p, hsa-miR-1260b

1828
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
80.78
84.65
85

hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-4306, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-

miR-532-3p

1829
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
80.78
88.56
85

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1830
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
80.78
83.37
83.33

hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-

miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-

miR-361-5p, hsa-miR-15b-3p

1831
hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-
80.78
85.7
81.67

miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age,

hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-

miR-15b-3p

1832
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
80.78
88.24
81.67

4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b-

3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1833
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p,
80.78
83.46
86.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

4306, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-

3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-5p,

hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1834
hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
80.78
88.24
83.33

2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-323b-

3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1835
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
80.78
88.31
80

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

2110, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1836
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa-
80.78
87.76
78.33

miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1837
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
80.78
89.78
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1838
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
80.74
89.31
81.67

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-128-3p, age, hsa-

miR-361-5p, hsa-miR-1260b, hsa-miR-532-3p

1839
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
80.74
90.2
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-

3p, hsa-miR-7-5p

1840
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
80.74
88.13
83.33

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

2110, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-miR-6803-

3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-15b-3p, hsa-miR-7-5p

1841
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
80.74
88.89
81.67

hsa-miR-2110, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, age, hsa-

miR-361-5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1842
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
80.74
88.48
81.67

hsa-miR-423-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-15b-3p

1843
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
80.69
87.65
81.67

hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p

1844
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p,
80.69
91.22
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1845
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p,
80.69
89.85
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-130a-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1846
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p,
79.96
85.61
81.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p, hsa-miR-15b-3p

1847
hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa-
79.91
86.43
81.67

miR-326, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1848
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
79.91
88.56
81.67

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-532-3p

1849
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.91
84.81
85

hsa-miR-326, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1850
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
79.91
81.26
85

197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1851
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.91
87.04
80

hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

15b-3p

1852
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.91
83.74
86.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1853
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
79.91
85.61
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-532-3p,

hsa-miR-15b-3p

1854
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.91
86.44
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-532-

3p, hsa-miR-15b-3p

1855
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.91
88.44
81.67

hsa-miR-326, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-361-5p, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1856
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.91
86.59
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1857
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.91
86.7
80

hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-

6803-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1858
hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa-
79.91
86.06
80

miR-326, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1859
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-1301-3p,
79.87
85.91
86.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-128-3p, hsa-miR-

361-5p, hsa-miR-579-3p, hsa-miR-15b-3p

1860
hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-423-5p, hsa-
79.87
86.94
83.33

miR-1301-3p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p,

hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p,

hsa-miR-532-3p

1861
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p,
79.87
83.65
85

hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-4306, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1862
hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
79.87
86.3
78.33

miR-326, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1863
hsa-miR-202-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
79.87
85.65
80

miR-326, hsa-miR-2110, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-15b-3p

1864
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
79.87
84.72
81.67

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p

1865
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
79.87
89.59
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-

3p, hsa-miR-7-5p

1866
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79.87
85.56
81.67

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-

miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p

1867
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
79.83
89.17
81.67

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-

miR-197-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-6803-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1868
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa-
79.83
89.61
81.67

miR-197-3p, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1869
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-423-5p,
79.83
83.8
85

hsa-miR-1301-3p, hsa-miR-197-3p, hsa-miR-101-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, hsa-miR-361-5p, hsa-miR-532-3p

1870
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
79.83
87.94
80

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-6803-3p, hsa-miR-323b-3p, age, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-15b-3p

1871
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
79.83
89.2
81.67

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

2110, hsa-miR-197-3p, hsa-miR-6803-3p, hsa-miR-323b-

3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-15b-3p

1872
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
79.83
88.35
81.67

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-2110, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-15b-3p

1873
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p,
79.83
87.09
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p,

hsa-miR-15b-3p, hsa-miR-7-5p

1874
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
79.78
85.17
81.67

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-

miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p

1875
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
79.78
87.61
78.33

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR-

494-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1876
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
79
85.63
80

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p

1877
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa-
79
85.61
81.67

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, age, hsa-

miR-361-5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-

miR-15b-3p

1878
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
79
85.91
83.33

miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1879
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-197-3p,
79
83.2
81.67

hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-

miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-

miR-494-3p, hsa-miR-361-5p, hsa-miR-532-3p

1880
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
79
81.44
83.33

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p, hsa-miR-15b-3p

1881
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-18a-5p, hsa-miR-
79
86.81
80

423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1882
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
79
83.59
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-494-3p, hsa-miR-579-3p, hsa-miR-532-

3p, hsa-miR-15b-3p

1883
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
78.96
79.7
81.67

197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1884
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
78.96
86.78
80

hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p

1885
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
78.96
84.56
81.67

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-4306, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1886
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
78.96
87.15
78.33

hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-

18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

15b-3p

1887
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
78.96
86.39
81.67

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-4306, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-

miR-532-3p

1888
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
78.96
82.61
83.33

197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-

15b-3p

1889
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p,
78.92
84.81
80

hsa-miR-423-5p, hsa-miR-326, hsa-miR-4306, hsa-miR-

664a-3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-532-3p

1890
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
78.92
86.52
80

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-6803-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1891
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
78.87
86.83
80

hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-

miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p, age,

hsa-miR-579-3p, hsa-miR-532-3p

1892
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p,
78.87
84.19
81.67

hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-18a-5p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-

miR-6803-3p, hsa-miR-664a-3p, hsa-miR-128-3p, age,

hsa-miR-361-5p, hsa-miR-579-3p, hsa-miR-15b-3p,

hsa-miR-7-5p

1893
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
78.87
87.26
80

miR-197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-494-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p, hsa-miR-7-5p

1894
hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-202-5p, hsa-
78.79
87.35
76.67

miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-

197-3p, hsa-miR-101-3p, hsa-miR-664a-3p, hsa-miR-494-

3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-532-

3p, hsa-miR-15b-3p, hsa-miR-7-5p

1895
hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-
78.1
84.65
78.33

miR-197-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p

1896
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-326, hsa-
78.1
80.59
83.33

miR-197-3p, hsa-miR-4306, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p, hsa-miR-15b-3p

1897
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-29c-5p,
78.1
84.06
85

hsa-miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p,

hsa-miR-532-3p, hsa-miR-15b-3p

1898
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-29c-5p,
78.1
85.17
81.67

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-532-3p, hsa-miR-15b-3p

1899
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
78.1
86.63
76.67

423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1900
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p,
78.05
84.43
83.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p

1901
hsa-miR-550a-3-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-
78.05
87.48
81.67

miR-197-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, age, hsa-

miR-1260b, hsa-miR-579-3p, hsa-miR-532-3p

1902
hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-
78.01
84.5
78.33

miR-29c-5p, hsa-miR-326, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-323b-3p, hsa-miR-128-

3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-532-3p, hsa-miR-7-5p

1903
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-
78.01
81.85
81.67

miR-197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-361-5p, hsa-miR-15b-3p

1904
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
78.01
84.37
80

hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

361-5p, hsa-miR-532-3p

1905
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
78.01
84.56
80

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

361-5p, hsa-miR-532-3p

1906
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p,
78.01
79.31
83.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-130a-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-361-5p

1907
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
78.01
87.3
80

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-3p,

hsa-miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b,

hsa-miR-579-3p, hsa-miR-15b-3p

1908
hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
78.01
86.22
80

miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-miR-579-

3p, hsa-miR-532-3p, hsa-miR-15b-3p

1909
hsa-miR-30b-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
78.01
83.67
83.33

miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-3p,

hsa-miR-532-3p, hsa-miR-15b-3p

1910
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
77.97
85.43
81.67

hsa-miR-29c-5p, hsa-miR-197-3p, hsa-miR-101-3p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

532-3p

1911
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
77.97
86.59
76.67

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-

miR-197-3p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-128-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-15b-3p, hsa-miR-7-5p

1912
hsa-miR-30b-5p, hsa-miR-181c-3p, hsa-miR-423-5p, hsa-
77.97
83.8
78.33

miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-

197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-

3p, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-1260b,

hsa-miR-579-3p, hsa-miR-7-5p

1913
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p,
77.97
82.22
81.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-128-3p, hsa-miR-361-5p,

hsa-miR-532-3p

1914
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-326, hsa-
77.23
81.94
80

miR-101-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p

1915
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
77.14
80.06
81.67

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-323b-3p, hsa-miR-494-3p, hsa-miR-532-3p,

hsa-miR-15b-3p

1916
hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-326, hsa-miR-
77.14
87.83
80

18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1917
hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-
77.14
85.41
81.67

miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, age, hsa-miR-1260b, hsa-miR-579-3p, hsa-miR-

532-3p, hsa-miR-15b-3p

1918
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
77.14
83.43
78.33

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-128-3p, hsa-miR-361-5p,

hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1919
hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-
77.14
87.31
76.67

miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1920
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
77.14
85.54
81.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-

130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1921
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
77.14
87.11
75

hsa-miR-326, hsa-miR-18a-5p, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1922
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-29c-5p,
77.14
85.56
78.33

hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-4306, hsa-

miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-

miR-323b-3p, hsa-miR-494-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-532-3p

1923
hsa-miR-30b-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
77.1
84.44
80

miR-326, hsa-miR-18a-5p, hsa-miR-4306, hsa-miR-423-

3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-494-3p,

hsa-miR-361-5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-

miR-15b-3p, hsa-miR-7-5p

1924
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p,
77.1
83.65
78.33

hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-197-3p, hsa-

miR-664a-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1925
hsa-miR-30b-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
77.1
78.39
81.67

miR-326, hsa-miR-197-3p, hsa-miR-101-3p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b-

3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1926
hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-2110, hsa-
77.1
82.46
75

miR-130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, age, hsa-miR-1260b, hsa-

miR-579-3p, hsa-miR-15b-3p

1927
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-181c-3p,
77.06
89.8
78.33

hsa-miR-202-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-4306,

hsa-miR-6803-3p, hsa-miR-664a-3p, age, hsa-miR-361-

5p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p,

hsa-miR-7-5p

1928
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
77.06
85.72
76.67

hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-101-3p, hsa-

miR-130a-3p, hsa-miR-423-3p, hsa-miR-128-3p, hsa-

miR-494-3p, age, hsa-miR-1260b, hsa-miR-15b-3p,

hsa-miR-7-5p

1929
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p,
76.32
83.76
76.67

hsa-miR-326, hsa-miR-101-3p, hsa-miR-4306, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p, hsa-miR-15b-3p

1930
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-326, hsa-
76.28
83.94
76.67

miR-197-3p, hsa-miR-101-3p, hsa-miR-130a-3p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p, hsa-miR-7-5p

1931
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
76.23
83.78
80

hsa-miR-326, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

4306, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-664a-

3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-3p,

hsa-miR-15b-3p, hsa-miR-7-5p

1932
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-202-5p,
76.23
82.54
81.67

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-423-

3p, hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p,

hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-

miR-15b-3p

1933
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
76.23
84.09
78.33

hsa-miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-

6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

361-5p, hsa-miR-15b-3p

1934
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-423-5p,
76.23
81.52
78.33

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

101-3p, hsa-miR-18a-5p, hsa-miR-6803-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

1260b, hsa-miR-532-3p, hsa-miR-7-5p

1935
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-423-5p,
76.23
80.96
81.67

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-

3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p,

hsa-miR-15b-3p

1936
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
76.23
84.35
76.67

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-6803-3p, hsa-miR-323b-

3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-15b-3p

1937
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-326, hsa-
76.23
88.17
80

miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, age, hsa-miR-361-5p, hsa-miR-

1260b, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1938
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
76.19
79.41
80

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-

miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-4306,

hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p,

hsa-miR-361-5p, hsa-miR-15b-3p

1939
hsa-miR-550a-3-5p, hsa-miR-1301-3p, hsa-miR-29c-5p,
76.15
80.65
80

hsa-miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-

miR-130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-

miR-128-3p, hsa-miR-361-5p

1940
hsa-miR-550a-3-5p, hsa-miR-423-5p, hsa-miR-1301-3p,
76.15
81.61
80

hsa-miR-29c-5p, hsa-miR-326, hsa-miR-2110, hsa-miR-

197-3p, hsa-miR-423-3p, hsa-miR-323b-3p, hsa-miR-

15b-3p

1941
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-29c-5p,
75.37
80.35
78.33

hsa-miR-326, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

664a-3p, hsa-miR-323b-3p, hsa-miR-361-5p, hsa-miR-

532-3p, hsa-miR-15b-3p

1942
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
75.28
75.44
80

197-3p, hsa-miR-4306, hsa-miR-664a-3p, hsa-miR-323b-

3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1943
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-202-5p,
75.28
81.57
78.33

hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-4306, hsa-

miR-6803-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-

15b-3p, hsa-miR-7-5p

1944
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-18a-5p, hsa-miR-
75.28
81.22
76.67

423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

494-3p, age, hsa-miR-361-5p, hsa-miR-1260b, hsa-miR-

532-3p, hsa-miR-15b-3p

1945
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-1301-3p,
75.28
82.94
80

hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-18a-5p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, hsa-miR-579-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1946
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
75.24
84.85
78.33

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-18a-5p, hsa-miR-

423-3p, hsa-miR-6803-3p, hsa-miR-128-3p, hsa-miR-361-

5p, hsa-miR-1260b, hsa-miR-7-5p

1947
hsa-miR-202-5p, hsa-miR-423-5p, hsa-miR-1301-3p, hsa-
75.19
80.24
80

miR-326, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-miR-

130a-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-323b-

3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-1260b,

hsa-miR-15b-3p, hsa-miR-7-5p

1948
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p,
75.19
80.83
78.33

hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-18a-5p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-miR-

128-3p, hsa-miR-361-5p, hsa-miR-532-3p, hsa-miR-7-5p

1949
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-
74.46
79.13
76.67

101-3p, hsa-miR-4306, hsa-miR-664a-3p, hsa-miR-323b-

3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-15b-3p

1950
hsa-miR-30b-5p, hsa-miR-326, hsa-miR-197-3p, hsa-miR-
74.46
76.76
78.33

4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-323b-

3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-532-3p,

hsa-miR-15b-3p

1951
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
74.37
82.94
76.67

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-6803-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-

15b-3p

1952
hsa-miR-550a-3-5p, hsa-miR-202-5p, hsa-miR-1301-3p,
74.37
81.44
76.67

hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-18a-5p, hsa-miR-130a-3p, hsa-miR-423-3p, hsa-miR-

6803-3p, hsa-miR-323b-3p, hsa-miR-361-5p, hsa-miR-

579-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1953
hsa-miR-423-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
74.37
84.28
76.67

197-3p, hsa-miR-4306, hsa-miR-423-3p, hsa-miR-6803-

3p, hsa-miR-323b-3p, age, hsa-miR-361-5p, hsa-miR-

532-3p

1954
hsa-miR-202-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
74.37
80.87
80

miR-101-3p, hsa-miR-130a-3p, hsa-miR-4306, hsa-miR-

6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-

494-3p, hsa-miR-1260b, hsa-miR-532-3p, hsa-miR-15b-3p

1955
hsa-miR-181c-3p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-
74.2
83.07
76.67

miR-326, hsa-miR-2110, hsa-miR-101-3p, hsa-miR-6803-

3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-128-3p,

hsa-miR-494-3p, age, hsa-miR-579-3p, hsa-miR-7-5p

1956
hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-326, hsa-
73.55
81.39
73.33

miR-18a-5p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p

1957
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
73.51
78.74
76.67

hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-miR-326, hsa-

miR-2110, hsa-miR-197-3p, hsa-miR-4306, hsa-miR-6803-

3p, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p,

hsa-miR-15b-3p

1958
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-202-5p,
73.46
78.2
76.67

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-29c-5p, hsa-

miR-326, hsa-miR-2110, hsa-miR-197-3p, hsa-miR-4306,

hsa-miR-6803-3p, hsa-miR-323b-3p, hsa-miR-128-3p,

hsa-miR-15b-3p

1959
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-1301-3p,
73.33
83.43
71.67

hsa-miR-29c-5p, hsa-miR-2110, hsa-miR-197-3p, hsa-

miR-130a-3p, hsa-miR-423-3p, hsa-miR-6803-3p, hsa-

miR-323b-3p, hsa-miR-128-3p, hsa-miR-361-5p, hsa-miR-

579-3p, hsa-miR-15b-3p, hsa-miR-7-5p

1960
hsa-miR-30b-5p, hsa-miR-423-5p, hsa-miR-29c-5p, hsa-
72.6
79.83
76.67

miR-326, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-494-3p, hsa-miR-532-3p, hsa-miR-

15b-3p

1961
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
72.55
79.56
78.33

423-3p, hsa-miR-664a-3p, hsa-miR-323b-3p, hsa-miR-

128-3p, hsa-miR-494-3p, hsa-miR-361-5p, hsa-miR-532-

3p, hsa-miR-15b-3p

1962
hsa-miR-550a-3-5p, hsa-miR-30b-5p, hsa-miR-202-5p,
71.6
83.37
76.67

hsa-miR-423-5p, hsa-miR-1301-3p, hsa-miR-197-3p, hsa-

miR-101-3p, hsa-miR-18a-5p, hsa-miR-130a-3p, hsa-miR-

4306, hsa-miR-323b-3p, hsa-miR-128-3p, hsa-miR-494-

3p, age, hsa-miR-579-3p, hsa-miR-15b-3p

1963
hsa-miR-550a-3-5p, hsa-miR-181c-3p, hsa-miR-423-5p,
71.56
78.3
71.67

hsa-miR-2110, hsa-miR-101-3p, hsa-miR-18a-5p, hsa-

miR-4306, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

128-3p, age, hsa-miR-532-3p

1964
hsa-miR-30b-5p, hsa-miR-29c-5p, hsa-miR-326, hsa-miR-
70.78
77.81
71.67

101-3p, hsa-miR-423-3p, hsa-miR-664a-3p, hsa-miR-

323b-3p, hsa-miR-128-3p, hsa-miR-494-3p, hsa-miR-361-

5p, hsa-miR-532-3p, hsa-miR-15b-3p

1965
combination 1723 + rs71384446
63.38
64.5
85.97

1966
combination 1723 + rs11647727
53.46
57.78
80.70

1967
combination 1724 + rs71384446
61.52
59
84.27

1968
combination 1725 + rs7193058
71.6
71
81.58

1969
combination 1725 + rs11647727
70.74
70.13
84.15

1970
combination 1735 + rs13335818
78.01
85.35
81.58

1971
combination 1735 + rs7193058
78.87
89.7
85.1

1972
combination 1739 + rs9928757
80.74
87.02
84.19

1973
combination 1744 + rs11862974
81.69
90.7
84.19

1974
combination 1745 + rs11647727
81.65
90.72
90.00

1975
combination 1747 + rs76563024
81.65
88.28
85.2

1976
combination 1750 + rs13335818
83.46
91.35
90.3

1977
combination 1877 + rs76563024
79.78
90.31
89.35

1978
combination 1877 + rs76563024
79.78
90.31
90.45

This is the list of the best 29 mRNA selected by the algorithm sorted by importance for diagnosis outcome: hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p, hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p, and hsa-miR-153-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for diagnosis (Table 25).

TABLE 25

Combinations that allow higher sensitivity, specificity,

accuracy and predictive power for diagnosis.

N
Combinations
Accuracy
ROCAUC
Recall

1979
hsa-miR-550a-3-5p
70
74.38
82.44

1980
hsa-miR-550a-3-5p, hsa-miR-132-3p
78.33
81.83
88.89

1981
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p
80
82.06
95.78

1982
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
76.67
80.14
96.89

hsa-miR-590-5p

1983
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
78.33
81.39
90.89

hsa-miR-590-5p, hsa-miR-590-3p

1984
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
81.67
83.89
96.89

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p

1985
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
81.67
80.65
97.78

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

1986
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
76.67
79.79
98.89

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p

1987
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
71.67
78.89
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

1988
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
78.33
84.4
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p

1989
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
76.67
81.55
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p

1990
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
76.67
82.36
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p

1991
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
85
91.06
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p

1992
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
83.33
90.95
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p

1993
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
81.67
90.32
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l

1994
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
81.67
88.22
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p

1995
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
85
88.96
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p

1996
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
88.33
95.05
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age

1997
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
88.33
95.16
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p

1998
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
86.67
94.19
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p

1999
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
86.67
92.94
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p

2000
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
86.67
97.04
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136

2001
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
86.67
97.04
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p

2002
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
85
94.65
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p

2003
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
85
95.39
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p

2004
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
83.33
93.52
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-122-5p

2005
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
85
93.91
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-196b-5p

2006
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
80
94.54
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p

2007
hsa-miR-550a-3-5p, hsa-miR-132-3p, hsa-miR-1180-3p,
85
93.91
100.0

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p, hsa-miR-4732-5p, hsa-miR-374a-3p,

hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-491-5p

2008
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
95
97.78
97.78

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p,

hsa-miR-500a-5p

2009
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
95
90.09
95.28

hsa-miR-103a-2-5p, age, hsa-miR-192-5p, hsa-miR-590-5p,

hsa-miR-590-3p

2010
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
95
95.56
97.78

age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

2011
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
95
95.56
97.78

age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2012
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
95
95.56
97.78

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2013
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
95
95.56
97.78

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2014
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
96.3
95.56

age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2015
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
94.77
95

hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p,

hsa-miR-374a-5p

2016
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
93.45
95.28

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-590-3p

2017
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
93.33
94.81
97.78

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2018
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
94.81
97.78

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2019
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
98.52
95.28

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p

2020
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
96.3
95.56

age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2021
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
95.56
95.28

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2022
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
93.45
95.28

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-374a-5p

2023
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
96.3
95.56

age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2024
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
93.33
90.83
95.28

hsa-miR-103a-2-5p, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p

2025
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
94.81
95.28

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p

2026
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
93.33
94.81
97.78

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p

2027
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
94.81
95.56

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2028
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
93.33
93.06
97.78

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2029
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
96.3
95.28

hsa-miR-548l, age, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

2030
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
93.33
91.57
95.28

hsa-miR-103a-2-5p, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2031
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
93.33
94.31
95.56

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2032
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
91.67
96.3
93.33

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2033
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
91.67
94.07
95.28

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2034
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
91.67
92.08
95.56

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p

2035
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
91.67
89.07
95

hsa-miR-103a-2-5p, hsa-miR-1277-3p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p

2036
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
91.67
98.52
95.28

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2037
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
91.67
95.51
92.78

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2038
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
91.67
92.82
95.56

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-491-5p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p

2039
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l,
91.67
97.04
92.78

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2040
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
91.67
95.56
95.28

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2041
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
91.67
97.04
95.56

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-590-3p, hsa-miR-500a-5p

2042
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
91.67
92.43
95.28

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2043
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l,
91.67
97.04
92.78

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-337-5p

2044
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
94.81
90.56

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2045
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
94.31
93.06

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2046
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
94.31
93.06

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2047
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
90
94.31
93.06

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2048
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
90
94.31
93.06

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2049
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
94.03
92.78

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2050
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
90
88.33
92.78

hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-374a-5p

2051
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
90
92.31
90.28

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-374a-5p

2052
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
97.15
90.56

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2053
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
90
94.81
90.83

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2054
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l,
90
97.78
90.56

hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2055
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, age,
90
91.85
90.83

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2056
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p,
90
95.67
93.06

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-337-5p

2057
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
90
93.52
90.28

hsa-miR-1277-3p, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2058
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
97.04
95.28

age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

2059
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
98.63
92.78

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-3p,

hsa-miR-500a-5p

2060
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
88.84
91.11

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2061
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
92.43
95.28

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2062
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
94.81
93.06

age, hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2063
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
97.78
92.78

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2064
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
92.71
90.56

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p

2065
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
90
95.56
93.33

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-130b-5p

2066
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
90
88.96
92.78

hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p

2067
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l, age,
88.33
95.79
95.28

hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2068
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
95.79
85.83

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2069
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
92.71
88.06

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p

2070
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
88.33
87.59
90.28

hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p

2071
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
92.94
93.06

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p

2072
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
96.41
93.06

age, hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

2073
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
92.94
86.11

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2074
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
88.33
95.56
95.56

hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2075
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
96.41
93.06

age, hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p

2076
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
90.83
90.56

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-628-3p, hsa-miR-153-3p, hsa-miR-590-3p

2077
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l,
88.33
95.9
88.33

hsa-miR-29c-5p, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p

2078
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
97.27
90.28

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p

2079
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
88.33
95.67
88.06

hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p, age,

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-337-5p

2080
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
89
88.33

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-628-3p, hsa-miR-590-3p

2081
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
98.63
90.28

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2082
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
90.72
90.83

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p,

hsa-miR-500a-5p

2083
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
86.9
90.83

hsa-miR-548l, age, hsa-miR-12136, hsa-miR-628-3p,

hsa-miR-590-3p

2084
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
91.85
92.78

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2085
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
88.33
90.56
90.56

age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-500a-5p

2086
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
88.33
95.05
85.56

hsa-miR-103a-2-5p, hsa-miR-1277-3p, age, hsa-miR-192-5p,

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p

2087
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
92.08
92.78

age, hsa-miR-192-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2088
hsa-miR-3613-3p, hsa-miR-103a-2-5p, age, hsa-miR-192-5p,
88.33
94.19
93.06

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2089
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
93.06
95.28

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2090
hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-181b-5p,
88.33
94.07
92.78

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-491-5p, hsa-miR-590-3p, hsa-miR-500a-5p

2091
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
93.06
88.33

age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p

2092
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
96.3
86.67

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-192-5p,

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p

2093
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
97.38
88.06

hsa-miR-548l, hsa-miR-1277-3p, age, hsa-miR-192-5p,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2094
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
91.11
88.61

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2095
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-548l,
88.33
95.67
88.33

hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2096
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p,
88.33
91.69
92.78

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2097
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
93.68
90.56

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2098
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
88.33
93.91
88.33

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p, hsa-miR-337-5p

2099
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
88.33
96.3
92.78

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2100
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
88.33
92.82
90.83

age, hsa-miR-192-5p, hsa-miR-628-3p, hsa-miR-122-5p,

hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2101
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
93.56
88.61

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2102
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
92.71
88.89

age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2103
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l,
86.67
93.45
85.83

hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-374a-5p, hsa-miR-130b-5p

2104
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
93.68
84.17

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2105
hsa-miR-3613-3p, hsa-miR-103a-2-5p, age, hsa-miR-192-5p,
86.67
93.45
93.06

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2106
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
88.22
88.06

hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-491-5p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2107
hsa-miR-4732-5p, hsa-miR-548l, hsa-miR-192-5p,
86.67
94.19
90.83

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p

2108
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
89.24
88.33

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2109
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
92.59
88.89

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-153-3p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2110
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
93.45
86.11

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2111
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
91.46
86.39

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2112
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
90.83
85.56

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-374a-5p

2113
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l,
86.67
94.07
83.89

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2114
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
91.57
86.11

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2115
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
88.73
95.28

age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p

2116
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
86.67
95.51
90.56

hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p,

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-337-5p

2117
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
82.25
93.06

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-374a-5p

2118
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
92.66
88.06

age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p

2119
hsa-miR-103a-2-5p, hsa-miR-548l, hsa-miR-1277-3p,
86.67
94.81
85.83

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-337-5p

2120
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l,
86.67
95.28
87.78

hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2121
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
86.16
88.89

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-153-3p,

hsa-miR-590-3p

2122
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
87.36
92.78

hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-628-3p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2123
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
88.38
92.5

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p

2124
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
91.57
88.33

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

2125
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
84.12
90

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p

2126
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
91.57
87.78

hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2127
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
92.43
88.06

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2128
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
92.71
88.06

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p,

hsa-miR-590-3p

2129
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
86.67
89.63
88.61

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p,

hsa-miR-19a-3p, hsa-miR-500a-5p

2130
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
92.2
88.33

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2131
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
93.8
88.33

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-500a-5p

2132
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
91.81
87.78

hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-374a-5p

2133
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
96.41
83.61

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2134
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-192-5p,
86.67
92.15
85.56

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-337-5p

2135
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
93.33
86.39

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2136
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
95.67
86.39

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2137
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
86.67
91.57
95.28

hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2138
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
86.67
94.93
88.61

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2139
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
96.41
88.33

age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2140
hsa-miR-4732-5p, hsa-miR-1277-3p, age, hsa-miR-192-5p,
86.67
96.41
87.78

hsa-miR-12136, hsa-miR-628-3p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2141
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
93.56
85.83

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-433-3p,

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2142
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
86.67
87.41
88.61

hsa-miR-548l, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-3p

2143
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-29c-5p,
86.67
92.2
86.11

age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2144
hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
86.67
93.33
88.61

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2145
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p,
85
92.43
88.61

hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2146
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
85
91.11
92.78

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2147
hsa-miR-4732-5p, hsa-miR-548l, hsa-miR-192-5p,
85
90.72
88.33

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-491-5p, hsa-miR-500a-5p

2148
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
88.22
88.61

hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p,

hsa-miR-181b-5p, hsa-miR-628-3p, hsa-miR-122-5p,

hsa-miR-196b-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-99a-3p, hsa-miR-337-5p

2149
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
85
88.45
88.33

hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-337-5p

2150
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
92.94
83.89

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2151
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l,
85
90.21
90.56

hsa-miR-12136, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p

2152
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
88.56
93.06

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2153
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
94.81
87.78

age, hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2154
hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-628-3p,
85
86.85
90.83

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2155
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
93.06
93.06

age, hsa-miR-192-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2156
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
87.36
88.06

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-374a-5p

2157
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
94.81
87.78

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2158
hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, age,
85
93.56
90.28

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2159
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-103a-2-5p,
85
84.75
85.83

hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p,

hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p

2160
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
85
91.3
81.39

hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p

2161
hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-192-5p,
85
94.07
86.67

hsa-miR-598-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p

2162
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
91.97
88.33

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p

2163
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
92.71
88.33

age, hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-590-3p, hsa-miR-500a-5p

2164
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
92.59
86.11

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-433-3p,

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-491-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-130b-5p

2165
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
92.43
88.06

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-122-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2166
hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-196b-5p,
85
91.57
88.33

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2167
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
91.57
85.28

hsa-miR-548l, hsa-miR-1277-3p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p,

hsa-miR-491-5p, hsa-miR-374a-5p

2168
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-181b-5p,
85
92.31
88.33

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2169
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
87.41
86.11

hsa-miR-548l, age, hsa-miR-12136, hsa-miR-628-3p,

hsa-miR-153-3p, hsa-miR-590-3p

2170
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
90.95
86.11

hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2171
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p,
85
87.48
90.83

hsa-miR-628-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2172
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
85
89.24
88.06

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-12136,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2173
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
85
87.94
81.11

hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2174
hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
85
97.78
83.61

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-590-3p, hsa-miR-500a-5p

2175
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l,
83.33
92.82
81.39

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-130b-5p, hsa-miR-337-5p

2176
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
94.81
85.28

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2177
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
92.08
86.39

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2178
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
84.56
86.67

hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2179
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-1277-3p,
83.33
88.29
81.11

hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-130b-5p, hsa-miR-337-5p

2180
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
83.33
90.09
83.33

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p

2181
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
93.29
85.56

hsa-miR-548l, age, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-590-3p, hsa-miR-500a-5p

2182
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
86
85.83

hsa-miR-548l, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-3p

2183
hsa-miR-4732-5p, hsa-miR-29c-5p, hsa-miR-433-3p,
83.33
90.44
83.61

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p

2184
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-3613-3p,
83.33
90.49
81.39

hsa-miR-103a-2-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2185
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-1277-3p,
83.33
91.34
85.83

hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-628-3p,

hsa-miR-196b-5p, hsa-miR-590-3p, hsa-miR-99a-3p,

hsa-miR-130b-5p, hsa-miR-337-5p

2186
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
91.46
83.89

hsa-miR-29c-5p, age, hsa-miR-433-3p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2187
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
91.23
86.39

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-3p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2188
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
90.09
85.56

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-374a-5p

2189
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l,
83.33
90.83
80.83

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2190
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
83.33
91.06
86.11

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p

2191
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
91.06
84.17

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2192
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
83.33
88.06
83.33

hsa-miR-1277-3p, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2193
hsa-miR-3613-3p, hsa-miR-103a-2-5p, age, hsa-miR-181b-5p,
83.33
84
90.56

hsa-miR-192-5p, hsa-miR-491-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2194
hsa-miR-4732-5p, hsa-miR-548l, hsa-miR-1277-3p,
83.33
89.98
88.61

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-337-5p

2195
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
91.81
83.33

hsa-miR-548l, hsa-miR-1277-3p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-491-5p, hsa-miR-590-5p

2196
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p,
83.33
92.08
88.33

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2197
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
87.36
90.56

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p

2198
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p,
83.33
90.83
88.33

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2199
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
83.33
89.47
88.06

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2200
hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-628-3p,
83.33
88.26
88.89

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-337-5p

2201
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
89.86
84.17

hsa-miR-29c-5p, age, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2202
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
89.58
85.56

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2203
hsa-miR-4732-5p, hsa-miR-1277-3p, hsa-miR-433-3p,
81.67
87.59
81.39

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2204
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
90.83
83.89

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2205
hsa-miR-4732-5p, hsa-miR-192-5p, hsa-miR-122-5p,
81.67
86.74
85.56

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2206
hsa-miR-4732-5p, hsa-miR-196b-5p, hsa-miR-215-5p,
81.67
87.48
85.83

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2207
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p,
81.67
91.46
88.33

hsa-miR-433-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2208
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p,
81.67
86.74
85.83

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-337-5p

2209
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
83.96
85.56

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2210
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-103a-2-5p,
81.67
88.45
81.11

hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-181b-5p,

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-337-5p

2211
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-103a-2-5p,
81.67
88.33
80.83

hsa-miR-29c-5p, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-99a-3p, hsa-miR-130b-5p,

hsa-miR-337-5p

2212
hsa-miR-374a-3p, hsa-miR-548l, hsa-miR-1277-3p,
81.67
83.56
79.17

hsa-miR-29c-5p, age, hsa-miR-181b-5p, hsa-miR-433-3p,

hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-130b-5p

2213
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-548l,
81.67
84.24
83.61

hsa-miR-29c-5p, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-433-3p, hsa-miR-598-3p, hsa-miR-19a-3p,

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-491-5p,

hsa-miR-153-3p, hsa-miR-590-5p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-130b-5p

2214
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
88.1
85.56

hsa-miR-548l, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2215
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
82.01
90.56

age, hsa-miR-192-5p, hsa-miR-122-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p

2216
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-29c-5p,
81.67
87.13
86.67

age, hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p,

hsa-miR-19a-3p, hsa-miR-153-3p, hsa-miR-590-3p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2217
hsa-miR-3613-3p, hsa-miR-548l, hsa-miR-29c-5p, age,
81.67
91.11
86.67

hsa-miR-192-5p, hsa-miR-598-3p, hsa-miR-122-5p,

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-374a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2218
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
90.09
88.61

hsa-miR-548l, hsa-miR-29c-5p, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-99a-3p

2219
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
81.67
90.44
79.17

hsa-miR-29c-5p, hsa-miR-192-5p, hsa-miR-433-3p,

hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p, hsa-miR-337-5p

2220
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-192-5p,
81.67
88.96
83.33

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2221
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
81.67
88.73
88.06

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2222
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l,
80
86
83.61

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-500a-5p

2223
hsa-miR-3613-3p, hsa-miR-103a-2-5p, hsa-miR-548l, age,
80
88.61
88.06

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-122-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p

2224
hsa-miR-4732-5p, hsa-miR-1277-3p, hsa-miR-628-3p,
80
83.61
79.17

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2225
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
80
90.95
81.39

hsa-miR-548l, hsa-miR-29c-5p, age, hsa-miR-628-3p,

hsa-miR-122-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2226
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-548l,
80
86
83.33

hsa-miR-1277-3p, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-628-3p, hsa-miR-19a-3p,

hsa-miR-491-5p, hsa-miR-500a-5p

2227
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
80
89.98
81.39

hsa-miR-29c-5p, age, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2228
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-122-5p,
80
86.34
87.78

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2229
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
80
86.27
74.72

hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age,

hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-491-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2230
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p,
80
90.32
88.33

hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2231
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
80
76.39
85.83

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-122-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-374a-5p

2232
hsa-miR-4732-5p, hsa-miR-1277-3p, hsa-miR-433-3p,
80
83.15
83.89

hsa-miR-628-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2233
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
80
84.86
78.89

hsa-miR-1277-3p, age, hsa-miR-181b-5p, hsa-miR-433-3p,

hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-590-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2234
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-433-3p,
80
89.58
88.33

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2235
hsa-miR-374a-3p, hsa-miR-103a-2-5p, hsa-miR-548l,
80
87.31
78.89

hsa-miR-1277-3p, hsa-miR-29c-5p, age, hsa-miR-181b-5p,

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-628-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-196b-5p,

hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-130b-5p, hsa-miR-337-5p

2236
hsa-miR-4732-5p, hsa-miR-122-5p, hsa-miR-196b-5p,
80
89.58
88.06

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2237
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-122-5p,
80
85.72
85.83

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-337-5p

2238
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-192-5p,
78.33
86.39
83.89

hsa-miR-12136, hsa-miR-598-3p, hsa-miR-628-3p,

hsa-miR-19a-3p, hsa-miR-153-3p, hsa-miR-590-3p

2239
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
78.33
84.86
79.44

hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age,

hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-122-5p, hsa-miR-491-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p

2240
hsa-miR-374a-3p, hsa-miR-548l, age, hsa-miR-181b-5p,
78.33
82.31
81.11

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-598-3p,

hsa-miR-122-5p, hsa-miR-215-5p, hsa-miR-491-5p,

hsa-miR-590-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2241
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
78.33
89.58
79.17

hsa-miR-29c-5p, age, hsa-miR-433-3p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-99a-3p,

hsa-miR-130b-5p

2242
hsa-miR-4732-5p, hsa-miR-433-3p, hsa-miR-122-5p,
78.33
88.73
86.11

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-337-5p

2243
hsa-miR-4732-5p, age, hsa-miR-122-5p, hsa-miR-196b-5p,
78.33
87.94
80.83

hsa-miR-215-5p, hsa-miR-590-5p, hsa-miR-590-3p,

hsa-miR-500a-5p, hsa-miR-374a-5p, hsa-miR-337-5p

2244
hsa-miR-374a-3p, hsa-miR-548l, hsa-miR-1277-3p,
78.33
87.2
76.67

hsa-miR-192-5p, hsa-miR-433-3p, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-590-5p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p

2245
hsa-miR-374a-3p, hsa-miR-1277-3p, hsa-miR-29c-5p,
78.33
79.58
81.39

hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-215-5p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-130b-5p

2246
hsa-miR-4732-5p, hsa-miR-628-3p, hsa-miR-122-5p,
78.33
79.56
83.33

hsa-miR-196b-5p, hsa-miR-215-5p, hsa-miR-153-3p,

hsa-miR-590-5p, hsa-miR-590-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p

2247
hsa-miR-374a-3p, hsa-miR-3613-3p, hsa-miR-29c-5p,
78.33
82.25
83.06

age, hsa-miR-181b-5p, hsa-miR-192-5p, hsa-miR-12136,

hsa-miR-598-3p, hsa-miR-19a-3p, hsa-miR-122-5p,

hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-130b-5p

2248
hsa-miR-374a-3p, hsa-miR-1277-3p, hsa-miR-181b-5p,
76.67
83.5
81.67

hsa-miR-628-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-491-5p, hsa-miR-153-3p, hsa-miR-374a-5p,

hsa-miR-99a-3p

2249
hsa-miR-4732-5p, hsa-miR-374a-3p, hsa-miR-29c-5p,
76.67
81.27
76.39

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-122-5p, hsa-miR-196b-5p, hsa-miR-491-5p,

hsa-miR-153-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-99a-3p, hsa-miR-130b-5p, hsa-miR-337-5p

2250
hsa-miR-4732-5p, hsa-miR-3613-3p, age, hsa-miR-181b-5p,
76.67
81.83
78.89

hsa-miR-192-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-500a-5p,

hsa-miR-374a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2251
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-548l,
76.67
83.38
76.67

hsa-miR-1277-3p, hsa-miR-181b-5p, hsa-miR-192-5p,

hsa-miR-433-3p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-196b-5p, hsa-miR-215-5p,

hsa-miR-491-5p, hsa-miR-590-5p, hsa-miR-500a-5p,

hsa-miR-337-5p

2252
hsa-miR-4732-5p, hsa-miR-3613-3p, hsa-miR-103a-2-5p,
76.67
79.33
79.17

hsa-miR-548l, hsa-miR-1277-3p, hsa-miR-29c-5p, age,

hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-628-3p, hsa-miR-19a-3p, hsa-miR-491-5p,

hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2253
hsa-miR-4732-5p, hsa-miR-628-3p, hsa-miR-196b-5p,
73.33
81.55
79.17

hsa-miR-215-5p, hsa-miR-153-3p, hsa-miR-590-5p,

hsa-miR-590-3p, hsa-miR-500a-5p, hsa-miR-374a-5p,

hsa-miR-337-5p

2254
hsa-miR-4732-5p, hsa-miR-103a-2-5p, hsa-miR-1277-3p,
73.33
82.29
76.94

age, hsa-miR-181b-5p, hsa-miR-12136, hsa-miR-598-3p,

hsa-miR-19a-3p, hsa-miR-491-5p, hsa-miR-153-3p,

hsa-miR-500a-5p, hsa-miR-99a-3p, hsa-miR-130b-5p

2255
combinazione1979+rs71384446
73.33
80.07
80.07

2256
combinazione1979+rs76563024
71.67
76.88
76.88

2257
combinazione1980+rs7204342
83.33
81.71
81.71

2258
combinazione1980+rs7193058
73.33
77.57
77.57

2259
combinazione1982+rs4297685
81.67
83.26
83.26

2260
combinazione1982+rs4297685
80
84.75
84.75

2261
combinazione1983+rs4297685
80
82.01
82.01

2262
combinazione1934+rs28640218
83.33
80.02
80.02

2263
combinazione1985+rs13335818
83.33
83.03
83.03

2264
combinazione1986+rs13335818
76.67
78.26
78.26

2265
combinazione1987+rs76563024
75
79.91
79.91

2266
combinazione1993+rs11647727
85
87.64
87.64

2267
combinazione1994+rs4297685
85
85.76
85.76

2268
combinazione1995+rs13333226
88.33
91.57
91.57

2269
combinazione2006+rs13333226
80
84.24
84.24

This is the list of the best 30 miRNA selected by the algorithm sorted by importance for tumour stage: hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, and hsa-miR-1301-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour stage (Table 26).

TABLE 26

Combinations that allow higher sensitivity, specificity,

accuracy and predictive power for tumour stage.

N
Combinations
Accuracy
ROC AUC
Recall

2270
hsa-miR-769-5p
81.67
80
74.44

2271
hsa-miR-769-5p, hsa-miR-548a-3p
81.67
84.29
72.5

2272
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p
83.89
90
85.83

2273
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
88.89
95.71
86.11

miR-190a-5p

2274
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.39
91.43
93.33

miR-190a-5p, hsa-miR-215-5p

2275
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.11
95.71
91.39

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p

2276
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
81.67
95.71
96.39

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p

2277
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
83.89
94.29
96.11

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421

2278
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
88.61
91.43
99.17

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p

2279
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.11
94.29
98.06

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2280
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
88.33
95.71
100.0

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p

2281
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
88.33
90
98.89

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p

2282
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
90.83
95.71
97.78

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p

2283
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
88.33
98.57
98.89

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p

2284
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.11
98.57
100.0

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p

2285
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
83.61
98.57
98.89

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p

2286
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.39
98.57
98.89

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941

2287
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
85.83
97.14
98.89

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p

2288
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
83.33
97.14
97.78

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p

2289
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
81.11
97.14
98.89

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p

2290
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
81.11
97.14
98.89

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p

2291
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
83.33
97.14
100.0

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p

2292
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.11
94.29
100.0

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p

2293
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.11
92.86
99.17

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p

2294
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.11
92.86
99.17

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-100-5p

2295
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
86.11
90
99.17

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p

2296
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
85.83
91.43
99.17

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p

2297
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
85.83
94.29
97.22

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-452-3p

2298
hsa-miR-769-5p, hsa-miR-548a-3p, hsa-miR-598-3p, hsa-
88.33
91.43
97.22

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306, hsa-

miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-

30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941,

hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p

2299
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
100
100
100

miR-941, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p

2300
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
100
100
100

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2301
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
100
100
100

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2302
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa-
100
100
100

miR-30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-

miR-452-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

421, hsa-miR-22-5p

2303
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
100
100
100

miR-664a-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2304
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
100
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-421

2305
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
100
100
100

miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2306
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
100
100
100

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-181c-5p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2307
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
100
100
100

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-421

2308
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
100
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-1301-

3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p,

hsa-miR-421

2309
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
97.78
100
100

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-

421

2310
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
100

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2311
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-

3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-1296-5p,

hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p,

hsa-miR-215-5p, hsa-miR-324-3p

2312
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
97.78
100
100

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-324-3p, hsa-miR-421

2313
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
100

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2314
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
97.78
100
100

miR-32-3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p,

hsa-miR-190a-5p, hsa-miR-143-3p, hsa-miR-421, hsa-

miR-22-5p, hsa-miR-4306

2315
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
100

miR-941, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR-30e-

5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p

2316
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-941, hsa-miR-
97.78
100
100

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-1301-3p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2317
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
97.78
100
90

miR-503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-324-3p, hsa-miR-421

2318
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-503-

5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-100-5p,

hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p,

hsa-miR-324-3p

2319
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-

miR-421

2320
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
90

miR-664a-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-

421

2321
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
97.78
100
100

miR-31-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-324-3p,

hsa-miR-143-3p, hsa-miR-421

2322
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
90

miR-664a-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2323
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-941, hsa-miR-
97.78
100
100

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-215-5p, hsa-miR-324-3p,

hsa-miR-143-3p, hsa-miR-421

2324
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa-
97.78
97.14
100

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p

2325
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.78
100
90

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421

2326
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
97.5
100
100

miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-452-3p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421

2327
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.5
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-503-5p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-421

2328
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
97.5
100
80

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421

2329
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.5
100
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p,

hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-1301-3p,

hsa-miR-324-3p, hsa-miR-421

2330
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
97.5
97.14
100

miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-20b-5p, hsa-miR-190a-5p, hsa-miR-22-

5p, hsa-miR-4306

2331
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
97.5
100
80

miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p

2332
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.5
100
80

miR-664a-3p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR-

100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2333
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.5
97.14
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p,

hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-

miR-1301-3p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-

miR-421

2334
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.5
100
100

let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2335
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.5
97.14
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p,

hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-

miR-324-3p, hsa-miR-421

2336
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
97.5
100
100

let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-421

2337
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
97.5
100
100

hsa-miR-941, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-

7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-

3p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-421

2338
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
97.5
100
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-143-3p,

hsa-miR-421

2339
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.56
100
100

miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-452-3p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421

2340
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.56
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2341
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.56
100
100

miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-452-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-421

2342
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa-
95.56
95.71
100

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-

5p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-22-5p,

hsa-miR-4306

2343
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.56
100
90

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2344
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
95.56
98.57
100

miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-323b-

3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p,

hsa-miR-143-3p, hsa-miR-421

2345
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.56
100
100

miR-664a-3p, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-215-5p, hsa-miR-324-3p

2346
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.56
95.71
100

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-324-

3p, hsa-miR-421, hsa-miR-22-5p

2347
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
95.56
100
100

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

452-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2348
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
95.56
100
100

miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-1249-3p, hsa-miR-1301-3p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p, hsa-miR-4306

2349
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
95.56
100
100

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-

421, hsa-miR-4306

2350
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
95.56
100
100

miR-32-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p

2351
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-
95.56
97.14
100

miR-30b-5p, hsa-miR-664a-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-

3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-1301-3p,

hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p

2352
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
95.56
98.57
90

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

20b-5p, hsa-miR-190a-5p, hsa-miR-143-3p, hsa-miR-421,

hsa-miR-22-5p, hsa-miR-4306

2353
hsa-miR-30b-5p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
95.56
100
80

140-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-

421, hsa-miR-22-5p, hsa-miR-4306

2354
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
95.28
100
100

miR-31-5p, hsa-miR-941, hsa-miR-503-5p, hsa-miR-30e-

5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-

miR-323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p

2355
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
95.28
100
70

miR-941, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-181c-

5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p,

hsa-miR-143-3p, hsa-miR-421

2356
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
95.28
100
100

hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-

miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-

miR-143-3p, hsa-miR-421

2357
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.28
100
80

miR-664a-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p

2358
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
95.28
95.71
100

hsa-miR-941, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-421

2359
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.28
97.14
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p,

hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-

miR-1301-3p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-

421

2360
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.28
100
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p,

hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-1301-3p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2361
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.28
100
80

miR-664a-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2362
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.28
100
100

miR-664a-3p, hsa-miR-503-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-421

2363
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.28
100
90

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

503-5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-

190a-5p

2364
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
95.28
97.14
100

miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-30e-

5p, hsa-miR-1296-5p, hsa-miR-181c-5p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-22-5p, hsa-

miR-4306

2365
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95.28
100
90

miR-503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-421,

hsa-miR-22-5p

2366
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
95.28
100
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

20b-5p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-

3p, hsa-miR-143-3p, hsa-miR-421

2367
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-941, hsa-miR-
95
100
100

32-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p,

hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p,

hsa-miR-20b-5p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-

miR-421, hsa-miR-22-5p, hsa-miR-4306

2368
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
95
94.29
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p,

hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-421, hsa-miR-22-5p

2369
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
95
94.29
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

503-5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-

215-5p, hsa-miR-421

2370
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
95
97.14
80

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-30e-

5p, hsa-let-7i-5p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-

miR-1301-3p, hsa-miR-190a-5p

2371
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
93.33
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-421, hsa-miR-4306

2372
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.33
98.57
90

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2373
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.33
100
90

miR-664a-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p

2374
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa-
93.33
94.29
90

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

452-3p, hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p,

hsa-miR-4306

2375
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.33
100
90

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-215-

5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2376
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.33
98.57
90

miR-503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p

2377
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-32-3p, hsa-
93.33
94.29
100

miR-30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-

miR-452-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

22-5p, hsa-miR-4306

2378
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-140-3p, hsa-
93.33
100
100

miR-30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-

miR-452-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2379
hsa-miR-132-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-
93.33
97.14
80

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-452-3p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421, hsa-miR-22-5p

2380
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.33
98.57
100

miR-664a-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p

2381
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
93.33
98.57
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p,

hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-1301-3p,

hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421, hsa-miR-22-5p, hsa-miR-4306

2382
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa-
93.33
97.14
90

let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-20b-5p, hsa-miR-421

2383
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.33
98.57
90

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p

2384
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
93.33
95.71
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-

4306

2385
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-30e-5p, hsa-
93.33
97.14
90

let-7i-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-

3p, hsa-miR-143-3p, hsa-miR-421

2386
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
93.06
97.14
100

miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-30e-

5p, hsa-miR-1296-5p, hsa-miR-181c-5p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-22-5p, hsa-miR-4306

2387
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
100
80

miR-664a-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p

2388
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
98.57
80

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-1301-3p, hsa-miR-215-5p

2389
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
93.06
95.71
100

hsa-miR-31-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p

2390
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
98.57
70

miR-664a-3p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-

miR-181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2391
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
97.14
90

miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-100-

5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-1301-

3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2392
hsa-miR-132-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
93.06
98.57
100

503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p,

hsa-miR-181c-5p, hsa-miR-452-3p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p, hsa-miR-4306

2393
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-

3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-

miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-421

2394
hsa-miR-132-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
93.06
95.71
90

140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-

4306

2395
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
97.14
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p,

hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p,

hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p,

hsa-miR-324-3p

2396
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
100
90

miR-664a-3p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-421

2397
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
93.06
97.14
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-

3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-

miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-

421

2398
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
93.06
97.14
100

hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421,

hsa-miR-22-5p

2399
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-30e-5p, hsa-
93.06
94.29
80

let-7i-5p, hsa-miR-1296-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-324-3p, hsa-miR-143-

3p

2400
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
92.78
100
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p,

hsa-miR-4306

2401
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
92.78
92.86
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-421

2402
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-
92.78
100
100

miR-664a-3p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-421

2403
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
92.78
97.14
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2404
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
91.11
100
100

miR-503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-324-3p

2405
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
91.11
94.29
90

miR-664a-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2406
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
91.11
97.14
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421, hsa-miR-22-5p

2407
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
91.11
95.71
100

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p,

hsa-miR-4306

2408
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
91.11
98.57
90

hsa-miR-941, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-

7i-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-1301-

3p, hsa-miR-215-5p, hsa-miR-324-3p

2409
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
91.11
97.14
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p, hsa-miR-4306

2410
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
91.11
98.57
90

miR-664a-3p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR-

100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p

2411
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
91.11
97.14
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-

3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-

miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-

143-3p

2412
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
91.11
98.57
90

miR-664a-3p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

503-5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-100-

5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-1301-3p,

hsa-miR-215-5p, hsa-miR-324-3p

2413
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
91.11
97.14
90

miR-664a-3p, hsa-miR-31-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-4306

2414
hsa-miR-132-3p, hsa-miR-32-3p, hsa-miR-30e-5p, hsa-let-
91.11
91.43
80

7i-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-452-

3p, hsa-miR-190a-5p, hsa-miR-22-5p, hsa-miR-4306

2415
hsa-miR-30b-5p, hsa-miR-31-5p, hsa-miR-140-3p, hsa-
91.11
97.14
80

miR-30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-

miR-452-3p, hsa-miR-20b-5p, hsa-miR-190a-5p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-22-5p, hsa-miR-4306

2416
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
91.11
95.71
90

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p

2417
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
98.57
70

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-215-

5p, hsa-miR-143-3p

2418
hsa-miR-132-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
90.83
97.14
80

503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p,

hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-

miR-190a-5p, hsa-miR-215-5p, hsa-miR-421, hsa-miR-22-

5p, hsa-miR-4306

2419
hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-miR-32-3p, hsa-
90.83
91.43
100

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-421,

hsa-miR-22-5p, hsa-miR-4306

2420
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
90.83
94.29
80

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-

324-3p

2421
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-32-3p, hsa-
90.83
92.86
60

miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-22-5p

2422
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
100
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421

2423
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
95.71
90

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p,

hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-421

2424
hsa-miR-132-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
90.83
98.57
80

30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p, hsa-miR-4306

2425
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
90.83
100
70

miR-30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-

miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421

2426
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
90.83
100
100

hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2427
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
90.83
98.57
100

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

4306

2428
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
90.83
95.71
70

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-1249-3p, hsa-miR-100-5p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-

5p, hsa-miR-4306

2429
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
95.71
90

miR-664a-3p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-

3p, hsa-miR-100-5p, hsa-miR-20b-5p, hsa-miR-1301-3p,

hsa-miR-324-3p, hsa-miR-421

2430
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
97.14
80

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p

2431
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
100
80

miR-664a-3p, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p

2432
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
98.57
80

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p

2433
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
90.83
100
100

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421

2434
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-140-3p, hsa-
90.83
100
70

miR-30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-

miR-452-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-

143-3p, hsa-miR-22-5p, hsa-miR-4306

2435
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
100
90

miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-

miR-421

2436
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-664a-3p, hsa-
90.83
91.43
90

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-1301-3p, hsa-miR-421, hsa-miR-22-5p

2437
hsa-miR-30b-5p, hsa-miR-503-5p, hsa-let-7i-5p, hsa-miR-
90.83
98.57
90

1249-3p, hsa-miR-181c-5p, hsa-miR-452-3p, hsa-miR-

421, hsa-miR-22-5p, hsa-miR-4306

2438
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
100
100

miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421

2439
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.83
98.57
90

miR-664a-3p, hsa-miR-31-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-

190a-5p, hsa-miR-143-3p, hsa-miR-421

2440
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa-
90.83
97.14
100

let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-421

2441
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.56
100
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-140-

3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2442
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.56
94.29
60

miR-664a-3p, hsa-miR-503-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-

miR-1301-3p, hsa-miR-215-5p

2443
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.56
94.29
60

miR-664a-3p, hsa-miR-941, hsa-miR-503-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p

2444
hsa-miR-335-5p, hsa-miR-664a-3p, hsa-miR-503-5p, hsa-
90.56
95.71
80

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-421

2445
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.56
100
80

miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-421

2446
hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-miR-664a-3p,
90.56
95.71
100

hsa-miR-941, hsa-miR-32-3p, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-181c-

5p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p,

hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p

2447
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.56
100
90

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-1301-3p,

hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-421

2448
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
90.56
94.29
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p,

hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421

2449
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.56
100
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-

3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-

miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421

2450
hsa-miR-106b-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-
90.56
90
90

miR-140-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-

421, hsa-miR-22-5p

2451
hsa-miR-30b-5p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-
90.56
95.71
80

let-7i-5p, hsa-miR-1296-5p, hsa-miR-421

2452
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
90.56
92.86
100

hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-100-5p,

hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421

2453
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
90.56
95.71
100

miR-31-5p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

190a-5p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421,

hsa-miR-22-5p, hsa-miR-4306

2454
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.56
98.57
90

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

190a-5p, hsa-miR-324-3p, hsa-miR-421

2455
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
90.28
92.86
60

miR-664a-3p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-100-5p,

hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-20b-5p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-421

2456
hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-
90.28
92.86
80

miR-140-3p, hsa-miR-503-5p, hsa-miR-1296-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

190a-5p, hsa-miR-215-5p, hsa-miR-421, hsa-miR-22-5p,

hsa-miR-4306

2457
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.89
92.86
80

miR-664a-3p, hsa-miR-31-5p, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-324-3p,

hsa-miR-143-3p, hsa-miR-421, hsa-miR-4306

2458
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
88.89
95.71
90

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-

5p, hsa-miR-4306

2459
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-32-3p, hsa-
88.89
94.29
90

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-324-

3p, hsa-miR-143-3p, hsa-miR-22-5p, hsa-miR-4306

2460
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
88.89
94.29
90

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-1249-3p, hsa-miR-100-5p, hsa-miR-1301-3p, hsa-

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2461
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
88.89
94.29
100

miR-664a-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2462
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
95.71
90

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p

2463
hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-miR-664a-3p,
88.61
94.29
90

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-1249-3p, hsa-miR-100-5p, hsa-miR-1301-3p, hsa-

miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2464
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-503-5p, hsa-
88.61
100
60

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-215-

5p

2465
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
88.61
98.57
90

hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2466
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
88.61
98.57
100

hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2467
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-941, hsa-miR-
88.61
98.57
100

32-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-100-

5p, hsa-miR-181c-5p, hsa-miR-20b-5p, hsa-miR-190a-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-4306

2468
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-
88.61
94.29
70

miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-

941, hsa-miR-30e-5p, hsa-miR-100-5p, hsa-miR-181c-5p,

hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-22-5p, hsa-

miR-4306

2469
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
88.61
92.86
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-30e-

5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p,

hsa-miR-100-5p, hsa-miR-1301-3p, hsa-miR-190a-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p, hsa-miR-4306

2470
hsa-miR-30b-5p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-
88.61
91.43
80

miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

20b-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p,

hsa-miR-4306

2471
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
95.71
90

miR-664a-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-

miR-1249-3p, hsa-miR-100-5p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2472
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
98.57
90

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-421

2473
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
98.57
80

miR-503-5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p

2474
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
88.61
97.14
100

hsa-miR-941, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2475
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
88.61
100
100

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421

2476
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
97.14
90

miR-664a-3p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-

5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-

miR-421

2477
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
92.86
80

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p,

hsa-miR-1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p,

hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-324-3p

2478
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
97.14
100

miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-1296-

5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-323b-3p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-421, hsa-miR-4306

2479
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-32-3p, hsa-
88.61
94.29
90

miR-140-3p, hsa-miR-30e-5p, hsa-miR-1249-3p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-324-

3p, hsa-miR-22-5p

2480
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.61
98.57
70

miR-664a-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p

2481
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
88.61
94.29
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-140-

3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-1249-3p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-

5p, hsa-miR-4306

2482
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.33
98.57
90

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-140-

3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-1249-3p, hsa-miR-100-5p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421

2483
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-
88.33
95.71
100

miR-30b-5p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-100-

5p, hsa-miR-181c-5p, hsa-miR-452-3p, hsa-miR-190a-5p,

hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p

2484
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.33
95.71
90

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-

3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-

miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-

421

2485
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
88.33
98.57
90

hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p,

hsa-miR-4306

2486
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.33
92.86
90

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-

3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-

miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2487
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
88.33
87.14
50

miR-31-5p, hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p,

hsa-miR-1249-3p, hsa-miR-190a-5p, hsa-miR-4306

2488
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.33
97.14
90

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-140-

3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-1249-3p, hsa-miR-100-5p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421

2489
hsa-miR-132-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
88.33
94.29
90

32-3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-miR-1296-

5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p,

hsa-miR-215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p, hsa-miR-4306

2490
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
88.33
95.71
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

20b-5p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2491
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
88.33
91.43
90

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-

323b-3p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2492
hsa-miR-503-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-
88.33
95.71
70

miR-181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-

miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421

2493
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-335-5p, hsa-
88.33
94.29
90

miR-30b-5p, hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p,

hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-1301-3p,

hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-421, hsa-

miR-4306

2494
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
88.33
88.57
50

miR-140-3p, hsa-miR-503-5p, hsa-miR-1296-5p, hsa-miR-

181c-5p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-miR-

143-3p, hsa-miR-22-5p, hsa-miR-4306

2495
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.33
90
80

miR-664a-3p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-4306

2496
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
88.06
95.71
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-

3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-miR-1296-5p,

hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-

miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-

5p

2497
hsa-miR-31-5p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-
88.06
92.86
70

7i-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-452-

3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-

miR-4306

2498
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-32-3p, hsa-
88.06
92.86
70

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-452-3p, hsa-miR-

20b-5p, hsa-miR-22-5p

2499
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
88.06
97.14
100

miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-

1296-5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-

452-3p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-421,

hsa-miR-22-5p, hsa-miR-4306

2500
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
86.67
95.71
90

hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2501
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
86.67
94.29
80

hsa-miR-941, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1249-3p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-421,

hsa-miR-22-5p, hsa-miR-4306

2502
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-941, hsa-
86.67
92.86
90

miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

1249-3p, hsa-miR-181c-5p, hsa-miR-452-3p, hsa-miR-

20b-5p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-

3p, hsa-miR-22-5p, hsa-miR-4306

2503
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
86.67
95.71
80

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-5p

2504
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
86.67
92.86
90

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-

miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-

421, hsa-miR-22-5p, hsa-miR-4306

2505
hsa-miR-132-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-
86.39
91.43
70

let-7i-5p, hsa-miR-1249-3p, hsa-miR-452-3p, hsa-miR-

421, hsa-miR-22-5p

2506
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
86.39
97.14
80

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-

miR-100-5p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421

2507
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
86.39
95.71
80

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421

2508
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-32-3p, hsa-
86.39
75.71
50

miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

215-5p, hsa-miR-421, hsa-miR-22-5p

2509
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
86.11
92.86
90

miR-32-3p, hsa-miR-140-3p, hsa-miR-1296-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

190a-5p, hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p,

hsa-miR-4306

2510
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
86.11
97.14
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-

1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-

324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-4306

2511
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
86.11
98.57
80

hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-

miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2512
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
86.11
88.57
60

miR-32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-

30e-5p, hsa-miR-1296-5p, hsa-miR-324-3p, hsa-miR-22-

5p

2513
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
86.11
100
80

miR-664a-3p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2514
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
86.11
88.57
90

miR-32-3p, hsa-miR-140-3p, hsa-miR-1296-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

190a-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421,

hsa-miR-22-5p, hsa-miR-4306

2515
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
86.11
94.29
50

miR-664a-3p, hsa-miR-1296-5p, hsa-miR-100-5p, hsa-

miR-181c-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-143-3p

2516
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
86.11
92.86
60

miR-31-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR-

181c-5p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-22-

5p

2517
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
86.11
95.71
100

miR-503-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-421

2518
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
86.11
98.57
60

miR-503-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p

2519
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
86.11
95.71
80

miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-100-

5p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-1301-

3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p,

hsa-miR-421

2520
hsa-miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
85.83
90
80

32-3p, hsa-miR-140-3p, hsa-miR-503-5p, hsa-miR-30e-

5p, hsa-miR-181c-5p, hsa-miR-452-3p, hsa-miR-20b-5p,

hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-22-5p, hsa-miR-4306

2521
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
85.83
91.43
100

miR-32-3p, hsa-miR-140-3p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-

215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421,

hsa-miR-22-5p, hsa-miR-4306

2522
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
85.83
94.29
100

miR-31-5p, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-

30e-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-452-

3p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-

22-5p

2523
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
85.83
94.29
100

miR-664a-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-32-

3p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-

miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-

miR-20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-

miR-215-5p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-

421, hsa-miR-4306

2524
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-664a-3p,
85.83
100
100

hsa-miR-31-5p, hsa-miR-140-3p, hsa-miR-30e-5p, hsa-let-

7i-5p, hsa-miR-100-5p, hsa-miR-323b-3p, hsa-miR-1301-

3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p,

hsa-miR-143-3p, hsa-miR-421, hsa-miR-4306

2525
hsa-miR-106b-3p, hsa-miR-941, hsa-miR-140-3p, hsa-
85.83
90
70

miR-503-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-181c-5p, hsa-miR-323b-3p, hsa-miR-

20b-5p, hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-

215-5p, hsa-miR-143-3p, hsa-miR-421

2526
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
84.44
91.43
80

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-100-5p, hsa-miR-

323b-3p, hsa-miR-1301-3p, hsa-miR-324-3p, hsa-miR-

143-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2527
hsa-miR-335-5p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
84.17
91.43
70

miR-503-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-20b-5p, hsa-miR-

1301-3p, hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421,

hsa-miR-22-5p

2528
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
84.17
91.43
80

miR-664a-3p, hsa-miR-32-3p, hsa-miR-30e-5p, hsa-miR-

1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-

20b-5p, hsa-miR-1301-3p, hsa-miR-215-5p, hsa-miR-324-

3p, hsa-miR-143-3p, hsa-miR-421

2529
hsa-miR-132-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-
84.17
94.29
70

let-7i-5p, hsa-miR-452-3p, hsa-miR-421, hsa-miR-22-5p

2530
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
83.89
94.29
100

hsa-miR-31-5p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-

100-5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-

190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-miR-143-

3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2531
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
83.89
97.14
80

miR-664a-3p, hsa-miR-941, hsa-let-7i-5p, hsa-miR-100-

5p, hsa-miR-323b-3p, hsa-miR-1301-3p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-421

2532
hsa-miR-335-5p, hsa-miR-941, hsa-miR-503-5p, hsa-miR-
83.89
92.86
70

30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-miR-452-3p,

hsa-miR-215-5p, hsa-miR-421

2533
hsa-miR-132-3p, hsa-miR-664a-3p, hsa-miR-503-5p, hsa-
83.89
88.57
60

let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-

181c-5p, hsa-miR-323b-3p, hsa-miR-452-3p, hsa-miR-

20b-5p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-4306

2534
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
83.61
88.57
80

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-1249-

3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-20b-5p,

hsa-miR-1301-3p, hsa-miR-190a-5p, hsa-miR-143-3p,

hsa-miR-421

2535
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
83.61
88.57
100

miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-

3p, hsa-miR-1249-3p, hsa-miR-181c-5p, hsa-miR-323b-

3p, hsa-miR-452-3p, hsa-miR-190a-5p, hsa-miR-215-5p,

hsa-miR-324-3p, hsa-miR-143-3p, hsa-miR-22-5p, hsa-

miR-4306

2536
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-664a-3p, hsa-
83.61
90
60

miR-31-5p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-

3p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-1301-3p,

hsa-miR-324-3p, hsa-miR-143-3p

2537
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
81.67
92.86
90

miR-664a-3p, hsa-miR-31-5p, hsa-miR-32-3p, hsa-miR-

140-3p, hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p,

hsa-miR-1249-3p, hsa-miR-100-5p, hsa-miR-20b-5p, hsa-

miR-1301-3p, hsa-miR-190a-5p, hsa-miR-215-5p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-4306

2538
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-503-5p, hsa-
81.67
82.86
40

miR-30e-5p, hsa-let-7i-5p, hsa-miR-1296-5p, hsa-miR-

1249-3p, hsa-miR-323b-3p

2539
hsa-miR-132-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
81.67
90
90

miR-664a-3p, hsa-miR-941, hsa-miR-32-3p, hsa-miR-140-

3p, hsa-miR-1296-5p, hsa-miR-1249-3p, hsa-miR-100-5p,

hsa-miR-452-3p, hsa-miR-20b-5p, hsa-miR-1301-3p, hsa-

miR-324-3p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-

5p, hsa-miR-4306

2540
hsa-miR-106b-3p, hsa-miR-335-5p, hsa-miR-30b-5p, hsa-
81.39
91.43
50

miR-664a-3p, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR-

1296-5p, hsa-miR-100-5p, hsa-miR-181c-5p, hsa-miR-

323b-3p, hsa-miR-215-5p, hsa-miR-143-3p

2541
hsa-miR-132-3p, hsa-miR-30b-5p, hsa-miR-31-5p, hsa-
81.11
94.29
70

miR-941, hsa-miR-32-3p, hsa-miR-140-3p, hsa-miR-503-

5p, hsa-miR-30e-5p, hsa-miR-1296-5p, hsa-miR-1301-3p,

hsa-miR-190a-5p, hsa-miR-215-5p, hsa-miR-324-3p, hsa-

miR-143-3p, hsa-miR-22-5p

2542
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-30b-5p, hsa-
81.11
87.14
80

miR-31-5p, hsa-miR-32-3p, hsa-miR-503-5p, hsa-miR-

1249-3p, hsa-miR-190a-5p, hsa-miR-324-3p, hsa-miR-421

2543
hsa-miR-132-3p, hsa-miR-31-5p, hsa-miR-941, hsa-miR-
79.44
94.29
70

32-3p, hsa-miR-503-5p, hsa-miR-30e-5p, hsa-let-7i-5p,

hsa-miR-1296-5p, hsa-miR-323b-3p, hsa-miR-452-3p,

hsa-miR-324-3p, hsa-miR-421, hsa-miR-22-5p, hsa-miR-

4306

2544
hsa-miR-132-3p, hsa-miR-106b-3p, hsa-miR-664a-3p,
76.94
85.71
70

hsa-miR-30e-5p, hsa-let-7i-5p, hsa-miR-1249-3p, hsa-

miR-100-5p, hsa-miR-181c-5p, hsa-miR-1301-3p, hsa-

miR-215-5p, hsa-miR-143-3p, hsa-miR-421, hsa-miR-22-

5p, hsa-miR-4306

2545
combination 2272 + rs12917707
84.17
80
53.33

2546
combination 2274 + rs9928757
84.44
90
63.33

2547
combination 2275 + rs13335818
91.11
95.71
71.67

2548
combination 2276 + rs13335818
88.61
94.29
78.33

2549
combination 2277 + rs76563024
88.89
95.71
81.67

2550
combination 2278 + rs4297685
86.67
94.29
93.33

2551
combination 2279 + rs9928757
88.89
92.86
91.39

2552
combination 2280 + rs71384446
91.11
97.14
96.39

2553
combination 2281 + rs13333226
93.33
98.57
96.11

2554
combination 2282 + rs7204342
93.33
100
100

2555
combination 2283 + rs11862974
90.83
95.71
99.17

2556
combination 2284 + rs13335818
93.33
98.57
98.06

2557
combination 2285 + rs13335818
93.33
98.57
100.0

2558
combination 2286 + rs13333226
88.89
100
100

2559
combination 2287 + rs13333226
90.83
95.71
93.33

2560
combination 2288 + rs13335818
93.06
95.71
91.39

2561
combination 2289 + rs4297685
88.33
94.29
96.39

2562
combination 2290 + rs76563024
88.33
94.29
96.11

2563
combination 2291 + rs71384446
86.11
94.29
99.17

2564
combination 2292 + rs71384446
86.11
94.29
98.06

2565
combination 2293 + rs71384446
95
94.29
100.0

2566
combination 2294 + rs11647727
95
94.29
98.89

2567
combination 2295 + rs11647727
92.78
92.86
97.78

2568
combination 2296 + rs11647727
92.78
92.86
98.89

2569
combination 2297 + rs13335818
87.78
90
98.89

2570
combination 2528 + rs12934455
85.28
90
98.89

2571
combination 2529 + rs12934455
85.28
90
98.89

2572
combination 2274 + rs4293393
88.61
91.43
97.78

2573
combination 2275 + rs4293393
91.11
95.71
98.89

2574
combination 2277 + rs4293393
88.89
94.29
98.89

2575
combination 2278 + rs4293393
91.11
94.29
100.0

2576
combination 2279 + rs4293393
86.67
90
100.0

2577
combination 2280 + rs4293393
88.61
88.57
99.17

2578
combination 2282 + rs4293393
90.83
94.29
99.17

2579
combination 2283 + rs4293393
92.78
94.29
99.17

2580
combination 2287 + rs4293393
90.56
95.71
99.17

2581
combination 2288 + rs4293393
90.56
92.86
97.22

2582
combination 2289 + rs4293393
90.56
95.71
97.22

2583
combination 2290 + rs4293393
90.56
92.86
91.39

2584
combination 2292 + rs4293393
95.28
97.14
96.39

2585
combination 2293 + rs4293393
92.78
95.71
96.11

2586
combination 2294 + rs4293393
90.56
95.71
99.17

2587
combination 2295 + rs4293393
90.56
94.29
98.06

2588
combination 2296 + rs4293393
88.06
91.43
93.33

2589
combination 2297 + rs4293393
88.06
91.43
91.39

This is the list of the best 30 mRNA selected by the algorithm sorted by importance for tumour grade: hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, and hsa-miR-15a-3p. The inventors combined these miRNAs, together or not with age and UMOD SNP variant, creating unique combinations leading to a further significant increase in sensitivity, specificity, accuracy and predictive power for tumour grade (Table 27).

TABLE 27

Combinations that allow higher sensitivity, specificity,

accuracy and predictive power for tumour grade.

N
Combinations
Accuracy
ROC AUC
Recall

2590
hsa-miR-4306
76.67
74.76
58.57

2591
hsa-miR-4306, hsa-miR-132-3p
70
63.33
76.40

2592
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p
79.17
80.79
85.51

2593
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
86.11
88.65
87.24

miR-148a-3p

2594
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
83.89
84.92
89.21

miR-148a-3p, hsa-miR-629-5p

2595
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
93.06
96.9
89.43

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p

2596
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.56
96.9
88.79

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p

2597
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.56
93.81
83.31

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p

2598
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.83
95.24
89.77

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2599
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.56
100
91.19

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p

2600
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
93.06
98.33
92.39

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p

2601
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.83
98.57
92.61

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p

2602
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
86.39
95.24
95.90

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p

2603
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
85.83
95
95.84

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p

2604
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
86.39
93.81
97.10

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p

2605
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.56
95.24
96.40

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p

2606
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
92.78
95.24
99.11

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p

2607
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.56
98.57
99.11

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p

2608
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
90.83
93.81
99.14

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p

2609
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
88.33
92.62
98.52

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p

2610
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
93.06
94.29
98.83

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p

2611
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
81.11
92.38
100.00

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p

2612
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
81.39
93.81
100.00

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p

2613
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
81.39
92.14
100.00

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p, hsa-miR-590-5p

2614
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
88.33
90.48
98.77

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p, hsa-miR-590-5p, hsa-miR-340-5p

2615
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
88.33
90.48
97.85

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p

2616
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
83.89
90.71
97.23

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p,

hsa-miR-505-5p

2617
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
83.61
86.19
97.57

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p,

hsa-miR-505-5p, hsa-miR-433-3p

2618
hsa-miR-4306, hsa-miR-132-3p, hsa-miR-125b-5p, hsa-
83.89
87.62
97.26

miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-

1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p, hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p,

hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p,

hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p

2619
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
97.78
98.57
100.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-590-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-let-7i-5p

2620
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
97.78
97.14
90.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2621
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
97.78
100.00
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-miR-1296-5p, hsa-let-7i-5p

2622
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
97.78
98.57
100.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-

5p

2623
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
97.78
100.00
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-let-7i-5p

2624
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
95.56
97.46
90.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-let-7i-5p,

hsa-miR-652-5p

2625
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
95.56
97.46
90.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2626
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
95.56
98.89
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-

miR-590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-

5p, hsa-let-7i-5p, hsa-miR-652-5p

2627
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
95.56
97.46
90.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-let-7i-5p,

hsa-miR-652-5p

2628
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
95.56
93.17
90.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-miR-1296-5p, hsa-let-7i-

5p, hsa-miR-652-5p

2629
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
95.56
97.46
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-let-7i-5p

2630
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
95.56
97.46
90.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-

5p, hsa-let-7i-5p, hsa-miR-652-5p

2631
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
95.56
100.00
90.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2632
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
95.56
98.57
100.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-

miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-

433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a-

3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p

2633
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
95.56
98.57
90.00

miR-202-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-652-

5p

2634
hsa-miR-424-5p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-
95.56
100.00
90.00

miR-584-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-

433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a-

3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p

2635
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
95.28
98.57
90.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-29b-3p, hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-miR-

545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-

5p

2636
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa-
95.28
98.57
80.00

miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2637
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
95.28
100.00
90.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-

5p, hsa-let-7i-5p, hsa-miR-652-5p

2638
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
95.28
96.67
90.00

miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-

miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-let-7i-5p,

hsa-miR-652-5p

2639
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
95.28
98.57
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-miR-545-5p, hsa-let-7i-5p

2640
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
95.28
98.33
100.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p, hsa-miR-545-5p

2641
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa-
95.00
98.33
90.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-150-5p, hsa-miR-

590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-29c-

5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p,

hsa-let-7i-5p, hsa-miR-652-5p

2642
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-1537-3p, hsa-
95.00
98.33
80.00

miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-

3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-652-5p

2643
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
93.33
96.35
93.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-

miR-590-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2644
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
93.33
98.57
83.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2645
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
93.33
92.86
100.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-15a-

3p, hsa-miR-1296-5p, hsa-let-7i-5p

2646
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
93.33
95.71
90.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-

433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p

2647
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
93.33
96.03
93.33

miR-202-5p, hsa-miR-744-5p, hsa-miR-433-3p, hsa-miR-

148a-3p, hsa-miR-629-5p

2648
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
93.33
91.43
90.00

miR-584-5p, hsa-miR-664a-3p, hsa-miR-1537-3p, hsa-

miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-

5p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa-miR-652-5p

2649
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
93.33
92.86
100.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-let-7i-5p

2650
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.33
91.43
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-433-

3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p,

hsa-miR-545-5p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa-

miR-652-5p

2651
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
93.33
98.57
83.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

1296-5p, hsa-let-7i-5p

2652
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.33
97.14
93.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-miR-148a-3p, hsa-let-7i-5p

2653
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.33
97.14
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-505-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2654
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
93.33
98.57
83.33

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2655
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.33
91.43
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-29c-

5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-5p,

hsa-miR-1296-5p, hsa-let-7i-5p, hsa-miR-652-5p

2656
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.33
94.29
90.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-148a-3p

2657
hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
93.33
97.14
90.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-let-7i-5p

2658
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.06
93.81
100.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-

miR-590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-629-

5p, hsa-miR-545-5p, hsa-miR-652-5p

2659
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.06
98.89
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-545-5p

2660
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.06
98.57
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-433-3p, hsa-miR-15a-3p

2661
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
93.06
94.05
90.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-29b-3p, hsa-miR-

15a-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-1296-

5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2662
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa-
93.06
91.90
90.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-590-5p, hsa-miR-

340-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-148a-

3p, hsa-miR-545-5p, hsa-let-7i-5p, hsa-miR-652-5p

2663
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
93.06
95.71
80.00

miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

148a-3p, hsa-miR-652-5p

2664
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
93.06
100.00
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-

miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-

5p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p

2665
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
93.06
98.89
83.33

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

545-5p

2666
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
93.06
100.00
100.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-

15a-3p, hsa-let-7i-5p

2667
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
92.78
96.90
80.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a-

3p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2668
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
92.78
94.05
90.00

miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-

miR-433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-let-

7i-5p, hsa-miR-652-5p

2669
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-1537-3p, hsa-
92.78
92.38
70.00

miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-148a-

3p, hsa-let-7i-5p, hsa-miR-652-5p

2670
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
92.78
93.57
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-15a-

3p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2671
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa-
92.50
96.67
80.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-150-5p, hsa-miR-

590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-29c-

5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-545-5p,

hsa-miR-652-5p

2672
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa-
92.50
93.33
80.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-29b-3p, hsa-miR-

590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-148a-

3p, hsa-miR-629-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p,

hsa-miR-652-5p

2673
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
91.11
92.86
100.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a-

5p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-let-7i-5p

2674
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
91.11
91.43
100.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2675
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
91.11
94.60
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2676
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
91.11
91.43
100.00

miR-202-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-let-7i-5p

2677
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
91.11
91.43
100.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-15a-

3p, hsa-let-7i-5p

2678
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
91.11
91.43
93.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-3p, hsa-miR-

1296-5p, hsa-let-7i-5p

2679
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.83
95.48
70.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p

2680
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
90.83
94.92
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-505-5p, hsa-miR-433-

3p, hsa-let-7i-5p

2681
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.83
97.14
80.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p

2682
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.83
92.62
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-150-5p, hsa-miR-590-5p, hsa-miR-340-

5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p,

hsa-miR-148a-3p, hsa-miR-652-5p

2683
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
90.83
95.24
83.33

miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-103a-

2-5p

2684
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
90.83
95.71
80.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2685
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
90.83
93.17
93.33

miR-664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-340-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

629-5p, hsa-let-7i-5p

2686
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
90.83
92.70
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-150-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-miR-629-5p

2687
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
90.83
93.49
90.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-

15a-3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-let-7i-5p

2688
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.83
97.46
83.33

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

545-5p, hsa-let-7i-5p

2689
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
90.83
97.22
83.33

miR-34a-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-miR-

590-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p,

hsa-let-7i-5p, hsa-miR-652-5p

2690
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.56
93.81
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2691
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.56
95.48
90.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-let-7i-5p

2692
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.56
98.57
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-29c-

5p, hsa-miR-15a-3p, hsa-let-7i-5p

2693
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.56
95.48
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-15a-

3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2694
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
90.56
98.33
80.00

miR-1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-

5p, hsa-let-7i-5p, hsa-miR-652-5p

2695
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
90.56
95.48
80.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-29b-3p, hsa-miR-340-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-545-5p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2696
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
90.56
98.57
80.00

miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2697
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
90.56
94.13
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-150-5p, hsa-miR-433-3p, hsa-miR-15a-

3p

2698
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
90.56
96.90
90.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-

3p, hsa-let-7i-5p

2699
hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
90.56
95.00
90.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

629-5p, hsa-miR-545-5p

2700
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.56
95.48
80.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2701
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.56
95.48
80.00

miR-744-5p, hsa-miR-1537-3p, hsa-miR-340-5p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

545-5p

2702
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
90.56
95.48
80.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2703
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
90.56
97.14
70.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

148a-3p, hsa-miR-652-5p

2704
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-410-3p, hsa-
90.28
92.14
90.00

miR-150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-148a-3p, hsa-miR-629-

5p, hsa-miR-545-5p, hsa-miR-652-5p

2705
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
90.28
95.24
80.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2706
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
90.28
93.33
70.00

miR-34a-5p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p,

hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-1296-5p,

hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p

2707
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.89
90.00
93.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-let-7i-5p

2708
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.89
96.35
86.67

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-miR-545-5p, hsa-let-7i-5p

2709
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.89
91.43
100.00

miR-202-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-let-7i-5p

2710
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.89
92.86
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-

15a-3p, hsa-miR-1296-5p, hsa-let-7i-5p

2711
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.61
98.57
100.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-629-5p

2712
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.61
97.14
80.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p

2713
hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
88.61
91.19
90.00

miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-3p, hsa-miR-

103a-2-5p, hsa-let-7i-5p

2714
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.61
88.41
90.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-629-5p

2715
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
88.61
96.03
76.67

miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-1296-5p, hsa-let-7i-5p

2716
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
88.61
91.43
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-629-5p

2717
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
88.61
97.14
83.33

miR-34a-5p, hsa-miR-32-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-505-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-629-5p,

hsa-let-7i-5p

2718
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.61
97.46
83.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-

miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-

148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2719
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-664a-3p, hsa-
88.61
86.90
80.00

miR-1537-3p, hsa-miR-150-5p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-505-5p, hsa-miR-29c-5p, hsa-miR-

1296-5p, hsa-let-7i-5p

2720
hsa-miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
88.61
95.48
83.33

miR-410-3p, hsa-miR-664a-3p, hsa-miR-29b-3p, hsa-

miR-629-5p, hsa-miR-1296-5p, hsa-let-7i-5p

2721
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.61
93.25
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-

584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-340-

5p, hsa-miR-15a-3p, hsa-let-7i-5p

2722
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
88.33
97.14
70.00

miR-744-5p, hsa-miR-29b-3p, hsa-miR-505-5p, hsa-miR-

433-3p, hsa-miR-629-5p, hsa-miR-1296-5p, hsa-miR-

103a-2-5p, hsa-let-7i-5p, hsa-miR-652-5p

2723
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
88.33
95.48
80.00

miR-34a-5p, hsa-miR-32-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-590-

5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-505-5p,

hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2724
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.33
93.81
83.33

miR-202-5p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-545-

5p

2725
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa-
88.33
94.68
73.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2726
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
88.33
91.43
70.00

miR-584-5p, hsa-miR-664a-3p, hsa-miR-1537-3p, hsa-

miR-29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-

15a-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-148a-

3p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-miR-103a-2-

5p, hsa-let-7i-5p, hsa-miR-652-5p

2727
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
88.33
92.14
83.33

miR-410-3p, hsa-miR-744-5p, hsa-miR-15a-5p, hsa-miR-

433-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-let-7i-5p

2728
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.33
90.95
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-29c-

5p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2729
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.33
93.81
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2730
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.33
92.62
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2731
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.33
93.81
80.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2732
hsa-miR-424-5p, hsa-miR-664a-3p, hsa-miR-1537-3p,
88.06
92.38
80.00

hsa-miR-150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-15a-3p, hsa-miR-

629-5p, hsa-miR-545-5p, hsa-miR-1296-5p, hsa-let-7i-5p,

hsa-miR-652-5p

2733
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.06
95.24
70.00

miR-202-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-

miR-590-5p, hsa-miR-340-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-545-

5p, hsa-miR-652-5p

2734
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.06
95.24
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-

584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2735
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
88.06
96.67
80.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-

433-3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-652-

5p

2736
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
88.06
91.90
80.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p, hsa-miR-545-5p

2737
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
88.06
95.56
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-545-5p

2738
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
88.06
91.90
90.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-629-5p, hsa-miR-545-5p

2739
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-202-5p, hsa-
87.78
91.11
70.00

miR-584-5p, hsa-miR-664a-3p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-let-7i-

5p

2740
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
87.78
93.81
90.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-629-5p, hsa-miR-545-5p, hsa-let-7i-5p

2741
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa-
86.39
98.89
83.33

miR-1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-

433-3p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p,

hsa-miR-652-5p

2742
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-202-5p, hsa-
86.39
96.11
76.67

miR-744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2743
hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
86.39
91.19
86.67

miR-584-5p, hsa-miR-744-5p, hsa-miR-433-3p, hsa-miR-

15a-3p

2744
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
86.39
88.10
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p

2745
hsa-miR-369-3p, hsa-miR-410-3p, hsa-miR-664a-3p, hsa-
86.39
84.84
73.33

miR-744-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-340-5p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-

1296-5p, hsa-let-7i-5p, hsa-miR-652-5p

2746
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
86.39
90.32
80.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

664a-3p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-

590-5p, hsa-miR-340-5p, hsa-miR-29c-5p, hsa-miR-15a-

3p, hsa-miR-148a-3p, hsa-miR-545-5p, hsa-miR-1296-5p,

hsa-let-7i-5p, hsa-miR-652-5p

2747
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
86.39
92.14
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-

433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-let-7i-5p

2748
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa-
86.39
94.92
83.33

miR-1537-3p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-

miR-15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-

652-5p

2749
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
86.11
95.71
80.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-

29b-3p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-545-

5p, hsa-miR-1296-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2750
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
86.11
92.62
70.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-

29b-3p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-miR-

103a-2-5p, hsa-let-7i-5p

2751
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
86.11
94.37
73.33

miR-32-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2752
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
86.11
90.95
80.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a-

5p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2753
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
86.11
90.95
90.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-

629-5p

2754
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
86.11
96.35
66.67

miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-

664a-3p, hsa-miR-1537-3p, hsa-miR-340-5p, hsa-miR-

15a-3p, hsa-miR-545-5p, hsa-let-7i-5p

2755
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
86.11
92.62
70.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-148a-3p, hsa-miR-629-5p,

hsa-miR-652-5p

2756
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa-
86.11
96.67
73.33

miR-1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-

433-3p, hsa-miR-15a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2757
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
86.11
96.03
63.33

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

148a-3p, hsa-let-7i-5p

2758
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-202-5p, hsa-
86.11
94.13
66.67

miR-584-5p, hsa-miR-1537-3p, hsa-miR-590-5p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2759
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
86.11
95.48
90.00

miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

15a-5p, hsa-miR-505-5p, hsa-miR-148a-3p, hsa-miR-629-

5p, hsa-miR-545-5p

2760
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
86.11
91.19
70.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a-

5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2761
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
86.11
92.38
90.00

miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-let-7i-5p

2762
hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
86.11
90.63
73.33

miR-744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-

433-3p, hsa-miR-15a-3p

2763
hsa-miR-128-3p, hsa-miR-34a-5p, hsa-miR-202-5p, hsa-
86.11
92.38
70.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-

3p, hsa-miR-148a-3p, hsa-let-7i-5p, hsa-miR-652-5p

2764
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
86.11
95.48
90.00

miR-32-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2765
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
86.11
93.49
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-340-5p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-545-5p, hsa-miR-652-5p

2766
hsa-miR-590-5p, hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-
85.83
97.14
50.00

miR-148a-3p

2767
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
85.83
94.13
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-545-5p,

hsa-let-7i-5p

2768
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
85.83
89.29
70.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a-

5p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2769
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
85.83
86.19
80.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-29b-3p, hsa-miR-15a-3p, hsa-miR-1296-

5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2770
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
85.83
93.81
80.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-29b-

3p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p,

hsa-miR-629-5p, hsa-miR-1296-5p, hsa-let-7i-5p, hsa-

miR-652-5p

2771
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
85.83
90.71
90.00

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-629-5p, hsa-let-7i-5p

2772
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
85.83
91.90
83.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-629-

5p, hsa-miR-545-5p, hsa-let-7i-5p

2773
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
85.83
95.56
73.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-545-5p

2774
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
85.83
86.27
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-miR-652-5p

2775
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
85.83
91.27
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-340-

5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p,

hsa-miR-629-5p

2776
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
85.83
93.81
70.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

29b-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-103a-

2-5p, hsa-let-7i-5p

2777
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
85.83
89.92
83.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-629-

5p, hsa-let-7i-5p

2778
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
85.56
89.05
70.00

miR-32-3p, hsa-miR-202-5p, hsa-miR-664a-3p, hsa-miR-

150-5p, hsa-miR-29b-3p, hsa-miR-340-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p

2779
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
85.56
93.57
73.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-let-7i-5p

2780
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
85.56
93.57
83.33

miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-545-

5p

2781
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
85.56
84.92
60.00

miR-202-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-

5p

2782
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
85.56
91.90
83.33

miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p, hsa-miR-545-5p

2783
hsa-miR-369-3p, hsa-miR-202-5p, hsa-miR-1537-3p, hsa-
85.28
92.22
70.00

miR-150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-

3p, hsa-miR-545-5p, hsa-miR-103a-2-5p, hsa-miR-652-5p

2784
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa-
84.17
92.38
76.67

miR-744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2785
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
84.17
93.17
73.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

433-3p

2786
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
84.17
91.83
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-

584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-148a-3p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2787
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
84.17
94.92
76.67

miR-32-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-let-7i-5p

2788
hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-584-5p, hsa-
84.17
91.43
70.00

miR-744-5p, hsa-miR-1537-3p, hsa-miR-15a-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2789
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa-
84.17
90.16
86.67

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-

1296-5p, hsa-let-7i-5p

2790
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-202-5p, hsa-
84.17
96.11
76.67

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-let-7i-5p

2791
hsa-miR-369-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
83.89
84.76
70.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-15a-

5p, hsa-miR-433-3p, hsa-miR-148a-3p, hsa-miR-629-5p,

hsa-miR-652-5p

2792
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
83.89
89.52
73.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-410-3p, hsa-miR-

584-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-let-7i-

5p

2793
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa-
83.89
96.03
80.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-

5p

2794
hsa-miR-369-3p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
83.89
91.35
83.33

miR-584-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-

miR-29c-5p, hsa-miR-15a-3p, hsa-miR-629-5p, hsa-miR-

1296-5p, hsa-let-7i-5p, hsa-miR-652-5p

2795
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa-
83.89
93.25
83.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-15a-

3p, hsa-let-7i-5p

2796
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
83.89
92.94
83.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-let-7i-5p

2797
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
83.89
96.35
73.33

miR-32-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2798
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-584-5p, hsa-
83.89
92.22
73.33

miR-1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-

433-3p, hsa-miR-15a-3p, hsa-let-7i-5p

2799
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
83.89
91.51
73.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-29c-

5p, hsa-miR-15a-3p, hsa-miR-1296-5p, hsa-let-7i-5p

2800
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
83.89
91.90
66.67

miR-32-3p, hsa-miR-1537-3p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-let-7i-5p

2801
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
83.89
84.29
70.00

miR-584-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-

miR-505-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-

148a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p, hsa-miR-652-

5p

2802
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
83.89
86.43
83.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-590-5p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-652-5p

2803
hsa-miR-128-3p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-
83.89
92.14
63.33

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-let-7i-5p

2804
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
83.89
94.44
66.67

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-let-7i-5p

2805
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
83.89
90.95
83.33

miR-32-3p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-433-

3p, hsa-miR-629-5p, hsa-miR-1296-5p, hsa-let-7i-5p

2806
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
83.89
96.67
73.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-629-5p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2807
hsa-miR-369-3p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
83.61
89.60
73.33

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-340-

5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p,

hsa-let-7i-5p

2808
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-584-5p, hsa-
83.61
87.62
60.00

miR-744-5p, hsa-miR-150-5p, hsa-miR-590-5p, hsa-miR-

433-3p, hsa-miR-1296-5p, hsa-miR-103a-2-5p

2809
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
83.61
88.17
73.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-let-7i-5p

2810
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
83.61
92.46
70.00

miR-34a-5p, hsa-miR-202-5p, hsa-miR-664a-3p, hsa-miR-

150-5p, hsa-miR-590-5p, hsa-miR-29c-5p, hsa-miR-545-

5p, hsa-let-7i-5p

2811
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
83.61
94.37
70.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-29b-3p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-15a-3p, hsa-miR-545-5p, hsa-miR-103a-

2-5p, hsa-let-7i-5p

2812
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
83.33
92.14
70.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-29b-3p, hsa-miR-433-3p, hsa-miR-629-

5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2813
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
83.33
87.14
70.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2814
hsa-miR-369-3p, hsa-miR-34a-5p, hsa-miR-410-3p, hsa-
83.33
87.14
90.00

miR-584-5p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

29b-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-505-

5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-15a-3p,

hsa-miR-629-5p, hsa-miR-545-5p, hsa-miR-1296-5p

2815
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
83.33
90.48
70.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-150-5p, hsa-miR-29b-3p, hsa-miR-433-

3p, hsa-miR-629-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2816
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
83.33
91.03
70.00

miR-34a-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-miR-

410-3p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-744-

5p, hsa-miR-1537-3p, hsa-miR-150-5p, hsa-miR-340-5p,

hsa-miR-433-3p, hsa-miR-15a-3p, hsa-miR-545-5p, hsa-

let-7i-5p

2817
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
83.33
89.13
73.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p, hsa-miR-545-5p, hsa-let-7i-5p

2818
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
81.94
86.51
83.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-505-5p, hsa-miR-29c-

5p, hsa-miR-15a-3p, hsa-miR-629-5p, hsa-let-7i-5p, hsa-

miR-652-5p

2819
hsa-miR-128-3p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
81.67
83.57
60.00

miR-202-5p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-340-5p, hsa-miR-29c-5p, hsa-miR-

148a-3p, hsa-miR-652-5p

2820
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa-
81.67
89.05
66.67

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-505-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-

7i-5p

2821
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
81.67
92.62
73.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-664a-3p, hsa-miR-

744-5p, hsa-miR-1537-3p, hsa-miR-29b-3p, hsa-miR-15a-

5p, hsa-miR-15a-3p, hsa-miR-629-5p, hsa-miR-103a-2-

5p, hsa-let-7i-5p

2822
hsa-miR-128-3p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
81.67
90.95
56.67

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-433-3p, hsa-miR-15a-3p, hsa-miR-103a-2-5p, hsa-

let-7i-5p

2823
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-32-3p, hsa-
81.67
93.81
73.33

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-

15a-3p, hsa-let-7i-5p

2824
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
81.39
83.65
90.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p

2825
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-202-5p, hsa-
81.39
93.02
56.67

miR-584-5p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-

miR-15a-5p, hsa-miR-433-3p, hsa-miR-15a-3p, hsa-let-7i-

5p

2826
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
81.39
92.70
73.33

miR-202-5p, hsa-miR-584-5p, hsa-miR-1537-3p, hsa-

miR-150-5p, hsa-miR-590-5p, hsa-miR-433-3p, hsa-miR-

29c-5p, hsa-miR-148a-3p, hsa-miR-629-5p, hsa-miR-652-

5p

2827
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
81.39
81.98
73.33

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

744-5p, hsa-miR-150-5p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-629-5p

2828
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
81.39
92.38
73.33

miR-410-3p, hsa-miR-744-5p, hsa-miR-15a-5p, hsa-miR-

433-3p, hsa-miR-29c-5p, hsa-miR-629-5p, hsa-let-7i-5p

2829
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-34a-5p, hsa-
81.39
94.05
70.00

miR-32-3p, hsa-miR-584-5p, hsa-miR-150-5p, hsa-miR-

29b-3p, hsa-miR-15a-5p, hsa-miR-505-5p, hsa-miR-103a-

2-5p

2830
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
81.11
89.05
73.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p, hsa-let-7i-5p

2831
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
80.83
88.25
63.33

miR-584-5p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-29c-5p, hsa-miR-629-

5p, hsa-let-7i-5p

2832
hsa-miR-128-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
80.83
82.62
60.00

miR-202-5p, hsa-miR-410-3p, hsa-miR-584-5p, hsa-miR-

664a-3p, hsa-miR-744-5p, hsa-miR-1537-3p, hsa-miR-

29b-3p, hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-miR-1296-

5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2833
hsa-miR-369-3p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-
80.83
84.29
60.00

miR-29b-3p, hsa-miR-590-5p, hsa-miR-15a-5p, hsa-miR-

505-5p, hsa-miR-29c-5p, hsa-miR-15a-3p, hsa-miR-629-

5p, hsa-miR-103a-2-5p

2834
hsa-miR-128-3p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
79.44
87.22
63.33

miR-410-3p, hsa-miR-664a-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-29b-3p, hsa-miR-340-5p, hsa-miR-15a-

5p, hsa-miR-29c-5p, hsa-miR-148a-3p, hsa-miR-1296-5p,

hsa-let-7i-5p, hsa-miR-652-5p

2835
hsa-miR-34a-5p, hsa-miR-202-5p, hsa-miR-584-5p, hsa-
79.17
83.10
63.33

miR-664a-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

505-5p, hsa-miR-433-3p, hsa-miR-629-5p, hsa-miR-545-

5p, hsa-miR-1296-5p, hsa-miR-652-5p

2836
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-424-5p, hsa-
78.89
87.94
43.33

miR-34a-5p, hsa-miR-32-3p, hsa-miR-744-5p, hsa-miR-

1537-3p, hsa-miR-590-5p, hsa-miR-340-5p, hsa-miR-433-

3p, hsa-miR-15a-3p

2837
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
78.61
86.59
63.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-29c-

5p, hsa-miR-629-5p, hsa-let-7i-5p

2838
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
78.61
93.33
70.00

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-29b-3p, hsa-miR-15a-5p, hsa-miR-433-

3p, hsa-miR-629-5p, hsa-miR-103a-2-5p, hsa-let-7i-5p

2839
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
78.61
80.08
53.33

miR-410-3p, hsa-miR-584-5p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p

2840
hsa-miR-424-5p, hsa-miR-32-3p, hsa-miR-202-5p, hsa-
76.94
82.22
73.33

miR-410-3p, hsa-miR-744-5p, hsa-miR-150-5p, hsa-miR-

15a-5p, hsa-miR-433-3p, hsa-miR-629-5p

2841
hsa-miR-369-3p, hsa-miR-128-3p, hsa-miR-34a-5p, hsa-
76.67
88.41
63.33

miR-32-3p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-505-5p, hsa-miR-433-3p, hsa-miR-629-

5p

2842
hsa-miR-424-5p, hsa-miR-34a-5p, hsa-miR-32-3p, hsa-
76.67
82.86
63.33

miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-433-3p, hsa-miR-629-5p

2843
hsa-miR-369-3p, hsa-miR-32-3p, hsa-miR-584-5p, hsa-
76.67
89.60
66.67

miR-744-5p, hsa-miR-150-5p, hsa-miR-505-5p, hsa-miR-

433-3p, hsa-miR-629-5p, hsa-miR-1296-5p, hsa-miR-

103a-2-5p, hsa-let-7i-5p

2844
hsa-miR-369-3p, hsa-miR-424-5p, hsa-miR-32-3p, hsa-
76.67
86.19
63.33

miR-202-5p, hsa-miR-410-3p, hsa-miR-744-5p, hsa-miR-

150-5p, hsa-miR-15a-5p, hsa-miR-433-3p, hsa-miR-629-

5p

2845
combination 2591 + rs13335818
74.44
49.29
57.31

2846
combination 2592 + rs11647727
83.61
85.32
75.17

2847
combination 2595 + rs4297685
95.28
98.33
85.85

2848
combination 2596 + rs4297685
95.28
96.9
87.82

2849
combination 2597 + rs4297685
95.28
98.33
89.49

2850
combination 2598 + rs13335818
93.06
98.33
89.37

2851
combination 2598 + rs4293393
90.83
90.71
80

2852
combination 2599 + rs4297685
95.28
98.57
89.31

2853
combination 2599 + rs4293393
90.83
90.71
86.51

2854
combination 2600 + rs13335818
97.5
100
89.31

2855
combination 2600 + rs4293393
90.83
91.03
83.44

2856
combination 2601 + rs13335818
93.06
98.57
94.09

2857
combination 2601 + rs4293393
93.06
93.81
87.15

2858
combination 2602 + rs4297685
95.28
98.57
97.66

2859
combination 2603 + rs11647727
90.83
98.33
99.14

2860
combination 2604 + rs13335818
93.06
100
99.14

2861
combination 2605 + rs11647727
90.83
96.9
99.14

2862
combination 2617 + rs11647727
85.56
87.62
99.14

2863
combination 2818 + rs11647727
83.33
87.62
99.08

2864
combination 2819 + rs11647727
83.33
87.62
95.63

2865
combination 2591 + rs4293393
74.44
49.29
58.92

Through statistical analysis, the inventors demonstrated that UMOD variants are significantly associated with renal mass presence, malignancy, and aggressiveness in patients. The present data also revealed multiple potential biomarkers (miRNAs) of presence, stage, grade, and metastatic potential of RCC. The combined use of genetic and miRNAs data, together with clinical parameters, could have the unique potential to aid patient management in the setting of screening, diagnosis and therapeutic decision-making with respect to surgical and medical strategy and prognostic. The use of such combined biomarkers panel can lead to a tailored and personalized treatment to avoid unnecessary and associated wasteful costs. Then the present molecular tool can reduce the burden on public and private health care system.

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BIOMARKERS FOR RENAL CELL CARCINOMA

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