Biosynthesis of Thyrotropin Releasing Hormone

Information

• NSF Award
• 8706694

Owner

• NEW ENGLAND MEDICAL CENTER HOSPITALS, INC.

• Award Id

  8706694

• Award Effective Date

  8/15/1987 - 36 years ago

• Award Expiration Date

  1/1/1990 - 34 years ago

• Award Amount

  $ 122,004.00

• Award Instrument

  Standard Grant

Thyrotropin releasing hormone (TRH) plays a central role in the hopothalamic-pituitary-thyroid axis. Despite nearly twenty years of work, virtually nothing is known about the regulation of TRH production. Dr. Goodman and collaborators propose to use a recently isolated TRH cDNA and TRH-producing cell line to characterize the factors and mechanisms that underlie TRH biosynthesis. He will use intact animals to compare TRH-like mRNAs in discrete brain regions and a rat cell line to identify agents that affect TRH biosynthesis and secretion. He will also test whether the TRH precursor can generate peptides in addition to TRH that affect pituitary function. Finally, he will use the TRH-producing cell line to identify the components of the TRH gene that are important for regulated and tissue-specific expression. Elucidation of the factors and mechanisms that control TRH biosynthesis and secretion would greatly increase our understanding of how the brain regulates endocrine function.

• Program Officer

  name not available

• Min Amd Letter Date

  7/31/1987 - 36 years ago

• Max Amd Letter Date

  7/31/1987 - 36 years ago

• ARRA Amount

• Name

  New England Medical Center Hospitals Incorporated

• City

  Boston

• State

  MA

• Country

  United States

• Address

  750 Washington St. Box 817

• Postal Code

  021111526

• Phone Number

  6176369914

• First Name

  Richard

• Last Name

  Goodman

• Start Date

  8/15/1987 12:00:00 AM

• First Name

  Kevin

• Last Name

  Sevarino

• Start Date

  8/15/1987 12:00:00 AM

• First Name

  Malcolm

• Last Name

  Low

• Email Address

  low@ohsu.edu

• Start Date

  8/15/1987 12:00:00 AM

• Name

  Life Science Biological

• Code

  61